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lanosterol 14-alpha-demethylase (128) 128
index medicus (116) 116
biochemistry & molecular biology (79) 79
cyp51 (72) 72
candida-albicans (67) 67
humans (66) 66
antifungal agents - pharmacology (65) 65
animals (61) 61
sterol 14-demethylase (47) 47
microbial sensitivity tests (46) 46
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chemistry, medicinal (44) 44
cytochrome p-450 enzyme system - metabolism (40) 40
lanosterol 14-alpha-demethylase cyp51 (40) 40
antifungal agents - chemistry (39) 39
pharmacology & pharmacy (37) 37
cytochrome p-450 enzyme system - genetics (36) 36
microbiology (34) 34
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sterol 14-demethylase - metabolism (33) 33
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mycobacterium-tuberculosis (32) 32
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cytochrome p450 (30) 30
female (30) 30
structure-activity relationship (30) 30
molecular docking (29) 29
saccharomyces-cerevisiae (29) 29
sterol 14-alpha-demethylase (29) 29
fluconazole (28) 28
mice (27) 27
biosynthesis (26) 26
candida albicans - drug effects (26) 26
drug design (26) 26
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sterols (26) 26
agents (25) 25
amino acid sequence (25) 25
azole antifungal agents (25) 25
cholesterol (25) 25
enzymes (25) 25
cytochrome-p450 (24) 24
lanosterol (24) 24
lanosterol 14 alpha-demethylase (24) 24
molecular sequence data (24) 24
oxidoreductases - genetics (24) 24
cytochrome p-450 (23) 23
fungi (23) 23
fungicides (23) 23
inhibitors (23) 23
protein binding (23) 23
sterol 14-demethylase - chemistry (23) 23
14-alpha demethylase inhibitors - pharmacology (22) 22
chemistry, multidisciplinary (22) 22
expression (22) 22
fluconazole - pharmacology (22) 22
in-vitro (22) 22
inhibition (22) 22
molecular structure (22) 22
analysis (21) 21
aspergillus-fumigatus (21) 21
azoles - pharmacology (21) 21
binding sites (21) 21
cytochrome p-450 enzyme system - chemistry (20) 20
fluconazole resistance (20) 20
lanosterol 14α-demethylase (20) 20
biophysics (19) 19
oxidoreductases - metabolism (19) 19
rats (19) 19
sterol 14-demethylase - genetics (18) 18
triazoles - pharmacology (18) 18
14-alpha demethylase inhibitors - chemistry (17) 17
azoles (17) 17
cholesterol - biosynthesis (17) 17
ergosterol (17) 17
gene (17) 17
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candida albicans (16) 16
cholesterol-biosynthesis (16) 16
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cytochrome p-450 enzyme inhibitors (14) 14
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endocrinology & metabolism (14) 14
fungal proteins - metabolism (14) 14
lipids (14) 14
p450 (14) 14
triazoles - chemistry (14) 14
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cell biology (13) 13
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Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 10/2010, Volume 54, Issue 10, pp. 4225 - 4234
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2001, Volume 98, Issue 6, pp. 3068 - 3073
Cytochrome P450 14α-sterol demethylases (CYP51) are essential enzymes in sterol biosynthesis in eukaryotes. CYP51 removes the 14α-methyl group from sterol... 
Antifungals | Fungi | Molecules | Enzymes | Biological Sciences | Azoles | Active sites | Crystals | Atoms | Binding sites | Crystal structure | DOMAIN | CANDIDA-ALBICANS | SEARCH | BIOSYNTHESIS | MULTIDISCIPLINARY SCIENCES | RESOLUTION | DRUGS | ANTIFUNGAL AGENTS | RESISTANCE | LANOSTEROL 14-ALPHA-DEMETHYLASE CYP51 | SACCHAROMYCES-CEREVISIAE
Journal Article
Parasitology, ISSN 0031-1820, 12/2018, Volume 145, Issue 14, pp. 1820 - 1836
Journal Article
The FEBS Journal, ISSN 1742-464X, 05/2012, Volume 279, Issue 9, pp. 1516 - 1533
Journal Article
Scientific Reports, ISSN 2045-2322, 2015, Volume 5, Issue 1, p. 8777
Journal Article
Biology Open, ISSN 2046-6390, 2018, Volume 7, Issue 11, p. bio035626
Lanosterol 14 alpha-demethylase (CYP51) plays a crucial role in cholesterol biosynthesis. In gamete development, CYP51 is involved in initiating meiosis... 
Meiosis | Chromosome synapsis | Oocytes | Primordial follicle formation | CYP51 | OVARY | PROTEIN | INITIATION | MOUSE | STEROLS | CHROMOSOMES | PRIMORDIAL FOLLICULOGENESIS | MEIOTIC PROPHASE | RESUMPTION | BIOLOGY | LANOSTEROL 14-ALPHA-DEMETHYLASE CYP51
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Journal Article
Journal Article