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l-659,066 (30) 30
veterinary sciences (19) 19
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Veterinary Anaesthesia and Analgesia, ISSN 1467-2987, 11/2018, Volume 45, Issue 6, pp. 788 - 793
To evaluate the effect of the peripherally acting α2-adrenoceptor antagonist vatinoxan (MK-467) on the sedative properties of medetomidine (MED) when injected... 
vatinoxan | atipamezole | medetomidine | MK-467 | sedation | sheep | L-659,066 | CATS | ANTAGONIST | PHARMACOKINETICS | DOGS | VETERINARY SCIENCES | DEXMEDETOMIDINE
Journal Article
Veterinary Anaesthesia and Analgesia, ISSN 1467-2987, 09/2008, Volume 35, Issue 5, pp. 409 - 413
To investigate the influence of L-659,066, a peripheral α2-adrenoceptor antagonist, on dexmedetomidine-induced sedation and reduction in pulse rate (PR) in... 
dexmedetomidine | heart rate | L-659,066 | atipamezole | dog | sedation | L‐659,066 | Heart rate | Sedation | Dog | Dexmedetomidine | Atipamezole
Journal Article
Veterinary Anaesthesia and Analgesia, ISSN 1467-2987, 07/2017, Volume 44, Issue 4, pp. 755 - 765
Journal Article
The Veterinary Journal, ISSN 1090-0233, 08/2012, Volume 193, Issue 2, pp. 481 - 485
Six healthy laboratory Beagles were treated IV with 10μg/kg dexmedetomidine (DEX) or 10μg/kg dexmedetomidine combined with 500μg/kg MK-467 in the same syringe... 
α-2 Adrenoceptor antagonists | α-2 Adrenoceptor agonists | Lactate | MK-467 | Insulin | Dexmedetomidine | L-659,066 | PERIOPERATIVE STRESS-RESPONSE | INTRAVENOUS DEXMEDETOMIDINE | alpha-2 Adrenoceptor antagonists | alpha-2 Adrenoceptor agonists | CONSCIOUS DOGS | SERUM-INSULIN | ATIPAMEZOLE | MEDETOMIDINE | HYPERGLYCEMIA | ALPHA-ADRENERGIC RECEPTOR ANTAGONIST | VETERINARY SCIENCES | XYLAZINE | Quinolizines - pharmacokinetics | Adrenergic alpha-2 Receptor Agonists - pharmacokinetics | Male | Colorimetry - veterinary | Insulin - blood | Adrenergic alpha-2 Receptor Antagonists - pharmacokinetics | Blood Gas Analysis - veterinary | Adrenergic alpha-2 Receptor Agonists - administration & dosage | Anesthetics, Intravenous - administration & dosage | Female | Adrenergic alpha-2 Receptor Antagonists - administration & dosage | Hydrocortisone - blood | Radioimmunoassay - veterinary | Quinolizines - administration & dosage | Dexmedetomidine - administration & dosage | Blood Glucose - analysis | Blood Chemical Analysis - veterinary | Dexmedetomidine - pharmacokinetics | Cross-Over Studies | Animals | Adrenergic alpha-2 Receptor Agonists - blood | Analysis of Variance | Adrenergic alpha-2 Receptor Antagonists - blood | Models, Biological | Dexmedetomidine - blood | Dogs | Anesthetics, Intravenous - pharmacokinetics | Quinolizines - blood | Anesthetics, Intravenous - blood | Drug Combinations | Administration, Intravenous - veterinary
Journal Article
Journal Article
DRUG METABOLISM AND DISPOSITION, ISSN 0090-9556, 03/2012, Volume 40, Issue 3, pp. 445 - 449
Growing evidence supports the use of (2R-trans)-N-(2-(1,3,4,7,12b-hexahydro-2'-oxo-spiro(2H-benzofuro(2,3-a) quinolizine-2,4'-imidazolidin)- 3'-yl)ethyl)... 
CONSCIOUS DOGS | CLEARANCE | L-659,066 | MEDETOMIDINE | HEMODYNAMIC-CHANGES | PHARMACOKINETICS | PLASMA-CONCENTRATIONS | PHARMACOLOGY | SEDATION | PHARMACOLOGY & PHARMACY | RECEPTOR ANTAGONIST
Journal Article
VETERINARY ANAESTHESIA AND ANALGESIA, ISSN 1467-2987, 11/2016, Volume 43, Issue 6, pp. 599 - 610
Objectives To investigate the effects of MK-467 on sedation quality, and cardiopulmonary and pharmacokinetic variables in horses sedated intravenously (IV)... 
peripheral antagonist | L-659,066 | CARDIOPULMONARY | INTRAVENOUS DEXMEDETOMIDINE | sedation | RECEPTOR ANTAGONIST | CONSCIOUS DOGS | MEDETOMIDINE | DETOMIDINE | ALPHA-2-ADRENOCEPTOR ANTAGONIST | VETERINARY SCIENCES | alpha-agonist | MK-467 | horses | MOTILITY
Journal Article
AMERICAN JOURNAL OF VETERINARY RESEARCH, ISSN 0002-9645, 05/2012, Volume 73, Issue 5, pp. 587 - 594
Objective-To evaluate the cardiopulmonary and sedative effects of the peripheral alpha(2)-adrenoceptor antagonist MK 0467 when administered IM or IV... 
CONSCIOUS DOGS | ATIPAMEZOLE | L-659,066 | COMBINATIONS | ROMIFIDINE | BUTORPHANOL | GLYCOPYRROLATE | ALPHA-2-ADRENOCEPTOR ANTAGONIST | VETERINARY SCIENCES | DEXMEDETOMIDINE | RECEPTOR ANTAGONIST
Journal Article
VETERINARY ANAESTHESIA AND ANALGESIA, ISSN 1467-2987, 01/2020, Volume 47, Issue 1, pp. 47 - 52
Objective To quantify the peripheral selectivity of vatinoxan (L-659,066, MK-467) in dogs by comparing the concentrations of vatinoxan, dexmedetomidine and... 
L-659,066 | CARDIOPULMONARY | PERIPHERAL ALPHA-2-ADRENOCEPTOR ANTAGONIST | DEXMEDETOMIDINE-INDUCED SEDATION | BRADYCARDIA | distribution | medetomidine | RECEPTOR ANTAGONIST | central nervous system | PHARMACOKINETICS | INFUSIONS | VETERINARY SCIENCES | vatinoxan | dog | MK-467
Journal Article
VETERINARY ANAESTHESIA AND ANALGESIA, ISSN 1467-2987, 01/2017, Volume 44, Issue 1, pp. 42 - 51
Objective To determine a dose of MK-467, a peripheral alpha(2)-adrenoceptor antagonist, which, when administered intravenously (IV) concomitantly with 25 mg... 
dexmedetomidine | heart rate | L-659,066 | ATROPINE | CARDIOPULMONARY | ISOFLURANE | sedation | RECEPTOR ANTAGONIST | ANESTHETIZED DOGS | COMBINATIONS | cat | CLINICAL-EFFICACY | ALPHA-2-ADRENOCEPTOR ANTAGONIST | VETERINARY SCIENCES | MK-467 | MEDETOMIDINE HYDROCHLORIDE
Journal Article
VETERINARY ANAESTHESIA AND ANALGESIA, ISSN 1467-2987, 05/2017, Volume 44, Issue 3, pp. 417 - 426
Objective We investigated the plasma concentrations and cardiovascular effects of intramuscularly (IM) administered medetomidine, administered alone or with... 
peripheral alpha-antagonist | L-659,066 | CARDIOPULMONARY | ISOFLURANE | INTRAVENOUS DEXMEDETOMIDINE | BUTORPHANOL | medetomidine | COMBINATION | CONSCIOUS DOGS | ALPHA-ADRENERGIC RECEPTOR ANTAGONIST | ADRENOCEPTORS | ALPHA-2-ADRENOCEPTOR ANTAGONIST | VETERINARY SCIENCES | alpha-agonist | dog | MK-467
Journal Article