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Journal of Virology, ISSN 0022-538X, 2015, Volume 89, Issue 20, pp. 10176 - 10189
The pharmaceutical reactivation of dormant HIV-1 proviruses by histone deacetylase inhibitors (HDACi) represents a possible strategy to reduce the reservoir of... 
TYPE-1 REPLICATION | CYTOLYTIC ACTIVITY | INTERFERON-ALPHA | VIROLOGY | HEPATITIS-C VIRUS | IL28B GENOTYPE | SET-POINT | HISTONE DEACETYLASE INHIBITORS | LYMPHOCYTE-ACTIVATION | ELITE CONTROLLERS | I INTERFERON | Antigens, CD - immunology | Cell Count | Dendritic Cells - immunology | Humans | HIV Infections - enzymology | CD4-Positive T-Lymphocytes - enzymology | Histone Deacetylases - immunology | Antigens, CD - genetics | Virus Latency - drug effects | CD4-Positive T-Lymphocytes - immunology | HIV Infections - immunology | Interleukins - genetics | HIV-1 - growth & development | Interleukins - immunology | DNA, Viral - antagonists & inhibitors | Killer Cells, Natural - immunology | Dendritic Cells - drug effects | CD4-Positive T-Lymphocytes - virology | Dendritic Cells - virology | Panobinostat | Gene Expression | Drug Administration Schedule | Histone Deacetylases - genetics | Immunity, Innate - drug effects | HIV-1 - drug effects | Killer Cells, Natural - virology | HIV Infections - virology | Genotype | CD8-Positive T-Lymphocytes - enzymology | Killer Cells, Natural - enzymology | Antiretroviral Therapy, Highly Active | DNA, Viral - immunology | HIV-1 - immunology | CD8-Positive T-Lymphocytes - virology | Dendritic Cells - enzymology | CD8-Positive T-Lymphocytes - drug effects | HIV Infections - drug therapy | Hydroxamic Acids - therapeutic use | Indoles - therapeutic use | Histone Deacetylase Inhibitors - therapeutic use | Killer Cells, Natural - drug effects | CD8-Positive T-Lymphocytes - immunology | DNA, Viral - genetics | CD4-Positive T-Lymphocytes - drug effects
Journal Article
European Journal of Immunology, ISSN 0014-2980, 06/2017, Volume 47, Issue 6, pp. 932 - 945
The phosphoinositide phosphatase SHIP is a critical regulator of immune cell activation. Despite considerable study, the mechanisms controlling SHIP activity... 
Inhibitory receptors | Homeostasis | Signal transduction | Protein–protein interactions | Cellular activation | SYSTEMIC-LUPUS-ERYTHEMATOSUS | IMMUNOLOGY | Protein-protein interactions | FC-GAMMA-RIIB | B-CELLS | BRUTONS TYROSINE KINASE | NEGATIVE REGULATION | IN-VIVO | INOSITOL POLYPHOSPHATE 5-PHOSPHATASE | ANTIGEN RECEPTOR | DOMAIN-CONTAINING INOSITOL-5-PHOSPHATASE | HEMATOPOIETIC STEM | Mast Cells - immunology | B-Lymphocytes - enzymology | Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases - genetics | Phosphorylation | T-Lymphocytes - enzymology | Dendritic Cells - immunology | Humans | Gene Expression Regulation | Phosphatidylinositol 3-Kinases - metabolism | Signal Transduction - genetics | Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases - chemistry | Mast Cells - enzymology | Killer Cells, Natural - enzymology | Macrophages - enzymology | Animals | B-Lymphocytes - immunology | Proteins - metabolism | Dendritic Cells - enzymology | Killer Cells, Natural - immunology | T-Lymphocytes - immunology | Mice | Macrophages - immunology | Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases - metabolism | Phosphatases | Dendritic cells | Cellular signal transduction | B cells | T cells | Health aspects | Phosphatidylinositol 3,4,5-triphosphate | Disorders | Activation | Lymphocytes T | T cell receptors | Macrophages | Phosphatase | Modulators | Fc receptors | Receptors | Cell activation | Control | Enzymatic activity | Lymphocytes B | Lymphocytes | Ships | Mast cells | Receptor mechanisms | Brakes | Inositol-1,4,5-trisphosphate 5-phosphatase | Activation analysis | Immune system
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 02/2010, Volume 159, Issue 4, pp. 842 - 855
Background and purpose:  Apremilast is an orally administered phosphodiesterase-4 inhibitor, currently in phase 2 clinical studies of psoriasis and other... 
immunopharmacology | anti-inflammatory drugs | PDE inhibitor | chemokines | inflammation | skin pharmacology | anti‐inflammatory drugs | Skin pharmacology | Inflammation | Anti-inflammatory drugs | Immunopharmacology | Chemokines | TRANSCRIPTION FACTORS | DIFFERENTIAL EXPRESSION | ELEMENT-BINDING PROTEIN | NECROSIS-FACTOR-ALPHA | PERITONEAL-MACROPHAGES | PDE4 INHIBITORS | OBSTRUCTIVE PULMONARY-DISEASE | CYCLIC-AMP PHOSPHODIESTERASE | PHARMACOLOGY & PHARMACY | NF-KAPPA-B | PLAQUE-TYPE PSORIASIS | Humans | Middle Aged | Thalidomide - pharmacology | RNA, Messenger - metabolism | Zymosan - metabolism | Thalidomide - analogs & derivatives | Ultraviolet Rays | Psoriasis - pathology | Time Factors | U937 Cells | Anti-Inflammatory Agents - administration & dosage | Skin Transplantation | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Cytokines - genetics | Keratinocytes - enzymology | Disease Models, Animal | Psoriasis - immunology | Leukocytes, Mononuclear - drug effects | Psoriasis - drug therapy | Administration, Oral | Anti-Inflammatory Agents - pharmacology | Thalidomide - administration & dosage | Skin - enzymology | Keratinocytes - immunology | Killer Cells, Natural - enzymology | Keratinocytes - drug effects | Lipopolysaccharides - pharmacology | Killer Cells, Natural - drug effects | Mice | Transplantation, Heterologous | Dose-Response Relationship, Drug | Psoriasis - genetics | Enterotoxins - immunology | Leukocytes, Mononuclear - immunology | Inflammation Mediators - metabolism | Phosphodiesterase 4 Inhibitors | Killer Cells, Natural - immunology | Adult | Skin - pathology | Skin - immunology | Severity of Illness Index | Cytokines - metabolism | Phosphodiesterase Inhibitors - pharmacology | Mice, SCID | Gene Expression Regulation - drug effects | Phosphodiesterase Inhibitors - administration & dosage | Animals | Skin - radiation effects | Leukocytes, Mononuclear - enzymology | Cell Proliferation - drug effects | Psoriasis - enzymology | Skin - drug effects | Psoriasis | Tumor necrosis factor-TNF | Rodents | Research Papers
Journal Article
Clinical Immunology, ISSN 1521-6616, 2013, Volume 149, Issue 3, pp. 556 - 565
Abstract PTPN22 is a protein tyrosine phosphatase expressed by the majority of cells belonging to the innate and adaptive immune systems. Polymorphisms in... 
Allergy and Immunology | Autoimmunity | Genetic predisposition | T regulatory cells (Treg) | PTPN22 | Autoreactive cells | Immune tolerance | RHEUMATOID-ARTHRITIS | ALLELE | SYSTEMIC-LUPUS-ERYTHEMATOSUS | IMMUNOLOGY | VARIANT | R620W POLYMORPHISM | INTERFERON | NK CELLS | REGULATORY T-CELLS | SUSCEPTIBILITY GENE | ASSOCIATION | T-Lymphocytes - enzymology | Dendritic Cells - immunology | Humans | Dendritic Cells - pathology | Killer Cells, Natural - pathology | Monocytes - immunology | Isoenzymes - metabolism | Lupus Erythematosus, Systemic - immunology | Monocytes - pathology | Killer Cells, Natural - immunology | Cell Differentiation | B-Lymphocytes - pathology | Diabetes Mellitus, Type 1 - immunology | T-Lymphocytes - pathology | Adaptive Immunity | Diabetes Mellitus, Type 1 - enzymology | Lupus Erythematosus, Systemic - enzymology | B-Lymphocytes - enzymology | Isoenzymes - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 22 - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 22 - metabolism | Diabetes Mellitus, Type 1 - pathology | Arthritis, Rheumatoid - enzymology | Immunity, Innate | Arthritis, Rheumatoid - pathology | Killer Cells, Natural - enzymology | Polymorphism, Genetic | Monocytes - enzymology | Animals | B-Lymphocytes - immunology | Dendritic Cells - enzymology | T-Lymphocytes - immunology | Arthritis, Rheumatoid - immunology | Lupus Erythematosus, Systemic - pathology | Tyrosine | Rheumatoid factor | Phosphatases | Dendritic cells | Type 1 diabetes | Phenols
Journal Article
Blood, ISSN 0006-4971, 12/2014, Volume 124, Issue 24, pp. 3583 - 3586
Chronic lymphocytic leukemia (CLL) displays constitutive phosphatidylinositol 3-kinase (PI3K) activation resulting from aberrant regulation of B-cell receptor... 
IBRUTINIB | MODELS | INHIBITOR | HEMATOLOGY | THERAPEUTIC TARGET | Class I Phosphatidylinositol 3-Kinases - genetics | Class I Phosphatidylinositol 3-Kinases - metabolism | T-Lymphocytes - enzymology | Class Ib Phosphatidylinositol 3-Kinase - genetics | Protein-Tyrosine Kinases - metabolism | Humans | Cell Survival - genetics | Male | Neoplasm Proteins - antagonists & inhibitors | Killer Cells, Natural - pathology | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Mutation, Missense | Neoplasm Proteins - metabolism | Protein-Tyrosine Kinases - genetics | Isoquinolines - pharmacology | Female | Antineoplastic Agents - pharmacology | B-Lymphocytes - pathology | T-Lymphocytes - pathology | Tumor Cells, Cultured | Neoplasm Proteins - genetics | Pyrazoles - pharmacology | Cell Survival - drug effects | B-Lymphocytes - enzymology | Purines - pharmacology | Enzyme Inhibitors - pharmacology | Signal Transduction - genetics | Pyrimidines - pharmacology | Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Killer Cells, Natural - enzymology | Drug Resistance, Neoplasm - genetics | Leukemia, Lymphocytic, Chronic, B-Cell - enzymology | Signal Transduction - drug effects | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Amino Acid Substitution | Drug Resistance, Neoplasm - drug effects | Lymphoid Neoplasia | Brief Report
Journal Article
Journal Article
Blood, ISSN 0006-4971, 01/2007, Volume 109, Issue 1, pp. 71 - 77
Journal Article