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International Journal of Oncology, ISSN 1019-6439, 07/2016, Volume 49, Issue 1, pp. 111 - 122
Journal Article
Autophagy, ISSN 1554-8627, 12/2014, Volume 10, Issue 12, pp. 2208 - 2222
Dysregulation of autophagy contributes to neuronal cell death in several neurodegenerative and lysosomal storage diseases. Markers of autophagy are also... 
β; AIF1/IBA1, allograft inflammatory factor 1 | SPTAN1, spectrin, α, non-erythrocytic 1 | LAMP1, lysosomal-associated membrane protein 1 | LC3, microtubule associated protein 1 light chain 3 | ACTB, actin | APC, adenomatous polyposis coli | ATG7, autophagy-related 7 | ULK1, unc-51 like autophagy activating kinase 1 | AIFM1, apoptosis-inducing factor, mitochondrion-associated, 1 | ATG5, autophagy-related 5 | autophagy flux | CASP3, caspase 3 | GFP, green fluorescent protein | autophagy | traumatic brain injury | CSPG4, chondroitin sulfate proteoglycan 4 | CAPS12, caspase 12 | neuronal cell death | ATG12, autophagy-related 12 | SQSTM1, sequestosome 1 | CD68, CD68 molecule | CCI, controlled cortical impact | RBFOX3, RNA binding protein, fox-1 homolog (C. elegans) 3 | LAMP2, lysosomal-associated membrane protein 2 | TBI, traumatic brain injury | lysosome | CTSD, cathepsin D | Traumatic brain injury | Autophagy | Neuronal cell death | Autophagy flux | Lysosome | NEURODEGENERATIVE DISEASE | UBIQUITIN | LYSOSOMAL STORAGE DISORDERS | CEREBRAL-CORTEX | RAT MODEL | CELL BIOLOGY | PATHWAY | DEGRADATION | MICE | EXPRESSION | PARKINSONS-DISEASE | Sequestosome-1 Protein | Heat-Shock Proteins - metabolism | Mice, Inbred C57BL | Phagosomes - metabolism | Neurons - cytology | Autophagy - physiology | Brain Injuries - metabolism | Apoptosis Regulatory Proteins - metabolism | Brain - metabolism | Animals | Cell Death - physiology | Neurons - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Brain Injuries - pathology | Disease Models, Animal | Index Medicus
Journal Article
ACS Nano, ISSN 1936-0851, 04/2014, Volume 8, Issue 4, pp. 3192 - 3201
Journal Article
Autophagy, ISSN 1554-8627, 03/2015, Volume 11, Issue 3, pp. 560 - 572
The lack of a rapid and quantitative autophagy assay has substantially hindered the development and implementation of autophagy-targeting therapies for a... 
RNA interference screen | GFP, green fluorescent protein | MTOR, mechanistic target of rapamycin | autophagy | autophagy response | RNAi, RNA interference | Cyto-ID | FBS, fetal bovine serum | LAMP1, lysosomal-associated membrane protein 1 | MAP3K6, mitogen-activated protein kinase kinase kinase 6 | shRNA, short-hairpin RNA | RAB5A, member RAS oncogene family | spectrophotometric assay | 3-MA, 3-methyladenine | SQSTM1, sequestosome 1 | MDC, monodansylcadaverine | NS, nonsilencing | WNK2, WNK lysine deficient protein kinase 2 | mRFP, monomeric red fluorescent protein | small molecule screen | autophagy flux | MAP1LC3B/LC3B, microtubule-associated protein 1 light chain 3 beta | Utophagy | Spectrophotometric assay | Autophagy flux | Small molecule screen | Autophagy response | member RAS oncogene family | RNA interference | LC3B | sequestosome 1 | mechanistic target of rapamycin | MDC | monodansylcadaverine | CELL BIOLOGY | GFP | MAP1LC3B | LAMP1 | shRNA | FBS | lysosomal-associated membrane protein 1 | MAP3K6 | LC3 | SIRNA SCREEN | CELLS | RNAi | WNK lysine deficient protein kinase 2 | MARKER | microtubule-associated protein 1 light chain 3 beta | mitogen-activated protein kinase kinase kinase 6 | nonsilencing | CHLOROQUINE | green fluorescent protein | MTOR | short-hairpin RNA | fetal bovine serum | WNK2 | DISEASE | 3-MA | monomeric red fluorescent protein | mRFP | RAB5A | SQSTM1 | 3-methyladenine | Fluorescent Dyes - chemistry | Neoplasm Transplantation | Spectrometry, Fluorescence - methods | Dactinomycin - chemistry | Lysosomes - chemistry | Cell Survival | Humans | Mice, Inbred C57BL | Leukemia - metabolism | MAP Kinase Kinase Kinases - metabolism | Gene Expression Regulation, Leukemic | Mice, SCID | Autophagy | Imatinib Mesylate - chemistry | Animals | RNA Interference | Chloroquine - chemistry | HEK293 Cells | K562 Cells | Endosomes - chemistry | Mice | HeLa Cells | Microscopy, Fluorescence | Protein-Serine-Threonine Kinases - metabolism | Index Medicus
Journal Article
Autophagy, ISSN 1554-8627, 03/2015, Volume 11, Issue 3, pp. 439 - 451
Phagophore nucleates from a subdomain of the endoplasmic reticulum (ER) termed the omegasome and also makes contact with other organelles such as mitochondria,... 
COPII, coat protein II | BSA, bovine serum albumin | autophagy | three dimensional | SB-EM, serial block-face scanning electron microscopy | MCS, membrane contact site | LAMP1, lysosomal-associated membrane protein 1 | MAP1LC3/LC3, microtubule-associated protein 1 light chain 3 | ATG, autophagy-related | serial block face scanning electron microscopy | mitochondrion | SEC31A, SEC31 homolog A (S. cerevisiae) | GOLGA2/GM130, golgin A2 | immunoEM | immunoEM, immuno electron microscopy | PBS, phosphate-buffered saline | TFRC, transferrin receptor | Golgi complex | 3D, 3 dimensional | ET, electron tomography | electron tomography | lysosome | ER, endoplasmic reticulum | WIPI2, WD repeat domain, phosphoinositide interacting 2 | Mitochondrion | ImmunoEM | Lysosome | Electron tomography | Autophagy | Serial block face scanning electron microscopy | Three dimensional | TFRC | EARLY STEPS | immuno electron microscopy | transferrin receptor | phosphate-buffered saline | ER EXIT SITES | CELL BIOLOGY | GOLGA2 | BSA | LAMP1 | autophagy-related | LC3 | MITOCHONDRIA CONTACTS | PBS | GM130 | TRAFFICKING | ELECTRON-MICROSCOPY | WIPI2 | MAP1LC3 | bovine serum albumin | 3 dimensional | phosphoinositide interacting 2 | microtubule-associated protein 1 light chain 3 | membrane contact site | TOMOGRAPHY REVEALS | MEMBRANE SOURCE | COPII | serial block-face scanning electron microscopy | SB-EM | cerevisiae | AUTOPHAGOSOME FORMATION | lysosomal-associated membrane protein 1 | coat protein II | SEC31A | golgin A2 | SEC31 homolog A (S | WD repeat domain | LIPID TRANSPORT | ATG | ENDOPLASMIC-RETICULUM | MCS | endoplasmic reticulum | Cell Line | Microscopy, Electron, Scanning | Electron Microscope Tomography | Rats | Cell Membrane - ultrastructure | Cytoplasm - ultrastructure | Kidney - cytology | Mitochondria - ultrastructure | Endoplasmic Reticulum - ultrastructure | Freezing | Lysosomes - ultrastructure | Endoplasmic Reticulum - pathology | Lipids - chemistry | Animals | Organelles - ultrastructure | Endosomes - ultrastructure | Golgi Apparatus - ultrastructure | Microscopy, Fluorescence | Index Medicus
Journal Article
Autophagy, ISSN 1554-8627, 12/2014, Volume 10, Issue 12, pp. 2310 - 2323
Journal Article
Autophagy, ISSN 1554-8627, 01/2015, Volume 11, Issue 1, pp. 88 - 99
Recently a noncanonical activity of autophagy proteins has been discovered that targets lipidation of microtubule-associated protein 1 light chain 3 (LC3) onto... 
RB1CC1/FIP200, RB1-inducible coiled-coil 1 | PIK3C3/VPS34, phosphatidylinositol 3-kinase | FYCO1, FYVE and coiled-coil domain containing 1 | V-ATPase, vacuolar-type H | ConA, concanamycin A | LAMP1, lysosomal-associated membrane protein 1 | MAP1LC3/LC3, microtubule-associated protein 1 light chain 3 | ATG, autophagy-related | chloroquine | Helicobacter pylori | ULK1/2, unc-51 like autophagy activating kinase 1/2 | entosis | LC3 | TLR, toll-like receptor | phagocytosis | LAP, LC3-associated phagocytosis | GFP, green fluorescent protein | MTOR, mechanistic target of rapamycin | autophagy | V-ATPase | SQSTM1/p62, sequestosome 1 | ATPase | PtdIns3K, phosphatidylinositol 3-kinase | CQ, chloroquine | TEM, transmission electron microscopy | PtdIns3P, phosphatidylinositol 3-phosphate | VacA, vacuolating toxin A | Baf, bafilomycin A | LAP | catalytic subunit type 3 | CALCOCO2/NDP52, calcium binding and coiled-coil domain 2 | lysosome | Entosis | Chloroquine | Lysosome | Autophagy | Phagocytosis | REACTIVE OXYGEN PRODUCTION | RAT HEPATOCYTES | VACUOLATING CYTOTOXIN | MEMBRANE | TOXIN | MACROPHAGES | CHAIN 3 PROTEIN | CELL BIOLOGY | NONCANONICAL AUTOPHAGY | EPITHELIAL-CELLS | HELICOBACTER-PYLORI | Lysosomes - drug effects | Water | Cell Line | Phagocytosis - drug effects | Phosphatidylinositol Phosphates - metabolism | Microtubule-Associated Proteins - metabolism | Humans | Monensin - pharmacology | Osmosis - drug effects | Vacuolar Proton-Translocating ATPases - metabolism | Autophagy - drug effects | Endosomes - metabolism | Lysosomes - ultrastructure | Chloroquine - pharmacology | Lipids - chemistry | Animals | Lysosomes - metabolism | Endosomes - drug effects | Endosomes - ultrastructure | Entosis - drug effects | Bacterial Proteins - metabolism | Mice | Index Medicus
Journal Article
Autophagy, ISSN 1554-8627, 11/2014, Volume 10, Issue 11, pp. 1895 - 1905
Journal Article
Autophagy, ISSN 1554-8627, 05/2015, Volume 11, Issue 5, pp. 769 - 784
CAV1 (caveolin 1, caveolae protein, 22kDa) is well known as a principal scaffolding protein of caveolae, a specialized plasma membrane structure. Relatively,... 
lipid rafts | CTxB, cholera toxin subunit B | transporting lysosomal 38kDa, V0 subunit d1 | EGF, epidermal growth factor | TSC, tuberous sclerosis complex | LAMP1, lysosomal-associated membrane protein 1 | MAP1LC3/LC3, microtubule-associated protein 1 light chain 3 | PTRF, polymerase I and transcript release factor | PBS, phosphate-buffered saline | CAV1, caveolin 1 | TFRC, transferrin receptor | CHO, water-soluble cholesterol | MEF, mouse embryonic fibroblasts | CQ, choloroquine | caveolin 1 | MTOR, mechanistic target of rapamycin | autophagy | PI, propidium iodide | WT, wild type | breast cancer | tfLC3B, mRFP-GFP tandem fluorescent-tagged LC3B | CTSL, cathepsin L | + | ATP6V0D1, ATPase H | 1 | PLA, proximity ligation assay | KO, knockout | Baf, bafilomycin A | DRF, detergent-resistant fraction | MBCD, methyl-β-cyclodextrin | lysosome | DSF, detergent-soluble fraction | Breast cancer | Lipid rafts | Caveolin 1 | Autophagy | Lysosome | ACTIVATION | PROTEIN | CHOLESTEROL | STROMAL CAVEOLIN-1 | DOWN-REGULATION | RECEPTOR | DEATH | PLASMA-MEMBRANE | CAVEOLIN-1-NULL MICE | CELL BIOLOGY | Membrane Fusion | Cell Survival | Membrane Microdomains - metabolism | Down-Regulation | Humans | Phagosomes - metabolism | Stress, Physiological | Caveolin 1 - deficiency | Vacuolar Proton-Translocating ATPases - metabolism | Breast Neoplasms - metabolism | Caveolin 1 - metabolism | Animals | Lysosomes - metabolism | MCF-7 Cells | Breast Neoplasms - pathology | Models, Biological | Female | Mice | Index Medicus
Journal Article
Autophagy, ISSN 1554-8627, 02/2015, Volume 11, Issue 2, pp. 385 - 402
Mitochondria-induced oxidative stress and flawed autophagy are common features of neurodegenerative and lysosomal storage diseases (LSDs). Although defective... 
Pompe disease | LSD, lysosomal storage disease | α, acid | LAMP1, lysosomal-associated membrane protein 1 | channel | EGTA, ethylene glycol-bis(2-aminoethylether)-N, N, N′, N′-tetraacetic acid | GAA, glucosidase | CCCP, carbonyl cyanide m-chlorophenylhydrazone | DMEM, Dulbecco's modified Eagle's medium | AIFM1, apoptosis-inducing factor, mitochondrion-associated, 1 | RFP, red fluorescent protein | ROS, reactive oxygen species | MitoG, MitoTracker Green | TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labeling | MOPS, 3-morpholinopropane-1-sulfonic acid | OMM, outer mitochondrial membrane | GFP, green fluorescent protein | autophagy | calcium | VDCC, voltage-dependent Ca | MAP1LC3A/B (LC3), microtubule-associated protein 1 light chain 3 α/β | mitochondria | Ub, ubiquitinated | mitophagy | lysosome | ERT, enzyme replacement therapy | Mitochondria | Calcium | Mitophagy | Autophagy | Lysosome | APOPTOSIS-INDUCING FACTOR | OXIDATIVE STRESS | LYSOSOMAL STORAGE DISEASE | DAMAGED MITOCHONDRIA | KINASE KINASE-BETA | ACID MALTASE DEFICIENCY | CELL BIOLOGY | SKELETAL-MUSCLE | MOUSE MODEL | CLINICAL-TRIALS | AUTOPHAGOSOME FORMATION | Reactive Oxygen Species - metabolism | Glycogen Storage Disease Type II - genetics | Humans | Autophagy - physiology | Mitochondria - metabolism | Calcium - deficiency | Animals | Homeostasis - physiology | Glycogen Storage Disease Type II - metabolism | Membrane Potential, Mitochondrial - physiology | Mice | Apoptosis - physiology | Muscle, Skeletal - pathology | alpha-Glucosidases - metabolism | Index Medicus
Journal Article