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late-stage functionalization (159) 159
chemistry, multidisciplinary (121) 121
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Chemical Reviews, ISSN 0009-2665, 07/2017, Volume 117, Issue 13, pp. 9302 - 9332
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 01/2016, Volume 138, Issue 1, pp. 2 - 24
Journal Article
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 10/2018, Volume 57, Issue 40, pp. 13106 - 13109
Journal Article
Chemistry – A European Journal, ISSN 0947-6539, 05/2019, Volume 25, Issue 28, pp. 6896 - 6901
o‐Alkenylation of unprotected phenols has been developed by direct C−H functionalization catalyzed by PdII. This work features phenol group as a directing... 
alkenylation | late-stage modification | phenols | palladium | tyrosine | Tyrosine | Phenols | Palladium | Hydroxides | Drug discovery | Regioselectivity | Hydrogen bonds | Catalysis | Phenolic compounds | Substrates | Hydroxyl groups
Journal Article
Organic and Biomolecular Chemistry, ISSN 1477-0520, 2017, Volume 15, Issue 3, pp. 536 - 540
A rhodium-catalyzed C-H functionalization with activated amides by decarbonylation has been developed. Notably, this is the first C-H arylation employing... 
DECARBONYLATION | DIRECT ARYLATION | LATE-STAGE DIVERSIFICATION | HETEROCYCLES | NITROGEN | CHEMISTRY, ORGANIC | RUTHENIUM | BOND ACTIVATION | ARYL | INDOLES | MOLECULES | Saccharin - chemical synthesis | Saccharin - chemistry | Amides - chemistry | Models, Molecular | Crystallography, X-Ray | Molecular Structure | Catalysis | Rhodium - chemistry
Journal Article
ACS Catalysis, ISSN 2155-5435, 09/2015, Volume 5, Issue 9, pp. 5031 - 5040
Quinoline is an important scaffold in many natural products, biologically active compounds, and functional materials. The C–H functionalization of quinoline... 
quinoline N-oxides | site-selectivity | C-H activation | transition metal catalysts | quinolines | RH(I)-CATALYZED DIRECT ARYLATION | CHEMISTRY, PHYSICAL | HETEROARENES SCOPE | NICKEL/LEWIS ACID CATALYSIS | N-OXIDES | HETEROAROMATIC-COMPOUNDS | OXIDATIVE OLEFINATION | ORGANOZINC REAGENTS | C-8 POSITION | BOND ACTIVATION | LATE-STAGE FUNCTIONALIZATION
Journal Article
Chemical science, ISSN 2041-6520, 08/2018, Volume 9, Issue 30, pp. 6374 - 6378
We describe a coinage-metal-catalyzed site-selective oxidation of secondary C(sp )-H bonds for aliphatic amine substrates. Broad amine scope, good functional... 
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 10/2016, Volume 138, Issue 42, pp. 13854 - 13857
Intermolecular functionalizations of aliphatic C–H bonds offer unique strategies for the synthesis and late-stage derivatization of complex molecules, but the... 
SELECTIVE OXIDATION | TRIFLUOROMETHYLTHIOLATION | AZIDATION | C(SP)-H BOND | NATURAL-PRODUCTS | CLICK CHEMISTRY | DRUG DISCOVERY | SITE-SELECTIVITY | FLUORINATION | CHEMISTRY, MULTIDISCIPLINARY | LATE-STAGE FUNCTIONALIZATION
Journal Article
The Journal of Organic Chemistry, ISSN 0022-3263, 08/2016, Volume 81, Issue 16, pp. 7161 - 7171
A visible light mediated highly selective benzylic C–H bond functionalization for intermolecular C–N and C–O bond formation is reported. This... 
UNACTIVATED SP CARBONS | C(SP)-H BONDS | PHOTOCATALYTIC OXYGENATION | METAL-FREE CONDITIONS | DEHYDROGENATIVE-COUPLING REACTIONS | PHOTOINDUCED ELECTRON-TRANSFER | INTERMOLECULAR AMIDATION | CHEMISTRY, ORGANIC | H BONDS | LATE-STAGE FUNCTIONALIZATION | MOLECULAR-OXYGEN
Journal Article
by Xu, Y and Yan, GB and Ren, Z and Dong, GB
NATURE CHEMISTRY, ISSN 1755-4330, 10/2015, Volume 7, Issue 10, pp. 829 - 834
Site-selective C-H functionalization has emerged as an attractive tool for derivatizing complex synthetic intermediates, but its use for late-stage... 
IRIDIUM-CATALYZED BORYLATION | DIRECTING GROUPS | PALLADIUM | ACTIVATION | LATE-STAGE DIVERSIFICATION | DRUG DISCOVERY | ARENES | CONSTRUCTION | BOND FUNCTIONALIZATION | CHEMISTRY | CHEMISTRY, MULTIDISCIPLINARY | Alcohols - chemistry | Sulfones - chemistry
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 03/2018, Volume 140, Issue 12, pp. 4213 - 4217
Journal Article
The Journal of Organic Chemistry, ISSN 0022-3263, 01/2018, Volume 83, Issue 1, pp. 516 - 520
(S)-(−)-Cotinine 2 undergoes direct and site-selective iridium-catalyzed borylation to provide boronate ester 3 and bromide 4 which offer flexible entry to a... 
SMOKING-CESSATION | CYTISINE | PROTODEBORONATION | VACCINE | ARENES | COTININE | CHEMISTRY, ORGANIC | C-H BORYLATION | NICOTINIC ACETYLCHOLINE-RECEPTORS | LATE-STAGE FUNCTIONALIZATION | BRAIN | Bromides | Usage | Catalysis | Iridium | Chemical properties
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 1900, Volume 137, Issue 13, pp. 4391 - 4397
Journal Article
Synthesis, ISSN 0039-7881, 01/2018, Volume 50, Issue 2, pp. 193 - 210
Abstract Data spanning the period 2000–2017 on the direct C–H functionalization of pyrimidines are collected and discussed in this review. This demonstrates... 
review | heteroarenes | materials | palladium | pyrimidines | C-H functionalization | cross-coupling reactions | medicinal chemistry | SUZUKI | ARYLATION | CHEMISTRY, ORGANIC | PROTONATED 1,3-DIAZINES | NITROAROMATIC EXPLOSIVES | NUCLEOPHILIC AROMATIC-SUBSTITUTION | ARYL | MICROWAVE-ASSISTED SYNTHESIS | EFFICIENT | LATE-STAGE FUNCTIONALIZATION
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 08/2017, Volume 139, Issue 32, pp. 11288 - 11299
Direct C–H functionalization of aromatic compounds is a useful synthetic strategy that has garnered much attention because of its application to... 
POTENT | AMINATION | INDOLE | ARENES | CHEMISTRY | PATTERNS | INHIBITORS | CHEMISTRY, MULTIDISCIPLINARY | LATE-STAGE FUNCTIONALIZATION | DISCOVERY | MOLECULES | Chemical bonds | Chemical reactions | Usage | Analysis
Journal Article