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kiss-1 (348) 348
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endocrinology & metabolism (244) 244
kisspeptins (221) 221
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expression (154) 154
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kiss-1 peptide (125) 125
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rats (108) 108
kisspeptins - metabolism (105) 105
receptors, g-protein-coupled - metabolism (105) 105
reproduction (104) 104
receptors, g-protein-coupled - genetics (99) 99
hypogonadotropic hypogonadism (98) 98
mice (95) 95
hormones, hormone substitutes, and hormone antagonists (83) 83
pituitary-gonadal axis (82) 82
hypothalamus (81) 81
neurosciences (81) 81
monkey macaca-mulatta (79) 79
metastin (78) 78
hypothalamic kiss-1 system (77) 77
kiss-1 messenger-rna (76) 76
arcuate nucleus (74) 74
gonadotropin-releasing hormone - metabolism (74) 74
natural ligand (74) 74
reproductive biology (74) 74
hypothalamus - metabolism (73) 73
biochemistry & molecular biology (71) 71
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gene expression (70) 70
neurons - metabolism (70) 70
secretion (70) 70
reproduction - physiology (69) 69
metastasis (67) 67
adult (65) 65
peptides (65) 65
tumor suppressor proteins - metabolism (62) 62
activation (61) 61
pregnancy (61) 61
cells (60) 60
gnrh (60) 60
luteinizing hormone - blood (60) 60
peptide (59) 59
kisspeptins - genetics (58) 58
gene (57) 57
gene-expression (57) 57
immunohistochemistry (56) 56
pharmacology & pharmacy (55) 55
endocrine system (54) 54
leptin (54) 54
gonadotropin-releasing hormone (53) 53
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rat (51) 51
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kiss1 (50) 50
kiss1 protein (50) 50
luteinizing hormone (50) 50
rats, wistar (50) 50
oncology (49) 49
reproductive axis (49) 49
research (49) 49
tumor suppressor proteins - genetics (49) 49
metastasis suppressor gene (48) 48
amino acid sequence (47) 47
abridged index medicus (46) 46
physiological aspects (46) 46
tumor suppressor proteins - physiology (44) 44
analysis (42) 42
kisspeptins - pharmacology (42) 42
obstetrics & gynecology (42) 42
gonadotropins (41) 41
molecular sequence data (41) 41
receptors, g-protein-coupled - physiology (41) 41
physiology (40) 40
signal transduction - physiology (40) 40
cancer (39) 39
luteinizing hormone - secretion (39) 39
proteins - metabolism (39) 39
receptor (39) 39
testosterone (39) 39
messenger-rna (38) 38
ribonucleic-acid expression (38) 38
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1. Full Text Kisspeptin immunoreactive cells of the ovine preoptic area and arcuate nucleus co-express estrogen receptor alpha
by Franceschini, I and Lomet, D and Cateau, M and Delsol, G and Tillet, Y and Caraty, A
Neuroscience Letters, ISSN 0304-3940, 07/2006, Volume 401, Issue 3, pp. 225 - 230
Kisspeptins are peptide ligands of the G protein-coupled receptor GPR54, recently shown to be essential to reproductive function. We have raised specific... 
KiSS-1 | Ovine | Estrogen receptor alpha | Hypothalamus | Antibody | ACTIVATION | antibody | GONADOTROPIN-RELEASING-HORMONE | GPR54 | estrogen receptor alpha | ovine | NEUROSCIENCES | KISS-1 PEPTIDE | MESSENGER-RIBONUCLEIC-ACID | GENE | PROTEIN-COUPLED RECEPTOR | NEURONS | EXPRESSION | hypothalamus | BRAIN | Tumor Suppressor Proteins - metabolism | Humans | Arcuate Nucleus of Hypothalamus - cytology | Preoptic Area - cytology | Kisspeptins | Immunohistochemistry - methods | Animals | Estrogen Receptor alpha - metabolism | Female | Sheep | Mice | Neurons - metabolism | Radioimmunoassay - methods | Phenols | Hormones | Peptides | Estradiol | Membrane proteins
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2. Full Text Experimental obesity and diabetes reduce male fertility: Potential involvement of hypothalamic Kiss-1, pituitary nitric oxide, serum vaspin and visfatin
by Abdel-Fadeil, Mahmoud R and Abd Allah, Eman S.H and Iraqy, Heba M and Elgamal, Dalia A and Abdel-Ghani, Mohammed A
Pathophysiology, ISSN 0928-4680, 2019
Reproductive dysfunction is a common consequence of both obesity and diabetes. This study investigated the impact of obesity and diabetes, alone or combined,... 
Vaspin | Obesity | Diabetes | Kiss-1 | Visfatin | Nitric oxide
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3. Full Text Ontogeny and mechanisms of action for the stimulatory effect of kisspeptin on gonadotropin-releasing hormone system of the rat
by Castellano, J.M and Navarro, V.M and Fernández-Fernández, R and Castaño, J.P and Malagón, M.M and Aguilar, E and Dieguez, C and Magni, P and Pinilla, L and Tena-Sempere, M
Molecular and Cellular Endocrinology, ISSN 0303-7207, 2006, Volume 257, pp. 75 - 83
Kisspeptins have recently emerged as essential regulators of gonadotropin secretion and puberty onset. These functions are primarily conducted by stimulation... 
KiSS-1 | Gonadotropins | Hypothalamus | Rat | GnRH | GPR54 | rat | CANCER CELLS | PORCINE SOMATOTROPE SUBPOPULATIONS | gonadotropins | HYPOTHALAMIC KISS-1 | NATURAL LIGAND | CELL BIOLOGY | PROTEIN-COUPLED RECEPTOR | KISS-1 MESSENGER-RNA | IN-VIVO | ENDOCRINOLOGY & METABOLISM | PITUITARY-GONADAL AXIS | GENE-EXPRESSION | REPRODUCTIVE AXIS | hypothalamus | Gonadotropin-Releasing Hormone - secretion | Cricetinae | Luteinizing Hormone - blood | Rats, Wistar | Rats | Male | Sexual Maturation - drug effects | Growth and Development - drug effects | Kisspeptins | Dose-Response Relationship, Drug | Animals | Animals, Newborn - growth & development | Gonadotropin-Releasing Hormone - metabolism | Female | Mice | Oligopeptides - pharmacology | CHO Cells | Luteinizing Hormone - secretion | Prostaglandins | Synthesis | Physiological aspects | Hormones | Universities and colleges | Phosphotransferases | Antitank weapons
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4. Full Text The KiSS-1 receptor GPR54 is essential for the development of the murine reproductive system
by Funes, Sandrine and Hedrick, Joseph A and Vassileva, Galya and Markowitz, Lisa and Abbondanzo, Susan and Golovko, Andrei and Yang, Shijun and Monsma, Frederick J and Gustafson, Eric L
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 2003, Volume 312, Issue 4, pp. 1357 - 1363
GPR54 is a G-protein-coupled receptor that displays a high percentage of identity in the transmembrane domains with the galanin receptors. The ligand for GPR54... 
KiSS-1 | Reproductive function | Metastin | GPR54 | Knockout mouse | BIOCHEMISTRY & MOLECULAR BIOLOGY | PLACENTA | TUMOR | IDENTIFICATION | HORMONE | BIOPHYSICS | PROTEIN-COUPLED RECEPTOR | CLONING | CELL-MIGRATION | GALANIN | METASTASIS-SUPPRESSOR GENE | HYPOGONADOTROPIC HYPOGONADISM | knockout mouse | reproductive function | metastin | Hypogonadism - pathology | Receptors, Neuropeptide - deficiency | Receptors, G-Protein-Coupled | Reproduction - physiology | Male | Receptors, Neuropeptide - metabolism | Sexual Maturation - physiology | Organ Specificity | Genitalia - embryology | Kisspeptins | Mice, Knockout | Tissue Distribution | Phenotype | Animals | Proteins - metabolism | Female | Genitalia - physiology | Hypogonadism - physiopathology | Mice | Mutation | Receptors, Kisspeptin-1 | Genitalia - cytology | KiSS-1 gene | GPR54 gene
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5. Full Text New frontiers in kisspeptin/GPR54 physiology as fundamental gatekeepers of reproductive function
by Roa, Juan and Aguilar, Enrique and Dieguez, Carlos and Pinilla, Leonor and Tena-Sempere, Manuel
Frontiers in Neuroendocrinology, ISSN 0091-3022, 2007, Volume 29, Issue 1, pp. 48 - 69
Abstract Identification, in late 2003, of inactivating mutations of the G protein-coupled receptor GPR54 as causative factor for absence of puberty and... 
Endocrinology & Metabolism | Kisspeptin | Puberty | Energy balance | Gonadotropin-releasing hormone (GnRH) | GPR54 | Leptin | KiSS-1 | Gonadotropins | Ovulation | Hypogonadism | HYPOTHALAMIC KISS-1 SYSTEM | MONKEY MACACA-MULATTA | kisspeptin | GONADOTROPIN-RELEASING-HORMONE | ESTROGEN-POSITIVE FEEDBACK | RIBONUCLEIC-ACID EXPRESSION | gonadotropins | gonadotropin-releasing hormone (GnRH) | energy balance | leptin | NEUROSCIENCES | LUTEINIZING-HORMONE | hypogonadism | ISOLATED HYPOGONADOTROPIC HYPOGONADISM | PROTEIN-COUPLED RECEPTOR | ENDOCRINOLOGY & METABOLISM | PITUITARY-GONADAL AXIS | puberty | METASTASIS-SUPPRESSOR GENE | ovulation | Ovulation - genetics | Gonads - physiology | Humans | Reproduction - genetics | Reproduction - physiology | Puberty - physiology | Kisspeptins | Puberty - genetics | Tumor Suppressor Proteins - physiology | Metabolic Networks and Pathways - genetics | Animals | Models, Biological | Tumor Suppressor Proteins - genetics | Metabolic Networks and Pathways - physiology | Receptors, G-Protein-Coupled - genetics | Hypothalamo-Hypophyseal System - physiology | Receptors, Kisspeptin-1 | Ovulation - physiology | Receptors, G-Protein-Coupled - physiology
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6. Full Text The role of kisspeptin system in cancer biology
by Stathaki, Martha and Stamatiou, Maria Evanthia and Magioris, George and Simantiris, Spyridon and Syrigos, Nikolaos and Dourakis, Spyridon and Koutsilieris, Michael and Armakolas, Athanasios
Critical Reviews in Oncology / Hematology, ISSN 1040-8428, 10/2019, Volume 142, pp. 130 - 140
Kisspeptins are a family of neuropeptides that are known to be critical in puberty initiation and ovulation. Apart from that kisspeptin derived peptides (KPs)... 
Kisspeptin | KiSS-1 | KiSS-1R | Metastases inhibition | Cancer | MOLECULAR-BIOLOGY | KISS-1 | MEDIATED TRANSFER | CELL LUNG-CANCER | BREAST-CANCER | ONCOLOGY | PROTEIN-COUPLED RECEPTOR | MECHANISTIC INSIGHTS | TUMOR-METASTASIS | KISS-1 EXPRESSION | PLASMA KISSPEPTIN | HEMATOLOGY | METASTASIS SUPPRESSOR GENE | Prevention | Medical colleges | Physiological aspects | Neuropeptides | Metastasis | G proteins | Drug resistance | Ovarian cancer
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7. Full Text Novel signals for the integration of energy balance and reproduction
by Fernandez-Fernandez, R and Martini, A.C and Navarro, V.M and Castellano, J.M and Dieguez, C and Aguilar, E and Pinilla, L and Tena-Sempere, M
Molecular and Cellular Endocrinology, ISSN 0303-7207, 2006, Volume 254, pp. 127 - 132
Although the close link between body weight and fertility has been known for eons, only recently have the peripheral signals and neuroendocrine networks... 
Energy balance | GH-secretagogue receptor (GHS-R) | Ghrelin | GPR54 | Leptin | KiSS-1 | Gonadotropins | GnRH | PYY 3-36 | PYY | ENDOGENOUS LIGAND | PYY3-36 | FOOD-INTAKE | GONADOTROPIN-SECRETION | PREPUBERTAL RATS | gonadotropins | energy balance | HYPOTHALAMIC KISS-1 | leptin | NEUROPEPTIDE-Y | CELL BIOLOGY | BODY-WEIGHT | ghrelin | IN-VITRO | GROWTH-HORMONE | LUTEINIZING-HORMONE SECRETION | ENDOCRINOLOGY & METABOLISM | Gonadotropins - physiology | Peptide Fragments | Humans | Reproduction - physiology | Gonadotropin-Releasing Hormone - physiology | Peptide YY - physiology | Puberty - physiology | Kisspeptins | Tumor Suppressor Proteins - physiology | Animals | Gastric Mucosa - secretion | Models, Biological | Signal Transduction - physiology | Appetite Regulation - physiology | Body Weight - physiology | Energy Metabolism - physiology | Peptide Hormones - physiology | Hormones
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8. Full Text Direct Pituitary Effects of Kisspeptin: Activation of Gonadotrophs and Somatotrophs and Stimulation of Luteinising Hormone and Growth Hormone Secretion
by Gutiérrez‐Pascual, E and Martínez‐Fuentes, A. J and Pinilla, L and Tena‐Sempere, M and Malagón, M. M and Castaño, J. P
Journal of Neuroendocrinology, ISSN 0953-8194, 07/2007, Volume 19, Issue 7, pp. 521 - 530
Recent, compelling evidence indicates that kisspeptins, the products of KiSS‐1 gene, and their receptor GPR54, represent key elements in the neuroendocrine... 
pituitary | Ca2 | gonadotrophs | KiSS | GPR54 | somatotrophs | Gonadotrophs | Somatotrophs | Pituitary | MALE-RAT | PORCINE SOMATOTROPES | HYPOTHALAMIC KISS-1 | NATURAL LIGAND | NEUROSCIENCES | PEPTIDE | PROTEIN-COUPLED RECEPTOR | KISS-1 MESSENGER-RNA | ENDOCRINOLOGY & METABOLISM | METASTASIS-SUPPRESSOR GENE | REPRODUCTIVE AXIS | Animals | Rats, Wistar | Fluorescent Antibody Technique | Rats | Tumor Suppressor Proteins - pharmacology | Female | Male | Pituitary Gland - secretion | Growth Hormone - secretion | Pituitary Gland - drug effects | Kisspeptins | Luteinizing Hormone - secretion | Physiological aspects | Analysis | Hormones
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9. Full Text Activation of Aryl Hydrocarbon Receptor by Kynurenine Impairs Progression and Metastasis of Neuroblastoma
by Wu, PY and Yu, IS and Lin, YC and Chang, YT and Chen, CC and Lin, KH and Tseng, TH and Kargren, M and Tai, YL and Shen, TL and Liu, YL and Wang, BJ and Chang, CH and Chen, WM and Juan, HF and Huang, SF and Chan, YY and Liao, YF and Hsu, WM and Lee, H
CANCER RESEARCH, ISSN 0008-5472, 11/2019, Volume 79, Issue 21, pp. 5550 - 5562
Neuroblastoma is the most common malignant disease of infancy, and amplification of the MYCN oncogene is closely associated with poor prognosis. Recently,... 
BREAST-CANCER CELLS | PROTEIN | MELANOMA | ONCOLOGY | GENE-EXPRESSION | N-MYC | AH RECEPTOR | KISS-1 EXPRESSION | PROLIFERATION | INDUCTION | IDENTIFICATION
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10. The Kiss-1/Kiss-1R complex as a negative regulator of cell motility and cancer metastasis (Review)
by Ji, Ke and Ye, Lin and Mason, Malcolm D and Jiang, Wen G
International Journal of Molecular Medicine, ISSN 1107-3756, 10/2013, Volume 32, Issue 4, pp. 747 - 754
Metastasis is a complex multistep process that involves the impairment of cell-cell adhesion in the neoplastic epithelium, invasion into adjacent tissues and... 
G protein-coupled receptor 54 | Kiss-1 receptor | Kiss-1 | Tumour metastasis suppressor | Invasion and migration | MEDICINE, RESEARCH & EXPERIMENTAL | SUPPRESSOR GENE KISS1 | tumour metastasis suppressor | MAP KINASE | OVARIAN-CANCER | invasion and migration | BREAST-CANCER | PROTEIN-COUPLED RECEPTOR | THYROID-CANCER | POOR-PROGNOSIS | PROSTATE-CANCER | MELANOMA-CELLS | EXPRESSION
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11. Full Text KiSS-1/kisspeptins and the metabolic control of reproduction: Physiologic roles and putative physiopathological implications
by Castellano, J.M and Roa, J and Luque, R.M and Dieguez, C and Aguilar, E and Pinilla, L and Tena-Sempere, M
Peptides, ISSN 0196-9781, 2009, Volume 30, Issue 1, pp. 139 - 145
It is well established that reproductive function is gated by the state of energy reserves of the organism; conditions of metabolic stress and energy... 
Energy balance | Mouse | Rat | GPR54 | Body weight | Leptin | KiSS-1 | gonadotropins | FSH | GnRH | Kisspeptins | HYPOTHALAMIC KISS-1 SYSTEM | GONADOTROPIN-SECRETION | FOOD-INTAKE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BODY-WEIGHT | LUTEINIZING-HORMONE SECRETION | FEMALE RATS | ENDOCRINOLOGY & METABOLISM | KISSPEPTIN | PHARMACOLOGY & PHARMACY | GnRH gonadotropins | LH-SECRETION | AXIS | Tumor Suppressor Proteins - metabolism | Animals | Energy Metabolism | Gonads - physiology | Receptors, G-Protein-Coupled - metabolism | Humans | Leptin - metabolism | Tumor Suppressor Proteins - genetics | Reproduction - physiology | Receptors, G-Protein-Coupled - genetics | Hypothalamo-Hypophyseal System - physiology | Fertility - physiology | Glycoproteins | Anorexia nervosa | Hormones | Gonadotropin | Peptides | Membrane proteins
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12. Full Text Kisspeptin Signaling in the Brain
by Oakley, Amy E and Clifton, Donald K and Steiner, Robert A
Endocrine Reviews, ISSN 0163-769X, 10/2009, Volume 30, Issue 6, pp. 713 - 743
Kisspeptin (a product of the Kiss1 gene) and its receptor (GPR54 or Kiss1r) have emerged as key players in the regulation of reproduction. Mutations in humans... 
HOMOLOGOUS DOWN-REGULATION | ANTEROVENTRAL PERIVENTRICULAR NUCLEUS | HYPOTHALAMIC KISS-1 SYSTEM | MESSENGER-RIBONUCLEIC-ACID | MONKEY MACACA-MULATTA | GONADOTROPIN-RELEASING-HORMONE | ESTROGEN-POSITIVE FEEDBACK | ENDOCRINOLOGY & METABOLISM | FOLLICLE-STIMULATING-HORMONE | METASTASIS-SUPPRESSOR GENE | PROTEIN-COUPLED-RECEPTOR | Mammals - metabolism | Fishes - metabolism | Tumor Suppressor Proteins - metabolism | Signal Transduction | Zebrafish Proteins - metabolism | Humans | Terminology as Topic | Hypothalamo-Hypophyseal System - metabolism | Kisspeptins | Brain - metabolism | Tumor Suppressor Proteins - physiology | Reproduction | Animals | Proteins - metabolism | Neurons - metabolism
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13. Full Text Comparative N-glycoproteomic and phosphoproteomic profiling of human placental plasma membrane between normal and preeclampsia pregnancies with high-resolution mass spectrometry
by Wang, Fuqiang and Wang, Ling and Shi, Zhonghua and Liang, Gaolin
PLoS ONE, ISSN 1932-6203, 11/2013, Volume 8, Issue 11, p. e80480
Preeclampsia is a serious complication of pregnancy, which affects 2-8% of all pregnancies and is one of the leading causes of maternal and perinatal mortality... 
UTERINE ARTERY DOPPLER | METASTASIS SUPPRESSOR | LATE-ONSET PREECLAMPSIA | IN-VITRO | QUANTITATIVE PROTEOMICS | TROPHOBLAST INVASION | PROTEIN-COUPLED RECEPTOR | KISS-1 | MULTIDISCIPLINARY SCIENCES | EXPRESSION | SIGNALING NETWORKS | Immunohistochemistry | Humans | Computational Biology | Glycoproteins - metabolism | Receptors, Cell Surface - metabolism | Proteome | Phosphoproteins - metabolism | Pre-Eclampsia - pathology | Antigens, CD - metabolism | Placenta - metabolism | Pregnancy | Endoglin | Tandem Mass Spectrometry | Placenta - pathology | Female | Pre-Eclampsia - metabolism | Proteomics - methods | Chorion - metabolism | Proteins | Pregnant women | Mortality | Preeclampsia | Cell membranes | Comparative analysis | Health aspects | Reproductive health | High resolution | Phosphorylation | Profiling | Sucrose | Laboratories | Mass spectroscopy | Pre-eclampsia | Gene expression | Morbidity | Placenta | Molecular modelling | Proteomics | Mass spectrometry | Bioinformatics | Apoptosis | Veins & arteries
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14. Full Text Transcriptional expression of genes involved in cell invasion and migration by norn and tumoral trophoblast cells
by Janneau, Jean-Louis and Maldonado-Estrada, Juan and Tachdjian, Gérard and Miran, Isabelle and Motté, Nelly and Saulnier, Patrick and Sabourin, Jean-Christophe and Coté, Jean-François and Simon, Bénédicte and Frydman, René and Chaouat, Gérard and Bellet, Dominique
Journal of Clinical Endocrinology and Metabolism, ISSN 0021-972X, 11/2002, Volume 87, Issue 11, pp. 5336 - 5339
Once initiated, invasion of trophoblast cells must be tightly regulated. particularly in early pregnancy, The mechanisms necessary for the invasion and... 
KISS-1 | METASTASIS-SUPPRESSOR GENE | ENDOCRINOLOGY & METABOLISM
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