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Journal Article
Neuroscience, ISSN 0306-4522, 2014, Volume 285, pp. 97 - 106
Journal Article
Neuropharmacology, ISSN 0028-3908, 2011, Volume 60, Issue 7, pp. 1227 - 1231
Journal Article
Journal of Pain, ISSN 1526-5900, 2017, Volume 18, Issue 10, pp. 1184 - 1196
Abstract Upon systemic administration in rats, the prodrug L-4-chlorokynurenine (4-Cl-KYN) (AV-101) is rapidly absorbed, actively transported across the... 
Anesthesia & Perioperative Care | Pain Medicine | N-methyl-D-aspartate (NMDA) receptor | inflammatory pain | glycine site antagonist | neuropathic pain | 7-Chlorokynurenic acid | L-4-chlorokynurenine | NMDA RECEPTOR | CENTRAL SENSITIZATION | RANDOMIZED CONTROLLED-TRIAL | D-ASPARTATE RECEPTOR | NEUROSCIENCES | DORSAL-HORN | CLINICAL NEUROLOGY | QUINOLINIC ACID FORMATION | GLYCINE-SITE ANTAGONIST | THERMAL NOCICEPTION | IN-VIVO | Analgesics - pharmacology | Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors | Spinal Cord - drug effects | Spinal Cord - metabolism | Gabapentin | Receptors, N-Methyl-D-Aspartate - metabolism | Analgesics - metabolism | Male | Kynurenic Acid - metabolism | Prodrugs - metabolism | Brain - metabolism | Dose-Response Relationship, Drug | Kynurenic Acid - analogs & derivatives | Kynurenine - metabolism | Disease Models, Animal | Hyperalgesia - metabolism | Kynurenine - pharmacology | gamma-Aminobutyric Acid - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Kynurenine - analogs & derivatives | Rats, Sprague-Dawley | Brain - drug effects | Animals | Hyperalgesia - drug therapy | Cyclohexanecarboxylic Acids - pharmacology | Dizocilpine Maleate - pharmacology | Amines - pharmacology | Prodrugs - pharmacology | Methyl aspartate | Medical colleges | Carrageenin | Analysis | Therapeutics | Glycine | Formaldehyde | Homeopathy | Materia medica and therapeutics | Metabolites
Journal Article
Journal Article
Nature Immunology, ISSN 1529-2908, 11/2002, Volume 3, Issue 11, pp. 1097 - 1101
Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) plays a critical role in peripheral tolerance. However, regulatory pathways initiated by the interactions... 
ALLOGRAFT-REJECTION | DENDRITIC CELLS | INTERFERON-GAMMA | INDOLEAMINE 2,3-DIOXYGENASE | IN-VIVO | T-CELL ACTIVATION | MICE | IMMUNOLOGY | NF-KAPPA-B | CARDIAC ALLOGRAFTS | EXPRESSION | Recombinant Fusion Proteins - pharmacology | Male | NF-kappa B - metabolism | Tryptophan - metabolism | Trans-Activators - physiology | Immunoconjugates - pharmacology | Isoantigens - immunology | p38 Mitogen-Activated Protein Kinases | DNA-Binding Proteins - physiology | NF-kappa B - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Imidazoles - pharmacology | Antigens, Differentiation - physiology | Mice, Knockout | CTLA-4 Antigen | Dendritic Cells - classification | STAT1 Transcription Factor | Cells, Cultured - metabolism | Mice | Mice, Inbred BALB C | Antigens, CD | Immunoconjugates - toxicity | Diabetes Mellitus, Experimental - surgery | Kynurenine - biosynthesis | Recombinant Fusion Proteins - therapeutic use | Abatacept | Immune Tolerance - immunology | Immunoglobulin G - pharmacology | Islets of Langerhans Transplantation | Dendritic Cells - drug effects | Dendritic Cells - metabolism | Immune Tolerance - drug effects | B7-1 Antigen - immunology | Mice, Inbred C57BL | Interferon-gamma - physiology | B7-1 Antigen - metabolism | Enzyme Activation - drug effects | Transplantation, Homologous - immunology | Graft Enhancement, Immunologic | Peptides - pharmacology | Gene Expression Regulation - drug effects | Tryptophan Oxygenase - metabolism | Animals | MAP Kinase Signaling System - drug effects | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Antigen Presentation - drug effects | Pyridines - pharmacology | Graft Survival - drug effects | Interferon-gamma - biosynthesis
Journal Article
The Journal of Immunology, ISSN 0022-1767, 10/2008, Volume 181, Issue 8, pp. 5396 - 5404
Human plasmacytoid dendritic cells (PDCs) can drive naive, allogeneic CD4(+)CD25(-) T cells to differentiate into CD4(+)CD25(+) Foxp3(+) regulatory T cells... 
IMMUNOSUPPRESSIVE PATHWAY | TGF-BETA | IN-VIVO | CD4(+) | INDUCTION | IMMUNOLOGY | EX-VIVO | VERSUS-HOST-DISEASE | DRAINING LYMPH-NODES | TRYPTOPHAN CATABOLISM | CUTTING EDGE | Forkhead Transcription Factors - immunology | Gene Expression Regulation, Enzymologic - drug effects | Adjuvants, Immunologic - pharmacology | Coculture Techniques | Dendritic Cells - immunology | Humans | Indoleamine-Pyrrole 2,3,-Dioxygenase - immunology | T-Lymphocytes, Regulatory - immunology | Plasma Cells - enzymology | Toll-Like Receptor 9 - immunology | Forkhead Transcription Factors - metabolism | Tryptophan - analogs & derivatives | B7-1 Antigen - biosynthesis | Tryptophan - antagonists & inhibitors | Indoleamine-Pyrrole 2,3,-Dioxygenase - biosynthesis | B7-1 Antigen - immunology | Kynurenine - pharmacology | Cells, Cultured | Enzyme Inhibitors - pharmacology | Up-Regulation - drug effects | Cell Differentiation - immunology | Up-Regulation - immunology | Cell Differentiation - drug effects | Dendritic Cells - enzymology | Kynurenine - antagonists & inhibitors | HLA-DR Antigens - immunology | Tryptophan - pharmacology | Gene Expression Regulation, Enzymologic - immunology | HLA-DR Antigens - biosynthesis | Oligodeoxyribonucleotides - pharmacology | Toll-Like Receptor 9 - metabolism | T-Lymphocytes, Regulatory - enzymology | Plasma Cells - immunology
Journal Article
Molecular Psychiatry, ISSN 1359-4184, 05/2009, Volume 14, Issue 5, pp. 511 - 522
Although elevated activity of the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase (IDO) has been proposed to mediate comorbid depression in... 
Kynurenine | Minocycline | Tryptophan | 1-methyltryptophan | Forced-swim test | Tail suspension test | tail suspension test | RHEUMATOID-ARTHRITIS | forced-swim test | DENDRITIC CELLS | KYNURENINE PATHWAY | PSYCHIATRY | BIOCHEMISTRY & MOLECULAR BIOLOGY | kynurenine | NECROSIS-FACTOR-ALPHA | PROINFLAMMATORY CYTOKINES | NEUROSCIENCES | INTERFERON-ALPHA | QUINOLINIC ACID | CANCER-PATIENTS | minocycline | INDUCED SICKNESS BEHAVIOR | TRYPTOPHAN DEGRADATION | tryptophan | Indoleamine-Pyrrole 2,3,-Dioxygenase - genetics | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Minocycline - pharmacology | Kynurenine - adverse effects | Motor Activity - drug effects | Male | Chromatography, High Pressure Liquid | Dose-Response Relationship, Drug | Kynurenine - blood | Tryptophan - blood | Time Factors | Minocycline - therapeutic use | Tryptophan - analogs & derivatives | Depression - chemically induced | Behavior, Animal - drug effects | Swimming | Disease Models, Animal | Enzyme Inhibitors - pharmacology | Enzyme Activation - drug effects | Hindlimb Suspension - methods | Enzyme Inhibitors - therapeutic use | Mice, Inbred ICR | Gene Expression Regulation - drug effects | Animals | Lipopolysaccharides - pharmacology | Cytokinins - metabolism | Mice | Tryptophan - pharmacology | Tryptophan - therapeutic use | Indoleamine-Pyrrole 2,3,-Dioxygenase - antagonists & inhibitors | Depression - blood | Mediators | Depression, Mental | Indole | Physiological aspects | Development and progression | Inflammation | Research | Enzyme activation | serotonin | interferon-γ | tumor necrosis factor-α | depression | interleukin-1β | forced swim test
Journal Article
Neuropharmacology, ISSN 0028-3908, 07/2014, Volume 82, pp. 11 - 18
Journal Article
Journal of the American College of Nutrition, ISSN 0731-5724, 05/2015, Volume 34, Issue 3, pp. 212 - 223
Objectives: Coffee consumption is considered to exert an influence on mood, the immune system, cardiovascular disease, and cancer development, but the... 
peripheral blood mononuclear cells | Kyn/Trp = kynurenine to tryptophan ratio | Kyn = kynurenine | ORAC = oxygen radical absorbance capacity assay | Abbreviations: CTB = cell titer blue | neopterin | 3-dioxygenase | indoleamine 2 | TE = trolox equivalent | coffee | PHA = phytohaemagglutinin | Trp = tryptophan | IFN = interferon | PBMC = peripheral blood mononuclear cells | FCS = fetal calf serum | IDO = indoleamine 2,3-dioxygenase | tryptophan | GCH1 = GTP-cyclohydrolase I | ANTIOXIDANT ACTIVITY | INDOLEAMINE 2,3-DIOXYGENASE | NECROSIS-FACTOR-ALPHA | NEOPTERIN PRODUCTION | NUTRITION & DIETETICS | INTERFERON-GAMMA | CHLOROGENIC ACID | CAFFEIC ACID | indoleamine 2, 3-dioxygenase | NITRIC-OXIDE | IMMUNE ACTIVATION | PARKINSONS-DISEASE | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Serotonin - biosynthesis | Leukocytes, Mononuclear - metabolism | Gallic Acid - pharmacology | Immunosuppressive Agents | Leukocytes, Mononuclear - drug effects | Mitogens - pharmacology | Anti-Inflammatory Agents | Chlorogenic Acid - pharmacology | Plant Extracts - pharmacology | Humans | Cells, Cultured | Caffeic Acids - pharmacology | Tryptophan - metabolism | Leukocytes, Mononuclear - chemistry | Phytohemagglutinins - pharmacology | Coffea - chemistry | Neopterin - metabolism | Immunologic Factors - pharmacology | Interferon-gamma - pharmacology
Journal Article