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1. Full Text Administration of Excitatory Amino Acid Antagonists via Microdialysis Attenuates the Increase in Glucose Utilization Seen Following Concussive Brain Injury
by Kawamata, Tatsuro and Katayama, Yoichi and Hovda, David A and Yoshino, Atsuo and Becker, Donald P
Journal of Cerebral Blood Flow & Metabolism, ISSN 0271-678X, 01/1992, Volume 12, Issue 1, pp. 12 - 24
Ionic flux | Glucose utilization | N-methyl-D-aspartate | Hypermetabolism | Concussion | Excitatory amino acid antagonist | Endocrinology & Metabolism | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Hematology | Science & Technology | Neurology | Biological and medical sciences | Medical sciences | Nervous system involvement in other diseases. Miscellaneous | 6-Cyano-7-nitroquinoxaline-2,3-dione | Brain Concussion - physiopathology | 2-Amino-5-phosphonovalerate - pharmacology | Rats | Ions | Male | Rats, Inbred Strains | N-Methylaspartate - antagonists & inhibitors | Brain - metabolism | Glutamic Acid | Quinoxalines - pharmacology | Animals | Glucose - metabolism | Dialysis | Kynurenic Acid - pharmacology | Excitatory Amino Acid Antagonists | Brain Concussion - metabolism | Energy Metabolism - drug effects | Index Medicus
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2. Full Text Angiotensin II type 1 receptor blockers decrease kynurenic acid production in rat kidney in vitro
by Zakrocka, Izabela and Zakrocka, Izabela and Targowska-Duda, Katarzyna M and Targowska-Duda, Katarzyna M and Wnorowski, Artur and Wnorowski, Artur and Kocki, Tomasz and Kocki, Tomasz and Jóźwiak, Krzysztof and Jóźwiak, Krzysztof and Turski, Waldemar A and Turski, Waldemar A
Naunyn-Schmiedeberg's archives of pharmacology, ISSN 0028-1298, 2/2019, Volume 392, Issue 2, pp. 209 - 217
Neurosciences | Biomedicine | Rat | Angiotensin II type 1 receptor blockers | Nephroprotection | Kynurenic acid | Pharmacology/Toxicology | Renin-angiotensin system | Kidney | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Kidney - drug effects | Telmisartan - pharmacology | Tetrazoles - pharmacology | Rats, Wistar | Humans | Losartan - pharmacology | Transaminases - antagonists & inhibitors | Male | Imidazoles - pharmacology | Kynurenic Acid - metabolism | Angiotensin II Type 1 Receptor Blockers - pharmacology | Valsartan - pharmacology | Kidney - metabolism | Animals | Transaminases - metabolism | Benzimidazoles - pharmacology | Irbesartan - pharmacology | Enzymes | Production management | Methyl aspartate | Medical colleges | Glutamate | Angiotensin | Brain | Kidneys | Glutamic acid receptors (ionotropic) | N-Methyl-D-aspartic acid receptors | Acid production | Molecular docking | Receptors | Inhibitors | Synthesis | Acids | Rodents | Inhibition | Receptor mechanisms | Angiotensin II | Index Medicus
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3. Full Text Oral administration of a specific kynurenic acid synthesis (KAT II) inhibitor attenuates evoked glutamate release in rat prefrontal cortex
by Bortz, D.M and Wu, H.-Q and Schwarcz, R and Bruno, J.P
Neuropharmacology, ISSN 0028-3908, 07/2017, Volume 121, pp. 69 - 78
Schizophrenia | Microelectrode array | Kynurenic acid | Prefrontal cortex | KAT II | glutamate | Pharmacology & Pharmacy | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Neural Pathways - drug effects | Rats, Wistar | Heterocyclic Compounds, 3-Ring - pharmacology | Transaminases - antagonists & inhibitors | Male | Kynurenic Acid - metabolism | Nucleus Accumbens - physiology | Neural Pathways - physiology | N-Methylaspartate - pharmacology | Dose-Response Relationship, Drug | Electrodes | Enzyme Inhibitors - administration & dosage | Prefrontal Cortex - drug effects | Transaminases - metabolism | Thiazolidinediones - pharmacology | Drug Administration Routes | Administration, Oral | Kynurenine - pharmacology | Enzyme Inhibitors - pharmacology | Rats | Excitatory Amino Acid Agonists - pharmacology | Animals | Microdialysis | Analysis of Variance | Prefrontal Cortex - metabolism | Glutamic Acid - metabolism | Nucleus Accumbens - drug effects | Medical colleges | Amino acids | Antipsychotic drugs | Glutamate | Methyl aspartate | Index Medicus | microelectrode array | schizophrenia | kynurenic acid | prefrontal cortex
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4. Full Text On the antioxidant properties of kynurenic acid: Free radical scavenging activity and inhibition of oxidative stress
by Lugo-Huitrón, R and Blanco-Ayala, T and Ugalde-Muñiz, P and Carrillo-Mora, P and Pedraza-Chaverrí, J and Silva-Adaya, D and Maldonado, P.D and Torres, I and Pinzón, E and Ortiz-Islas, E and López, T and García, E and Pineda, B and Torres-Ramos, M and Santamaría, A and La Cruz, V. Pérez-De
Neurotoxicology and teratology, ISSN 0892-0362, 2011, Volume 33, Issue 5, pp. 538 - 547
Medical Education | Emergency | Lipid peroxidation | Oxidative stress | Kynurenic acid | Iron sulfate | Antioxidant defense | ROS formation | Neurosciences | Toxicology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Biological and medical sciences | Medical sciences | Chemical and industrial products toxicology. Toxic occupational diseases | Metals and various inorganic compounds | Free Radical Scavengers - pharmacology | Propionates - pharmacology | Reactive Oxygen Species - metabolism | Rats, Wistar | Cerebellum - drug effects | Male | Corpus Striatum - metabolism | Propionates - antagonists & inhibitors | Prosencephalon - drug effects | Dose-Response Relationship, Drug | Hydroxides - metabolism | Ferrous Compounds - pharmacology | Lipid Peroxidation - drug effects | Nitro Compounds - pharmacology | Kynurenic Acid - pharmacology | Prosencephalon - metabolism | Ferrous Compounds - antagonists & inhibitors | Microinjections | Oocytes - metabolism | Cerebellum - metabolism | Xenopus laevis | Cells, Cultured | Rats | Antioxidants - pharmacology | Animals | Antioxidants - administration & dosage | Corpus Striatum - drug effects | Oxidative Stress - drug effects | Kynurenic Acid - administration & dosage | Nitro Compounds - antagonists & inhibitors | Antioxidants | Tryptophan | Evaluation | Methyl aspartate | Analysis | Index Medicus | Free radicals | N-Methyl-D-aspartic acid receptors | Glutamic acid receptors | Degradation | Controlled conditions | Anions | Metabolites | Hydroxyl radicals | superoxide anions
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5. Pharmacological manipulation of kynurenic acid: Potential in the treatment of psychiatric disorders
by Erhardt, Sophie and Olsson, Sara K and Engberg, Göran
CNS drugs, ISSN 1172-7047, 2009, Volume 23, Issue 2, pp. 91 - 101
Pharmacology & Pharmacy | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Psychiatry | Science & Technology | Excitatory Amino Acid Antagonists - metabolism | Excitatory Amino Acid Antagonists - therapeutic use | Schizophrenia - metabolism | Humans | Mental Disorders - metabolism | Cognition Disorders - metabolism | Excitatory Amino Acid Antagonists - pharmacology | Kynurenic Acid - therapeutic use | Cognition Disorders - drug therapy | Animals | Mental Disorders - drug therapy | Kynurenic Acid - pharmacology | Kynurenine - metabolism | Schizophrenia - drug therapy | Kynurenic Acid - chemistry
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6. Full Text Connecting inflammation with glutamate agonism in suicidality
by Erhardt, Sophie and Lim, Chai K and Linderholm, Klas R and Janelidze, Shorena and Lindqvist, Daniel and Samuelsson, Martin and Lundberg, Kristina and Postolache, Teodor T and Träskman-Bendz, Lil and Guillemin, Gilles J and Brundin, Lena
Neuropsychopharmacology (New York, N.Y.), ISSN 0893-133X, 04/2013, Volume 38, Issue 5, pp. 743 - 752
cytokine | quinolinic acid | depression | glutamate | suicide | Pharmacology & Pharmacy | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Psychiatry | Science & Technology | Psychology. Psychoanalysis. Psychiatry | Adult and adolescent clinical studies | Psychopathology. Psychiatry | Mood disorders | Biological and medical sciences | Depression | Medical sciences | Suicide | Encephalitis - psychology | Excitatory Amino Acid Agonists - cerebrospinal fluid | Kynurenine - cerebrospinal fluid | Quinolinic Acid - cerebrospinal fluid | Excitatory Amino Acid Agonists - therapeutic use | Follow-Up Studies | Somatosensory Disorders - complications | Spinal Puncture | Humans | Middle Aged | Male | Mental Disorders - complications | Kynurenic Acid - cerebrospinal fluid | Mental Disorders - psychology | Young Adult | Psychiatric Status Rating Scales | Tritium - cerebrospinal fluid | Encephalitis - cerebrospinal fluid | Suicide - psychology | Adult | Female | Aged | Retrospective Studies | Interleukin-6 - metabolism | Index Medicus | Brain | Glutamic acid | Glutamic acid receptors (ionotropic) | Mass spectroscopy | N-Methyl-D-aspartic acid receptors | Glutamic acid receptors | Inflammation | Cerebrospinal fluid | High-performance liquid chromatography | Interleukin 6 | Gas chromatography | Ketamine | Glutamatergic transmission | Kynurenic acid | Quinolinic acid | Neurotransmission | Original | Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Farmakologi och toxikologi | Pharmacology and Toxicology
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7. Full Text G-protein coupled receptor 35 (GPR35) activation and inflammatory pain: Studies on the antinociceptive effects of kynurenic acid and zaprinast
by Cosi, Cristina and Mannaioni, Guido and Cozzi, Andrea and Carlà, Vincenzo and Sili, Maria and Cavone, Leonardo and Maratea, Dario and Moroni, Flavio
Neuropharmacology, ISSN 0028-3908, 2011, Volume 60, Issue 7, pp. 1227 - 1231
Kynurenine | Analgesia | Zaprinast | Pain | Kynurenic acid | GPR35 | Pharmacology & Pharmacy | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Analgesics - pharmacology | Kynurenic Acid - blood | Spinal Cord - drug effects | Spinal Cord - metabolism | Gene Expression - drug effects | Receptors, G-Protein-Coupled - metabolism | Probenecid - blood | Male | Pain - chemically induced | Purinones - blood | Receptors, G-Protein-Coupled - agonists | Kynurenic Acid - metabolism | Pain - metabolism | Tryptophan - metabolism | Dose-Response Relationship, Drug | Inflammation - metabolism | Kynurenine - blood | Drug Interactions | Pain - drug therapy | Analgesics - blood | Kynurenine - pharmacology | Probenecid - pharmacology | Phosphodiesterase Inhibitors - pharmacology | Pain Measurement - drug effects | Antidepressive Agents, Second-Generation - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Phosphodiesterase Inhibitors - blood | Excitatory Amino Acid Antagonists - blood | Animals | Purinones - pharmacology | Neuroglia - metabolism | Mice | Receptors, G-Protein-Coupled - genetics | Ganglia, Spinal - drug effects | Ganglia, Spinal - metabolism | Index Medicus
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8. Full Text Endogenous kynurenic acid regulates extracellular GABA levels in the rat prefrontal cortex
by Beggiato, Sarah and Tanganelli, Sergio and Fuxe, Kjell and Antonelli, Tiziana and Schwarcz, Robert and Ferraro, Luca
Neuropharmacology, ISSN 0028-3908, 07/2014, Volume 82, pp. 11 - 18
7-Chlorokynurenic acid | Microdialysis | Galantamine | Astrocytes | Kynurenine aminotransferase II | Pharmacology & Pharmacy | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | gamma-Aminobutyric Acid - metabolism | Cholinergic Agents - pharmacology | Extracellular Space - drug effects | Male | Excitatory Amino Acid Antagonists - pharmacology | Kynurenic Acid - metabolism | Rats, Sprague-Dawley | Receptors, Glycine - antagonists & inhibitors | Schiff Bases - pharmacology | Galantamine - pharmacology | Extracellular Space - metabolism | Animals | Prefrontal Cortex - drug effects | Central Nervous System Agents - pharmacology | Prefrontal Cortex - metabolism | 6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology | Glutamic Acid - metabolism | alpha7 Nicotinic Acetylcholine Receptor - metabolism | Receptors, Glycine - metabolism | Kynurenic Acid - antagonists & inhibitors | Metabolites | Tryptophan | Schizophrenia | GABA | Glutamate | Galanthamine | Index Medicus | Medicin och hälsovetenskap
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