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Mass Spectrometry Reviews, ISSN 0277-7037, 01/2018, Volume 37, Issue 1, pp. 3 - 21
Journal Article
Trends in Pharmacological Sciences, ISSN 0165-6147, 03/2018, Volume 39, Issue 3, pp. 307 - 325
Indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase 2 (TDO2) catalyze the commitment step of the kynurenine (KYN) metabolic pathway.... 
KYN | AhR | immuno-oncology | TDO2 | KYNase | IDO1 | MALIGNANT GLIOMA | ARYL-HYDROCARBON RECEPTOR | DENDRITIC CELL IMMUNOGENICITY | INDOLEAMINE 2,3-DIOXYGENASE | REGULATORY T-CELLS | PHARMACOLOGY & PHARMACY | INHIBITOR | EXPRESSION | 2,3-DIOXYGENASE 1 IDO1 | TRYPTOPHAN CATABOLISM | CUTTING EDGE
Journal Article
OPEN FORUM INFECTIOUS DISEASES, ISSN 2328-8957, 07/2019, Volume 6, Issue 7, p. ofz281
Background. Tryptophan catabolism, measured by the kynurenine:tryptophan (kyn/trp) ratio, is associated with gut microbiota alterations in people with HIV... 
INFECTIOUS DISEASES | CATABOLISM | kyn/trp ratio | INDOLEAMINE 2,3-DIOXYGENASE | MICROBIOLOGY | IMMUNOLOGY | HUMAN-IMMUNODEFICIENCY-VIRUS | PATHOGENESIS | liver fibrosis | HEPATIC STELLATE CELLS | SIMPLE NONINVASIVE INDEX | PATHWAY | IMMUNE ACTIVATION | HIV/HCV coinfection | INFECTION | MICROBIAL TRANSLOCATION
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 10/2019, Volume 168, pp. 214 - 223
[Display omitted] Targeting Trp-Kyn pathways has been identified as an attractive approach for the cancer immunotherapies. In this study, a novel... 
Epacadostat | NSCLC | IDO1 inhibitors | Phosphonamidate | Trp-Kyn | RESISTANCE MECHANISM | IMMUNOTHERAPY | INDOLEAMINE 2,3-DIOXYGENASE | PHARMACOLOGY & PHARMACY | INHIBITORS | DISCOVERY | Enzymes | Chemotherapy | Hydrogen | Analysis | Pharmacy | Immunotherapy | Tryptophan | Biological response modifiers | T cells | Interferon gamma | Cancer
Journal Article
Frontiers in Immunology, ISSN 1664-3224, 2014, Volume 5, pp. 1 - 12
Journal Article
Cancer Cell, ISSN 1535-6108, 03/2018, Volume 33, Issue 3, pp. 480 - 494.e7
Journal Article
Journal of the American College of Nutrition, ISSN 0731-5724, 05/2015, Volume 34, Issue 3, pp. 212 - 223
Objectives: Coffee consumption is considered to exert an influence on mood, the immune system, cardiovascular disease, and cancer development, but the... 
peripheral blood mononuclear cells | Kyn/Trp = kynurenine to tryptophan ratio | Kyn = kynurenine | ORAC = oxygen radical absorbance capacity assay | Abbreviations: CTB = cell titer blue | neopterin | 3-dioxygenase | indoleamine 2 | TE = trolox equivalent | coffee | PHA = phytohaemagglutinin | Trp = tryptophan | IFN = interferon | PBMC = peripheral blood mononuclear cells | FCS = fetal calf serum | IDO = indoleamine 2,3-dioxygenase | tryptophan | GCH1 = GTP-cyclohydrolase I | ANTIOXIDANT ACTIVITY | INDOLEAMINE 2,3-DIOXYGENASE | NECROSIS-FACTOR-ALPHA | NEOPTERIN PRODUCTION | NUTRITION & DIETETICS | INTERFERON-GAMMA | CHLOROGENIC ACID | CAFFEIC ACID | indoleamine 2, 3-dioxygenase | NITRIC-OXIDE | IMMUNE ACTIVATION | PARKINSONS-DISEASE | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Serotonin - biosynthesis | Leukocytes, Mononuclear - metabolism | Gallic Acid - pharmacology | Immunosuppressive Agents | Leukocytes, Mononuclear - drug effects | Mitogens - pharmacology | Anti-Inflammatory Agents | Chlorogenic Acid - pharmacology | Plant Extracts - pharmacology | Humans | Cells, Cultured | Caffeic Acids - pharmacology | Tryptophan - metabolism | Leukocytes, Mononuclear - chemistry | Phytohemagglutinins - pharmacology | Coffea - chemistry | Neopterin - metabolism | Immunologic Factors - pharmacology | Interferon-gamma - pharmacology
Journal Article
International Journal of Cancer, ISSN 0020-7136, 09/2018, Volume 143, Issue 6, pp. 1516 - 1529
Indoleamine 2,3‐dioxygenase 1 (IDO1), known as IDO, catabolizes tryptophan through kynurenine pathway, whose activity is correlated with impaired clinical... 
CDC20 | Kyn | colorectal cancer | IDO | TARGET | DENDRITIC CELLS | INDOLEAMINE 2,3-DIOXYGENASE | PROLIFERATION | DEXTRO-1-METHYL TRYPTOPHAN | D-1-METHYL-TRYPTOPHAN | CHEMOTHERAPY | ONCOLOGY | PATHWAY | COLORECTAL-CANCER | TUMORIGENESIS | Indoleamine-Pyrrole 2,3,-Dioxygenase - genetics | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Cell Proliferation | Colonic Neoplasms - prevention & control | Mitosis | Humans | Colitis - complications | Male | Azoxymethane - toxicity | Carcinogens - toxicity | Colitis - chemically induced | Cdc20 Proteins - antagonists & inhibitors | Tumor Cells, Cultured | Cdc20 Proteins - genetics | Colonic Neoplasms - etiology | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Mice, Knockout | Animals | Cell Cycle | Cdc20 Proteins - metabolism | Colonic Neoplasms - enzymology | Mice | Homeodomain Proteins - physiology | Indoleamine-Pyrrole 2,3,-Dioxygenase - antagonists & inhibitors | Apoptosis | Prevention | Dextran | Colon cancer | Mortality | Cancer cells | Tryptophan | Nuclear nonproliferation | Colitis | Sulfates | Cancer | Cell proliferation | Transcription | Colorectal carcinoma | Colorectal cancer | Sodium sulfates | Carcinogenesis | Immunity | Mitochondria | Carcinogens | Azoxymethane | Sodium sulfate | Cell cycle | Colon | Inhibition | Dioxygenase | Adaptive immunity | Epithelium | Chemotherapy | Inhibitors | Sodium | RAG1 protein | Tumors | Index Medicus
Journal Article
Frontiers in Cellular Neuroscience, ISSN 1662-5102, 07/2015, Volume 9, Issue JULY, p. 268
Journal Article