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animals (337) 337
kv1.1 potassium channel (187) 187
potassium channels, voltage-gated (161) 161
index medicus (142) 142
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rats (130) 130
mice (126) 126
kv1.1 potassium channel - metabolism (122) 122
humans (121) 121
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male (81) 81
biochemistry & molecular biology (79) 79
female (79) 79
molecular sequence data (73) 73
amino acid sequence (66) 66
expression (66) 66
kv1.2 potassium channel (62) 62
potassium channel (59) 59
k+ channels (58) 58
kv1.1 (55) 55
potassium channels - physiology (53) 53
neurons - metabolism (52) 52
rat-brain (43) 43
mice, knockout (42) 42
mutation (42) 42
cell biology (41) 41
cell membrane - metabolism (41) 41
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ion channels (40) 40
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rna, messenger - metabolism (40) 40
article (39) 39
nervous system (39) 39
xenopus laevis (39) 39
physiology (38) 38
brain (35) 35
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xenopus (33) 33
biophysics (32) 32
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membrane potentials - physiology (32) 32
potassium - metabolism (32) 32
action potentials - physiology (31) 31
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gated k+ channels (31) 31
k+ channel (31) 31
kv1.4 potassium channel (30) 30
models, molecular (30) 30
cho cells (29) 29
cricetinae (29) 29
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analysis (27) 27
channels (27) 27
neurons - physiology (27) 27
oocytes (26) 26
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neurons - drug effects (25) 25
oocytes - physiology (25) 25
potassium channels - biosynthesis (25) 25
xenopus-oocytes (25) 25
axons - metabolism (24) 24
delayed rectifier potassium channels (24) 24
hippocampus - metabolism (24) 24
kv1.1 potassium channel - antagonists & inhibitors (24) 24
mammalian brain (24) 24
membrane potentials - drug effects (24) 24
protein binding (24) 24
transfection (24) 24
clinical neurology (23) 23
inactivation (23) 23
kv1.3 potassium channel (23) 23
multidisciplinary sciences (23) 23
protein structure, tertiary (23) 23
sequence homology, amino acid (23) 23
time factors (23) 23
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cells (22) 22
gated potassium channels (22) 22
ion channel gating (22) 22
kcna1 (22) 22
mice, inbred c57bl (22) 22
oocytes - metabolism (22) 22
potassium channel blockers (22) 22
rats, wistar (22) 22
research (22) 22
ion channel gating - physiology (21) 21
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Journal of Biological Chemistry, ISSN 0021-9258, 03/2016, Volume 291, Issue 13, pp. 7097 - 7106
The structural similarity between defensins and scorpion neurotoxins suggests that they might have evolved from a common ancestor. However, there is no direct... 
VENOM | PORE REGION | bacteria | TOXIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | structure-function | KV1.3 CHANNEL | STRUCTURAL BASIS | FUNGAL DEFENSIN | defensin | INSECT DEFENSINS | neurotoxin | potassium channel | MESOBUTHUS-MARTENSII | PROTEOMIC ANALYSIS | K+ CHANNELS | Kv1.2 Potassium Channel - antagonists & inhibitors | Humans | Micrococcus luteus - growth & development | Potassium Channel Blockers - metabolism | Bacillus subtilis - growth & development | Defensins - pharmacology | Kv1.3 Potassium Channel - metabolism | Potassium Channel Blockers - pharmacology | Kv1.1 Potassium Channel - genetics | Amino Acid Sequence | Gene Expression | Methicillin-Resistant Staphylococcus aureus - drug effects | Models, Molecular | Recombinant Proteins - chemistry | Methicillin-Resistant Staphylococcus aureus - growth & development | Scorpion Venoms - chemistry | Kv1.2 Potassium Channel - metabolism | Neurotoxins - metabolism | Anti-Bacterial Agents - pharmacology | Mice | Scorpion Venoms - biosynthesis | Potassium Channel Blockers - chemistry | Defensins - metabolism | Defensins - genetics | Kv1.1 Potassium Channel - metabolism | Molecular Sequence Data | Neurotoxins - genetics | Structure-Activity Relationship | Defensins - chemistry | Kv1.3 Potassium Channel - genetics | Micrococcus luteus - drug effects | Scorpions - physiology | Anti-Bacterial Agents - chemistry | Protein Interaction Domains and Motifs | Recombinant Proteins - metabolism | Neurotoxins - chemistry | Protein Structure, Secondary | Kv1.1 Potassium Channel - antagonists & inhibitors | Anti-Bacterial Agents - metabolism | Scorpions - chemistry | Recombinant Proteins - genetics | Kv1.3 Potassium Channel - antagonists & inhibitors | Recombinant Proteins - pharmacology | Neurotoxins - pharmacology | Kv1.2 Potassium Channel - genetics | Sequence Alignment | Animals | Structural Homology, Protein | Staphylococcus aureus - drug effects | Staphylococcus aureus - growth & development | Bacillus subtilis - drug effects | Index Medicus | Cell Biology
Journal Article
Journal Article
Journal Article
Journal Article
Cell Death and Differentiation, ISSN 1350-9047, 01/2010, Volume 17, Issue 1, pp. 134 - 144
Journal Article
Journal Article
FEBS Letters, ISSN 0014-5793, 11/2012, Volume 586, Issue 22, pp. 3996 - 4001
► ShK is a potent blocker of potassium channels. ► A new ShK analogue with a C-terminal Lys residue and amide was designed. ► ShK-K-amide is a potent and... 
Electrophysiology | Potential of mean force | Potassium channel | Umbrella sampling | C-terminal amide | ShK | ShK with a C-terminal Lys and amide | effector memory T-cells | ShK-K-amide | PMF | voltage-gated K+ channel | molecular dynamics | potential of mean force | K+ channel toxin from Stichodactyla helianthus | ShK-amide | TEM | C-terminally amidated ShK | MOLECULAR-DYNAMICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | SEA-ANEMONE TOXIN | PEPTIDE | CELL BIOLOGY | BIOPHYSICS | AUTOIMMUNE-DISEASES | STICHODACTYLA-HELIANTHUS | RAT-BRAIN | INHIBITOR | MEMORY T-CELLS | FREE-ENERGY | K+ CHANNELS | Kv1.1 Potassium Channel - metabolism | Humans | Cnidarian Venoms - metabolism | Kv1.3 Potassium Channel - genetics | Cnidarian Venoms - pharmacology | Potassium Channel Blockers - metabolism | Kv1.1 Potassium Channel - physiology | Dose-Response Relationship, Drug | Ion Channel Gating - physiology | T-Lymphocytes - drug effects | Kv1.3 Potassium Channel - metabolism | Binding Sites | Potassium Channel Blockers - pharmacology | Binding, Competitive | Kv1.1 Potassium Channel - genetics | Protein Structure, Tertiary | Cells, Cultured | Models, Molecular | Kv1.3 Potassium Channel - physiology | Molecular Dynamics Simulation | Cnidarian Venoms - chemistry | Patch-Clamp Techniques | Algorithms | Animals | Ion Channel Gating - genetics | T-Lymphocytes - cytology | Amides - chemistry | Cell Line, Tumor | Protein Binding | Cell Proliferation - drug effects | Mice | Potassium Channel Blockers - chemistry | Ion Channel Gating - drug effects | Potassium channels | Peptides | T cells | Analysis | potassium channel | umbrella sampling | electrophysiology
Journal Article
Current Pharmaceutical Design, ISSN 1381-6128, 2014, Volume 20, Issue 2, pp. 189 - 200
Journal Article
Acta neuropathologica, ISSN 0001-6322, 2012, Volume 123, Issue 4, pp. 473 - 484
Medulloblastoma is the most common malignant brain tumor in childhood. Molecular studies from several groups around the world demonstrated that medulloblastoma... 
Pathology | Neurosciences | Medicine & Public Health | Medulloblastoma | Pediatric brain tumor | Subgroups | Meta-analysis | PROFILES | SUBTYPES | DISTINCT | PATHOLOGY | NEUROSCIENCES | ADULT | CLINICAL NEUROLOGY | PEDIATRIC MEDULLOBLASTOMAS | BETA-CATENIN STATUS | CHILDHOOD MEDULLOBLASTOMA | Multivariate Analysis | Meta-Analysis as Topic | Age Distribution | Kv1.1 Potassium Channel - metabolism | Cerebellar Neoplasms - diagnosis | Humans | Transcriptome | Child, Preschool | Hedgehog Proteins - metabolism | Male | Gene Expression Profiling | Wnt Proteins - metabolism | Young Adult | Chromosomes, Human, Pair 3 | Wnt Proteins - genetics | Hedgehog Proteins - genetics | Microarray Analysis | Adult | Female | Retrospective Studies | Cerebellar Neoplasms - classification | Medulloblastoma - genetics | Child | Gene Expression Regulation, Neoplastic - physiology | Kv1.1 Potassium Channel - genetics | Receptors, Atrial Natriuretic Factor - metabolism | Medulloblastoma - diagnosis | International Cooperation | Cerebellar Neoplasms - genetics | Chromosomes, Human, Pair 17 | Adolescent | Chromosome Aberrations | Survival Analysis | Cytogenetics | Receptors, Atrial Natriuretic Factor - genetics | Medulloblastoma - classification | Cohort Studies | Immunohistochemistry | Demography | Wnt protein | Brain tumors | Data processing | Single-nucleotide polymorphism | Gene expression | Survival | Reviews | Hedgehog protein | DNA | Children | Original Paper
Journal Article