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Molecular Cell, ISSN 1097-2765, 08/2017, Volume 67, Issue 3, pp. 387 - 399.e5
The DNA-mediated innate immune response underpins anti-microbial defenses and certain autoimmune diseases. Here we used immunoprecipitation, mass spectrometry,... 
HEXIM1 | DNA-PK | innate immune response | herpesvirus | paraspeckles | cGAS | NEAT1 | interferon stimulatory DNA | DEFENSE | PROTEIN | INHIBITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | SENSOR | POLYMERASE-II | 7SK RNA | BINDING | GMP-AMP SYNTHASE | P-TEFB | CELL BIOLOGY | Human Umbilical Vein Endothelial Cells - metabolism | Humans | Octamer Transcription Factors - immunology | Intracellular Signaling Peptides and Proteins - metabolism | Herpesvirus 8, Human - immunology | RNA, Long Noncoding - immunology | PTB-Associated Splicing Factor - genetics | RNA Interference | Calcium-Binding Proteins - immunology | Octamer Transcription Factors - genetics | Nucleotidyltransferases - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Signal Transduction | Membrane Proteins - genetics | RNA-Binding Proteins - immunology | PTB-Associated Splicing Factor - metabolism | Nuclear Matrix-Associated Proteins - metabolism | PTB-Associated Splicing Factor - immunology | DNA - metabolism | Host-Pathogen Interactions | Nuclear Matrix-Associated Proteins - genetics | HeLa Cells | RNA-Binding Proteins - metabolism | Calcium-Binding Proteins - genetics | RNA-Binding Proteins - genetics | Multiprotein Complexes | Human Umbilical Vein Endothelial Cells - immunology | Intracellular Signaling Peptides and Proteins - immunology | Human Umbilical Vein Endothelial Cells - virology | Interferon Regulatory Factor-3 - genetics | Ku Autoantigen - genetics | Transfection | HEK293 Cells | Membrane Proteins - metabolism | Nuclear Proteins - genetics | Octamer Transcription Factors - metabolism | Interferon Regulatory Factor-3 - immunology | Calcium-Binding Proteins - metabolism | DNA - immunology | Nuclear Matrix-Associated Proteins - immunology | Ku Autoantigen - immunology | Membrane Proteins - immunology | Nuclear Proteins - metabolism | Ku Autoantigen - metabolism | RNA, Long Noncoding - genetics | Immunity, Innate | Nuclear Proteins - immunology | DNA - genetics | Interferon Regulatory Factor-3 - metabolism | Nucleotidyltransferases - genetics | Protein Binding | Nucleotidyltransferases - immunology | RNA, Long Noncoding - metabolism | RNA sequencing | Immune response | RNA | DNA | Genetic research | Interferon | Biological response modifiers | Mass spectrometry | Index Medicus | Human Umbilical Vein Endothelial Cells | Nuclear Matrix-Associated Proteins | Herpesvirus 8, Human | RNA-Binding Proteins | Life Sciences | Interferon Regulatory Factor-3 | Genetics | Calcium-Binding Proteins | Intracellular Signaling Peptides and Proteins | PTB-Associated Splicing Factor | Nuclear Proteins | Membrane Proteins | Nucleotidyltransferases | Ku Autoantigen | Octamer Transcription Factors | RNA, Long Noncoding
Journal Article
Journal Article
Nanomedicine: Nanotechnology, Biology, and Medicine, ISSN 1549-9634, 2015, Volume 12, Issue 2, pp. 387 - 397
Abstract Though combination chemotherapy or antitumor nanomedicine is extensively investigated, their combining remains in infancy. Additionally, enhanced... 
Internal Medicine | Luminal A breast cancer | Tamoxifen | Doxorubicin | Penta-peptide QLPVM | Nanomedicine based combinational therapy | KU70 | MEDICINE, RESEARCH & EXPERIMENTAL | EFFICACY | SUBTYPES | NANOSCIENCE & NANOTECHNOLOGY | CELL-PENETRATING PEPTIDES | RELEASE | TUMORS | DELIVERY | NANOPARTICLES | BIOLOGY | Doxorubicin - therapeutic use | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Humans | Breast - metabolism | Polyethylene Glycols - therapeutic use | Tamoxifen - administration & dosage | Breast Neoplasms - metabolism | Antineoplastic Agents, Hormonal - therapeutic use | Doxorubicin - analogs & derivatives | Female | Breast - pathology | Nanomedicine | Oligopeptides - chemistry | Cell-Penetrating Peptides - chemistry | Doxorubicin - administration & dosage | Antineoplastic Agents, Hormonal - administration & dosage | Ku Autoantigen - chemistry | bcl-2-Associated X Protein - metabolism | Ku Autoantigen - metabolism | Oligopeptides - metabolism | Breast Neoplasms - drug therapy | Polyethylene Glycols - administration & dosage | Antibiotics, Antineoplastic - administration & dosage | Liposomes - chemistry | Animals | Antibiotics, Antineoplastic - therapeutic use | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Breast - drug effects | Breast Neoplasms - pathology | Mice, Nude | Tamoxifen - therapeutic use | Cell Line, Tumor | Liposomes - metabolism | Drug Combinations | Cell-Penetrating Peptides - metabolism | Chemotherapy | Anthracyclines | Peptides | Estrogen | Breast cancer | Drug therapy, Combination | Cancer | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2016, Volume 291, Issue 53, pp. 26987 - 27006
DNA double-strand break (DSB) repair by non-homologous end joining (NHEJ) in human cells is initiated by Ku heterodimer binding to a DSB, followed by... 
REPAIR PROTEINS | STRUCTURAL INSIGHTS | DAMAGE RESPONSE | BIOLOGICAL MACROMOLECULES | SMALL-ANGLE SCATTERING | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEPENDENT PROTEIN-KINASE | DOUBLE-STRAND BREAKS | X-RAY-SCATTERING | IONIZING-RADIATION | Phosphorylation | Immunoprecipitation | Humans | DNA Breaks, Double-Stranded | DNA-Activated Protein Kinase - chemistry | DNA-Binding Proteins - metabolism | Poly-ADP-Ribose Binding Proteins | DNA-(Apurinic or Apyrimidinic Site) Lyase - genetics | Ku Autoantigen - genetics | DNA Ligase ATP - genetics | X-Ray Diffraction | DNA-Activated Protein Kinase - genetics | DNA-Activated Protein Kinase - metabolism | DNA Ligase ATP - metabolism | Nuclear Proteins - genetics | Cross-Linking Reagents | DNA End-Joining Repair - genetics | Ku Autoantigen - chemistry | Models, Molecular | Scattering, Small Angle | Nuclear Proteins - metabolism | Ku Autoantigen - metabolism | DNA-Binding Proteins - genetics | Nuclear Proteins - chemistry | DNA-Binding Proteins - chemistry | Blotting, Western | DNA-(Apurinic or Apyrimidinic Site) Lyase - chemistry | DNA-(Apurinic or Apyrimidinic Site) Lyase - metabolism | DNA Ligase ATP - chemistry | Protein Binding | Protein Conformation | HeLa Cells | Index Medicus | DNA-dependent serine/threonine protein kinase (DNA-PK) | small-angle x-ray scattering (SAXS) | INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY | intrinsically disordered protein | XRCC4 | BASIC BIOLOGICAL SCIENCES | APLF | DNA ligase IV | non-homologous end joining | protein complex | DNA repair | DNA and Chromosomes | small-angle X-ray scattering (SAXS) | DNA-dependent serine | threonine protein kinase (DNA-PK)
Journal Article
Journal Article
DNA Repair, ISSN 1568-7864, 07/2016, Volume 43, pp. 98 - 106
Non-Homologous End-Joining (NHEJ) is the predominant pathway for the repair of DNA double strand breaks (DSBs) in human cells. The NHEJ pathway is frequently... 
Chemotherapy | Ku70/80 | Non-Homologous End-Joining | DNA double strand break | Small molecule inhibitor | Radiation | CELLS | HUMAN PROSTATE | KINASE | CANCER | BIOLOGY | GENETICS & HEREDITY | TOXICOLOGY | DNA-Activated Protein Kinase - antagonists & inhibitors | Gamma Rays | Small Molecule Libraries - pharmacology | Pyrimidines - chemical synthesis | Humans | Protein Multimerization | Crystallography, X-Ray | DNA Breaks, Double-Stranded | DNA-Activated Protein Kinase - chemistry | Ku Autoantigen - antagonists & inhibitors | Ku Autoantigen - genetics | DNA-Activated Protein Kinase - genetics | DNA-Activated Protein Kinase - metabolism | Protein Domains | Nuclear Proteins - genetics | DNA End-Joining Repair - drug effects | Recombinant Proteins - metabolism | Cell Survival - drug effects | Gene Expression | Protein Structure, Secondary | Ku Autoantigen - chemistry | Small Molecule Libraries - chemical synthesis | Nuclear Proteins - metabolism | Ku Autoantigen - metabolism | Recombinant Proteins - genetics | DNA - metabolism | Pyrimidines - pharmacology | Nuclear Proteins - chemistry | Cell Survival - radiation effects | DNA - genetics | Nuclear Proteins - antagonists & inhibitors | Molecular Docking Simulation | HeLa Cells | Ionizing radiation | DNA | DNA repair | Cells | Cancer | Medical imaging equipment | Index Medicus
Journal Article
Journal Article
Journal Article
Molecular Cell, ISSN 1097-2765, 10/2016, Volume 64, Issue 1, pp. 189 - 198
Journal Article