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American Journal of Physiology - Endocrinology and Metabolism, ISSN 0193-1849, 05/2010, Volume 298, Issue 5, pp. E1011 - E1018
Journal Article
Biochemical Journal, ISSN 0264-6021, 09/2015, Volume 470, Issue 2, pp. 207 - 221
The mammalian or mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) is a ubiquitously expressed multimeric protein kinase complex that integrates... 
Sodium-coupled neutral amino acid transporter 2 (SNAT2) | Amino acid | Growth | Transcription factor EB (TFEB) | L-type (leucine) amino acid transporter 1 (LAT1) | Uncoordinated-51-like kinase (ULK1) | Leucine | Proliferation | Autophagy | Insulin | p70S6K1 | leucine | MAMMALIAN TARGET | autophagy | PROTEIN | insulin | proliferation | amino acid | MTOR COMPLEX 1 | CONSTITUTIVE ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TSC2 | SYNTHASE KINASE 3 | GAP ACTIVITY | uncoordinated-51-like kinase (ULK1) | RAPAMYCIN MTOR | SKELETAL-MUSCLE CELLS | transcription factor EB (TFEB) | growth | sodium-coupled neutral amino acid transporter 2 (SNAT2) | RNA, Small Interfering - genetics | Phosphorylation | Cell Proliferation | TOR Serine-Threonine Kinases - metabolism | Humans | Molecular Sequence Data | Mechanistic Target of Rapamycin Complex 1 | Amino Acids - metabolism | Multiprotein Complexes - metabolism | Lysosomes - metabolism | Regulatory-Associated Protein of mTOR | Amino Acid Sequence | Cell Line | Signal Transduction | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Gene Silencing | Rats | Serine - genetics | Glycogen Synthase Kinase 3 - metabolism | Serine - metabolism | Animals | Glycogen Synthase Kinase 3 - genetics | Adaptor Proteins, Signal Transducing - genetics | Mice | Mutation | Adaptor Proteins, Signal Transducing - metabolism
Journal Article
American Journal of Physiology - Endocrinology and Metabolism, ISSN 0193-1849, 05/2012, Volume 302, Issue 9, pp. E1113 - E1122
Journal Article
American Journal of Cancer Research, ISSN 2156-6976, 2015, Volume 5, Issue 4, pp. 1281 - 1294
The L-type amino acid transporter (LAT) family are Na+-independent transporters, which deliver neutral amino acids into cells. The four LATs, LAT1 (SLC7A5),... 
L-type amino acid | Transport | mtorc1 pathway | Cancer | SYSTEM-L | BLADDER-CARCINOMA CELLS | UPPER URINARY-TRACT | RAG GTPASES | mTORC1 pathway | transport | BREAST-CANCER | ONCOLOGY | TRANSFER-RNA SYNTHETASE | 4F2 HEAVY-CHAIN | cancer | 1 LAT1 EXPRESSION | PROGNOSTIC-SIGNIFICANCE | RESISTANT PROSTATE-CANCER
Journal Article
Journal Article
Journal of Applied Physiology, ISSN 8750-7587, 07/2011, Volume 111, Issue 1, pp. 135 - 142
Journal Article
The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 01/2020, Volume 145, Issue 1, pp. 199 - 214.e11
Psoriasis is a frequent inflammatory skin disease that is mainly mediated by IL-23, IL-1β, and IL-17 cytokines. Although psoriasis is a hyperproliferative skin... 
SLC7A5 | γδ T cells | mammalian target of rapamycin | L-type amino acid transporter 1 | TH17 | psoriasis | PATHWAYS | ACTIVATION | gamma delta T cells | IMMUNOLOGY | LAT1 | MEMORY | ALLERGY | T(H)17 | IL-17 | EXPANSION | EXPRESSION | MYD88
Journal Article
Pharmaceutical Research, ISSN 0724-8741, 12/2018, Volume 35, Issue 12, pp. 1 - 9
The anti-epileptic drug pregabalin crosses the blood-brain barrier (BBB) in spite of its low lipophilicity. This study was performed to determine whether... 
Biochemistry, general | blood-brain barrier | L-type amino acid transporter | Biomedicine | Pharmacy | Medical Law | pregabalin | Pharmacology/Toxicology | Biomedical Engineering and Bioengineering | anti-epileptic drug | SYSTEM-L | ACTIVATION | INVOLVEMENT | IDENTIFICATION | GABAPENTIN | CHEMISTRY, MULTIDISCIPLINARY | LAT1 | INHIBITION | FUNCTIONAL EXPRESSION | PHARMACOLOGY & PHARMACY | BARRIER MODEL | OCTN1 | Endothelium, Vascular - cytology | Cell Line | Leucine - metabolism | RNA, Small Interfering - genetics | Anticonvulsants - pharmacokinetics | Pregabalin - pharmacokinetics | Endothelial Cells - metabolism | Large Neutral Amino Acid-Transporter 1 - metabolism | Humans | Pregabalin - metabolism | Anticonvulsants - metabolism | Rats | Amino Acid Transport System y+ - genetics | Large Neutral Amino Acid-Transporter 1 - genetics | Fusion Regulatory Protein 1, Light Chains - genetics | Permeability | Blood-Brain Barrier - metabolism | Brain - blood supply | Amino Acid Transport System y+ - metabolism | Animals | Fusion Regulatory Protein 1, Light Chains - metabolism | Biological Transport | Endothelial Cells - drug effects | Brain | Amino acids | Pregabalin | RNA | Analysis | Endothelium | Heptanes | Epilepsy | mRNA | siRNA | Carboxylic acids | Gene expression | Substrates | Endothelial cells | Polymerase chain reaction | Inhibitors | Sodium | Blood-brain barrier | Inhibition | Transport | Transporter | Lipophilicity | Research Paper
Journal Article
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 05/2019, Volume 20, Issue 10, p. 2428
Chronic proliferation is a major hallmark of tumor cells. Rapidly proliferating cancer cells are highly dependent on nutrients in order to duplicate their cell... 
Preclinical studies | Inhibitor | Targeted therapy | L-type amino acid transporter LAT1 | Cancer | l -type amino acid transporter LAT1 | targeted therapy | cancer | inhibitor | preclinical studies
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 02/2019, Volume 20, Issue 4, p. 931
Heteromeric amino acid transporters (HATs) are protein complexes that catalyze the transport of amino acids across plasma membranes. HATs are composed of two... 
Direct electron detector | LAT2 | Volta phase plate | L-type amino acid transporter | 4F2hc | Cryo-EM | Heteromeric amino acid transporter | SLC7 | SLC3 | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | FOCUS | CHEMISTRY, MULTIDISCIPLINARY | FEATURES | heteromeric amino acid transporter | direct electron detector | HEAVY-CHAIN | cryo-EM | PEPTIDE TRANSPORTER
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 08/2018, Volume 19, Issue 8, p. 2373
The progression of cancer is associated with increases in amino acid uptake by cancer cells. Upon their entry into cells through specific transporters,... 
mTOR | SLC7A