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by Song, B and Zheng, C and Zha, C and Hu, S and Yang, X and Wang, L and Xiao, H
Journal of Applied Microbiology, ISSN 1364-5072, 02/2020, Volume 128, Issue 2, pp. 574 - 583
Aims Leucine supplementation promotes intestinal health, but the mechanism is largely unknown. This study aimed to elucidate the mechanisms underlying the... 
mTOR pathway | SIgA secretion | l‐leucine | intestinal health | gut microbiota
Journal Article
Bioprocess and biosystems engineering, ISSN 1615-7591, 01/2020, Volume 43, Issue 1, pp. 85 - 95
Evolution is a powerful tool for the breeding of microorganisms, while the connection between the changes of intracellular metabolism and different evolution... 
Metabolomics | Trehalose | L-leucine | Chain branching | Proline | Pyruvic acid | Amino acids | Leucine | Engineering | Microorganisms | Synthesis | Metabolites | Corynebacterium glutamicum | Random mutagenesis | Evolution | Strains (organisms) | Inositol | Breeding | Metabolism | Fermentation | Environmental stress | Mutagenesis | Valine | Metabolic engineering | Intracellular | L-Valine | Index Medicus
Journal Article
International Journal of Pharmaceutics, ISSN 0378-5173, 12/2019, Volume 572, p. 118724
The use of amino acids as excipients is a promising approach to improve the physical stability and powder dispersibility of spray-dried powders for inhalation.... 
Spray drying | Amino acids | Stabilization | Simvastatin | Inhalation | DRUG | SURFACE CRYSTALLIZATION | AMORPHOUS SOLID DISPERSIONS | DRY POWDER | IN-VITRO | L-LEUCINE | FORMULATIONS | PHARMACOLOGY & PHARMACY | MOISTURE-INDUCED DETERIORATION | PHYSICAL STABILITY | WATER
Journal Article
SCIENTIFIC REPORTS, ISSN 2045-2322, 09/2019, Volume 9, Issue 1, pp. 12860 - 12
L-Type Amino Acid Transporter 1 (LAT1/Lat1) is responsible for carrying large, neutral L-amino acids as well as several drugs and prodrugs across the... 
LAT1 | HUMAN BRAIN | MULTIDISCIPLINARY SCIENCES | PERFORIN | CENTRAL-NERVOUS-SYSTEM | FUNCTIONAL-CHARACTERIZATION | VALPROIC ACID | IDENTIFICATION | EXPRESSION | CANCER | NEURODEGENERATIVE DISEASES | Drugs | Brain | Phenotypes | Prodrugs | Astrocytes | L-leucine | Amino acids | Drug delivery | Cell membranes | Leucine | Microglia | Blood-brain barrier | Protein transport
Journal Article
BMC pulmonary medicine, ISSN 1471-2466, 02/2019, Volume 19, Issue 1, pp. 42 - 11
BackgroundAerosol delivery through a nasal high flow (NHF) system is attractive for clinicians as it allows for simultaneous administration of oxygen and... 
Powders | Lungs | Aerosol | Nasal cannula | Nasal high flow | Pulmonary disease, chronic obstructive | Inhalable drugs | Pulmonary disease | GENERATION PHARMACEUTICAL IMPACTOR | DEPOSITION | ADULTS | AIR-FLOW | MICROMETER-SIZED PARTICLES | CANNULA | OXYGEN | L-LEUCINE | EXTRATHORACIC AIRWAYS | RESPIRATORY SYSTEM | EXACERBATIONS | chronic obstructive | Drugs | Drug delivery systems | Vehicles
Journal Article
International Journal of Pharmaceutics, ISSN 0378-5173, 11/2019, Volume 571, p. 118714
L-Type amino acid transporter 1 (LAT1)–utilizing prodrugs has been designed to improve drug delivery and targeting into the brain or cancer cells, since LAT1... 
Targeted drug delivery | Prodrugs | Organic anion transporting polypeptides (OATPs) | Affinity | Intrinsic clearance (CLint) | Transport capacity | L-Type amino acid transporter 1 (LAT1) | DRUG-DELIVERY | VALPROIC ACID | MECHANISMS | BLOOD-BRAIN-BARRIER | P-GLYCOPROTEIN | LAT1 | L-LEUCINE | EPITHELIAL-CELLS | PHARMACOLOGY & PHARMACY | CENTRAL-NERVOUS-SYSTEM | EXPRESSION
Journal Article
CELL DEATH & DISEASE, ISSN 2041-4889, 10/2019, Volume 10, Issue 11, pp. 1 - 17
Journal Article
International Journal of Pharmaceutics, ISSN 0378-5173, 10/2019, Volume 570, p. 118689
Drug-resistant tuberculosis (DR-TB) is an emerging health problem, challenging the effective control of global TB. Current treatment of DR-TB includes... 
Tuberculosis | Moxifloxacin | Pyrazinamide | Formulation | Bedaquiline | Inhalation | LARGE POROUS PARTICLES | IMPROVE | AEROSOLIZATION | IN-VITRO | L-LEUCINE | PHARMACOKINETICS | PHARMACOLOGY & PHARMACY | TMC207
Journal Article