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1. Full Text The real threat of Klebsiella pneumoniae carbapenemase-producing bacteria
by Nordmann, Patrice, MD and Cuzon, Gaelle, PharmD and Naas, Thierry, PhD
Lancet Infectious Diseases, The, ISSN 1473-3099, 2009, Volume 9, Issue 4, pp. 228 - 236
Summary From early this decade, Enterobacteriaceae that produce Klebsiella pneumoniae carbapenemases (KPC) were reported in the USA and subsequently worldwide.... 
Infectious Disease | CITROBACTER-FREUNDII | INFECTIOUS DISEASES | HYDROLYZING BETA-LACTAMASE | NEW-YORK-CITY | PSEUDOMONAS-AERUGINOSA | ESCHERICHIA-COLI | IMIPENEM RESISTANCE | ANTIMICROBIAL SURVEILLANCE PROGRAM | SERRATIA-MARCESCENS | ENTEROBACTER-CLOACAE | CLINICAL ISOLATE | Enterobacteriaceae - enzymology | Klebsiella Infections - epidemiology | Carbapenems - pharmacology | Klebsiella Infections - drug therapy | Klebsiella pneumoniae - drug effects | Drug Resistance, Multiple, Bacterial | Humans | Enterobacteriaceae - drug effects | Klebsiella pneumoniae - enzymology | Bacterial Proteins - metabolism | Klebsiella Infections - microbiology | beta-Lactamases - metabolism | Bacteria | Pneumonia | Antibacterial agents | Bacterial pneumonia
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2. Full Text Predictors of Mortality in Bloodstream Infections Caused by Klebsiella pneumoniae Carbapenemase—Producing K. pneumoniae: Importance of Combination Therapy
by Mario Tumbarello and Pierluigi Viale and Claudio Viscoli and Enrico Maria Trecarichi and Fabio Tumietto and Anna Marchese and Teresa Spanu and Simone Ambretti and Francesca Ginocchio and Francesco Cristini and Angela Raffaella Losito and Sara Tedeschi and Roberto Cauda and Matteo Bassetti
Clinical Infectious Diseases, ISSN 1058-4838, 10/2012, Volume 55, Issue 7, pp. 943 - 950
Background. The spread of Klebsiella pneumoniae (Kp) strains that produce K. pneumoniae carbapenemases (KPCs) has become a significant problem, and treatment... 
Health outcomes | Microbial sensitivity tests | Infectious diseases | Antimicrobials | Mortality | Septic shock | Infections | ARTICLES AND COMMENTARIES | Carbapenems | Klebsiella pneumoniae | Blood | MOLECULAR CHARACTERIZATION | INFECTIOUS DISEASES | MICROBIOLOGY | IMMUNOLOGY | EMERGENCE | KPC-2 CARBAPENEMASE | NEW-YORK-CITY | ANTIMICROBIAL TREATMENT | HOSPITALIZED ADULTS | OUTCOMES | SPREAD | EPIDEMIOLOGY | ENTEROBACTERIACEAE | Klebsiella pneumoniae - isolation & purification | Prognosis | Humans | Middle Aged | Bacteremia - mortality | Male | Bacterial Proteins - secretion | Bacteremia - microbiology | Anti-Bacterial Agents - therapeutic use | Aged, 80 and over | Adult | Female | Retrospective Studies | Severity of Illness Index | Risk Factors | Decision Support Techniques | Bacteremia - diagnosis | Klebsiella Infections - microbiology | beta-Lactamases - secretion | Drug Therapy, Combination - methods | Klebsiella pneumoniae - enzymology | Survival Analysis | Klebsiella Infections - diagnosis | Italy | Klebsiella Infections - mortality | Aged | Cohort Studies | Klebsiella infections | Blood-borne diseases | Patient outcomes | Dosage and administration | Research | Drug therapy, Combination | Drug therapy | Bacterial infections | Gram-negative bacteria | Clinical outcomes
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3. Full Text Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases
by Munoz-Price, L Silvia, Dr and Poirel, Laurent, PhD and Bonomo, Robert A, MD and Schwaber, Mitchell J, MD and Daikos, George L, MD and Cormican, Martin, PhD and Cornaglia, Giuseppe, MD and Garau, Javier, MD and Gniadkowski, Marek, PhD and Hayden, Mary K, MD and Kumarasamy, Karthikeyan, PhD and Livermore, David M, PhD and Maya, Juan J, MD and Nordmann, Patrice, PhD and Patel, Jean B, PhD and Paterson, David L, MD and Pitout, Johann, MD and Villegas, Maria Virginia, MD and Wang, Hui, PhD and Woodford, Neil, PhD and Quinn, John P, MD
Lancet Infectious Diseases, The, ISSN 1473-3099, 2013, Volume 13, Issue 9, pp. 785 - 796
Summary Klebsiella pneumoniae carbapenemases (KPCs) were originally identified in the USA in 1996. Since then, these versatile β-lactamases have spread... 
Infectious Disease | RESISTANT ENTEROBACTERIACEAE | UNITED-STATES | KPC-PRODUCING ENTEROBACTERIACEAE | INFECTIOUS DISEASES | HYDROLYZING BETA-LACTAMASE | GRAM-NEGATIVE BACILLI | ACUTE-CARE FACILITIES | NEW-YORK-CITY | PSEUDOMONAS-AERUGINOSA | ESCHERICHIA-COLI | K.-PNEUMONIAE | Geography | Klebsiella pneumoniae - isolation & purification | Klebsiella Infections - drug therapy | Klebsiella Infections - prevention & control | Minocycline - pharmacology | Humans | Minocycline - analogs & derivatives | Bacteremia - drug therapy | Treatment Outcome | Communicable Disease Control | Klebsiella Infections - epidemiology | Colistin - pharmacology | Klebsiella pneumoniae - enzymology | Bacterial Proteins - metabolism | Anti-Bacterial Agents - pharmacology | beta-Lactamases - metabolism | Aminoglycosides - pharmacology | Tigecycline | Beta lactamases | Pneumonia | Epidemiology | Bacterial pneumonia
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4. Full Text An Outbreak of Infection due to β-Lactamase Klebsiella pneumoniae Carbapenemase 2–Producing K. pneumoniae in a Greek University Hospital: Molecular Characterization, Epidemiology, and Outcomes
by Maria Souli and Irene Galani and Anastasia Antoniadou and Evangelos Papadomichelakis and Garyphallia Poulakou and Theofano Panagea and Sofia Vourli and Loukia Zerva and Apostolos Armaganidis and Kyriaki Kanellakopoulou and Helen Giamarellou
Clinical Infectious Diseases, ISSN 1058-4838, 2/2010, Volume 50, Issue 3, pp. 364 - 373
Background. We describe the emergence and spread of Klebsiella pneumoniae carbapenemase 2 (KPC-2)–producing K. pneumoniae at a Greek University hospital.... 
Intensive care units | Health outcomes | Microbial sensitivity tests | Antimicrobials | Hospital admissions | Hospital units | Infections | ARTICLES AND COMMENTARIES | Carbapenems | Klebsiella pneumoniae | Bacteremia | STRAINS | CRITERIA | INFECTIOUS DISEASES | KPC-2 | CONSENSUS CONFERENCE | SEQUENCE TYPE 258 | MICROBIOLOGY | SEPSIS | IMMUNOLOGY | EMERGENCE | DEFINITIONS | THERAPIES | NEW-YORK | Klebsiella pneumoniae - isolation & purification | beta-Lactam Resistance | DNA Fingerprinting | Humans | Middle Aged | Male | Klebsiella pneumoniae - classification | beta-Lactamases - biosynthesis | Microbial Sensitivity Tests | Anti-Bacterial Agents - therapeutic use | Klebsiella Infections - epidemiology | Disease Outbreaks | Bacterial Typing Techniques | Aged, 80 and over | Adult | Female | Intensive Care Units | Klebsiella Infections - drug therapy | Hospitals, University | Treatment Outcome | Greece - epidemiology | Klebsiella Infections - microbiology | Electrophoresis, Gel, Pulsed-Field | Molecular Epidemiology | Klebsiella pneumoniae - enzymology | Aged | Bacterial Proteins - biosynthesis
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5. Full Text Klebsiella pneumoniae Carbapenemase, Canada
by Pillai, Dylan R and Melano, Roberto and Rawte, Prasad and Lo, Stephen and Tijet, Nathalie and Fuksa, Milan and Roda, Nancy and Farrell, David J and Krajden, Sigmund
Emerging Infectious Diseases, ISSN 1080-6040, 05/2009, Volume 15, Issue 5, pp. 827 - 829
INFECTIOUS DISEASES | BETA-LACTAMASE | IMMUNOLOGY | Sputum - microbiology | beta-Lactam Resistance | Klebsiella pneumoniae - drug effects | Humans | Bacterial Proteins - genetics | Male | Klebsiella Infections - microbiology | beta-Lactamases - biosynthesis | Canada | Carbapenems - pharmacology | beta-Lactamases - genetics | Fatal Outcome | Klebsiella pneumoniae - enzymology | Klebsiella pneumoniae - genetics | Aged | Anti-Bacterial Agents - pharmacology | Bacterial Proteins - biosynthesis | Microbial Sensitivity Tests - methods | Urine - microbiology | Klebsiella | Beta lactamases | Genetic aspects | Research | Health aspects | Distribution | bacteria | letter | Letters to the Editor | Gram negative | Antimicrobial resistance | carbapenemase | respiratory infections
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6. Full Text Colistin-Resistant, Klebsiella pneumoniae Carbapenemase (KPC)—Producing Klebsiella pneumoniae Belonging to the International Epidemic Clone ST258
by Tatiana Bogdanovich and Jennifer M. Adams-Haduch and Guo-Bao Tian and Minh Hong Nguyen and Eun Jeong Kwak and Carlene A. Muto and Yohei Doi
Clinical Infectious Diseases, ISSN 1058-4838, 8/2011, Volume 53, Issue 4, pp. 373 - 376
Five cases of infection due to colistin-resistant, Klebsiella pneumoniae carbapenemase—producing K. pneumoniae belonging to the international epidemic clone... 
BRIEF REPORT | Epidemics | Intensive care units | Infectious diseases | Disease transmission | Infections | Klebsiella pneumoniae | Labor standards | Inoculum | Polymyxins | SEQUENCE TYPE 258 | INFECTIOUS DISEASES | MICROBIOLOGY | IMMUNOLOGY | POLYMYXIN-B | Klebsiella pneumoniae - isolation & purification | Klebsiella pneumoniae - drug effects | Humans | Klebsiella Infections - microbiology | beta-Lactamases - biosynthesis | Microbial Sensitivity Tests | Klebsiella Infections - epidemiology | beta-Lactams - pharmacology | Colistin - pharmacology | Cross Infection - microbiology | Drug Resistance, Multiple, Bacterial | Klebsiella pneumoniae - enzymology | Anti-Bacterial Agents - pharmacology | Bacterial Proteins - biosynthesis | Complications and side effects | Drug resistance in microorganisms | Klebsiella infections | Colistin | Distribution | Reports | Genetic aspects | Bacterial infections | Drug resistance | Cloning | Brief Reports
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7. Full Text Emergence and Rapid Regional Spread of Klebsiella pneumoniae Carbapenemase—Producing Enterobacteriaceae
by Sarah Y. Won and L. Silvia Munoz-Price and Karen Lolans and Bala Hota and Robert A. Weinstein and Mary K. Hayden and Ctr Dis Control & Prevention Epict and Centers for Disease Control and Prevention Epicenter Program and for the Centers for Disease Control and Prevention Epicenter Program
Clinical Infectious Diseases, ISSN 1058-4838, 9/2011, Volume 53, Issue 6, pp. 532 - 540
Background. Klebsiella pneumoniae carbapenemase (KPC)—producing Enterobacteriaceae are an emerging antibiotic resistance threat with demonstrated epidemic... 
Polymerase chain reaction | Nursing homes | Network analysis | Hospital admissions | Bacteria | Infections | Patient surveillance | Health care facilities | ARTICLES AND COMMENTARIES | Klebsiella pneumoniae | Enterobacteriaceae | UNITED-STATES | INFECTIOUS DISEASES | HYDROLYZING BETA-LACTAMASE | ESCHERICHIA-COLI | SEQUENCE TYPE 258 | ANTIBIOTIC-RESISTANCE | MICROBIOLOGY | ACUTE-CARE HOSPITALS | IMMUNOLOGY | RESISTANT-KLEBSIELLA | KPC CARBAPENEMASE | MOLECULAR EPIDEMIOLOGY | FIELD GEL-ELECTROPHORESIS | Klebsiella pneumoniae - isolation & purification | Klebsiella pneumoniae - drug effects | Humans | Middle Aged | Male | Multilocus Sequence Typing | beta-Lactamases - biosynthesis | Cross Infection - transmission | Indiana - epidemiology | Klebsiella Infections - epidemiology | Disease Outbreaks | Bacterial Typing Techniques | Drug Resistance, Multiple, Bacterial | Klebsiella pneumoniae - genetics | Aged, 80 and over | Female | Klebsiella Infections - transmission | Cross Infection - epidemiology | Klebsiella Infections - drug therapy | Klebsiella Infections - microbiology | Cross Infection - drug therapy | Contact Tracing | Illinois - epidemiology | Molecular Epidemiology | Cross Infection - microbiology | Klebsiella pneumoniae - enzymology | Aged | Bacterial Proteins - biosynthesis | Klebsiella infections | Enterobacteriaceae infections | Cross infection | Research | Nosocomial infections | Distribution | Epidemics | Hospitalization | Gram-negative bacteria | Drug resistance | Epidemiology
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8. Full Text Risk factors and clinical impact of klebsiella pneumoniae carbapenemase-producing K. pneumoniae
by Gasink, Leanne B and Edelstein, Paul H and Lautenbach, Ebbing and Synnestvedt, Marie and Fishman, Neil O
Infection Control and Hospital Epidemiology, ISSN 0899-823X, 12/2009, Volume 30, Issue 12, pp. 1180 - 1185
BACKGROUND. Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae is an emerging pathogen with serious clinical and infection control implications.... 
FLUOROQUINOLONE USE | INFECTIOUS DISEASES | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | BETA-LACTAMASE | KPC-2 | NEW-YORK-CITY | ACQUISITION | INTENSIVE-CARE UNITS | ANTIBIOTIC-RESISTANCE | INFECTION | RESISTANT PSEUDOMONAS-AERUGINOSA | EMERGENCE | beta-Lactam Resistance | Klebsiella Infections - drug therapy | Klebsiella pneumoniae - drug effects | Humans | Risk Factors | Male | Klebsiella Infections - microbiology | beta-Lactamases - biosynthesis | Case-Control Studies | Klebsiella pneumoniae - pathogenicity | Cross Infection - microbiology | Klebsiella pneumoniae - enzymology | Female | Klebsiella Infections - mortality | Bacterial Proteins - biosynthesis | Cohort Studies
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9. Full Text Efficacy of Ceftazidime-Avibactam Salvage Therapy in Patients With Infections Caused by Klebsiella pneumoniae Carbapenemase-producing K. pneumoniae
by Tumbarello, Mario and Trecarichi, Enrico Maria and Corona, Alberto and De Rosa, Francesco Giuseppe and Bassetti, Matteo and Mussini, Cristina and Menichetti, Francesco and Viscoli, Claudio and Campoli, Caterina and Venditti, Mario and De Gasperi, Andrea and Mularoni, Alessandra and Tascini, Carlo and Parruti, Giustino and Pallotto, Carlo and Sica, Simona and Concia, Ercole and Cultrera, Rosario and De Pascale, Gennaro and Capone, Alessandro and Antinori, Spinello and Corcione, Silvia and Righi, Elda and Losito, Angela Raffaella and Digaetano, Margherita and Amadori, Francesco and Giacobbe, Daniele Roberto and Ceccarelli, Giancarlo and Mazza, Ernestina and Raffaelli, Francesca and Spanu, Teresa and Cauda, Roberto and Viale, Pierluigi
Clinical Infectious Diseases, ISSN 1058-4838, 01/2019, Volume 68, Issue 3, pp. 355 - 364
Abstract Background Ceftazidime-avibactam (CAZ-AVI) has been approved in Europe for the treatment of complicated intra-abdominal and urinary tract infections,... 
carbapenemases | ceftazidime-avibactam | KPC-producing Klebsiella pneumoniae | RESISTANT ENTEROBACTERIACEAE | MORTALITY | INFECTIOUS DISEASES | URINARY-TRACT-INFECTIONS | SAFETY | MICROBIOLOGY | PLUS METRONIDAZOLE | IMMUNOLOGY | MEROPENEM | INCLUDING ACUTE PYELONEPHRITIS | PREDICTORS | DOUBLE-BLIND | BETA-LACTAMASE PRODUCTION
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10. Full Text Emergence of Klebsiella pneumoniae carbapenemase-producing bacteria
by Arnold, Ryan S and Thom, Kerri A and Sharma, Saarika and Phillips, Michael and Kristie Johnson, J and Morgan, Daniel J
Southern Medical Journal, ISSN 0038-4348, 01/2011, Volume 104, Issue 1, pp. 40 - 45
Klebsiella pneumoniae carbapenemase (KPC)-producing bacteria are a group of emerging highly drug-resistant Gram-negative bacilli causing infections associated... 
carbapenem-resistant | Klebsiella multi-drug resistant | Enterobacteriaceae | INFECTIONS | HYDROLYZING BETA-LACTAMASE | POLYMYXIN-B | MEDICINE, GENERAL & INTERNAL | KPC-2 CARBAPENEMASE | TIGECYCLINE | MOLECULAR EPIDEMIOLOGY | OUTCOMES | RESISTANT KLEBSIELLA | IN-VITRO ACTIVITY | Diagnosis, Differential | Klebsiella pneumoniae - isolation & purification | Klebsiella Infections - drug therapy | Bacteriological Techniques - methods | Humans | Klebsiella Infections - microbiology | Bacterial Proteins - analysis | beta-Lactamases - biosynthesis | Metalloproteins | Anti-Bacterial Agents - therapeutic use | beta-Lactamases - analysis | Klebsiella pneumoniae - enzymology | Klebsiella Infections - diagnosis | Bacterial Proteins - biosynthesis | Klebsiella | Drug resistance in microorganisms | Complications and side effects | Care and treatment | Carbapenems | Distribution | multi-drug resistant
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11. Full Text Predictors of outcome in ICU patients with septic shock caused by Klebsiella pneumoniae carbapenemase–producing K. pneumoniae
by Falcone, M and Russo, A and Iacovelli, A and Restuccia, G and Ceccarelli, G and Giordano, A and Farcomeni, A and Morelli, A and Venditti, M
Clinical Microbiology and Infection, ISSN 1198-743X, 05/2016, Volume 22, Issue 5, pp. 444 - 450
The aim of this study was to identify factors associated with mortality in intensive care unit patients with carbapenemase–producing (KPC-Kp) septic shock. A... 
carbapenem-resistant Klebsiella pneumoniae strain | septic shock | KPC-Kp | Adequate source control | colistin-resistance | Septic shock | Colistin-resistance | Carbapenem-resistant Klebsiella pneumoniae strain | MORTALITY | INFECTIOUS DISEASES | INFECTIONS | MANAGEMENT | GUIDELINES | MICROBIOLOGY | COLISTIN RESISTANCE | EMERGENCE | KPC-2 CARBAPENEMASE | IMPACT | SURVIVING SEPSIS CAMPAIGN | SPREAD | Klebsiella pneumoniae - isolation & purification | Prognosis | Humans | Middle Aged | Male | Bacterial Proteins - secretion | Anti-Bacterial Agents - therapeutic use | Hospitals, Teaching | Shock, Septic - drug therapy | Aged, 80 and over | Adult | Female | Retrospective Studies | Intensive Care Units | Klebsiella Infections - drug therapy | Treatment Outcome | Klebsiella Infections - microbiology | Shock, Septic - mortality | beta-Lactamases - secretion | Shock, Septic - microbiology | Adolescent | Klebsiella pneumoniae - enzymology | Survival Analysis | Klebsiella Infections - mortality | Aged
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12. Full Text Prevention of colonization and infection by klebsiella pneumoniae carbapenemase-producing enterobacteriaceae in long-term acute-care hospitals
by Hayden, Mary K and Lin, Michael Y and Lolans, Karen and Weiner, Shayna and Blom, Donald and Moore, Nicholas M and Fogg, Louis and Henry, David and Lyles, Rosie and Thurlow, Caroline and Sikka, Monica and Hines, David and Weinstein, Robert A and Ctr Dis Control Prevention Epictr and Centers for Disease Control and Prevention Epicenters Program and for the Centers for Disease Control and Prevention Epicenters Program
Clinical Infectious Diseases, ISSN 1058-4838, 04/2015, Volume 60, Issue 8, pp. 1154 - 1161
Background. Klebsiella pneumoniae carbapenemase-producing Enterobacteriaceae (hereafter "KPC") are an increasing threat to healthcare institutions. Long-term... 
carbapenem-resistant Enterobacteriaceae | Klebsiella pneumoniae carbapenemase | healthcare-associated infection | long-term acute-care hospital | infection prevention | INFECTIOUS DISEASES | CRITICAL ILLNESS | FACILITIES | MICROBIOLOGY | IMMUNOLOGY | SPECIMENS | SURVEILLANCE | CHLORHEXIDINE | MULTIDRUG-RESISTANT ORGANISMS | HEALTH-CARE | OUTBREAK | SPREAD | BURDEN | Klebsiella pneumoniae - isolation & purification | Klebsiella Infections - prevention & control | Cross Infection - prevention & control | Humans | Middle Aged | Carrier State - microbiology | Male | Long-Term Care | Bacterial Proteins - secretion | Klebsiella Infections - microbiology | Infection Control - methods | beta-Lactamases - secretion | Hospitals | Carrier State - prevention & control | Cross Infection - microbiology | Klebsiella pneumoniae - enzymology | Aged, 80 and over | Female | Aged | Intervention | Long term health care | Gram-negative bacteria | Bacterial proteins | Patients
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