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American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 07/2009, Volume 297, Issue 1, pp. H1 - H7
Journal Article
Nature Communications, ISSN 2041-1723, 01/2016, Volume 7, Issue 1, p. 10366
Mechanosensitive ion channels are force-transducing enzymes that couple mechanical stimuli to ion flux. Understanding the gating mechanism of mechanosensitive... 
LARGE-CONDUCTANCE | ACTIVATED ION-CHANNEL | CELL MOTILITY | MULTIDISCIPLINARY SCIENCES | BACTERIAL MECHANOSENSITIVE CHANNEL | BLEBS | MSCL | PATCH-CLAMPED MEMBRANES | PLASMA-MEMBRANE | LIVING CELLS | MECHANOTRANSDUCTION | Cytoskeleton - metabolism | Lipid Bilayers - metabolism | Ion Channels - metabolism | Humans | Cell Survival - physiology | HEK293 Cells
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 07/2011, Volume 301, Issue 1, pp. 29 - 40
Mechanisms underlying obesity-related vascular dysfunction are unclear. This study examined the effect of diet-induced obesity on expression and function of... 
Arteriolar remodeling | Myogenic tone | Large conductance calcium-activated potassium channel
Journal Article
American journal of physiology. Renal physiology, ISSN 1931-857X, 02/2019, Volume 316, Issue 2, pp. F341 - F350
Special high-K diets have cardioprotective effects and are often warranted in conjunction with diuretics such as furosemide for treating hypertension. However,... 
furosemide | large conductance Ca-activated K | high-K diet | urine pH
Journal Article
Journal Article
American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 12/2011, Volume 301, Issue 6, pp. C1404 - C1414
Journal Article
DIABETES, ISSN 0012-1797, 10/2017, Volume 66, Issue 10, pp. 2538 - 2540
Journal Article
Cell and Tissue Research, ISSN 0302-766X, 12/2017, Volume 370, Issue 3, pp. 365 - 377
Vessel disease is a kind of severe complication in diabetic patients. However, few pharmacologic agents can directly recover diabetic vascular function.... 
Salidroside | Relaxation | Vascular smooth muscle cells (VSMCs) | channel (BK | Large conductance calcium-activated K | β1-subunit
Journal Article
Journal of Molecular and Cellular Cardiology, ISSN 0022-2828, 06/2019, Volume 131, pp. 20 - 28
Angiotensin II (Ang II) modulates blood pressure via Ang II type 1 receptor (AT R) and type 2 receptor (AT R). The activation of AT R relaxes vascular tone... 
Hypertension | Vasodilatation | Vascular smooth muscle | Angiotensin II type 2 receptor | Angiotensin II | Large conductance calcium-activated potassium channel
Journal Article
NATURE NEUROSCIENCE, ISSN 1097-6256, 12/2005, Volume 8, Issue 12, pp. 1752 - 1759
Synaptic inhibition within the hippocampus dentate gyrus serves a 'low-pass filtering' function that protects against hyperexcitability that leads to temporal... 
LARGE-CONDUCTANCE | MOSSY CELLS | INHIBITION | SPIKE FREQUENCY ADAPTATION | RAT LATERAL AMYGDALA | PYRAMIDAL CELLS | CA2+-ACTIVATED K+ CHANNELS | NEURONS | ACTIVATED POTASSIUM CHANNEL | GRANULE CELLS | NEUROSCIENCES
Journal Article
Biochimica et Biophysica Acta - Molecular Basis of Disease, ISSN 0925-4439, 08/2015, Volume 1852, Issue 8, pp. 1599 - 1609
Podocytes are highly specialized cells that wrap around glomerular capillaries and comprise a key component of the glomerular filtration barrier. They are... 
Constriction apparatus | Podocyte | Insulin | Filtration barrier permeability | Large-conductance Ca 2+ -activated K + channels
Journal Article
SCIENTIFIC REPORTS, ISSN 2045-2322, 07/2019, Volume 9
The accessory beta 1 subunit modulates the Ca2+- and voltage-activated K+ (BK) channel gating properties mainly by increasing its apparent Ca2+ sensitivity.... 
LARGE-CONDUCTANCE | ACTIVATION | ALPHA-SUBUNIT | DETERMINANTS | MULTIDISCIPLINARY SCIENCES | BETA-1-SUBUNIT | CA2+ BINDING | POLYMORPHISM | CORONARY-HEART-DISEASE | STACKING INTERACTIONS | MODULATION
Journal Article
Circulation Research, ISSN 0009-7330, 06/2019, Volume 124, Issue 12, pp. 1686 - 1688
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 01/2012, Volume 302, Issue 1, pp. H115 - H123
Journal Article
Biophysical Journal, ISSN 0006-3495, 06/2018, Volume 114, Issue 11, pp. 2493 - 2497
Two families of accessory proteins, and , modulate BK channel gating and pharmacology. Notably, in the absence of internal Ca , the 1 subunit promotes a large... 
Boron Compounds - chemistry | Fluorescence Resonance Energy Transfer | Large-Conductance Calcium-Activated Potassium Channels - chemistry | Protein Subunits - chemistry | Lanthanoid Series Elements - chemistry | Biophysical Letter
Journal Article