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Molecular Cell, ISSN 1097-2765, 06/2019, Volume 74, Issue 5, pp. 936 - 950.e5
CRISPR-Cas systems enable microbial adaptive immunity and provide eukaryotic genome editing tools. These tools employ a single effector enzyme of type II or V... 
genome editing | Cas3 | embryonic stem cell | long-range | chromosome | CRISPR-Cas | large genome deletion | RNA-guided | type I CRISPR | Cascade | Enzymes | Biotechnology | Anopheles | RNA | Analysis | Genomics | Embryonic stem cells
Journal Article
Journal Article
Frontiers in Microbiology, ISSN 1664-302X, 06/2017, Volume 8, p. 1167
In Bacillus subtilis, large genomic deletions have been carried out for genome reduction, antibiotic overproduction, and heterologous protein overexpression.... 
Genomic point mutation | Genome engineering | Gene insertion | Large genomic deletion | Bacillus subtilis | CRISPR-Cas9 | CRISPR-CAS SYSTEMS | MARKER-FREE DELETIONS | RNA | gene insertion | ESCHERICHIA-COLI | PLASMID | genomic point mutation | MICROBIOLOGY | large genomic deletion | VECTOR | HETEROLOGOUS HOST | DNA | PROMOTER | genome engineering
Journal Article
Journal Article
Journal Article
Hereditary Cancer in Clinical Practice, ISSN 1731-2302, 2015, Volume 13, Issue 1, pp. 2 - 2
Background: Male breast cancer (MBC) is an uncommon disease that has been the focus of limited research. It is estimated that approximately 10% of men with... 
Male Breast Cancer (MBC) | BRCA2 mutation | Next-generation sequencing | Large genomic deletion | POPULATION | ONCOLOGY | DISEASE | GERMLINE MUTATIONS | OVARIAN | CARCINOMA | Codon | Gene mutations | Oncology, Experimental | Breast cancer | Genetic aspects | Research | Risk factors | Ovarian cancer | Cancer
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 12/2018, Volume 19, Issue 12, p. 3835
At present, the application of CRISPR/Cas9 in soybean (Glycine max (L.) Merr.) has been mainly focused on knocking out target genes, and most site-directed... 
Dual-sgRNA/Cas9 design | Agrobacterium tumefaciens-mediated transformation | Soybean | CRISPR/Cas9 | Large fragment deletion | soybean | SYSTEM | DUPLICATIONS | WEB-TOOL | SPECIFICITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, MULTIDISCIPLINARY | dual-sgRNA/Cas9 design | GENE | large fragment deletion | PLANTS | TARGETED MUTAGENESIS | INVERSIONS
Journal Article
Oncotarget, ISSN 1949-2553, 04/2018, Volume 9, Issue 29, pp. 20721 - 20733
The Hyperparathyroidism with Jaw-Tumours syndrome is caused by mutations of the gene: it has been suggested that early onset of the disease and high Ca levels... 
HPT-JT | Early onset | Large genomic deletion | CDC73
Journal Article