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1. Full Text Discovery of ‘molecular switches’ within a GIRK activator scaffold that afford selective GIRK inhibitors
by Wen, Wandong and Wu, Wenjun and Romaine, Ian M and Kaufmann, Kristian and Du, Yu and Sulikowski, Gary A and Weaver, C. David and Lindsley, Craig W
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 08/2013, Volume 23, Issue 16, pp. 4562 - 4566
Activators | GIRK | Inhibitors | Thallium flux | Kir3.x | GIRK K | 3.x | Biotransformation | G Protein-Coupled Inwardly-Rectifying Potassium Channels - chemistry | Pharmaceutical Preparations - chemistry | Models, Molecular | Protein Binding | Molecular Structure | Structure-Activity Relationship | Pharmaceutical Preparations - chemical synthesis | Drug Discovery | G Protein-Coupled Inwardly-Rectifying Potassium Channels - antagonists & inhibitors | Index Medicus
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2. Full Text Increased functional coupling of 5-HT1A autoreceptors to GIRK channels in Tph2-/- mice
by Mlinar, Boris and Montalbano, Alberto and Waider, Jonas and Lesch, Klaus-Peter and Corradetti, Renato
European neuropsychopharmacology, ISSN 0924-977X, 12/2017, Volume 27, Issue 12, pp. 1258 - 1267
G-Protein | Kir3 Potassium Channel | 5-HT1A Receptor | Depression | Anxiety | Dorsal raphe | NEURONAL-ACTIVITY | PANIC DISORDER | ANTIDEPRESSANT-TREATMENT | BRAIN 5-HT | RECEPTOR GENE POLYMORPHISM | POSITRON-EMISSION-TOMOGRAPHY | IN-VIVO | MAJOR DEPRESSIVE DISORDER | DORSAL RAPHE NUCLEUS | SEROTONIN 1A BINDING | Neurosciences | Clinical Neurology | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Neurosciences & Neurology | Psychiatry | Science & Technology | Index Medicus
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3. Full Text GIRK channels modulate opioid-induced motor activity in a cell type- and subunit-dependent manner
by Kotecki, Lydia and Hearing, Matthew and McCall, Nora M and de Velasco, Ezequiel Marron Fernandez and Pravetoni, Marco and Arora, Devinder and Victoria, Nicole C and Munoz, Michaelanne B and Xia, Zhilian and Slesinger, Paul A and Weaver, C. David and Wickman, Kevin
The Journal of neuroscience, ISSN 0270-6474, 05/2015, Volume 35, Issue 18, pp. 7131 - 7142
Rostromedial tegmental area | Conditional knockout | Morphine | GIRK | Kir3 | Ventral tegmental area | Motor Activity - physiology | Ventral Tegmental Area - drug effects | Mice, Inbred C57BL | Analgesics, Opioid - pharmacology | GABAergic Neurons - drug effects | Motor Activity - drug effects | GABAergic Neurons - physiology | G Protein-Coupled Inwardly-Rectifying Potassium Channels - physiology | Ventral Tegmental Area - physiology | Mice, Knockout | Dose-Response Relationship, Drug | Animals | Dopaminergic Neurons - drug effects | Dopaminergic Neurons - physiology | Mice | Protein Subunits - physiology | Index Medicus | ventral tegmental area | conditional knockout | rostromedial tegmental area | morphine
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4. Full Text Atrial GIRK channels mediate the effects of vagus nerve stimulation on heart rate dynamics and arrhythmogenesis
by Lee, Steven W and Anderson, Allison and Guzman, Pilar A and Nakano, Atsushi and Tolkacheva, Elena G and Wickman, Kevin
Frontiers in physiology, ISSN 1664-042X, 07/2018, Volume 9, pp. 943 - 943
GIRK channel | Parasympathetic | Arrhythmogenesis | Vagus nerve stimulation | Kir3 | Atrial | Life Sciences & Biomedicine | Physiology | Science & Technology | Heart beat | Research | Arrhythmia | Analysis | vagus nerve stimulation | atrial | parasympathetic | arrhythmogenesis
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5. Full Text Discovery and Characterization of VU0529331, a Synthetic Small-Molecule Activator of Homomeric G Protein-Gated, Inwardly Rectifying, Potassium (GIRK) Channels
by Kozek, Krystian A and Du, Yu and Sharma, Swagat and Prael, Francis J and Spitznagel, Brittany D and Kharade, Sujay V and Denton, Jerod S and Hopkins, Corey R and Weaver, C. David
ACS chemical neuroscience, ISSN 1948-7193, 01/2019, Volume 10, Issue 1, pp. 358 - 370
GIRK channel | small molecule | modulator | whole-cell patch-clamp electrophysiology | ion channel | high-throughput screening | activator | Kir3 | thallium flux assay | GIRK2 | Biochemistry & Molecular Biology | Neurosciences | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Neurosciences & Neurology | Chemistry, Medicinal | Science & Technology | Dose-Response Relationship, Drug | Pyrazines - chemistry | Ion Channel Gating - physiology | G Protein-Coupled Inwardly-Rectifying Potassium Channels - agonists | Humans | HEK293 Cells | G Protein-Coupled Inwardly-Rectifying Potassium Channels - metabolism | Drug Discovery - methods | Neurons - metabolism | Neurons - drug effects | Pyrazines - pharmacology | Ion Channel Gating - drug effects | Index Medicus
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6. Full Text GIRK Channel Activity in Dopamine Neurons of the Ventral Tegmental Area Bidirectionally Regulates Behavioral Sensitivity to Cocaine
by McCall, Nora M and de Velasco, Ezequiel Marron Fernandez and Wickman, Kevin
The Journal of neuroscience, ISSN 0270-6474, 05/2019, Volume 39, Issue 19, pp. 3600 - 3610
Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Drug abuse | Activation | Mental depression | Drug development | Proteins | Receptors | Anxiety | Behavior | Dopamine D2 receptors | Locomotor activity | Dopamine receptors | Ventral tegmentum | γ-Aminobutyric acid B receptors | Dopamine | Narcotics | Potassium channels (inwardly-rectifying) | Neurons | Therapeutic applications | Channel gating | Excitability | Locomotion | Signaling | Sensitivity | Mice | Cocaine | Neurotransmission | Index Medicus | VTA | Kir3 | dopamine | GABAB | D2 dopamine receptor | G protein
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7. Full Text G-Protein-Coupled inwardly Rectifying Potassium (GIRK) channel activation by the p75 neurotrophin receptor is required for amyloid β toxicity
by May, Linda M and Anggono, Victor and Gooch, Helen M and Jang, Se E and Matusica, Dusan and Kerbler, Georg M and Meunier, Frederic A and Sah, Pankaj and Coulson, Elizabeth J
Frontiers in neuroscience, ISSN 1662-4548, 08/2017, Volume 11, pp. 455 - 455
GIRK channel | Neurodegeneration | Amyloid β | Excitotoxicity | Kir3 | Potassium flux | Alzheimer's disease | p75 | Brain | Peptides | Neurodegenerative diseases | Potassium channels (inwardly-rectifying) | Neurons | Channel gating | Cognitive ability | Potassium channels | Kinases | Proteins | Signal transduction | Neurotoxicity | Brain-derived neurotrophic factor | Cell death | Degeneration | Alzheimers disease | Apoptosis | neurodegeneration | p75NTR | excitotoxicity | amyloid β | potassium flux
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8. Full Text Cholesterol-Binding Sites in GIRK Channels: The Devil is in the Details
by Rosenhouse-Dantsker, Avia
Lipid insights, ISSN 1178-6353, 02/2018, Volume 11, pp. 1178635317754071 - 1178635317754071
channel modulation | GIRK channel | Kir3 channel | ion channel | protein-lipid interaction | structure-function | membrane protein | potassium channel | G protein–gated inwardly rectifying potassium channels | Cholesterol | Residues | Authorship | Nucleotide sequence | Potassium channels (inwardly-rectifying) | Channel gating | Helices | Potassium channels | Proteins | Computer applications | Ion channels | Mutation | Potassium | Hippocampus | Binding sites
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9. Full Text G Protein-Activated (GIRK) Current in Rat Ventricular Myocytes is Masked by Constitutive Inward Rectifier Current (IK1)
by Beckmann, Christian and Rinne, Andreas and Littwitz, Christoph and Mintert, Elisa and Bösche, Leif I and Kienitz, Marie-Cécile and Pott, Lutz and Bender, Kirsten
Cellular physiology and biochemistry, ISSN 1015-8987, 04/2008, Volume 21, Issue 4, pp. 259 - 268
Original Paper | Gene transfer | Inward rectifier | channel | GIRK | siRNA | Cardiac myocytes | Kir2, Kir3 | Physiology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | RNA, Small Interfering - genetics | Myocytes, Cardiac - cytology | Cell Survival | Cells, Cultured | Electrophysiology | Rats | Potassium Channels, Inwardly Rectifying - genetics | Arteries - metabolism | Patch-Clamp Techniques | Animals | G Protein-Coupled Inwardly-Rectifying Potassium Channels - metabolism | Myocytes, Cardiac - metabolism | Potassium Channels, Inwardly Rectifying - metabolism | Index Medicus
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10. Full Text Pre‐ and postsynaptic regulation of locus coeruleus neurons after chronic morphine treatment: a study of GIRK‐knockout mice
by Torrecilla, Maria and Quillinan, Nidia and Williams, John T and Wickman, Kevin
The European journal of neuroscience, ISSN 0953-816X, 08/2008, Volume 28, Issue 3, pp. 618 - 624
dependence | withdrawal | Kir3 | tolerance | opioid | Opioid | Tolerance | Withdrawal | Dependence | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Membrane Potentials - drug effects | Morphine - pharmacology | Locus Coeruleus - drug effects | Locus Coeruleus - physiology | Male | G Protein-Coupled Inwardly-Rectifying Potassium Channels - genetics | Membrane Potentials - physiology | Mice, Knockout | Patch-Clamp Techniques | Animals | Locus Coeruleus - cytology | Colforsin - metabolism | Neurons - physiology | G Protein-Coupled Inwardly-Rectifying Potassium Channels - metabolism | Female | Mice | Narcotics - pharmacology | Neurons - drug effects | Cyclic AMP - metabolism | Neurons | Morphine | Index Medicus
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11. Full Text GIRK Channels: A Potential Link Between Learning and Addiction
by Tipps, Megan E and Buck, Kari J
International Review of Neurobiology, ISSN 0074-7742, 2015, Volume 123, pp. 239 - 277
Learning | Depotentiation | Addiction | Memory | Synaptic plasticity | Homeostatic plasticity | GIRK | Kir3 | Learning - physiology | Substance-Related Disorders - metabolism | Animals | Neuronal Plasticity - physiology | Humans | G Protein-Coupled Inwardly-Rectifying Potassium Channels - metabolism | Neurons - metabolism | Behavior, Addictive - metabolism | Index Medicus
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12. Full Text GPCR-dependent biasing of GIRK channel signaling dynamics by RGS6 in mouse sinoatrial nodal cells
by Anderson, Allison and Masuho, Ikuo and De Velasco, Ezequiel Marron Fernandez and Nakano, Atsushi and Birnbaumer, Lutz and Birnbaumer, Lutz and Martemyanov, Kirill A and Wickman, Kevin
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 06/2020, Volume 117, Issue 25, pp. 14522 - 14531
Heart rate | Adenosine | Muscarinic | Kir3 | G protein | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Medical examination | Analysis | Sinoatrial node | Cellular signal transduction | G proteins | Properties | Muscarinic receptors | Heart | Surgical implants | Bioluminescence | Amplitudes | Deactivation | G protein-coupled receptors | Acetylcholine receptors (muscarinic) | Potassium channels (inwardly-rectifying) | Catalytic activity | Ablation | Substrates | Proteins | Signaling | Receptors | Pacemakers | Isoforms | Reaction kinetics | Substrate preferences | Sensitivity enhancement | Kinetics | Receptor mechanisms | Coupling | Energy transfer | Index Medicus | adenosine | Biological Sciences | muscarinic | heart rate
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