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Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 4/2003, Volume 161, Issue 2, pp. 281 - 294
The proper segregation of sister chromatids in mitosis depends on bipolar attachment of all chromosomes to the mitotic spindle. We have identified the small... 
Mitosis | Kinetochores | Chromatids | Microtubules | HeLa cells | Cellular immunity | Chromosomes | Anaphase | Cells | Mitotic spindle apparatus | Chemical biology | Spindle assembly checkpoint | Chromosome segregation | KINASE-ACTIVITY | MAD2 | BUDDING YEAST | spindle assembly checkpoint | TENSION | G/M TRANSITION | mitosis | HISTONE H3 PHOSPHORYLATION | MAMMALIAN-CELLS | CELL BIOLOGY | kinetochores | chromosome segregation | chemical biology | VERTEBRATE SOMATIC-CELLS | Cell Cycle Proteins - drug effects | Protein Kinases - metabolism | RNA, Small Interfering - genetics | Paclitaxel - pharmacology | Humans | Nocodazole - pharmacology | Chromosome Segregation - drug effects | Mitosis - genetics | Aurora Kinase B | Microtubules - drug effects | Spindle Apparatus - genetics | Cell Cycle Proteins - genetics | Genes, cdc - physiology | Indoles - pharmacology | Kinetochores - enzymology | Protein-Serine-Threonine Kinases - metabolism | Aneugens - pharmacology | Eukaryotic Cells - enzymology | Polyploidy | Protein Kinases - drug effects | Separase | Protein-Serine-Threonine Kinases - genetics | Genes, cdc - drug effects | Aurora Kinases | Pyrimidines - pharmacology | Sulfonamides - pharmacology | Anaphase - drug effects | Phenotype | Anaphase - genetics | Animals | Eukaryotic Cells - drug effects | Mitosis - drug effects | Microtubules - genetics | Microtubules - enzymology | Protein-Serine-Threonine Kinases - drug effects | Eukaryotic Cells - cytology | Kinetochores - drug effects | Spindle Apparatus - drug effects | HeLa Cells | Thiones - pharmacology | Endopeptidases | Chromosome Segregation - genetics | Spindle Apparatus - enzymology | Research | mitosis; chromosome segregation; kinetochores; spindle assembly checkpoint; chemical biology
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 4/2003, Volume 161, Issue 2, pp. 267 - 280
The Aurora/Ipl1 family of protein kinases plays multiple roles in mitosis and cytokinesis. Here, we describe ZM447439, a novel selective Aurora kinase... 
Mitotic index | Mitosis | Kinetochores | Microtubules | DNA | Cell lines | HeLa cells | Cultured cells | Chromosomes | Cells | Chemical biology | Aneuploidy | Spindle checkpoint | ZM447439 | KINASE-ACTIVITY | LOCALIZATION | BUDDING YEAST | PHOSPHORYLATION | TENSION | mitosis | MAMMALIAN-CELLS | CELL BIOLOGY | chemical biology | CENTROSOME AMPLIFICATION | HISTONE H3 | aneuploidy | spindle checkpoint | Protein Kinases - metabolism | Protein Kinases - genetics | Paclitaxel - pharmacology | DNA Replication - drug effects | Humans | Chromosome Segregation - drug effects | Mitosis - genetics | Tumor Suppressor Protein p53 - genetics | Aurora Kinase B | Spindle Apparatus - genetics | Eukaryotic Cells - ultrastructure | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Benzamides - pharmacology | Mad2 Proteins | Phosphorylation - drug effects | Calcium-Binding Proteins - metabolism | Eukaryotic Cells - enzymology | Chromosomal Proteins, Non-Histone - metabolism | Kinetochores - metabolism | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Repressor Proteins - genetics | Genes, cdc - drug effects | Aurora Kinases | Tumor Suppressor Protein p53 - drug effects | Anaphase - drug effects | Chromosomal Proteins, Non-Histone - genetics | Anaphase - genetics | Eukaryotic Cells - drug effects | Mitosis - drug effects | DNA Replication - genetics | Repressor Proteins - drug effects | Kinetochores - drug effects | Spindle Apparatus - drug effects | HeLa Cells | Quinazolines - pharmacology | Cell Cycle Proteins | Calcium-Binding Proteins - genetics | Chromosome Segregation - genetics | Research | Cytokinesis | Protein kinases | mitosis; spindle checkpoint; chemical biology; aneuploidy; ZM447439
Journal Article
New Phytologist, ISSN 0028-646X, 9/2015, Volume 207, Issue 4, pp. 1061 - 1074
Journal Article
Journal Article
The Plant Cell, ISSN 1040-4651, 9/2007, Volume 19, Issue 9, pp. 2763 - 2775
Controlling microtubule dynamics and spatial organization is a fundamental requirement of eukaryotic cell function. Members of the ORBIT/MAST/CLASP family of... 
Proteins | Dendritic cells | Microtubules | Epidermal cells | Plant roots | Fluorescence | Plants | Microtubule associated proteins | Animal cells | Plant cells | ROOT-CELLS | PLUS-END | BAND ORGANIZATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PLANT-CELLS | MICROFILAMENT CROSS-TALK | PLANT SCIENCES | CELL BIOLOGY | CORTICAL MICROTUBULES | CELLULOSE MICROFIBRIL ALIGNMENT | MITOTIC SPINDLE | DYNAMICS | HELICAL GROWTH | Microtubule-Associated Proteins - chemistry | Microtubule-Associated Proteins - genetics | Dinitrobenzenes - pharmacology | Phylogeny | Plant Epidermis - ultrastructure | Recombinant Fusion Proteins - metabolism | Plant Roots - drug effects | Microtubules - metabolism | Microtubules - drug effects | Plant Epidermis - cytology | Plant Leaves - drug effects | Plant Roots - growth & development | Cytokinesis - drug effects | Protein Structure, Tertiary | Green Fluorescent Proteins - metabolism | Arabidopsis Proteins - genetics | Arabidopsis - drug effects | Arabidopsis - cytology | Cell Size - drug effects | Plant Roots - cytology | Plant Epidermis - drug effects | Mutation - genetics | Cell Division - drug effects | Plant Leaves - cytology | Arabidopsis - metabolism | Arabidopsis - genetics | Gene Expression Regulation, Plant - drug effects | Mitosis - drug effects | Arabidopsis Proteins - chemistry | Cell Proliferation - drug effects | Interphase - drug effects | Plant Leaves - ultrastructure | Sulfanilamides - pharmacology | Arabidopsis thaliana | Growth | Mitosis | Kinetochores | Genetic aspects | Research | Properties | Observations | Gene expression
Journal Article
Cancer Letters, ISSN 0304-3835, 2017, Volume 403, pp. 74 - 85
Abstract Neuroblastoma is a biologically and clinically heterogeneous pediatric malignancy that includes a high-risk subset for which new therapeutic agents... 
Hematology, Oncology and Palliative Medicine | YK-4-279 | Chemotherapy | Drug resistance/synergy | Neuroblastoma | Mitosis | PROTEIN | KINASE | REARRANGEMENTS | LINES | TRIAL | THERAPY | ONCOLOGY | VINCRISTINE | GENES | HIGH-RISK NEUROBLASTOMA | PHASE-I | Vincristine - pharmacology | Paclitaxel - pharmacology | Apoptosis - drug effects | Drug Resistance, Multiple | Humans | Drug Resistance, Neoplasm | Aurora Kinase A - antagonists & inhibitors | Aurora Kinase A - metabolism | Tumor Suppressor Protein p53 - genetics | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Dose-Response Relationship, Drug | Transfection | RNA Interference | Time Factors | Inhibitory Concentration 50 | Prometaphase - drug effects | Indoles - pharmacology | Neuroblastoma - pathology | Neuroblastoma - genetics | Tumor Suppressor Protein p53 - metabolism | Spindle Apparatus - pathology | Pyrimidines - pharmacology | Azepines - pharmacology | Drug Synergism | Kinetochores - pathology | Mitosis - drug effects | Signal Transduction - drug effects | Neuroblastoma - drug therapy | Cell Line, Tumor | Antimitotic Agents - pharmacology | Kinetochores - drug effects | Neuroblastoma - metabolism | Protein Kinase Inhibitors - pharmacology | Spindle Apparatus - drug effects | Cell Cycle - drug effects | Cell death | Analysis | Development and progression | Lymphomas | Drug resistance | Tumor proteins | Mitogens | Cancer | Cell culture | Flow cytometry | Biotechnology | Transcription factors | Risk | Aurora kinase | Genomes | Malignancy | Kinases | Cancer therapies | Neuroblastoma cells | Proteins | Poisons | Molecules | Cell cycle | Paclitaxel | Acetylation | Drug dosages | Risk groups | Abnormalities | Extracellular signal-regulated kinase | Cell division | Pharmacology | Gene expression | Chemical compounds | Vincristine | Gene amplification | Inhibitors | Microtubules | Cell lines | Mutation | Spindles | Apoptosis | Index Medicus | TERT, Telomerase reverse transcriptase | GFP, green fluorescent protein | synergy | EGF, Epidermal growth factor | ERK, extracellular signal-regulated kinases | kDa, kilodaltons | QVD, quinolyl-valyl-O-methylaspartyl-(-2,6-difluorophenoxy)- methyl ketone | SDS-PAGE, sodium-dodecyl sulphate-polyacrylamide gel electrophoresis | RNase A, ribonuclease A | MTT, 3-(4,5-Dimethylthiazol-2-Yl)-2,5-Diphenyltetrazolium Bromide | ALK, Anaplastic Lymphoma kinase | pHH3, phospho-histone H3 (ser10) | PBS, Phosphate-buffered saline | Original | MAPK, mitogen-activated protein kinase | MEK, Mitogen-activated protein kinase kinase
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 08/2012, Volume 109, Issue 33, pp. E2205 - E2214
Journal Article
Cell Cycle, ISSN 1538-4101, 03/2010, Volume 9, Issue 6, pp. 1112 - 1121
Journal Article
Oncogene, ISSN 0950-9232, 01/2018, Volume 37, Issue 2, pp. 231 - 240
Highly expressed in cancer protein 1 (Hec1) is a subunit of the kinetochore (KT)-associated Ndc80 complex, which ensures proper segregation of sister... 
NDC80 COMPLEX | ATTACHMENT | CATASTROPHE | INSTABILITY | STABILITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | SPINDLE | HEC1 | CELL BIOLOGY | ANEUPLOIDY | ONCOLOGY | GENETICS & HEREDITY | DYNAMICS | BINDING-SITE | Apoptosis - drug effects | Humans | Male | Antineoplastic Agents - therapeutic use | Chromosome Segregation - drug effects | Protein Domains - drug effects | Microtubules - metabolism | Microtubules - drug effects | Computer Simulation | Inhibitory Concentration 50 | Antineoplastic Agents - pharmacology | Nuclear Proteins - genetics | Drug Screening Assays, Antitumor - methods | Kinetochores - metabolism | Chromosomal Instability - drug effects | Nuclear Proteins - metabolism | Antineoplastic Agents - chemistry | Nuclear Proteins - chemistry | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Chromosomal Instability - genetics | Animals | Mitosis - drug effects | Mice, Nude | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Molecular Docking Simulation | Neoplasms - pathology | Interphase - drug effects | Antimitotic agents | Care and treatment | Microtubules | Cancer cells | Dosage and administration | Diagnosis | Research | Antineoplastic agents | Chromosomes | Cancer | Sister chromatids | Microbiology | Interphase | Mitosis | Cytotoxicity | Aneuploidy | mRNA | Depolymerization | Proteins | Cell growth | Antitumor agents | Cellular biology | Cell death | Chromatids | Xenografts | Apoptosis | Original
Journal Article
Journal Article