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FEBS Letters, ISSN 0014-5793, 2004, Volume 565, Issue 1, pp. 143 - 147
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2007, Volume 117, Issue 12, pp. 4003 - 4008
Phosphate homeostasis is maintained by a counterbalance between efflux from the kidney and influx from intestine and bone. FGF23 is a bone-derived phosphaturic... 
PHOSPHATE | MEDICINE, RESEARCH & EXPERIMENTAL | HORMONE GENE-EXPRESSION | IN-VIVO | CALCIUM | GROWTH | KLOTHO PROTEIN | SECONDARY HYPERPARATHYROIDISM | VITAMIN-D-RECEPTOR | DOMINANT HYPOPHOSPHATEMIC RICKETS | MICE | MAP Kinase Signaling System - physiology | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Fibroblast Growth Factors - genetics | Intestines - metabolism | Parathyroid Hormone - genetics | Fibroblast Growth Factors - metabolism | Parathyroid Glands - cytology | RNA, Messenger - biosynthesis | Kidney - metabolism | Parathyroid Hormone - biosynthesis | Bone and Bones - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | Early Growth Response Protein 1 - genetics | Receptors, Fibroblast Growth Factor - genetics | Homeostasis - drug effects | Mitogen-Activated Protein Kinase 3 - genetics | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | RNA, Messenger - genetics | Cells, Cultured | Gene Expression Regulation - physiology | Rats | Fibroblast Growth Factors - pharmacology | Gene Expression Regulation - drug effects | Phosphates - metabolism | Animals | Glucuronidase - biosynthesis | MAP Kinase Signaling System - drug effects | Early Growth Response Protein 1 - biosynthesis | Glucuronidase - genetics | Mitogen-Activated Protein Kinase 3 - metabolism | Homeostasis - physiology | Receptors, Fibroblast Growth Factor - metabolism | Vitamin D - metabolism | Protein Kinase Inhibitors - pharmacology | Mitogen-Activated Protein Kinase 1 - metabolism | Parathyroid Glands - metabolism | Homeostasis | Parathyroid glands | Fibroblast growth factors | Dosage and administration | Genetic aspects | Research | Health aspects
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 09/2002, Volume 22, Issue 17, pp. 7380 - 7388
Tg2576 mice overexpress a mutant form of human amyloid precursor protein with the Swedish mutation (APP(Sw)), resulting in high beta-amyloid (Abeta) levels in... 
Neuroprotection | Insulin-like growth factor | Microarray | Alzheimer's disease | Transthyretin | Tg2576 | transthyretin | ALZHEIMERS-DISEASE | KINASE | KLOTHO GENE | NEURONAL LOSS | NEUROSCIENCES | microarray | neuroprotection | BETA-PROTEIN | insulin-like growth factor | ANIMAL-MODEL | RAT-BRAIN | C-JUN | EXPRESSION | GROWTH-FACTOR-I | Immunohistochemistry | Prealbumin - genetics | Receptor, IGF Type 1 - metabolism | Phosphorylation | Oligonucleotide Array Sequence Analysis | Humans | Protein-Serine-Threonine Kinases | Male | RNA, Messenger - metabolism | Insulin-Like Growth Factor II - genetics | Mitogen-Activated Protein Kinase 1 - genetics | Cell Survival - physiology | Proto-Oncogene Proteins - metabolism | Cerebellum - metabolism | Mice, Inbred C57BL | Mice, Transgenic | Proto-Oncogene Proteins - genetics | Hippocampus - pathology | Disease Progression | Insulin-Like Growth Factor II - metabolism | Proto-Oncogene Proteins c-akt | Carrier Proteins - genetics | Hippocampus - metabolism | Amyloid Neuropathies - pathology | Amyloid beta-Protein Precursor - genetics | Animals | Carrier Proteins - metabolism | Prealbumin - metabolism | Mitogen-Activated Protein Kinases - genetics | Signal Transduction - physiology | Amyloid Neuropathies - metabolism | Mice | Mutation | Alzheimer Disease - genetics | Amyloid Neuropathies - genetics | bcl-Associated Death Protein | Mitogen-Activated Protein Kinase 3 | Amyloid beta-Protein Precursor - biosynthesis | Mitogen-Activated Protein Kinase 1 - metabolism | Mitogen-Activated Protein Kinases - metabolism | ARTICLE
Journal Article
Science, ISSN 0036-8075, 3/2011, Volume 331, Issue 6024, pp. 1621 - 1624
Journal Article
Journal Article
Cell Death and Disease, ISSN 2041-4889, 08/2017, Volume 8, Issue 8, pp. e2972 - e2972
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2013, Volume 8, Issue 4, p. e61432
The endocrine hormone FGF21 has attracted considerable interest as a potential therapeutic for treating diabetes and obesity. As an alternative to the native... 
BETA-KLOTHO | METABOLIC REGULATOR | FIBROBLAST-GROWTH-FACTOR-21 | HUMAN SERUM-ALBUMIN | FGF19 | MULTIDISCIPLINARY SCIENCES | FUSION PROTEIN | RECEPTOR | FIBROBLAST-GROWTH-FACTOR | INSULIN SENSITIVITY | INDUCED OBESE MICE | Receptor, Fibroblast Growth Factor, Type 4 - chemistry | Obesity - drug therapy | Peptides - pharmacokinetics | Body Weight - drug effects | Macaca fascicularis | Molecular Sequence Data | Male | Insulin - blood | Obesity - blood | Fibroblast Growth Factors - chemistry | Recombinant Fusion Proteins - antagonists & inhibitors | Molecular Mimicry | Anti-Obesity Agents - pharmacokinetics | Drug Evaluation, Preclinical | Binding Sites | Serum Albumin - pharmacokinetics | Fibroblast Growth Factors - physiology | Binding, Competitive | Recombinant Fusion Proteins - biosynthesis | Amino Acid Sequence | Cell Line | Signal Transduction | Rats | Receptor, Fibroblast Growth Factor, Type 1 - antagonists & inhibitors | Peptides - pharmacology | Membrane Proteins - biosynthesis | Animals | Membrane Proteins - antagonists & inhibitors | Serum Albumin - pharmacology | Triglycerides - blood | Protein Binding | Mice | Anti-Obesity Agents - pharmacology | Obesity | Polyethylene | Polypeptides | Body weight | Diabetes mellitus | Triglycerides | Monkeys | Insulin | Proteins | Klotho protein | Rodents | Weight reduction | Fibroblasts | Libraries | Diabetes | Laboratory animals | Growth factors | Metabolic disorders
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2010, Volume 107, Issue 40, pp. 17362 - 17367
Amyloidogenic processing of the amyloid precursor protein (APP) generates a large secreted ectodomain fragment (APPsβ), β-amyloid (Aβ) peptides, and an APP... 
Proteins | Receptors | Neurons | Liver | Antibodies | Protein precursors | Mice | Gene expression regulation | Amyloids | Synapses | β-secretase | Conditional knockout | Knockin | Alzheimer's disease | Neuromuscular synapse | knockin | neuromuscular synapse | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | DEFICIENT MICE | CEREBROSPINAL-FLUID | DEPENDENT TRANSCRIPTIONAL CONTROL | MICE LACKING | APOLIPOPROTEIN-E | DEGRADING ENZYME NEPRILYSIN | NEURITE OUTGROWTH | beta-secretase | BETA-PROTEIN | conditional knockout | INTRACELLULAR DOMAINS | Prealbumin - genetics | Humans | Cells, Cultured | Gene Expression Regulation | Glucuronidase - metabolism | Genotype | Neurons - cytology | Gene Expression Profiling | Nerve Tissue Proteins - genetics | Mice, Knockout | Nerve Tissue Proteins - metabolism | Amyloid beta-Protein Precursor - genetics | Animals | Glucuronidase - genetics | Prealbumin - metabolism | Microarray Analysis | Amyloid beta-Protein Precursor - metabolism | Neurons - physiology | Amyloid beta-protein | Physiological aspects | Development and progression | Genetic aspects | Properties | Gene expression | Enzymes | Plasma | Signal transduction | Peptides | Cells | Amyloidogenesis | Neurodegenerative diseases | Transcription | Gene regulation | transthyretin | beta -Amyloid | Lethality | Amyloid precursor protein | Cell death | Klotho protein | Aging | Pruning | Neuromuscular junctions | Biological Sciences
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2014, Volume 289, Issue 43, pp. 29751 - 29765
Background: Although both are involved in metabolic homeostasis, the interconnection between ER stress and FGF21 remains incompletely understood. Results:... 
BETA-KLOTHO | PPAR-ALPHA | Fibroblast Growth Factor (FGF) | FATTY LIVER-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | INSULIN SENSITIVITY | Unfolded Protein Response (UPR) | Liver Metabolism | ENERGY-EXPENDITURE | ER Stress | Hepatocyte | METABOLIC REGULATOR | MESSENGER-RNA | TRANSCRIPTION FACTOR | FGF21 | Organ Specificity - drug effects | Non-alcoholic Fatty Liver Disease - pathology | Transcription, Genetic - drug effects | Transcriptional Activation - genetics | Fatty Liver - pathology | Humans | Transcriptional Activation - drug effects | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Fibroblast Growth Factors - genetics | Molecular Sequence Data | Hepatocytes - pathology | Male | Extracellular Signal-Regulated MAP Kinases - metabolism | Hepatocytes - metabolism | Endoplasmic Reticulum Stress - genetics | Promoter Regions, Genetic - genetics | X-Box Binding Protein 1 | DNA-Binding Proteins - metabolism | Fibroblast Growth Factors - metabolism | Organ Specificity - genetics | Base Sequence | Hepatocytes - drug effects | Protein-Serine-Threonine Kinases - metabolism | Fatty Liver - genetics | Unfolded Protein Response - drug effects | Endoribonucleases - metabolism | Unfolded Protein Response - genetics | Mice, Inbred C57BL | Non-alcoholic Fatty Liver Disease - metabolism | Signal Transduction - genetics | Recombinant Proteins - pharmacology | Enzyme Activation - drug effects | Regulatory Factor X Transcription Factors | Hep G2 Cells | Transcription Factors - metabolism | Animals | Diet | Signal Transduction - drug effects | Mice, Obese | Molecular Biophysics
Journal Article
Life Sciences, ISSN 0024-3205, 05/2018, Volume 200, pp. 56 - 62
Journal Article