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Journal Article
Journal of Virology, ISSN 0022-538X, 08/2018, Volume 92, Issue 16
Journal Article
Antiviral Research, ISSN 0166-3542, 07/2019, Volume 167, pp. 68 - 77
Lassa virus (LASV) causes Lassa hemorrhagic fever in humans and poses a significant threat to public health in West Africa. Current therapeutic treatments for... 
SSP-GP2 | Drug repurposing | Entry inhibitor | Losmapimod | Lassa virus | FUSION | RECEPTOR | ESTABLISHMENT | DYSTROGLYCAN | STABLE SIGNAL PEPTIDE | VIROLOGY | ARENAVIRUS ENVELOPE GLYCOPROTEIN | DRUGS | PHARMACOLOGY & PHARMACY | INHIBITORS | CELL ENTRY
Journal Article
Journal Article
PATHOGENS, ISSN 2076-0817, 01/2019, Volume 8, Issue 1, p. 17
Lassa virus (LASV) is the causative agent of Lassa fever, a human hemorrhagic disease associated with high mortality and morbidity rates, particularly... 
replication | ALPHA-DYSTROGLYCAN | HUMAN DENDRITIC CELLS | DYSTROPHIN-GLYCOPROTEIN COMPLEX | I INTERFERON RESPONSE | MICROBIOLOGY | LYMPHOCYTIC CHORIOMENINGITIS VIRUS | NEW-WORLD ARENAVIRUS | arenavirus | entry | Lassa fever | C-TYPE LECTINS | virus-host interactions | Z-PROTEIN | BOX RNA HELICASE | DC-SIGN | LASV | virus–host interactions
Journal Article
PLoS Pathogens, ISSN 1553-7366, 09/2018, Volume 14, Issue 9, p. e1007322
Lassa fever virus (LASV) is endemic in West Africa and causes severe hemorrhagic fever and sensorineural hearing loss. We identified a small molecule inhibitor... 
ALPHA-DYSTROGLYCAN | ENVELOPE GLYCOPROTEIN | MICROBIOLOGY | DEPENDENCE | NIEMANN-PICK C1 | VIROLOGY | LOW PH | PATHWAY | INFECTION | PROTEINS | CELL ENTRY | BINDING | PARASITOLOGY | Lysosome-Associated Membrane Glycoproteins - antagonists & inhibitors | Lassa virus - drug effects | Humans | Cercopithecus aethiops | Receptors, Virus - genetics | Virus Internalization - drug effects | Lysosome-Associated Membrane Glycoproteins - physiology | Receptors, Virus - physiology | Antiviral Agents - chemistry | HEK293 Cells | Protein Stability | Vero Cells | Adamantane - analogs & derivatives | Protein Structure, Tertiary | Cell Line | Viral Envelope Proteins - physiology | Adamantane - pharmacology | Antiviral Agents - pharmacology | Viral Envelope Proteins - genetics | Models, Molecular | Cholesterol - metabolism | Lassa virus - pathogenicity | Lassa virus - physiology | Animals | Host-Pathogen Interactions - genetics | Viral Envelope Proteins - chemistry | Lysosome-Associated Membrane Glycoproteins - genetics | Adamantane - chemistry | Lassa Fever - etiology | Mutation | Receptors, Virus - antagonists & inhibitors | Host-Pathogen Interactions - physiology | Lassa fever | Cell receptors | Physiological aspects | Development and progression | Genetic aspects | Research | Drug therapy | Hemorrhagic fever | Target recognition | Hematology | Glycoprotein | Viruses | Infections | Glycoproteins | Hemorrhage | Cholesterol | Fever | Medical schools | Hearing loss | Membrane proteins | Proteins | Medicine | Ebola virus | Hospitals | Inhibitors | Antiviral activity | Docking | Binding sites
Journal Article
Science Translational Medicine, ISSN 1946-6234, 09/2013, Volume 5, Issue 204, pp. 204ra131 - 204ra131
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 2018, Volume 1604, pp. 135 - 155
Host cell entry is the first and most fundamental step of every virus infection and represents a major barrier for zoonotic transmission and viral emergence.... 
Viral entry | Endocytosis | Inhibitor | Lassa virus | Receptor | Endosome | Lassa virus - physiology | Dynamins - metabolism | Animals | Lassa virus - metabolism | Humans | Protein Binding | Lysosomal-Associated Membrane Protein 1 - metabolism | Endocytosis - genetics | Clathrin - metabolism | Endosomes - metabolism | Virus Internalization | Endocytosis - physiology
Journal Article
Journal Article