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Journal of Biological Chemistry, ISSN 0021-9258, 03/2016, Volume 291, Issue 13, pp. 7097 - 7106
The structural similarity between defensins and scorpion neurotoxins suggests that they might have evolved from a common ancestor. However, there is no direct... 
VENOM | PORE REGION | bacteria | TOXIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | structure-function | KV1.3 CHANNEL | STRUCTURAL BASIS | FUNGAL DEFENSIN | defensin | INSECT DEFENSINS | neurotoxin | potassium channel | MESOBUTHUS-MARTENSII | PROTEOMIC ANALYSIS | K+ CHANNELS | Kv1.2 Potassium Channel - antagonists & inhibitors | Humans | Micrococcus luteus - growth & development | Potassium Channel Blockers - metabolism | Bacillus subtilis - growth & development | Defensins - pharmacology | Kv1.3 Potassium Channel - metabolism | Potassium Channel Blockers - pharmacology | Kv1.1 Potassium Channel - genetics | Amino Acid Sequence | Gene Expression | Methicillin-Resistant Staphylococcus aureus - drug effects | Models, Molecular | Recombinant Proteins - chemistry | Methicillin-Resistant Staphylococcus aureus - growth & development | Scorpion Venoms - chemistry | Kv1.2 Potassium Channel - metabolism | Neurotoxins - metabolism | Anti-Bacterial Agents - pharmacology | Mice | Scorpion Venoms - biosynthesis | Potassium Channel Blockers - chemistry | Defensins - metabolism | Defensins - genetics | Kv1.1 Potassium Channel - metabolism | Molecular Sequence Data | Neurotoxins - genetics | Structure-Activity Relationship | Defensins - chemistry | Kv1.3 Potassium Channel - genetics | Micrococcus luteus - drug effects | Scorpions - physiology | Anti-Bacterial Agents - chemistry | Protein Interaction Domains and Motifs | Recombinant Proteins - metabolism | Neurotoxins - chemistry | Protein Structure, Secondary | Kv1.1 Potassium Channel - antagonists & inhibitors | Anti-Bacterial Agents - metabolism | Scorpions - chemistry | Recombinant Proteins - genetics | Kv1.3 Potassium Channel - antagonists & inhibitors | Recombinant Proteins - pharmacology | Neurotoxins - pharmacology | Kv1.2 Potassium Channel - genetics | Sequence Alignment | Animals | Structural Homology, Protein | Staphylococcus aureus - drug effects | Staphylococcus aureus - growth & development | Bacillus subtilis - drug effects | Index Medicus | Cell Biology
Journal Article
FEBS Journal, ISSN 1742-464X, 06/2015, Volume 282, Issue 12, pp. 2247 - 2259
The voltage‐gated potassium channel Kv1.3 is an important target for the treatment of autoimmune diseases and asthma. Blockade of Kv1.3 by the sea anemone... 
electrophysiology | molecular dynamics | N‐terminal extension | potassium channels | ShK | Electrophysiology | Molecular dynamics | Potassium channels | N-terminal extension | RHEUMATOID-ARTHRITIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | SEA-ANEMONE TOXIN | SHK TOXIN | MULTIPLE-SCLEROSIS | AUTOIMMUNE-DISEASES | THERAPEUTIC TARGETS | FORCE-FIELD | INHIBITOR | MEMORY T-CELLS | LYMPHOCYTES | Recombinant Fusion Proteins - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Neurotoxins - genetics | Isoenzymes - chemistry | Structure-Activity Relationship | Cnidarian Venoms | Kv1.3 Potassium Channel - genetics | Potassium Channel Blockers - metabolism | Recombinant Fusion Proteins - metabolism | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Mutant Proteins - pharmacology | Sea Anemones | Kv1.3 Potassium Channel - chemistry | Isoenzymes - metabolism | Drug Design | Kv1.3 Potassium Channel - metabolism | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Binding Sites | Oligopeptides - chemistry | Potassium Channel Blockers - pharmacology | Recombinant Proteins - metabolism | Cell Line | Neurotoxins - chemistry | Oligopeptides - genetics | Models, Molecular | Recombinant Proteins - chemistry | Mutant Proteins - metabolism | Recombinant Proteins - genetics | Kv1.3 Potassium Channel - antagonists & inhibitors | Oligopeptides - metabolism | Recombinant Fusion Proteins - chemistry | Molecular Dynamics Simulation | Neurotoxins - pharmacology | Patch-Clamp Techniques | Animals | Mutant Proteins - chemistry | Neurotoxins - metabolism | Protein Conformation | Mice | Kinetics | Oligopeptides - pharmacology | Isoenzymes - antagonists & inhibitors | Potassium Channel Blockers - chemistry | Proteins | Amino acids | Toxins | Autoimmune diseases | Lymphocytes | Asthma | Index Medicus
Journal Article
Journal Article
Cancer Cell, ISSN 1535-6108, 04/2017, Volume 31, Issue 4, pp. 516 - 531.e10
The potassium channel Kv1.3 is highly expressed in the mitochondria of various cancerous cells. Here we show that direct inhibition of Kv1.3 using two... 
chronic lymphocytic leukemia | bioenergetics | ROS-induced apoptosis | mitochondrial potassium channels | pharmacokinetics | orthotopic melanoma model | mitochondriotropic inhibitors | ion channels and cancer | mitochondrial metabolism | pancreatic ductal adenocarcinoma | ROS RELEASE | BAX-INDUCED APOPTOSIS | ONCOLOGY | COMPLEX-I | KV1.3 POTASSIUM CHANNEL | AUTOIMMUNE-DISEASES | CHRONIC LYMPHOCYTIC-LEUKEMIA | MECHANISMS | CANCER-THERAPY | T-LYMPHOCYTES | PERMEABILITY TRANSITION | CELL BIOLOGY | Antineoplastic Agents - chemical synthesis | Humans | Middle Aged | Male | Molecular Targeted Therapy | Case-Control Studies | Pancreatic Neoplasms - drug therapy | Organophosphorus Compounds - pharmacology | Female | Kv1.3 Potassium Channel - metabolism | Antineoplastic Agents - pharmacology | Potassium Channel Blockers - pharmacology | Drug Stability | Mice, Inbred C57BL | Pancreatic Neoplasms - pathology | Mitochondria - metabolism | Kv1.3 Potassium Channel - antagonists & inhibitors | Melanoma - pathology | Mitochondria - drug effects | Antineoplastic Agents - chemistry | Potassium Channel Blockers - chemical synthesis | Carcinoma, Pancreatic Ductal - pathology | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Coumarins - pharmacology | Carcinoma, Pancreatic Ductal - drug therapy | Animals | Melanoma - drug therapy | Aged | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Potassium Channel Blockers - chemistry | Analysis | Pancreatic cancer | Leukemia | Melanoma | B cells | Potassium channels | Molecular biology | Tumor proteins | Index Medicus
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2015, Volume 58, Issue 17, pp. 6784 - 6802
Journal Article
Cell Death and Differentiation, ISSN 1350-9047, 01/2010, Volume 17, Issue 1, pp. 134 - 144
Journal Article
EMBO Molecular Medicine, ISSN 1757-4676, 07/2012, Volume 4, Issue 7, pp. 577 - 593
Journal Article
PloS one, ISSN 1932-6203, 2017, Volume 12, Issue 7, pp. e0180762 - e0180762
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 09/2012, Volume 342, Issue 3, pp. 642 - 653
The Kv1.3 channel is a recognized target for pharmaceutical development to treat autoimmune diseases and organ rejection. ShK-186, a specific peptide inhibitor... 
EFFECTOR | MULTIPLE-SCLEROSIS | POTASSIUM CHANNELS | EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS | EXTRAJUNCTIONAL ACETYLCHOLINE-RECEPTORS | PHARMACOLOGY & PHARMACY | IMMUNOGLOBULIN THERAPY | RAT DIAPHRAGM | GUINEA-PIGS | K+ CHANNEL | LYMPHOCYTES | Potassium Channel Blockers - pharmacokinetics | Leukocytes, Mononuclear - metabolism | Arthritis - metabolism | Encephalomyelitis, Autoimmune, Experimental - metabolism | Humans | Encephalomyelitis, Autoimmune, Experimental - immunology | Macaca fascicularis | Tissue Distribution - immunology | Absorption - immunology | Dose-Response Relationship, Drug | T-Lymphocytes - metabolism | T-Lymphocytes - drug effects | Leukocytes, Mononuclear - immunology | Potassium Channel Blockers - immunology | Arthritis - immunology | Inhibitory Concentration 50 | Female | Kv1.3 Potassium Channel - metabolism | Autoimmune Diseases - metabolism | Autoimmune Diseases - drug therapy | Potassium Channel Blockers - pharmacology | Cytokines - immunology | Disease Models, Animal | Tissue Distribution - drug effects | Leukocytes, Mononuclear - drug effects | Cytokines - metabolism | Proteins - pharmacokinetics | Encephalomyelitis, Autoimmune, Experimental - drug therapy | Autoimmune Diseases - immunology | Rats | Saimiri | Kv1.3 Potassium Channel - antagonists & inhibitors | Rats, Sprague-Dawley | Animals | Arthritis - drug therapy | Absorption - drug effects | T-Lymphocytes - immunology | Proteins - pharmacology | Kv1.3 Potassium Channel - immunology | Index Medicus | Drug Discovery and Translational Medicine
Journal Article
BBA - Proteins and Proteomics, ISSN 1570-9639, 05/2017, Volume 1865, Issue 5, pp. 465 - 472
Journal Article