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JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, ISSN 0098-7484, 09/2018, Volume 320, Issue 10, pp. 984 - 994
IMPORTANCE Extended-spectrum beta-lactamases mediate resistance to third-generation cephalosporins (eg, ceftriaxone) in Escherichia coli and Klebsiella... 
UNITED-STATES | MEDICINE, GENERAL & INTERNAL | EXTENDED-SPECTRUM | CEFEPIME | THERAPY | BACTEREMIA | LACTAMASE-PRODUCING ENTEROBACTERIACEAE | SPECTRUM BETA-LACTAMASES | EXTENSION | Escherichia coli Infections - mortality | Klebsiella pneumoniae - drug effects | Escherichia coli - drug effects | Humans | Middle Aged | Drug Resistance, Bacterial | Bacteremia - mortality | Ceftriaxone - pharmacology | Male | Cause of Death | Anti-Bacterial Agents - therapeutic use | Penicillanic Acid - therapeutic use | Adult | Female | Anti-Bacterial Agents - adverse effects | Meropenem | Penicillanic Acid - adverse effects | Thienamycins - adverse effects | Penicillanic Acid - analogs & derivatives | Thienamycins - therapeutic use | Escherichia coli Infections - drug therapy | Klebsiella Infections - drug therapy | Piperacillin, Tazobactam Drug Combination | Bacteremia - drug therapy | Piperacillin - adverse effects | Klebsiella Infections - mortality | Aged | Anti-Bacterial Agents - pharmacology | Piperacillin - therapeutic use | Klebsiella | Treatment outcome | Safety and security measures | Tazobactam | Escherichia coli | Patient outcomes | Analysis | Comparative analysis | Risk factors | Bacterial infections | Intravenous administration | Mortality | Clinical trials | Piperacillin-tazobactam | Infections | Ceftriaxone | Drug resistance | Patients | Side effects | Randomization | Cephalosporins | Piperacillin | Drug therapy | Blood diseases | Blood culture | Carbapenems | Index Medicus | Abridged Index Medicus | Original Investigation | Research
Journal Article
PLoS Pathogens, ISSN 1553-7366, 2014, Volume 10, Issue 5, pp. e1004152 - e1004152
Bacteria form multicellular communities known as biofilms that cause two thirds of all infections and demonstrate a 10 to 1000 fold increase in adaptive... 
BACTERIA | (P)PPGPP | ESCHERICHIA-COLI | ANTIBACTERIAL | MICROBIOLOGY | PPGPP | VIRULENCE | RELA | VIROLOGY | STRINGENT RESPONSE | PSEUDOMONAS | GROWTH | PARASITOLOGY | Klebsiella pneumoniae - drug effects | Salmonella typhimurium - growth & development | Escherichia coli - drug effects | Ligases - genetics | Pseudomonas aeruginosa - growth & development | Biofilms - growth & development | Burkholderia cenocepacia - genetics | Peptide Fragments - pharmacology | Genetic Complementation Test | Microbial Sensitivity Tests | Anti-Bacterial Agents - chemistry | Klebsiella pneumoniae - genetics | Salmonella typhimurium - drug effects | Stress, Physiological - drug effects | Escherichia coli - growth & development | Acinetobacter baumannii - growth & development | Methicillin-Resistant Staphylococcus aureus - genetics | Biofilms - drug effects | Burkholderia cenocepacia - growth & development | Salmonella typhimurium - genetics | Methicillin-Resistant Staphylococcus aureus - drug effects | Ligases - metabolism | Pseudomonas aeruginosa - drug effects | Methicillin-Resistant Staphylococcus aureus - growth & development | Pseudomonas aeruginosa - genetics | Burkholderia cenocepacia - drug effects | Escherichia coli - genetics | Klebsiella pneumoniae - growth & development | Anti-Bacterial Agents - pharmacology | Acinetobacter baumannii - drug effects | Acinetobacter baumannii - genetics | Antibiotics | Genetic aspects | Research | Planktonic bacteria | Microbial mats | Health aspects | Sugars | Monosaccharides | Index Medicus | Medical research | Biofilms | Peptides | Bacteria | Infections | Drug resistance | Stress response | Bacteriology
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2015, Volume 10, Issue 4, pp. e0124595 - e0124595
Staphylococcus aureus is a Gram-positive bacterium that has become the leading cause of hospital acquired infections in the US. Repurposing Food and Drug... 
INTRINSIC RESISTANCE | EFFLUX PUMP(S) | CAENORHABDITIS-ELEGANS | EVOLUTION | VIRULENCE FACTORS | PSEUDOMONAS-AERUGINOSA | MULTIDISCIPLINARY SCIENCES | MODEL HOST | MRSA | INHIBITORS | IDENTIFICATION | Oxyclozanide - pharmacology | Cell Survival - drug effects | Enterococcus faecium - drug effects | Microbial Viability - drug effects | Humans | Methicillin-Resistant Staphylococcus aureus - drug effects | Drug Repositioning | Erythrocytes - drug effects | Hep G2 Cells | Microbial Sensitivity Tests | Gram-Negative Bacteria - drug effects | Methicillin-Resistant Staphylococcus aureus - growth & development | Animals | Anthelmintics - pharmacology | Niclosamide - pharmacology | Gram-Negative Bacteria - growth & development | Erythrocytes - cytology | Sheep | Anti-Bacterial Agents - pharmacology | Enterococcus faecium - growth & development | Drug Resistance, Multiple, Bacterial - drug effects | Drugs | Veterinary supplies industry | Staphylococcus aureus infections | Cross infection | Nosocomial infections | Drug resistance | Comparative analysis | Health aspects | Antibacterial agents | Drug approval | Staphylococcus aureus | Klebsiella | Linezolid | Regulatory agencies | Antimicrobial activity | Low concentrations | Laboratories | Toxicity | Liver | Erythrocytes | Daptomycin | Niclosamide | Gram-positive bacteria | Clinical isolates | Genomes | Infections | Vancomycin | Drug development | Kinases | Veterinary medicine | Antiinfectives and antibacterials | Medical schools | Risk factors | Methicillin | Cell growth | Red blood cells | Pseudomonas aeruginosa | Bacteria | Biocompatibility | Pharmaceutical industry | Aerogenes | Staphylococcus infections | Antimicrobial agents | Bacteriology | Studies | Chemotherapy | Hospitals | Infectious diseases | Biofilms | Antibiotics | Hepatocytes | Minimum inhibitory concentration | Index Medicus
Journal Article
International Journal of Antimicrobial Agents, ISSN 0924-8579, 2013, Volume 43, Issue 1, pp. 52 - 59
Abstract Fosfomycin is active in vitro against extensively drug-resistant (XDR) and pandrug-resistant (PDR) Pseudomonas aeruginosa and Klebsiella pneumoniae... 
Infectious Disease | Klebsiella | Pseudomonas | Critically ill | XDR | Fosfomycin | PDR | DEFINITION | MORTALITY | INFECTIOUS DISEASES | COMBINATION THERAPY | MICROBIOLOGY | INTRAVENOUS FOSFOMYCIN | K.-PNEUMONIAE | IMPACT | PREDICTORS | PHARMACOLOGY & PHARMACY | KLEBSIELLA-PNEUMONIAE | ENTEROBACTERIACEAE | Klebsiella pneumoniae - isolation & purification | Pseudomonas aeruginosa - isolation & purification | Klebsiella pneumoniae - drug effects | Prospective Studies | Humans | Middle Aged | Minocycline - analogs & derivatives | Critical Illness | Male | Bacterial Proteins - secretion | Anti-Bacterial Agents - therapeutic use | Drug Therapy, Combination - adverse effects | Minocycline - adverse effects | Minocycline - therapeutic use | Pseudomonas aeruginosa - enzymology | Drug Resistance, Multiple, Bacterial | Aged, 80 and over | Adult | Colistin - therapeutic use | Female | Anti-Bacterial Agents - adverse effects | Colistin - adverse effects | Intensive Care Units | Fosfomycin - therapeutic use | Klebsiella Infections - drug therapy | Pseudomonas Infections - drug therapy | Fosfomycin - adverse effects | Treatment Outcome | Klebsiella Infections - microbiology | Pseudomonas aeruginosa - drug effects | Pseudomonas Infections - microbiology | beta-Lactamases - secretion | Administration, Intravenous | Drug Therapy, Combination - methods | Klebsiella pneumoniae - enzymology | Aged | Care and treatment | Pneumonia | Microbiology | Patient outcomes | Analysis | Bacterial pneumonia | Mortality | Bacteria | Drug resistance | Index Medicus
Journal Article
Journal Article
Journal of Infection, ISSN 0163-4453, 2014, Volume 69, Issue 3, pp. 266 - 277
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 458 - 8
Plasmid-borne colistin resistance mediated by mcr-1 may contribute to the dissemination of pan-resistant Gram-negative bacteria. Here, we show that mcr-1... 
STRAINS | ACINETOBACTER-BAUMANNII | GRAM-NEGATIVE BACTERIA | PHARMACOKINETICS | PSEUDOMONAS-AERUGINOSA | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | CRITICALLY-ILL PATIENTS | IN-VITRO SYNERGY | METHANESULFONATE | POLYMYXIN-B | Enterobacter aerogenes - drug effects | Enterobacter aerogenes - genetics | Klebsiella pneumoniae - drug effects | Escherichia coli - drug effects | Microbial Sensitivity Tests | Colistin - pharmacology | Klebsiella pneumoniae - genetics | Drug Resistance, Bacterial - genetics | Drug Therapy, Combination | Escherichia coli Infections - drug therapy | Enterobacter cloacae - drug effects | Enterobacter cloacae - genetics | Ethanolaminephosphotransferase - genetics | Klebsiella Infections - drug therapy | Enterobacteriaceae Infections - microbiology | Bacteremia - drug therapy | Enterobacteriaceae - genetics | Escherichia coli Infections - microbiology | Klebsiella Infections - microbiology | Animals | Escherichia coli - genetics | Enterobacteriaceae - drug effects | Escherichia coli Proteins - genetics | Anti-Bacterial Agents - pharmacology | Mice | Enterobacteriaceae Infections - drug therapy | Klebsiella | Breakpoints | Clarithromycin | Animal models | Colistin | Thigh | Gram-positive bacteria | Drug resistance | Bacteremia | Antibiotics | Cell death | Lysis | Bacteria | Gram-negative bacteria | Index Medicus
Journal Article
Lancet Infectious Diseases, The, ISSN 1473-3099, 2017, Volume 17, Issue 7, pp. 726 - 734
Journal Article
Hepatology, ISSN 0270-9139, 05/2012, Volume 55, Issue 5, pp. 1551 - 1561
Epidemiology, risk factors, and clinical effect of infections by multiresistant bacteria in cirrhosis are poorly known. This work was a prospective evaluation... 
PERITONITIS | LIVER-CIRRHOSIS | ACQUIRED INFECTIONS | ESCHERICHIA-COLI | ACQUISITION | RESISTANCE | HEPATORENAL-SYNDROME | SEPSIS | NORFLOXACIN PROPHYLAXIS | GASTROENTEROLOGY & HEPATOLOGY | KLEBSIELLA-PNEUMONIAE | Multivariate Analysis | Prevalence | Prognosis | Community-Acquired Infections - epidemiology | Gram-Positive Bacteria - drug effects | Humans | Middle Aged | Male | Enterobacteriaceae - isolation & purification | Gram-Negative Bacteria - isolation & purification | Liver Cirrhosis - epidemiology | Microbial Sensitivity Tests | Community-Acquired Infections - drug therapy | Drug Resistance, Multiple, Bacterial | Statistics, Nonparametric | Female | Retrospective Studies | beta-Lactamases - metabolism | Bacterial Infections - microbiology | Cross Infection - epidemiology | Liver Cirrhosis - diagnosis | Bacterial Infections - drug therapy | Methicillin-Resistant Staphylococcus aureus - drug effects | Risk Factors | Proportional Hazards Models | Cross Infection - drug therapy | Gram-Negative Bacteria - drug effects | Spain - epidemiology | Cross Infection - microbiology | Bacterial Infections - epidemiology | Enterobacteriaceae - drug effects | Survival Analysis | Gram-Positive Bacteria - isolation & purification | Liver Cirrhosis - microbiology | Aged | Methicillin-Resistant Staphylococcus aureus - isolation & purification | Community-Acquired Infections - microbiology | Cohort Studies | Bacterial infections | Antibiotics | Mortality | Bacteria | Staphylococcus infections | Nosocomial infections | Epidemiology | Index Medicus
Journal Article