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JOURNAL OF CELL SCIENCE, ISSN 0021-9533, 06/2019, Volume 132, Issue 12, p. jcs228411
LAG1 was the first longevity assurance gene discovered in Saccharomyces cerevisiae. The Lag1 protein is a ceramide synthase and its homolog, Lac1, has a... 
Yeast | PROTEIN | BUDDING YEAST | Lac1 | SPHINGOLIPIDS | SEGREGATION | SPHINGOID BASE | SACCHAROMYCES-CEREVISIAE | Phytoceramide | CELL BIOLOGY | GENE | BIOSYNTHESIS | Aging | COMPARTMENTALIZATION | ENDOPLASMIC-RETICULUM | Lag1 | Saccharomyces cerevisiae | Dihydroceramide | Ceramide synthases
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 10/2004, Volume 279, Issue 43, pp. 44311 - 44319
In this study, endogenous long chain ceramides were measured in 32 human head and neck squamous cell carcinoma (HNSCC) and 10 nonsquamous head and neck... 
YEAST | ACTIVATION | INHIBITION | INDUCED APOPTOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | TELOMERASE ACTIVITY | GENERATION | TANDEM MASS-SPECTROMETRY | LAG1 | ENDOGENOUS CERAMIDE | CANCER
Journal Article
JOURNAL OF LIPID RESEARCH, ISSN 0022-2275, 05/2019, Volume 60, Issue 5, pp. 913 - 918
Ceramide is a critical bioactive lipid involved in diverse cellular processes. It has been proposed to regulate cellular processes by influencing membrane... 
animal models | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | OXIDATIVE STRESS | membrane | receptors | plasma membrane | multiple sclerosis | BIOCHEMISTRY & MOLECULAR BIOLOGY | INVOLVEMENT | AKT | MEMBRANE BIOPHYSICAL PROPERTIES | SPHINGOLIPIDS | fluidity | METABOLISM | heart disease | SYNTHASES | TARGETS | cancer | aging | LAG1 | lipid signaling | lipidomics | obesity
Journal Article
The EMBO Journal, ISSN 0261-4189, 02/2005, Volume 24, Issue 4, pp. 730 - 741
Ceramide plays a crucial role as a basic building block of sphingolipids, but also as a signalling molecule mediating the fate of the cell. Although Lac1p and... 
LAC1 | Fumonisin B1 | LAG1 | sphingolipids | yeast | C26‐fatty acyl‐CoA | Sphingolipids | C26-fatty acyl-CoA | Yeast | LAC1, LAG1 | SPHINGOID BASE SYNTHESIS | fumonisin B1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | STRESS-RESPONSE | ALKALINE CERAMIDASE | INOSITOL PHOSPHORYLCERAMIDE | MAMMALIAN-CELLS | CELL BIOLOGY | YEAST SACCHAROMYCES-CEREVISIAE | POLYACRYLAMIDE-GELS | BRAIN MICROSOMES | SERINE PALMITOYLTRANSFERASE | ENDOPLASMIC-RETICULUM | Sphingolipids - biosynthesis | Saccharomyces cerevisiae - genetics | Endoplasmic Reticulum - metabolism | Molecular Sequence Data | Cytoplasm - metabolism | Oxidoreductases - chemistry | Protein Subunits - metabolism | Oxidoreductases - isolation & purification | Protein Subunits - isolation & purification | Saccharomyces cerevisiae Proteins - isolation & purification | Membrane Proteins - metabolism | Protein Subunits - genetics | Amino Acid Sequence | Membrane Proteins - isolation & purification | Oxidoreductases - metabolism | Membrane Proteins - genetics | Saccharomyces cerevisiae Proteins - genetics | Mutation - genetics | Saccharomyces cerevisiae - cytology | Sequence Alignment | Membrane Proteins - chemistry | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Saccharomyces cerevisiae - enzymology | Protein Subunits - chemistry | Saccharomyces cerevisiae - growth & development | Saccharomyces cerevisiae Proteins - chemistry
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2007, Volume 401, Issue 1, pp. 205 - 216
Synthesis of VLCFAs (very long chain fatty acids) and biosynthesis of DHS (dihydrosphingosine) both are of vital importance for Saccharomyces cerevisiae. The... 
Ceramide | Longevity-assurance gene 1 (LAG1) | Sphingolipid | Ceramide synthase | Lass5 | Fatty acid elongation | MEMBRANE ANCHORS | SUPPRESSOR GENE | sphingolipid | CERAMIDE SYNTHESIS | GLYCOSYLPHOSPHATIDYLINOSITOL-ANCHORED PROTEINS | BIOCHEMISTRY & MOLECULAR BIOLOGY | fatty acid elongation | ceramide synthase | GOLGI-APPARATUS | ALKALINE CERAMIDASE | INOSITOL PHOSPHORYLCERAMIDE | SACCHAROMYCES-CEREVISIAE | PLASMA-MEMBRANE | longevity-assurance gene 1 (LAG1) | ceramide | ENDOPLASMIC-RETICULUM | Recombinant Proteins - metabolism | Sphingolipids - chemistry | Fatty Acids - chemistry | Oxidoreductases - metabolism | Oxidoreductases - genetics | Saccharomyces cerevisiae - genetics | Genotype | Sphingolipids - metabolism | Structure-Activity Relationship | DNA Primers | Mammals | Saccharomyces cerevisiae - metabolism | Animals | Cloning, Molecular | Polymerase Chain Reaction | Saccharomyces cerevisiae - enzymology | Fatty Acids - metabolism | LAG1, longevity-assurance gene 1 | WT, wild-type | ESI, electrospray ionization | IPC, inositolphosphorylceramide | PHS, phytosphingosine | ts, temperature sensitive | SLC1, sphingolipid compensation 1 | Lac1p interacting protein 1 | LAC1, longevity-assurance gene cognate 1 | Ypc1p, yeast phytoceramidase | Lip1p, Lag1p | PI, phosphatidylinositol | VLCFA, very long chain fatty acid | Ydc1p, yeast dihydroceramidase | TSC13, temperature-sensitive Csg2 suppressor | LCB, long chain base | LCFA, long chain fatty acid | PE, phosphatidylethanolamine | GPI, glycosylphosphatidylinositol | URA3, URAcil requiring | LM, Lester medium | 4Δ, lag1Δlac1Δypc1Δydc1Δ | MIPC, mannosylated IPC | DHS, dihydrosphingosine | Gas1p, glycophospholipid-anchored surface protein | M(IP)2C, inositolphosphoryl-MIPC | ER, endoplasmic reticulum
Journal Article
Biochemical Journal, ISSN 0264-6021, 08/2005, Volume 390, Issue 1, pp. 263 - 271
The Lass (longevity-assurance homologue) family members, which are highly conserved among eukaryotes, function in ceramide synthesis. In the mouse, there are... 
Sphingolipid | Topology | Ceramide synthase | Longevity assurance homologue (Lass) | N-glycosylation | RAT-LIVER | CYTOSOLIC SURFACE | sphingolipid | longevity assurance homologue (Lass) | topology | BIOCHEMISTRY & MOLECULAR BIOLOGY | ceramide synthase | MEMBRANE-PROTEIN | ASSURANCE GENE LAG1 | SPHINGOLIPIDS | YEAST | GLUCOSYLCERAMIDE SYNTHESIS | ENDOPLASMIC-RETICULUM | DIFFERENTIATION | Multigene Family - genetics | Amino Acid Sequence | Cell Line | Multigene Family - physiology | Oxidoreductases - metabolism | Membrane Proteins - genetics | Humans | Gene Expression Regulation - physiology | Molecular Sequence Data | Substrate Specificity | Phylogeny | RNA, Messenger - metabolism | Intracellular Membranes - chemistry | Ceramides - biosynthesis | Tissue Distribution | Endoplasmic Reticulum - chemistry | Animals | Cloning, Molecular | Membrane Proteins - metabolism | Mice | Endo Hf, endoglycosidase H | CHO, Chinese hamster ovary | Lass, longevity-assurance homologue | Lag, longevity-assurance gene | HEK, human embryonic kidney | HOX, homeobox | Lag1p | EST, expressed sequence tag | TRH, TRAM homologue | PNGase F, N-glycosidase F | Lip1p, Lag1p | TLC domain, TRAM | GFP, green fluorescent protein | ORF, open reading frame | TRAM, translocating chain-associating membrane | HA, haemagglutinin | LAG | CLN8 (ceroid-lipofuscinoses, neuronal 8) domain | TM1 (etc.), transmembrane segment 1 (etc.) | ER, endoplasmic reticulum | FB1, fumonisin B1 | Lac1p-interacting protein
Journal Article
Cancer Biology & Therapy, ISSN 1538-4047, 03/2015, Volume 16, Issue 3, pp. 353 - 359
Hes1 is one mammalian counterpart of the Hairy and Enhancer of split proteins that play a critical role in many physiological processes including cellular... 
chemotherapy resistance | Notch signaling pathway | Hes1 | cancer stem cell | non-canonical Notch | metastasis | Cancer stem cell | Chemotherapy resistance | Metastasis | Non-canonical Notch | basic helix-loop-helix | ABC | HDACs | OSTEOBLAST DIFFERENTIATION | Suppressor of Hairless | NEURONAL DIFFERENTIATION | TLE | BETA-CATENIN | bHLH | MAML | MASH-1 | CBF1 | PROSTATE-CANCER | histone deacetylases | epithelial-mesenchymal transition | ENHANCES SENSITIVITY | cancer stem cells | dnMAM | Lag1 | GSI | Mammalian achaete-scute homolog-1 | CSL | Runt-related protein 2 | CSCs | Runx2 | PROGENITOR CELLS | OSTEOMIMETIC PROPERTIES | secretase inhibitor | EMT | TRANSCRIPTION REPRESSION | ONCOLOGY | Mastermind-like protein family | transducin-like Enhancer of split | ATP-binding cassette | NICD | SQUAMOUS-CELL CARCINOMA | dominant-negative mastermind | Notch intracellular domain | Transcription Factor HES-1 | Basic Helix-Loop-Helix Transcription Factors - genetics | Homeodomain Proteins - metabolism | Humans | Carcinogenesis - genetics | Apoptosis - genetics | Receptors, Notch - genetics | Signal Transduction - genetics | Epithelial-Mesenchymal Transition - genetics | Homeodomain Proteins - genetics | Drug Resistance, Neoplasm - genetics | Neoplasm Metastasis | Basic Helix-Loop-Helix Transcription Factors - metabolism | Neoplastic Stem Cells - metabolism | Neoplastic Stem Cells - pathology | Index Medicus
Journal Article
Science, ISSN 0036-8075, 4/2009, Volume 324, Issue 5925, pp. 381 - 384
Journal Article