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Cell, ISSN 0092-8674, 2011, Volume 145, Issue 6, pp. 863 - 874
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2014, Volume 9, Issue 11, p. e112945
The kynurenine pathway (KP) is the principal route of L-tryptophan (TRP) catabolism leading to the production of kynurenine (KYN), the neuroprotectants,... 
QUINOLINIC ACID | INHIBITION | METABOLISM | AMINOTRANSFERASE | MULTIDISCIPLINARY SCIENCES | INDOLEAMINE 2,3-DIOXYGENASE | T-CELL | TUMORAL IMMUNE RESISTANCE | TRYPTOPHAN DEGRADATION | IDO EXPRESSION | BRAIN | Immunohistochemistry | Indoleamine-Pyrrole 2,3,-Dioxygenase - genetics | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Kynurenic Acid - blood | Gene Expression - drug effects | Humans | Kynurenine - biosynthesis | Brain Neoplasms - physiopathology | Picolinic Acids - blood | Quinolinic Acid - blood | Chromatography, High Pressure Liquid | Glial Fibrillary Acidic Protein - metabolism | Kynurenic Acid - metabolism | Carboxy-Lyases - genetics | Tryptophan - metabolism | Brain Neoplasms - metabolism | Picolinic Acids - metabolism | Antigens, CD - metabolism | Glioma - metabolism | Glioma - genetics | Kynurenine - blood | Tryptophan - blood | Carboxy-Lyases - metabolism | Tumor Cells, Cultured | Astrocytes - drug effects | Disaccharides | Cells, Cultured | Brain Neoplasms - genetics | Biosynthetic Pathways | Reverse Transcriptase Polymerase Chain Reaction | Glucuronates | Tryptophan Oxygenase - metabolism | Tryptophan Oxygenase - genetics | Antigens, Differentiation, Myelomonocytic - metabolism | Quinolinic Acid - metabolism | CD11b Antigen - metabolism | Glioma - physiopathology | Interferon-gamma - pharmacology | Astrocytes - metabolism | Tryptophan | Niacinamide | Methyl aspartate | Enzymes | Metabolites | Gliomas | NADPH | Neuroprotection | Brain | Brain tumors | Brain cancer | Glioblastoma | Tryptophan 2,3-dioxygenase | Immunity | DNA repair | Picolinic acid | Rodents | Glioma cells | L-Tryptophan | Kynurenic acid | Quinolinic acid | Deoxyribonucleic acid--DNA | Pyridines | Medical research | Hydroxylase | Adenine | Kynurenine-oxoglutarate transaminase | NAD | Acids | γ-Interferon | Nicotinamide adenine dinucleotide | Catabolism | Nicotinamide | Interferon | Tumors | Deoxyribonucleic acid | DNA
Journal Article
Journal of Separation Science, ISSN 1615-9306, 05/2014, Volume 37, Issue 9-10, pp. 1058 - 1066
In previous nephrotoxicity metabonomic studies, several potential biomarkers were found and evaluated. To investigate the relationship between the... 
Biomarkers | Radix Glycyrrhizae | Semen Strychni | Nephrotoxicity | Renal failure | ACUTE KIDNEY INJURY | UV-DETECTION | CHEMISTRY, ANALYTICAL | CREATININE VALUES | MORNING GLORY SEED | GUANIDINOACETIC ACID | TONG ARISTOLOCHIA-MANSHURIENSIS | GLOMERULAR-FILTRATION-RATE | PLASMA | BRUCINE | HPLC-TOF/MS | Glycine - analogs & derivatives | Plant Extracts - chemistry | Biomarkers - urine | Kynurenic Acid - blood | Succinates - urine | Glycine - urine | Taurine - urine | Male | Indican - blood | Indoleacetic Acids - urine | Uric Acid - urine | Renal Insufficiency - chemically induced | Mass Spectrometry | Chromatography, Liquid | Xanthurenates - blood | Molecular Structure | Renal Insufficiency - drug therapy | Uric Acid - blood | Drugs, Chinese Herbal - therapeutic use | Xanthurenates - urine | Succinates - blood | Glycine - blood | Indican - urine | Medicine, Chinese Traditional | Guanidines - blood | Rats | Citric Acid - urine | Biomarkers - blood | Creatinine - urine | Rats, Sprague-Dawley | Hippurates - urine | Taurine - blood | Citric Acid - blood | Drugs, Chinese Herbal - toxicity | Animals | Indoleacetic Acids - blood | Hippurates - blood | Drugs, Chinese Herbal - chemistry | Creatinine - blood | Kynurenic Acid - urine | Guanidines - urine | Taurine | Kidney failure | Auxin | Liquid chromatography | Uric acid | Acetic acid | Sulfates | Biological markers | Mass spectrometry | Citric acid | Urine | Acids | Toxicity | Kidney diseases | Chromatography | Methyl alcohol | Semen | Run time (computers) | Serums | Failure
Journal Article
Journal Article
Molecular Psychiatry, ISSN 1359-4184, 04/2010, Volume 15, Issue 4, pp. 393 - 403
Cytokine-induced activation of indoleamine 2,3-dioxygenase (IDO) catabolizes L-tryptophan (TRP) into L-kynurenine (KYN), which is metabolized to quinolinic... 
Kynurenine | Depression | Indoleamine 2,3-dioxygenase | Kynurenic acid | Quinolinic acid | Cytokines | NEUROLOGICAL DISEASE | PSYCHIATRY | BIOCHEMISTRY & MOLECULAR BIOLOGY | quinolinic acid | kynurenine | NECROSIS-FACTOR-ALPHA | MAJOR DEPRESSION | NEUROSCIENCES | QUINOLINIC ACID FORMATION | INTERFERON-ALPHA | DECREASED SERUM TRYPTOPHAN | cytokines | PATHWAY METABOLISM | indoleamine 2,3-dioxygenase | depression | INDOLEAMINE DIOXYGENASE | ENDOGENOUS-DEPRESSION | kynurenic acid | HEPATITIS-C | Enzyme-Linked Immunosorbent Assay - methods | Kynurenine - cerebrospinal fluid | Quinolinic Acid - cerebrospinal fluid | Chromatography, High Pressure Liquid - methods | Humans | Middle Aged | Quinolinic Acid - blood | Male | Receptors, Tumor Necrosis Factor, Type II - cerebrospinal fluid | Statistics as Topic | Depression - etiology | Tryptophan - cerebrospinal fluid | Chemokine CCL2 - cerebrospinal fluid | Hepatitis C - immunology | Kynurenine - blood | Tryptophan - blood | Depression - cerebrospinal fluid | Hepatitis C - blood | Adult | Female | Hepatitis C - complications | Antiviral Agents - therapeutic use | Ribavirin - therapeutic use | Interferon-alpha - therapeutic use | Cytokines - cerebrospinal fluid | Hepatitis C - cerebrospinal fluid | Longitudinal Studies | indoleamine 2 | 3 dioxygenase | interferon-alpha | chemokines | tryptophan
Journal Article
Nephrology Dialysis Transplantation, ISSN 0931-0509, 6/2009, Volume 24, Issue 6, pp. 1901 - 1908
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2017, Volume 12, Issue 2, p. e0172699
Journal Article
Journal Article
Brain, Behavior, and Immunity, ISSN 0889-1591, 2015, Volume 53, pp. 39 - 48
Highlights • Thickness of right BA24 and right BA32 was reduced in major depressive disorder. • Serum KynA/3HK and KynA/QA was reduced in MDD. • CRP was... 
Psychiatry | Allergy and Immunology | Kynurenine | Medial prefrontal cortex | Inflammation | Quinolinic acid | Magnetic resonance imaging | Major depressive disorder | ANTERIOR CINGULATE CORTEX | HUMAN BRAIN | SURFACE-AREA | BIPOLAR-DISORDER | IMMUNOLOGY | NEUROSCIENCES | ALPHA TREATMENT | 3-MONOOXYGENASE INHIBITION | HUMAN CEREBRAL-CORTEX | MOOD DISORDERS | SEX-DIFFERENCES | Depressive Disorder, Major - blood | Kynurenic Acid - blood | Depressive Disorder, Major - metabolism | Humans | Cerebral Cortex - pathology | Quinolinic Acid - blood | Male | Kynurenic Acid - metabolism | Case-Control Studies | Cerebral Cortex - metabolism | Prefrontal Cortex - pathology | Brain - metabolism | Kynurenine - blood | C-Reactive Protein - metabolism | Tryptophan - blood | Neurotoxicity Syndromes - pathology | Neurotoxicity Syndromes - blood | Gray Matter - metabolism | Adult | Female | Kynurenine - metabolism | Depressive Disorder, Major - pathology | Depressive Disorder, Major - diagnostic imaging | Kynurenine - analogs & derivatives | Magnetic Resonance Imaging | Quinolinic Acid - metabolism | Gray Matter - pathology | Prefrontal Cortex - metabolism | Brain - pathology | Neurotoxicity Syndromes - metabolism | Prefrontal Cortex - diagnostic imaging | Metabolites | quinolinic acid | magnetic resonance imaging | kynurenine | medial prefrontal cortex | inflammation
Journal Article