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Journal of Experimental Medicine, ISSN 0022-1007, 06/2013, Volume 210, Issue 6, pp. 1189 - 1200
The forkhead O transcription factors (FOXO) integrate a range of extracellular signals, including growth factor signaling, inflammation, oxidative stress, and... 
TRANSCRIPTION FACTORS | EFFECTOR | MEDICINE, RESEARCH & EXPERIMENTAL | OXIDATIVE STRESS | L-SELECTIN | IN-VIVO | INFECTION | IMMUNOLOGY | BETA-CATENIN | NAIVE | EXPRESSION | CUTTING EDGE | Forkhead Transcription Factors - immunology | Lymphocytic choriomeningitis virus - immunology | Antigens, CD - immunology | CD8-Positive T-Lymphocytes - cytology | Granzymes - metabolism | Lectins, C-Type - immunology | Cell Survival - genetics | T-Box Domain Proteins - immunology | Granzymes - genetics | Lectins, C-Type - genetics | Lymphocytic Choriomeningitis - immunology | Antigens, CD - genetics | Antigens, CD - metabolism | Cell Differentiation - genetics | Lectins, C-Type - metabolism | Lymphocyte Activation - genetics | Lymphocyte Activation - immunology | Forkhead Transcription Factors - metabolism | CD8-Positive T-Lymphocytes - metabolism | Granzymes - immunology | T Cell Transcription Factor 1 - metabolism | Immunologic Memory - genetics | Immunologic Memory - immunology | Antigens, Differentiation, T-Lymphocyte - immunology | Mice, Inbred C57BL | Hepatocyte Nuclear Factor 1-alpha | Antigens, Differentiation, T-Lymphocyte - metabolism | Mice, Transgenic | Cell Survival - immunology | Forkhead Transcription Factors - genetics | T-Box Domain Proteins - genetics | T-Box Domain Proteins - metabolism | T Cell Transcription Factor 1 - genetics | Cell Differentiation - immunology | Animals | Up-Regulation - immunology | Antigens, Differentiation, T-Lymphocyte - genetics | T Cell Transcription Factor 1 - immunology | Forkhead Box Protein O1 | Mice | CD8-Positive T-Lymphocytes - immunology | 309
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2017, Volume 292, Issue 15, pp. 6339 - 6351
We previously showed that the cell adhesion molecule Nectin-4 is overexpressed in ovarian cancer tumors, and its cleaved extracellular domain can be detected... 
BREAST-CANCER | CARCINOMA ASCITES SPHEROIDS | METALLOPROTEASE-17 ADAM17 | L-SELECTIN | GROWTH-FACTOR-RECEPTOR | LYSOPHOSPHATIDIC ACID | PERITONEAL MESOTHELIAL CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | NECROSIS-FACTOR-ALPHA | TNF-ALPHA | CONVERTING-ENZYME | Amyloid Precursor Protein Secretases - genetics | Cell Adhesion Molecules - genetics | ADAM10 Protein - genetics | Humans | Ovarian Neoplasms - pathology | ADAM10 Protein - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | RNA, Messenger - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | RNA, Neoplasm - metabolism | Proto-Oncogene Proteins c-akt - genetics | ADAM17 Protein - metabolism | Ovarian Neoplasms - genetics | Neoplasm Metastasis | MAP Kinase Signaling System - genetics | Protein Domains | Female | Membrane Proteins - metabolism | Ovarian Neoplasms - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Membrane Proteins - genetics | Proto-Oncogene Proteins c-jun - genetics | RNA, Messenger - genetics | Cell Adhesion Molecules - metabolism | ADAM17 Protein - genetics | Amyloid Precursor Protein Secretases - metabolism | Proto-Oncogene Proteins c-jun - metabolism | Cell Line, Tumor | RNA, Neoplasm - genetics | Nectin-4 | ADAM | ADAM17 | ovarian cancer | cell migration | ADAM10 | cancer biology | biomarker | Cell Biology
Journal Article
Journal Article
Blood, ISSN 0006-4971, 04/2001, Volume 97, Issue 7, pp. 2121 - 2129
Leukostasis and tissue infiltration by leukemic cells are poorly understood life-threatening complications of acute leukemia. This study has tested the... 
SELECTIN GLYCOPROTEIN LIGAND-1 | INTERCELLULAR-ADHESION MOLECULE-1 | COLONY-STIMULATING FACTOR | IN-VIVO | P-SELECTIN | ACUTE MYELOID-LEUKEMIA | LEUKOCYTE ADHESION | HEMATOLOGY | NF-KAPPA-B | GRANULOCYTE-MACROPHAGE | HUMAN T-CELLS | Neoplastic Stem Cells - cytology | Lymphocyte Function-Associated Antigen-1 - biosynthesis | Coculture Techniques | Humans | Leukemia, Myeloid - genetics | Antigens, CD - genetics | Neoplastic Stem Cells - metabolism | E-Selectin - genetics | E-Selectin - biosynthesis | Leukostasis - genetics | Neoplasm Proteins - genetics | CD18 Antigens - genetics | Gene Expression Regulation, Leukemic | Cell Adhesion | Leukostasis - metabolism | Endothelium, Vascular - metabolism | Lymphocyte Function-Associated Antigen-1 - genetics | Macrophage-1 Antigen - genetics | Intercellular Adhesion Molecule-1 - genetics | Endothelium, Vascular - pathology | Vascular Cell Adhesion Molecule-1 - biosynthesis | Integrin beta1 - genetics | Macrophage-1 Antigen - biosynthesis | Receptors, Lymphocyte Homing - genetics | Tumor Necrosis Factor-alpha - metabolism | Cell Adhesion Molecules - genetics | Leukemic Infiltration - genetics | Lewis X Antigen - genetics | Antigens, CD - biosynthesis | Integrin alphaXbeta2 - biosynthesis | L-Selectin - genetics | Neoplasm Proteins - metabolism | L-Selectin - biosynthesis | Leukemia, Myeloid - pathology | Integrin alphaXbeta2 - genetics | Intercellular Adhesion Molecule-1 - biosynthesis | Vascular Cell Adhesion Molecule-1 - genetics | Tumor Cells, Cultured | Integrin alpha6 | Leukemic Infiltration - metabolism | Interleukin-1 - metabolism | Integrin alpha4 | Integrin alpha5 | Cell Adhesion Molecules - biosynthesis | Neoplasm Proteins - biosynthesis | Cells, Cultured | Integrin beta1 - biosynthesis | Receptors, Lymphocyte Homing - biosynthesis | Leukemia, Myeloid - metabolism | Lewis X Antigen - biosynthesis | CD18 Antigens - biosynthesis
Journal Article
European Journal of Immunology, ISSN 0014-2980, 08/2015, Volume 45, Issue 8, pp. 2389 - 2395
Journal Article
Journal of Immunology, ISSN 0022-1767, 05/2008, Volume 180, Issue 9, pp. 5935 - 5945
IFN-gamma-producing CD8(+) T lymphocytes are essential effector cells that mediate protective immunity during murine toxoplasmosis, and yet their effector... 
INTRACELLULAR PATHOGEN | PROTECTIVE IMMUNITY | NATURAL-KILLER | MEDIATED-IMMUNITY | MEMORY FORMATION | TYROSINE PHOSPHORYLATION | INTERFERON-GAMMA | CLONAL EXPANSION | IMMUNOLOGY | VIRAL-INFECTION | CUTTING EDGE | Toxoplasma - immunology | Toxoplasmosis, Animal - genetics | Interleukin-12 - genetics | CD8-Positive T-Lymphocytes - parasitology | Interferon-gamma - metabolism | L-Selectin - genetics | Protozoan Proteins - genetics | Toxoplasma - enzymology | Carbon-Nitrogen Ligases - genetics | L-Selectin - metabolism | Cell Differentiation - genetics | Signal Transduction - immunology | L-Selectin - immunology | Receptors, Interleukin-7 - genetics | Protozoan Proteins - metabolism | CD8-Positive T-Lymphocytes - metabolism | Interferon-gamma - genetics | Receptors, Immunologic - immunology | Receptors, Interleukin-7 - immunology | Tumor Necrosis Factor Receptor Superfamily, Member 7 - immunology | Receptors, Interleukin-7 - metabolism | Protozoan Vaccines - genetics | Carbon-Nitrogen Ligases - metabolism | Protozoan Vaccines - immunology | Toxoplasmosis, Animal - enzymology | Interleukin-12 - metabolism | Signal Transduction - genetics | Tumor Necrosis Factor Receptor Superfamily, Member 7 - genetics | Down-Regulation - genetics | Mice, Knockout | Cell Differentiation - immunology | Protozoan Vaccines - metabolism | Animals | Down-Regulation - immunology | Tumor Necrosis Factor Receptor Superfamily, Member 7 - metabolism | Interferon-gamma - immunology | Interleukin-12 - immunology | Toxoplasmosis, Animal - immunology | Carbon-Nitrogen Ligases - immunology | Mice | Mutation | CD8-Positive T-Lymphocytes - immunology | Receptors, Immunologic - genetics | Protozoan Proteins - immunology | Receptors, Immunologic - metabolism
Journal Article
Virology, ISSN 0042-6822, 10/2018, Volume 523, pp. 121 - 128
The HIV-1 accessory protein Vpr displays various activities that can favor viral replication such as G cell cycle arrest. Vpr also modulates host gene... 
HIV-1 | CD62L | Vpr | DDR | Nef | ATR | TRANSCRIPTION FACTORS | PROTEIN VPR | ACTIVATION | DNA-DAMAGE RESPONSE | NKG2D RECEPTOR | HUMAN-IMMUNODEFICIENCY-VIRUS | CLASS-I HDACS | VIROLOGY | LIGANDS | TYPE-1 | T-CELLS | Ataxia Telangiectasia Mutated Proteins - metabolism | Humans | L-Selectin - genetics | vif Gene Products, Human Immunodeficiency Virus - genetics | RNA, Messenger - metabolism | L-Selectin - metabolism | vif Gene Products, Human Immunodeficiency Virus - metabolism | nef Gene Products, Human Immunodeficiency Virus - metabolism | CD4-Positive T-Lymphocytes - virology | vpr Gene Products, Human Immunodeficiency Virus - metabolism | HIV-1 - metabolism | Signal Transduction | Jurkat Cells | RNA, Messenger - genetics | Viral Regulatory and Accessory Proteins - genetics | CD4-Positive T-Lymphocytes - metabolism | Gene Expression Regulation | HIV-1 - genetics | Viral Regulatory and Accessory Proteins - metabolism | Host-Pathogen Interactions | Human Immunodeficiency Virus Proteins - metabolism | G2 Phase Cell Cycle Checkpoints - genetics | Histones - genetics | nef Gene Products, Human Immunodeficiency Virus - genetics | Human Immunodeficiency Virus Proteins - genetics | Histones - metabolism | Primary Cell Culture | Ataxia Telangiectasia Mutated Proteins - genetics | vpr Gene Products, Human Immunodeficiency Virus - genetics | RNA | T cells | HIV (Viruses) | Gene expression | Analysis
Journal Article
Journal Article
The Journal of Immunology, ISSN 0022-1767, 08/2007, Volume 179, Issue 4, pp. 2143 - 2152
The Ras-guanyl nucleotide exchange factor RasGRP1 is an important link between TCR-mediated signaling and the activation of Ras and its downstream effectors.... 
SURVIVAL | POSITIVE SELECTION | AUTOIMMUNITY | EXPANSION | DISEASE | MUTATION | INSUFFICIENCY | DIFFERENTIATION | IMMUNOLOGY | CHRONIC VIRAL-INFECTION | HOMEOSTATIC PROLIFERATION | Lymphocytic choriomeningitis virus - immunology | Cell Cycle - genetics | Common Variable Immunodeficiency - immunology | Autoimmunity - genetics | Cell Survival - genetics | Adoptive Transfer | L-Selectin - genetics | Listeria monocytogenes - immunology | Lymphocytic Choriomeningitis - immunology | Autoantigens - genetics | CD4-Positive T-Lymphocytes - immunology | Cell Differentiation - genetics | Signal Transduction - immunology | L-Selectin - immunology | Lymphocyte Activation - genetics | Lymphocyte Activation - immunology | Autoimmunity - immunology | Immune Tolerance - immunology | Cell Cycle - immunology | Listeriosis - immunology | Apoptosis Regulatory Proteins - genetics | Receptors, Antigen, T-Cell - immunology | Guanine Nucleotide Exchange Factors - deficiency | Lymphocytic Choriomeningitis - genetics | Apoptosis Regulatory Proteins - immunology | Gene Expression Regulation - genetics | Gene Expression Regulation - immunology | Listeriosis - genetics | Antigens, Surface - genetics | Antigen Presentation - genetics | Common Variable Immunodeficiency - genetics | Signal Transduction - genetics | Antigen Presentation - immunology | Cell Survival - immunology | Mice, Knockout | Cell Differentiation - immunology | Animals | Autoantigens - immunology | Guanine Nucleotide Exchange Factors - immunology | Immune Tolerance - genetics | Programmed Cell Death 1 Receptor | Thymus Gland - immunology | Mice | Receptors, Antigen, T-Cell - genetics | Antigens, Surface - immunology | Chronic Disease
Journal Article
Diabetes Care, ISSN 0149-5992, 09/2013, Volume 36, Issue 9, pp. 2794 - 2802
Journal Article
Journal Article
Blood, ISSN 0006-4971, 01/2007, Volume 109, Issue 1, pp. 194 - 202
Regulatory T cells (Tregs) are crucial for the induction and maintenance of self-tolerance and are present in peripheral tissues such as skin and gut under... 
X-LINKED SYNDROME | ENTEROPATHY | RESIDENT | INTERLEUKIN-15 | TRANSCRIPTION FACTOR FOXP3 | NECROSIS-FACTOR-ALPHA | POLYENDOCRINOPATHY | SCURFY MOUSE MUTANT | PERIPHERAL-TISSUES | HEMATOLOGY | SELF-TOLERANCE | Skin - cytology | Fibroblasts - physiology | Coculture Techniques | Humans | Membrane Glycoproteins - biosynthesis | Antigens, Neoplasm - biosynthesis | Interleukin-2 Receptor alpha Subunit - biosynthesis | Antigens, CD - genetics | T-Lymphocytes, Regulatory - immunology | Receptors, Chemokine - genetics | Antibodies, Monoclonal - immunology | Receptors, Nerve Growth Factor - biosynthesis | Antibodies, Monoclonal - pharmacology | Lectins, C-Type | Cell Division - drug effects | CTLA-4 Antigen | Interleukin-15 - pharmacology | Antigens, Differentiation - biosynthesis | Glycoproteins - immunology | Models, Immunological | T-Lymphocytes, Regulatory - drug effects | Interleukin-10 - antagonists & inhibitors | CD3 Complex - immunology | Biomarkers | Antigens, Differentiation - genetics | Antigens, Differentiation, T-Lymphocyte - biosynthesis | Adenosine Deaminase - immunology | T-Lymphocytes, Regulatory - metabolism | T-Lymphocyte Subsets - cytology | Antigens, CD - biosynthesis | Dermatitis - immunology | Blood - immunology | Homeostasis | L-Selectin - genetics | Interleukin-10 - physiology | L-Selectin - biosynthesis | Interleukin-2 Receptor alpha Subunit - genetics | Receptors, Chemokine - biosynthesis | T-Lymphocytes, Regulatory - cytology | Transforming Growth Factor beta - antagonists & inhibitors | Dipeptidyl Peptidase 4 - immunology | Receptors, Tumor Necrosis Factor - genetics | Skin - immunology | Antigens, Neoplasm - genetics | Forkhead Transcription Factors - biosynthesis | Glucocorticoid-Induced TNFR-Related Protein | Transforming Growth Factor beta - physiology | Cell Communication | Immunophenotyping | Forkhead Transcription Factors - genetics | Receptors, Nerve Growth Factor - genetics | Membrane Glycoproteins - genetics | Dermatitis - pathology | Antigens, Differentiation, T-Lymphocyte - genetics | Receptors, Tumor Necrosis Factor - biosynthesis | Receptors, CCR6 | Receptors, CCR4 | Immunobiology
Journal Article
Journal Article
Clinical & Experimental Immunology, ISSN 0009-9104, 08/2015, Volume 181, Issue 2, pp. 343 - 356
Exaggerated activation of lymphocytes contributes to the pathogenesis of inflammatory bowel disease (IBD). Medical therapies are linked to the BCL‐2... 
BCL‐2 | apoptosis | IBD | mucosal T cell turnover | ABT‐737 | BIM | Mucosal T cell turnover | ABT-737 | BCL-2 | Apoptosis | SURVIVAL | SYSTEMIC-LUPUS-ERYTHEMATOSUS | CROHNS-DISEASE | AZATHIOPRINE | T-CELL | IMMUNOLOGY | LAMINA PROPRIA | INFLAMMATORY-BOWEL-DISEASE | IN-VIVO | RESISTANCE | MICE | Colitis | Lymphocytes | Analysis | Translational
Journal Article