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Endocrinology, ISSN 0013-7227, 05/2014, Volume 155, Issue 5, pp. 1864 - 1873
The novel neuropeptide spexin (SPX) was discovered using bioinformatics. The function of this peptide is currently under investigation. Here, we identified SPX... 
RAT-TISSUES | EVOLUTION | MESSENGER-RNA | ENDOCRINOLOGY & METABOLISM | KISSPEPTIN | PROTEIN-COUPLED RECEPTORS | PREOPTIC AREA | DENTATE GYRUS | EXPRESSION | HORMONE RELEASE | PEPTIDE | Gene Duplication | Receptors, G-Protein-Coupled - metabolism | Humans | Kisspeptins - chemistry | Synteny | Galanin - chemistry | Phylogeny | Receptor, Galanin, Type 3 - agonists | Receptor, Galanin, Type 3 - genetics | Peptide Hormones - genetics | Galanin - metabolism | Peptide Hormones - metabolism | Kisspeptins - genetics | Protein Isoforms - metabolism | Protein Isoforms - chemistry | Databases, Protein | HEK293 Cells | Receptor, Galanin, Type 2 - chemistry | Receptor, Galanin, Type 2 - genetics | Peptide Hormones - chemistry | Neuropeptides - genetics | Receptor, Galanin, Type 1 - chemistry | Recombinant Proteins - metabolism | Zebrafish Proteins - chemistry | Zebrafish Proteins - metabolism | Receptor, Galanin, Type 3 - chemistry | Recombinant Proteins - chemistry | Neuropeptides - metabolism | Receptor, Galanin, Type 3 - metabolism | Chromosome Mapping | Receptor, Galanin, Type 1 - agonists | Kisspeptins - metabolism | Sequence Alignment | Animals | Receptor, Galanin, Type 1 - genetics | Receptor, Galanin, Type 2 - agonists | Ligands | Receptor, Galanin, Type 2 - metabolism | Receptor, Galanin, Type 1 - metabolism | Receptors, G-Protein-Coupled - genetics | Zebrafish Proteins - genetics | Galanin - genetics | Receptors, Kisspeptin-1 | Databases, Nucleic Acid | Receptors, G-Protein-Coupled - chemistry | Evolution, Molecular | Neuropeptides - chemistry | Protein Isoforms - genetics
Journal Article
Peptides, ISSN 0196-9781, 09/2017, Volume 95, pp. 62 - 67
Journal Article
Endocrinology, ISSN 0013-7227, 01/2018, Volume 159, Issue 1, pp. 163 - 183
The kisspeptin neuronal system, which consists of a neuropeptide kisspeptin and its receptor Gpr54, is considered in mammals a key factor of reproductive... 
AFRICAN CICHLID FISH | MESSENGER-RNA EXPRESSION | ESTROGEN-RECEPTOR-ALPHA | ARGININE-VASOTOCIN | ONCORHYNCHUS-MYKISS | ENDOCRINOLOGY & METABOLISM | GOLDFISH CARASSIUS-AURATUS | PITUITARY-GONADAL AXIS | SEXUAL-BEHAVIOR | MEDAKA ORYZIAS-LATIPES | NEUROPEPTIDE-Y | Nerve Tissue Proteins - secretion | Gonads - physiology | Male | Neurons - cytology | Axons - physiology | Green Fluorescent Proteins - genetics | Preoptic Area - metabolism | Axons - secretion | Preoptic Area - cytology | Recombinant Fusion Proteins - metabolism | Hypothalamo-Hypophyseal System - secretion | Oryzias - metabolism | Fish Proteins - genetics | Gonads - cytology | Kisspeptins - genetics | Protein Isoforms - metabolism | Neurons - physiology | Pituitary Hormones - metabolism | Female | Receptors, Kisspeptin-1 - genetics | Neurons - metabolism | Oryzias - genetics | Hypothalamo-Hypophyseal System - physiology | Preoptic Area - physiology | Gonads - secretion | Green Fluorescent Proteins - metabolism | Axons - metabolism | Fish Proteins - metabolism | Pituitary Hormones - secretion | Fish Proteins - secretion | Gene Knockout Techniques | Kisspeptins - metabolism | Animals, Genetically Modified - metabolism | Nerve Tissue Proteins - genetics | Hypothalamo-Hypophyseal System - metabolism | Nerve Tissue Proteins - metabolism | Gonads - metabolism | Patch-Clamp Techniques | Animals | Hypothalamo-Hypophyseal System - cytology | Animals, Genetically Modified - genetics | Receptors, Kisspeptin-1 - metabolism | Recombinant Fusion Proteins - genetics | Crosses, Genetic | Evolution, Molecular | Protein Isoforms - genetics | Regulations | Genes | Gene regulation | Transgenic | Fluorescence | Neuropeptides | Hypothalamus | Fertility | Vasotocin | Genetic modification | Firing pattern | Preoptic area | Neurons | Birds | Pituitary (anterior) | Gonadotropins | Hypothalamic-pituitary-gonadal axis | Gene expression | Vertebrates | Pituitary | Green fluorescent protein | Gonadotropin-releasing hormone | In vivo methods and tests | Kiss1 protein | Cholecystokinin
Journal Article
Cellular Signalling, ISSN 0898-6568, 01/2018, Volume 42, pp. 1 - 10
The invasive and metastatic phenotypes of breast cancer correlate with high recurrence rates and poor survival outcomes. Transforming growth factor-β (TGFβ)... 
KiSS1 | Lymph node positive | p234 kisspeptin antagonist | TGFβ | MMP9 | Triple negative breast cancer | Cancer cell invasion | BLADDER-CANCER | METASTASIS-SUPPRESSOR GENES | GPR54 | KISSPEPTIN ANTAGONISTS | CELL BIOLOGY | EPITHELIAL-MESENCHYMAL TRANSITION | PROTEIN-COUPLED RECEPTOR | TUMOR-SUPPRESSOR | GROWTH-FACTOR | TGF beta | EXPRESSION | PROGRESSION | Adenocarcinoma - pathology | Humans | Gene Expression Regulation, Neoplastic | Extracellular Signal-Regulated MAP Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Kisspeptins - genetics | Matrix Metalloproteinase 9 - metabolism | Adenocarcinoma - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Protein Isoforms - metabolism | MCF-7 Cells | Matrix Metalloproteinase 9 - genetics | Smad2 Protein - genetics | Triple Negative Breast Neoplasms - pathology | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Female | Adenocarcinoma - genetics | Antineoplastic Agents - pharmacology | Kisspeptins - antagonists & inhibitors | Signal Transduction | Smad2 Protein - metabolism | Lymphatic Metastasis | Kisspeptins - metabolism | Cell Movement - drug effects | Adenocarcinoma - diagnosis | Feedback, Physiological | Transforming Growth Factor beta - genetics | Triple Negative Breast Neoplasms - genetics | Triple Negative Breast Neoplasms - diagnosis | Triple Negative Breast Neoplasms - metabolism | Cell Line, Tumor | Mitogen-Activated Protein Kinases - genetics | Cell Proliferation - drug effects | Kisspeptins - pharmacology | Transforming Growth Factor beta - metabolism | Mitogen-Activated Protein Kinases - metabolism | Protein Isoforms - genetics
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 02/2017, Volume 114, Issue 9, pp. 2413 - 2418
Mammalian reproductive function depends upon a neuroendocrine circuit that evokes the pulsatile release of gonadotropin hormones (luteinizing hormone and... 
Agouti-related peptide | Kisspeptin | Fertility | Leptin | Gonadotrophin-releasing hormone | ACTIVATION | kisspeptin | MULTIDISCIPLINARY SCIENCES | fertility | PROOPIOMELANOCORTIN NEURONS | MOUSE | PULSATILE LUTEINIZING-HORMONE | ARCUATE NUCLEUS | leptin | NEUROPEPTIDE-Y | AGOUTI-RELATED PROTEIN | gonadotrophin-releasing hormone | agouti-related peptide | GENE-EXPRESSION | OB-OB | MICE | Estrous Cycle - physiology | Leptin - metabolism | Male | Neurons - cytology | Optogenetics | Luteinizing Hormone - metabolism | Clozapine - pharmacology | Fertility - genetics | Kisspeptins - genetics | Fertility - drug effects | Female | Agouti-Related Protein - deficiency | Neurons - metabolism | Hypothalamus - drug effects | Neurons - drug effects | Starvation - genetics | Luteinizing Hormone - genetics | Circadian Clocks - drug effects | Signal Transduction | Gonadotropin-Releasing Hormone - genetics | Gene Expression Regulation | Reproduction - genetics | Mice, Transgenic | Leptin - genetics | Clozapine - analogs & derivatives | Kisspeptins - metabolism | Estrous Cycle - drug effects | Stereotaxic Techniques | Reproduction - drug effects | Animals | Hypothalamus - metabolism | Agouti-Related Protein - genetics | Gonadotropin-Releasing Hormone - metabolism | Mice | Circadian Clocks - physiology | Reproduction | Neurosciences | Hormones | Peptides | Neurons | Biological Sciences
Journal Article
Nature Genetics, ISSN 1061-4036, 03/2009, Volume 41, Issue 3, pp. 354 - 358
Journal Article
Molecular and Cellular Endocrinology, ISSN 0303-7207, 2009, Volume 312, Issue 1, pp. 61 - 71
Journal Article
Journal Article
Endocrinology, ISSN 0013-7227, 08/2013, Volume 154, Issue 8, pp. 2784 - 2794
Journal Article
Journal Article
Journal Article