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animals (337) 337
kv1.1 potassium channel (187) 187
potassium channels, voltage-gated (161) 161
index medicus (142) 142
neurosciences (131) 131
rats (130) 130
mice (126) 126
kv1.1 potassium channel - metabolism (122) 122
humans (121) 121
potassium channels - metabolism (117) 117
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potassium channels (93) 93
potassium channels - genetics (92) 92
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male (81) 81
biochemistry & molecular biology (79) 79
female (79) 79
molecular sequence data (73) 73
amino acid sequence (66) 66
expression (66) 66
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potassium channel (59) 59
k+ channels (58) 58
kv1.1 (55) 55
potassium channels - physiology (53) 53
neurons - metabolism (52) 52
rat-brain (43) 43
mice, knockout (42) 42
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cell membrane - metabolism (41) 41
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neurons (41) 41
potassium channel blockers - pharmacology (41) 41
ion channels (40) 40
potassium channels - chemistry (40) 40
rna, messenger - metabolism (40) 40
article (39) 39
nervous system (39) 39
xenopus laevis (39) 39
physiology (38) 38
brain (35) 35
cells, cultured (35) 35
epilepsy (34) 34
brain - metabolism (33) 33
gene expression (33) 33
proteins (33) 33
rats, sprague-dawley (33) 33
xenopus (33) 33
biophysics (32) 32
cell line (32) 32
in vitro techniques (32) 32
membrane potentials - physiology (32) 32
potassium - metabolism (32) 32
action potentials - physiology (31) 31
disease models, animal (31) 31
gated k+ channels (31) 31
k+ channel (31) 31
kv1.4 potassium channel (30) 30
models, molecular (30) 30
cho cells (29) 29
cricetinae (29) 29
localization (29) 29
kinetics (28) 28
analysis (27) 27
channels (27) 27
neurons - physiology (27) 27
oocytes (26) 26
kv1.2 potassium channel - metabolism (25) 25
neurons - drug effects (25) 25
oocytes - physiology (25) 25
potassium channels - biosynthesis (25) 25
xenopus-oocytes (25) 25
axons - metabolism (24) 24
delayed rectifier potassium channels (24) 24
hippocampus - metabolism (24) 24
kv1.1 potassium channel - antagonists & inhibitors (24) 24
mammalian brain (24) 24
membrane potentials - drug effects (24) 24
protein binding (24) 24
transfection (24) 24
clinical neurology (23) 23
inactivation (23) 23
kv1.3 potassium channel (23) 23
multidisciplinary sciences (23) 23
protein structure, tertiary (23) 23
sequence homology, amino acid (23) 23
time factors (23) 23
action potentials - drug effects (22) 22
cells (22) 22
gated potassium channels (22) 22
ion channel gating (22) 22
kcna1 (22) 22
mice, inbred c57bl (22) 22
oocytes - metabolism (22) 22
potassium channel blockers (22) 22
rats, wistar (22) 22
research (22) 22
ion channel gating - physiology (21) 21
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1. Full Text Scorpion potassium channel-blocking defensin highlights a functional link with neurotoxin
by Meng, Lanxia and Xie, Zili and Zhang, Qian and Li, Yang and Yang, Fan and Chen, Zongyun and Li, Wenxin and Cao, Zhijian and Wu, Yingliang
Journal of Biological Chemistry, ISSN 0021-9258, 03/2016, Volume 291, Issue 13, pp. 7097 - 7106
The structural similarity between defensins and scorpion neurotoxins suggests that they might have evolved from a common ancestor. However, there is no direct... 
VENOM | PORE REGION | bacteria | TOXIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | structure-function | KV1.3 CHANNEL | STRUCTURAL BASIS | FUNGAL DEFENSIN | defensin | INSECT DEFENSINS | neurotoxin | potassium channel | MESOBUTHUS-MARTENSII | PROTEOMIC ANALYSIS | K+ CHANNELS | Kv1.2 Potassium Channel - antagonists & inhibitors | Humans | Micrococcus luteus - growth & development | Potassium Channel Blockers - metabolism | Bacillus subtilis - growth & development | Defensins - pharmacology | Kv1.3 Potassium Channel - metabolism | Potassium Channel Blockers - pharmacology | Kv1.1 Potassium Channel - genetics | Amino Acid Sequence | Gene Expression | Methicillin-Resistant Staphylococcus aureus - drug effects | Models, Molecular | Recombinant Proteins - chemistry | Methicillin-Resistant Staphylococcus aureus - growth & development | Scorpion Venoms - chemistry | Kv1.2 Potassium Channel - metabolism | Neurotoxins - metabolism | Anti-Bacterial Agents - pharmacology | Mice | Scorpion Venoms - biosynthesis | Potassium Channel Blockers - chemistry | Defensins - metabolism | Defensins - genetics | Kv1.1 Potassium Channel - metabolism | Molecular Sequence Data | Neurotoxins - genetics | Structure-Activity Relationship | Defensins - chemistry | Kv1.3 Potassium Channel - genetics | Micrococcus luteus - drug effects | Scorpions - physiology | Anti-Bacterial Agents - chemistry | Protein Interaction Domains and Motifs | Recombinant Proteins - metabolism | Neurotoxins - chemistry | Protein Structure, Secondary | Kv1.1 Potassium Channel - antagonists & inhibitors | Anti-Bacterial Agents - metabolism | Scorpions - chemistry | Recombinant Proteins - genetics | Kv1.3 Potassium Channel - antagonists & inhibitors | Recombinant Proteins - pharmacology | Neurotoxins - pharmacology | Kv1.2 Potassium Channel - genetics | Sequence Alignment | Animals | Structural Homology, Protein | Staphylococcus aureus - drug effects | Staphylococcus aureus - growth & development | Bacillus subtilis - drug effects | Index Medicus | Cell Biology
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2. Full Text Redistribution of Kv1 and Kv7 enhances neuronal excitability during structural axon initial segment plasticity
by Kuba, Hiroshi and Yamada, Rei and Ishiguro, Go and Adachi, Ryota
Nature Communications, ISSN 2041-1723, 11/2015, Volume 6, Issue 1, p. 8815
Structural plasticity of the axon initial segment (AIS), the trigger zone of neurons, is a powerful means for regulating neuronal activity. Here, we show that... 
ACTIVITY-DEPENDENT RELOCATION | PYRAMIDAL NEURONS | COCHLEAR NUCLEUS NEURONS | INTRINSIC EXCITABILITY | MULTIDISCIPLINARY SCIENCES | SPIKE INITIATION | MAGNOCELLULARIS | ACTION-POTENTIAL INITIATION | AUDITORY NEURONS | POTASSIUM CHANNEL SUBUNITS | K+ CHANNELS | Kv1.1 Potassium Channel - genetics | Kv1.1 Potassium Channel - chemistry | Kv1.1 Potassium Channel - metabolism | Neurons - chemistry | Axons - metabolism | Axons - chemistry | Protein Transport | KCNQ2 Potassium Channel - chemistry | Animals | KCNQ2 Potassium Channel - metabolism | Neuronal Plasticity | Chickens | KCNQ2 Potassium Channel - genetics | Neurons - metabolism | Kinetics | Resistance | Homeostasis | Cochlea | Neurons | Channels | Elongation
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3. Full Text Cell-Type-Dependent Molecular Composition of the Axon Initial Segment
by Lorincz, Andrea and Nusser, Zoltan
Journal of Neuroscience, ISSN 0270-6474, 12/2008, Volume 28, Issue 53, pp. 14329 - 14340
The exact site of initiation and shape of action potentials vary among different neuronal types. The reason for this variability is largely unknown, but the... 
Cerebellum | Immunohistochemistry | Voltage-gated ion channels | Cortex | Olfactory bulb | Axon initial segment | Hippocampus | cortex | PURKINJE NEURONS | olfactory bulb | hippocampus | SODIUM-CHANNELS | ACTION-POTENTIAL INITIATION | KV1 CHANNELS | NEUROSCIENCES | cerebellum | axon initial segment | PYRAMIDAL CELLS | GABAERGIC INTERNEURONS | SEVERE MYOCLONIC EPILEPSY | MICE | voltage-gated ion channels | immunohistochemistry | ION CHANNELS | K+ CHANNELS | Brain - cytology | Kv1.2 Potassium Channel - deficiency | Kv1.1 Potassium Channel - metabolism | Rats, Wistar | Rats | Male | Neurons - cytology | Axons - physiology | Mice, Knockout | Nerve Tissue Proteins - metabolism | NAV1.1 Voltage-Gated Sodium Channel | Neurons - classification | Kv1.1 Potassium Channel - deficiency | Animals | NAV1.6 Voltage-Gated Sodium Channel | Ion Channels - classification | Ion Channels - metabolism | Kv1.2 Potassium Channel - metabolism | Neurons - physiology | Sodium Channels - metabolism | Mice | Ion Channels - deficiency
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4. Full Text Enhancing the fidelity of neurotransmission by activity-dependent facilitation of presynaptic potassium currents
by Yang, Yi-Mei and Wang, Wei and Fedchyshyn, Michael J and Zhou, Zhuan and Ding, Jiuping and Wang, Lu-Yang
Nature Communications, ISSN 2041-1723, 07/2014, Volume 5, Issue 1, p. 4564
Neurons convey information in bursts of spikes across chemical synapses where the fidelity of information transfer critically depends on synaptic input-output... 
ACTION-POTENTIALS | PURKINJE NEURONS | TRANSMITTER RELEASE | ACTIVATION | IONIC CURRENTS | MULTIDISCIPLINARY SCIENCES | HELD SYNAPSE | SHAKER K+ CHANNELS | TERM SYNAPTIC PLASTICITY | GATING CURRENTS | DELAYED-RECTIFIER | Potassium - metabolism | Electric Stimulation | Synaptic Transmission - physiology | Cricetulus | Kv1.1 Potassium Channel - metabolism | Calcium - metabolism | Neurons - cytology | Cerebellum - physiology | Kv1.3 Potassium Channel - genetics | Excitatory Postsynaptic Potentials - physiology | Ion Channel Gating - physiology | Neurons - physiology | Kv1.3 Potassium Channel - metabolism | Synaptic Vesicles - physiology | CHO Cells | Microtomy | Kv1.1 Potassium Channel - genetics | Gene Expression | Tissue Culture Techniques | Presynaptic Terminals - physiology | Hippocampus - cytology | Action Potentials - physiology | Kv1.2 Potassium Channel - genetics | Patch-Clamp Techniques | Animals | Kv1.2 Potassium Channel - metabolism | Cerebellum - cytology | Mice | Hippocampus - physiology
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5. Full Text Kv1.1 potassium channel deficiency reveals brain-driven cardiac dysfunction as a candidate mechanism for sudden unexplained death in epilepsy
by Glasscock, Edward and Yoo, Jong W and Chen, Tim T and Klassen, Tara L and Noebels, Jeffrey L
Journal of Neuroscience, ISSN 0270-6474, 04/2010, Volume 30, Issue 15, pp. 5167 - 5175
Mice lacking Kv1.1 Shaker-like potassium channels encoded by the Kcna1 gene exhibit severe seizures and die prematurely. The channel is widely expressed in... 
MOUSE HIPPOCAMPUS | RISK-FACTORS | STIMULATION | ATRIOVENTRICULAR-CONDUCTION BLOCK | UNEXPECTED DEATH | GENE-EXPRESSION | ASYSTOLE | MICE | HEART-RATE | NEUROSCIENCES | ICTAL BRADYCARDIA | Kv1.1 Potassium Channel - metabolism | Anti-Arrhythmia Agents - pharmacology | Atrioventricular Block - drug therapy | Arrhythmias, Cardiac - physiopathology | Seizures - physiopathology | Propranolol - pharmacology | Ventricular Premature Complexes - physiopathology | Electrocardiography - methods | Heart - physiopathology | Kv1.1 Potassium Channel - genetics | Atrioventricular Block - physiopathology | Vagus Nerve - metabolism | Brain - physiopathology | Bradycardia - physiopathology | Atropine - pharmacology | Electroencephalography - methods | Parasympatholytics - pharmacology | Mice, Knockout | Arrhythmias, Cardiac - drug therapy | Kv1.1 Potassium Channel - deficiency | Animals | Ventricular Premature Complexes - drug therapy | Video Recording - methods | Heart - drug effects | Mice | Bradycardia - drug therapy
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6. Full Text A potent and Kv1.3-selective analogue of the scorpion toxin HsTX1 as a potential therapeutic for autoimmune diseases
by Rashid, M. Harunur and Huq, Redwan and Tanner, Mark R and Chhabra, Sandeep and Khoo, Keith K and Estrada, Rosendo and Dhawan, Vikas and Chauhan, Satendra and Pennington, Michael W and Beeton, Christine and Kuyucak, Serdar and Norton, Raymond S
Scientific Reports, ISSN 2045-2322, 03/2014, Volume 4, Issue 1, p. 4509
HsTX1 toxin, from the scorpion Heterometrus spinnifer, is a 34-residue, C-terminally amidated peptide cross-linked by four disulfide bridges. Here we describe... 
KV1 POTASSIUM CHANNELS | TARGET | MOLECULAR-DYNAMICS | PROTEIN | GATED K+ CHANNELS | BLOCKER SHK | MULTIDISCIPLINARY SCIENCES | MEMORY T-CELLS | BINDING | FREE-ENERGY SIMULATIONS | SHK TOXIN | Kv1.1 Potassium Channel - metabolism | Molecular Sequence Data | Kv1.3 Potassium Channel - chemistry | Inhibitory Concentration 50 | Kv1.3 Potassium Channel - metabolism | Protein Stability | Autoimmune Diseases - metabolism | Autoimmune Diseases - drug therapy | Potassium Channel Blockers - pharmacology | Amino Acid Sequence | Cell Line | Kv1.1 Potassium Channel - chemistry | Lymphocyte Activation | Kv1.1 Potassium Channel - antagonists & inhibitors | Autoimmune Diseases - immunology | Models, Molecular | Kv1.3 Potassium Channel - antagonists & inhibitors | Scorpion Venoms - pharmacology | Peptide Fragments - chemistry | Animals | Scorpion Venoms - chemistry | Protein Binding | Protein Conformation | Mice | Potassium Channel Blockers - chemistry
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7. Full Text Kv1.1 and Kv1.3 channels contribute to the degeneration of retinal ganglion cells after optic nerve transection in vivo
by Koeberle, P.D and Wang, Y and Schlichter, L.C
Cell Death and Differentiation, ISSN 1350-9047, 01/2010, Volume 17, Issue 1, pp. 134 - 144
Degeneration of retinal ganglion cells (RGCs) - an important cause of visual impairment - is often modeled by optic nerve transection, which leads to apoptotic... 
Kv channels | siRNA in vivo | apoptotic molecules | Kv blockers | Neurodegeneration | Shaker channels | NEURONAL APOPTOSIS | SURVIVAL | POTASSIUM CHANNELS | NEUROTROPHIC FACTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | neurodegeneration | ADULT-RATS | DEATH | PROLIFERATION | CELL BIOLOGY | K+ CHANNELS | AXOTOMY | Kv1.2 Potassium Channel - antagonists & inhibitors | Caspase 9 - metabolism | Kv1.1 Potassium Channel - metabolism | Caspase 3 - metabolism | Kv1.3 Potassium Channel - genetics | Retinal Ganglion Cells - metabolism | Nerve Degeneration - metabolism | Retinal Ganglion Cells - pathology | Axotomy | Kv1.5 Potassium Channel - genetics | Female | Kv1.3 Potassium Channel - metabolism | Kv1.1 Potassium Channel - genetics | Kv1.1 Potassium Channel - antagonists & inhibitors | Rats | Kv1.3 Potassium Channel - antagonists & inhibitors | Rats, Sprague-Dawley | Nerve Degeneration - pathology | Kv1.2 Potassium Channel - genetics | Animals | Scorpion Venoms - therapeutic use | Kv1.2 Potassium Channel - metabolism | Kv1.5 Potassium Channel - metabolism | Optic Nerve - surgery | Kv1.5 Potassium Channel - antagonists & inhibitors | Nerve Degeneration - etiology | bcl-X Protein - metabolism | bcl-Associated Death Protein | Apoptosis | RNA, Small Interfering - metabolism
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8. Full Text Distinct axo‐somato‐dendritic distributions of three potassium channels in CA1 hippocampal pyramidal cells
by Kirizs, Tekla and Kerti‐Szigeti, Katalin and Lorincz, Andrea and Nusser, Zoltan
European Journal of Neuroscience, ISSN 0953-816X, 06/2014, Volume 39, Issue 11, pp. 1771 - 1783
Potassium channels comprise the most diverse family of ion channels and play critical roles in a large variety of physiological and pathological processes. In... 
electron microscopy | immunohistochemistry | confocal microscopy | ion channels | Immunohistochemistry | Confocal microscopy | Ion channels | Electron microscopy | ALPHA-SUBUNITS | SURFACE EXPRESSION | SUBUNIT COMPOSITION | KV1 CHANNELS | NEUROSCIENCES | INITIAL SEGMENT | GATED ION CHANNELS | RAT-BRAIN | KV2.1 K+ CHANNEL | IN-SITU | PROTEINS GIRK1 | Kv1.1 Potassium Channel - genetics | Shab Potassium Channels - genetics | Dendrites - metabolism | Pyramidal Cells - metabolism | CA1 Region, Hippocampal - cytology | Kv1.1 Potassium Channel - metabolism | Rats, Wistar | Cells, Cultured | Axons - metabolism | Rats | Male | G Protein-Coupled Inwardly-Rectifying Potassium Channels - genetics | Protein Transport | Shab Potassium Channels - metabolism | Animals | G Protein-Coupled Inwardly-Rectifying Potassium Channels - metabolism | CA1 Region, Hippocampal - metabolism | GABA | Potassium channels | Special Issue | Editors' Issue 2014
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9. Full Text Structural Basis of a Potent Peptide Inhibitor Designed for Kv1.3 Channel, a Therapeutic Target of Autoimmune Disease
by Song Han and Hong Yi and Shi-Jin Yin and Zong-Yun Chen and Hui Liu and Zhi-Jian Cao and Ying-Liang Wu and Wen-Xin Li
Journal of Biological Chemistry, ISSN 0021-9258, 07/2008, Volume 283, Issue 27, pp. 19058 - 19065
The potassium channel Kv1.3 is an attractive pharmacological target for immunomodulation of T cell-mediated autoimmune diseases. Potent and selective blockers... 
SCORPION BUTHUS-MARTENSI | BLOCKERS | VENOM | MULTIPLE-SCLEROSIS | GATED K+ CHANNELS | POTASSIUM CHANNELS | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROLIFERATION | MODEL | MEMORY T-CELLS | SHK TOXIN | Kv1.2 Potassium Channel - antagonists & inhibitors | Kv1.1 Potassium Channel - metabolism | Peptides - chemistry | Protein Structure, Secondary | Humans | Kv1.1 Potassium Channel - antagonists & inhibitors | Models, Molecular | Potassium Channel Blockers - therapeutic use | Peptide Mapping - methods | Kv1.3 Potassium Channel - antagonists & inhibitors | Scorpion Venoms - pharmacology | Animals | Immunity, Cellular - drug effects | Scorpion Venoms - chemistry | T-Lymphocytes - metabolism | Kv1.2 Potassium Channel - metabolism | Drug Design | Protein Binding | Kv1.3 Potassium Channel - metabolism | Mice | Autoimmune Diseases - metabolism | Autoimmune Diseases - drug therapy | Peptides - therapeutic use | Potassium Channel Blockers - chemistry | Index Medicus
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10. Full Text A missense mutation in the Kv1.1 voltage-gated potassium channel-encoding gene KCNA1 is linked to human autosomal dominant hypomagnesemia
by Glaudemans, Bob and Wijst, J.A.J. van der and Scola, R.H and Lorenzoni, P.J and Heister, J.G.A.M and Kemp, J.W.C.M. van der and Slobbe-Knoers, V.V.A.M and Hoenderop, J.G.J and Bindels, R.J.M
Journal of Clinical Investigation, ISSN 0021-9738, 2009, Volume 119, Issue 4, pp. 936 - 942
Primary hypomagnesemia is a heterogeneous group of disorders characterized by renal or intestinal magnesium (Mg2+) wasting, resulting in tetany, cardiac... 
MEDICINE, RESEARCH & EXPERIMENTAL | SECONDARY HYPOCALCEMIA | TRANSPORT | CA2 | EPISODIC ATAXIA TYPE-1 | FAMILIAL HYPOMAGNESEMIA | LINKAGE ANALYSIS | ISAACS SYNDROME | K+ CHANNEL | TRPM6 | SUBUNIT | Kv1.1 Potassium Channel - metabolism | Humans | Molecular Sequence Data | Male | Mutation, Missense | Magnesium Deficiency - genetics | Kidney - metabolism | Transfection | Genes, Dominant | DNA Mutational Analysis | Base Sequence | Brazil | Female | Kv1.1 Potassium Channel - genetics | Recombinant Proteins - metabolism | Amino Acid Sequence | Cell Line | Kv1.1 Potassium Channel - chemistry | Models, Molecular | Chromosome Mapping | Recombinant Proteins - genetics | Magnesium Deficiency - metabolism | Sequence Homology, Amino Acid | Models, Biological | Pedigree | TRPM Cation Channels - metabolism
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11. Full Text A C-terminally amidated analogue of ShK is a potent and selective blocker of the voltage-gated potassium channel Kv1.3
by Pennington, Michael W and Harunur Rashid, M and Tajhya, Rajeev B and Beeton, Christine and Kuyucak, Serdar and Norton, Raymond S
FEBS Letters, ISSN 0014-5793, 11/2012, Volume 586, Issue 22, pp. 3996 - 4001
► ShK is a potent blocker of potassium channels. ► A new ShK analogue with a C-terminal Lys residue and amide was designed. ► ShK-K-amide is a potent and... 
Electrophysiology | Potential of mean force | Potassium channel | Umbrella sampling | C-terminal amide | ShK | ShK with a C-terminal Lys and amide | effector memory T-cells | ShK-K-amide | PMF | voltage-gated K+ channel | molecular dynamics | potential of mean force | K+ channel toxin from Stichodactyla helianthus | ShK-amide | TEM | C-terminally amidated ShK | MOLECULAR-DYNAMICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | SEA-ANEMONE TOXIN | PEPTIDE | CELL BIOLOGY | BIOPHYSICS | AUTOIMMUNE-DISEASES | STICHODACTYLA-HELIANTHUS | RAT-BRAIN | INHIBITOR | MEMORY T-CELLS | FREE-ENERGY | K+ CHANNELS | Kv1.1 Potassium Channel - metabolism | Humans | Cnidarian Venoms - metabolism | Kv1.3 Potassium Channel - genetics | Cnidarian Venoms - pharmacology | Potassium Channel Blockers - metabolism | Kv1.1 Potassium Channel - physiology | Dose-Response Relationship, Drug | Ion Channel Gating - physiology | T-Lymphocytes - drug effects | Kv1.3 Potassium Channel - metabolism | Binding Sites | Potassium Channel Blockers - pharmacology | Binding, Competitive | Kv1.1 Potassium Channel - genetics | Protein Structure, Tertiary | Cells, Cultured | Models, Molecular | Kv1.3 Potassium Channel - physiology | Molecular Dynamics Simulation | Cnidarian Venoms - chemistry | Patch-Clamp Techniques | Algorithms | Animals | Ion Channel Gating - genetics | T-Lymphocytes - cytology | Amides - chemistry | Cell Line, Tumor | Protein Binding | Cell Proliferation - drug effects | Mice | Potassium Channel Blockers - chemistry | Ion Channel Gating - drug effects | Potassium channels | Peptides | T cells | Analysis | potassium channel | umbrella sampling | electrophysiology
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12. Correlation between potassium channel expression and sensitivity to drug-induced cell death in tumor cell lines
by Leanza, Luigi and O'Reilly, Paul and Doyle, Anne and Venturini, Elisa and Zoratti, Mario and Szegezdi, Eva and Szabo, Ildiko
Current Pharmaceutical Design, ISSN 1381-6128, 2014, Volume 20, Issue 2, pp. 189 - 200
Plasma membrane (PM) and mitochondrial (mt) ion channels - particularly potassium channels - became oncological targets soon after the discovery that they are... 
Mitochondria | Potassium channels | Chemotherapeutic drugs | Kv1.3 inhibitors | Apoptosis | NEURONAL APOPTOSIS | mitochondria | apoptosis | chemotherapeutic drugs | GATED K+ CHANNEL | BREAST-CANCER | COLON-CANCER | BAX-INDUCED APOPTOSIS | IN-VITRO | PROSTATE-CANCER | PHARMACOLOGY & PHARMACY | UP-REGULATION | T-LYMPHOCYTES | TARGETING ION CHANNELS | Kv1.1 Potassium Channel - metabolism | Apoptosis - drug effects | Humans | Gene Expression Regulation, Neoplastic | Kv1.3 Potassium Channel - genetics | RNA, Messenger - metabolism | Neoplasms - genetics | Kv1.3 Potassium Channel - metabolism | Antineoplastic Agents - pharmacology | Cell Membrane - metabolism | Cell Death - drug effects | Potassium Channel Blockers - pharmacology | Kv1.1 Potassium Channel - genetics | Kv1.3 Potassium Channel - drug effects | Kv1.1 Potassium Channel - drug effects | Mitochondria - metabolism | Cisplatin - pharmacology | Mitochondria - drug effects | Neoplasms - drug therapy | Sphingosine - pharmacology | Sphingosine - analogs & derivatives | Tumor Burden - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Neoplasms - pathology | Staurosporine - pharmacology
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13. Full Text Free Energy Simulations of Binding of HsTx1 Toxin to Kv1 Potassium Channels: the Basis of Kv1.3/Kv1.1 Selectivity
by Rashid, M. Harunur and Kuyucak, Serdar
The Journal of Physical Chemistry B, ISSN 1520-6106, 01/2014, Volume 118, Issue 3, pp. 707 - 716
The voltage-gated potassium channel Kv1.3 is an established target for treatment of autoimmune diseases. Hence, there are intense efforts to develop... 
SHAKER K+ CHANNEL | BIOLOGICAL ION CHANNELS | LIGAND-BINDING | CHARYBDOTOXIN COMPLEX | AUTOIMMUNE-DISEASES | CHEMISTRY, PHYSICAL | SEA-ANEMONE TOXIN | MEMORY T-CELLS | MOLECULAR DYNAMIC SIMULATIONS | 4TH DISULFIDE BRIDGE | SCORPION TOXINS | Kv1.3 Potassium Channel - chemistry | Kv1.1 Potassium Channel - chemistry | Thermodynamics | Kv1.1 Potassium Channel - metabolism | Scorpion Venoms - chemistry | Kv1.2 Potassium Channel - metabolism | Substrate Specificity | Kv1.3 Potassium Channel - metabolism | Protein Conformation | Scorpion Venoms - metabolism | Molecular Dynamics Simulation | Kv1.2 Potassium Channel - chemistry | Thermal properties | Research | Potassium channels | Chemical properties | Computer simulation | Binding energy | Blocking | Selectivity | Toxins | Porosity | Channels | Free energy
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14. Full Text Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas
by Kool, Marcel and Korshunov, Aney and Remke, Marc and Jones, David T. W and Schlanstein, Maria and Northcott, Paul A and Cho, Yoon-Jae and Koster, Jan and Schouten-van Meeteren, Antoinette and van Vuurden, Dannis and Clifford, Steven C and Pietsch, Torsten and von Bueren, Ane O and Rutkowski, Stefan and McCabe, Martin and Collins, V. Peter and Bäcklund, Magnus L and Haberler, Christine and Bourdeaut, Franck and Delattre, Olivier and Doz, Francois and Ellison, David W and Gilbertson, Richard J and Pomeroy, Scott L and Taylor, Michael D and Lichter, Peter and Pfister, Stefan M
Acta neuropathologica, ISSN 0001-6322, 2012, Volume 123, Issue 4, pp. 473 - 484
Medulloblastoma is the most common malignant brain tumor in childhood. Molecular studies from several groups around the world demonstrated that medulloblastoma... 
Pathology | Neurosciences | Medicine & Public Health | Medulloblastoma | Pediatric brain tumor | Subgroups | Meta-analysis | PROFILES | SUBTYPES | DISTINCT | PATHOLOGY | NEUROSCIENCES | ADULT | CLINICAL NEUROLOGY | PEDIATRIC MEDULLOBLASTOMAS | BETA-CATENIN STATUS | CHILDHOOD MEDULLOBLASTOMA | Multivariate Analysis | Meta-Analysis as Topic | Age Distribution | Kv1.1 Potassium Channel - metabolism | Cerebellar Neoplasms - diagnosis | Humans | Transcriptome | Child, Preschool | Hedgehog Proteins - metabolism | Male | Gene Expression Profiling | Wnt Proteins - metabolism | Young Adult | Chromosomes, Human, Pair 3 | Wnt Proteins - genetics | Hedgehog Proteins - genetics | Microarray Analysis | Adult | Female | Retrospective Studies | Cerebellar Neoplasms - classification | Medulloblastoma - genetics | Child | Gene Expression Regulation, Neoplastic - physiology | Kv1.1 Potassium Channel - genetics | Receptors, Atrial Natriuretic Factor - metabolism | Medulloblastoma - diagnosis | International Cooperation | Cerebellar Neoplasms - genetics | Chromosomes, Human, Pair 17 | Adolescent | Chromosome Aberrations | Survival Analysis | Cytogenetics | Receptors, Atrial Natriuretic Factor - genetics | Medulloblastoma - classification | Cohort Studies | Immunohistochemistry | Demography | Wnt protein | Brain tumors | Data processing | Single-nucleotide polymorphism | Gene expression | Survival | Reviews | Hedgehog protein | DNA | Children | Original Paper
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