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Journal of Experimental Medicine, ISSN 0022-1007, 12/2012, Volume 209, Issue 13, pp. 2441 - 2453
mTORC1 (mammalian target of rapamycin complex 1) controls transcriptional programs that determine CD8(+) cytolytic T cell (CTL) fate. In some cell systems,... 
MAMMALIAN TARGET | RAPAMYCIN | SURVIVAL | MEDICINE, RESEARCH & EXPERIMENTAL | EFFECTOR FUNCTIONS | L-SELECTIN | ACTIVATION | KINASE | RECEPTOR | DIFFERENTIATION | IMMUNOLOGY | LYMPHOCYTES | CD8-Positive T-Lymphocytes - cytology | TOR Serine-Threonine Kinases - metabolism | Multiprotein Complexes | Phosphatidylinositol 3-Kinases - metabolism | Aryl Hydrocarbon Receptor Nuclear Translocator - metabolism | Hypoxia-Inducible Factor 1 - metabolism | Cell Movement - physiology | Hypoxia-Inducible Factor 1 - genetics | Mechanistic Target of Rapamycin Complex 1 | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Mice, Mutant Strains | CD8-Positive T-Lymphocytes - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Cell Differentiation - physiology | 3-Phosphoinositide-Dependent Protein Kinases | Protein-Serine-Threonine Kinases - metabolism | Receptors, Antigen, T-Cell - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Mice, Inbred C57BL | Receptors, Chemokine - metabolism | Gene Expression Regulation | Protein-Serine-Threonine Kinases - genetics | Mice, Transgenic | Phosphatidylinositol 3-Kinases - genetics | Animals | Proteins - metabolism | Glucose - metabolism | Glycolysis | Interleukin-2 - pharmacology | Aryl Hydrocarbon Receptor Nuclear Translocator - genetics | Chemokines - metabolism | Mice | CD8-Positive T-Lymphocytes - immunology
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 08/2010, Volume 207, Issue 8, pp. 1617 - 1624
The protease a disintegrin and metalloprotease (ADAM) 17 cleaves tumor necrosis factor (TNF), L-selectin, and epidermal growth factor receptor (EGF-R) ligands... 
MEDICINE, RESEARCH & EXPERIMENTAL | STAT3 ACTIVATION | EPITHELIAL-CELLS | SULFATE-INDUCED COLITIS | EPIDERMAL-GROWTH-FACTOR | IN-VIVO | DISEASE | IMMUNOLOGY | FACTOR RECEPTOR | CANCER | T-CELLS | FACTOR-ALPHA | ADAM17 Protein | Tumor Necrosis Factor-alpha - metabolism | Cyclin D1 - metabolism | Epithelial Cells - metabolism | Animal Structures - abnormalities | Gene Expression - genetics | Epithelial Cells - drug effects | Inflammatory Bowel Diseases - immunology | Gene Expression Profiling | L-Selectin - metabolism | Brain - metabolism | Mammary Glands, Animal - growth & development | Receptors, Tumor Necrosis Factor, Type II - blood | Inflammatory Bowel Diseases - enzymology | Intestinal Mucosa - immunology | Inflammatory Bowel Diseases - pathology | Intestinal Mucosa - enzymology | Female | Inflammatory Bowel Diseases - chemically induced | Phosphorylation - drug effects | Epithelial Cells - cytology | Transforming Growth Factor alpha - metabolism | STAT3 Transcription Factor - metabolism | Transforming Growth Factor alpha - pharmacology | Dextran Sulfate - pharmacology | Cytokines - metabolism | Colon - pathology | Liver - metabolism | Mice, Inbred C57BL | ADAM Proteins - deficiency | Mice, Transgenic | Permeability | Colon - metabolism | Intestinal Mucosa - physiology | Regeneration | ADAM Proteins - metabolism | Animals | Cell Proliferation - drug effects | Chemokines - metabolism | Mice | ADAM Proteins - genetics | Animal Structures - metabolism | Intestinal Mucosa - pathology | Peroxidase - metabolism | Brief Definitive Report
Journal Article
Gut, ISSN 0017-5749, 02/2018, Volume 67, Issue 2, pp. 320 - 332
ObjectiveLimited efficacy of immune checkpoint inhibitors in pancreatic ductal adenocarcinoma (PDAC) has prompted investigation into combination therapy. We... 
INTERLEUKINS | IMMUNOTHERAPY | PANCREATIC CANCER | MULTIPLE-MYELOMA | INTERFERON-ALPHA | ACTIVATION | ADENOCARCINOMA | SILTUXIMAB | MONOCLONAL-ANTIBODY | MICE | SUPPRESSOR-CELLS | INTERLEUKIN-6 | GASTROENTEROLOGY & HEPATOLOGY | T-CELLS | Antineoplastic Agents, Immunological - administration & dosage | Interleukin-6 - antagonists & inhibitors | Pancreatic Neoplasms - metabolism | Humans | Actins - metabolism | Carcinoma, Pancreatic Ductal - metabolism | STAT Transcription Factors - metabolism | Janus Kinases - metabolism | L-Selectin - metabolism | Pancreatic Neoplasms - drug therapy | Th1 Cells - metabolism | Pancreatic Stellate Cells - immunology | Hyaluronan Receptors - metabolism | Female | Lymphocytes, Tumor-Infiltrating - metabolism | Carcinoma, Pancreatic Ductal - immunology | Interleukin-6 - metabolism | Disease Models, Animal | Mice, Inbred C57BL | Survival Rate | B7-H1 Antigen - immunology | Disease Progression | Tumor Microenvironment - immunology | Xenograft Model Antitumor Assays | Carcinoma, Pancreatic Ductal - drug therapy | B7-H1 Antigen - metabolism | Animals | B7-H1 Antigen - antagonists & inhibitors | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Pancreatic Neoplasms - immunology | Interleukin-6 - immunology | Mice | Pancreatic Stellate Cells - metabolism | Adenocarcinoma | Immunohistochemistry | Flow cytometry | Animal models | Transcription | CD8 antigen | Multiple myeloma | Smooth muscle | Lymphocytes T | Kinases | Metastases | Interleukin 6 | Lymphocytes | Actin | CD44 antigen | Immunotherapy | Fibroblasts | BRCA2 protein | Stellate cells | Cytokines | Secretion | Stroma | CD62L protein | CD4 antigen | Immune checkpoint | Antibiotics | Pancreatic cancer | Medical prognosis | PD-L1 protein | Cell lines | Ligands | Genetic engineering | Apoptosis | PD-L1 | pancreatic cancer | IL-6
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 2015, Volume 212, Issue 2, pp. 217 - 233
Journal Article
Circulation Research, ISSN 0009-7330, 05/2016, Volume 118, Issue 10, pp. 1540 - 1552
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 02/2012, Volume 32, Issue 2, pp. 264 - 272
Journal Article
Nature Medicine, ISSN 1078-8956, 10/2011, Volume 17, Issue 10, pp. 1290 - 1297
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2015, Volume 112, Issue 19, pp. 6080 - 6085
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2012, Volume 131, Issue 2, pp. 353 - 360.e2
Journal Article
Laboratory Investigation, ISSN 0023-6837, 12/2016, Volume 96, Issue 12, pp. 1246 - 1255
Journal Article
Journal of Immunology, ISSN 0022-1767, 08/2010, Volume 185, Issue 4, pp. 2502 - 2515
Mice s.c. injected with bleomycin, an experimental model for human systemic sclerosis, develop skin and lung fibrosis, which is mediated by inflammatory cell... 
SELECTIN GLYCOPROTEIN LIGAND-1 | LEUKOCYTE RECRUITMENT | INDUCED PULMONARY-FIBROSIS | IMMUNE-COMPLEX DEPOSITION | INDUCED LUNG INJURY | P-SELECTIN | CD4(+) T-CELLS | T-HELPER-2 CELLS | IMMUNOLOGY | SYSTEMIC-SCLEROSIS | CLINICAL CORRELATIONS | Membrane Glycoproteins - metabolism | P-Selectin - metabolism | Skin - metabolism | Interleukin-17 - immunology | Male | Pulmonary Fibrosis - genetics | Th2 Cells - immunology | L-Selectin - genetics | Th1 Cells - immunology | Th1 Cells - metabolism | L-Selectin - immunology | Bleomycin | Flow Cytometry | E-Selectin - genetics | T-Lymphocytes, Helper-Inducer - immunology | Fibrosis - immunology | Female | Pulmonary Fibrosis - metabolism | Cytokines - genetics | Skin - pathology | Fibroblasts - metabolism | Skin - immunology | T-Lymphocytes, Helper-Inducer - metabolism | Cytokines - metabolism | Intercellular Adhesion Molecule-1 - immunology | Mice, Inbred C57BL | Pulmonary Fibrosis - immunology | Scleroderma, Systemic - genetics | E-Selectin - metabolism | Scleroderma, Systemic - immunology | P-Selectin - genetics | Reverse Transcriptase Polymerase Chain Reaction | Th2 Cells - metabolism | Membrane Glycoproteins - genetics | Mice, Knockout | Scleroderma, Systemic - chemically induced | Interleukin-17 - metabolism | Animals | Intercellular Adhesion Molecule-1 - genetics | Fibroblasts - immunology | Mice
Journal Article