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PLoS ONE, ISSN 1932-6203, 08/2018, Volume 13, Issue 8, p. e0201092
We screened a library of botanical compounds purified from plants of Vietnam for modulators of the activity of a two-pore domain K+ channel, TREK-1, and we... 
RILUZOLE | INHIBITION | ANXIETY | MULTIDISCIPLINARY SCIENCES | COUMARIN | PLANTS | REGULATIONS | STRESS | K+ CHANNELS | BEHAVIORS | POTASSIUM CHANNEL | Humans | Ether-A-Go-Go Potassium Channels - metabolism | Kv1.4 Potassium Channel - metabolism | Male | Anxiety - drug therapy | Brain - metabolism | Dose-Response Relationship, Drug | Kv1.4 Potassium Channel - antagonists & inhibitors | Depression - drug therapy | Depression - metabolism | Neurotransmitter Agents - pharmacology | HEK293 Cells | Potassium Channels, Inwardly Rectifying - antagonists & inhibitors | Antidepressive Agents - pharmacology | Drug Evaluation, Preclinical | Anxiety - metabolism | Potassium Channels, Tandem Pore Domain - metabolism | Nerve Tissue Proteins - antagonists & inhibitors | Anti-Anxiety Agents - pharmacology | Potassium Channels, Tandem Pore Domain - agonists | Mice, Inbred ICR | Brain - drug effects | Ether-A-Go-Go Potassium Channels - antagonists & inhibitors | Nerve Tissue Proteins - metabolism | Umbelliferones - pharmacology | Animals | Potassium Channels, Tandem Pore Domain - antagonists & inhibitors | Amlodipine - pharmacology | Phytochemicals - pharmacology | Potassium Channels, Inwardly Rectifying - metabolism | Care and treatment | Depression, Mental | Analysis | Dosage and administration | Research | Potassium channels | T cells | Antianxiety agents | Neurosciences | Amygdala | Mental disorders | Mental depression | Paraventricular nucleus | Nuclei | Channels | Modulators | Antidepressants | Dorsal raphe nucleus | Rodents | Rectifiers | Raphe nuclei | Physiology | Life sciences | Anxiety | Potassium channels (voltage-gated) | Behavior | Inhibition | c-Fos protein | Serotonin | Potassium channels (inwardly-rectifying) | Immunomodulation | Septum | Chemistry | Mood | Anxieties | Natural products | Psychopharmacology | KCNQ1 protein | Immunoreactivity | Potassium
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2013, Volume 110, Issue 41, pp. 16657 - 16662
Journal Article
Journal Article
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2016, Volume 39, Issue 6, pp. 1069 - 1072
Journal Article
Journal Article
Journal of Neurophysiology, ISSN 0022-3077, 11/2014, Volume 112, Issue 10, pp. 2492 - 2504
Journal Article
Journal Article
Brain Structure and Function, ISSN 1863-2653, 1/2013, Volume 218, Issue 1, pp. 239 - 254
Journal Article