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Journal of Natural Products, ISSN 0163-3864, 11/2018, Volume 81, Issue 11, pp. 2539 - 2544
Four new compounds (2-5) structurally related to the microtubule-stabilizing agent (-)-zampanolide (1) have been isolated from the Tongan marine sponge... 
(-)-DACTYLOLIDE | LATRUNCULIN | CHEMISTRY, MEDICINAL | FORMAL SYNTHESIS | PHARMACOLOGY & PHARMACY | (-)-ZAMPANOLIDE | PLANT SCIENCES
Journal Article
FEBS Letters, ISSN 0014-5793, 2010, Volume 584, Issue 24, pp. 4872 - 4877
To detect its cognate antigen, each B lymphocyte contains up to 120 000 B cell antigen receptor (BCR) complexes on its cell surface. How these abundant... 
B cell antigen receptor | Dissociation activation model | Cross-linking model | IP-FCM | CLM | LatA | cyan fluorescent protein | Forkhead box O1 | Zeta-chain-associated protein kinase 70 | membrane-bound immunoglobulin | PI3K | protein-arginine-methyl-transferase1 | Syk | spleen tyrosine kinase | PRMT1 | PKB | BCAP | T cell antigen receptor | BCR | ZAP70 | SH2 domain-containing leukocyte protein of 65 kDa | ITAM | phosphoinositide 3-kinase | Förster resonance energy transfer | ERM | TCR | ezrin–radixin–moesin | SLP-65 | transmembrane | CFP | EGFR | FOXO1 | B-cell adapter for PI3K | Src homology 2 | yellow fluorescent protein | bifluorescence complementation assay | FRET | protein kinase B | YFP | BN-PAGE | epidermal growth factor receptor | mIg | immunoreceptor tyrosine-based activation motif | DAM | Latrunculin A | insulin receptor | BiFC | SH2 | blue native polyacrylamide gel electrophoresis | immunoprecipitation of multiprotein complexes detected by flow cytometry | FC-EPSILON-RI | ERM PROTEINS | TYROSINE PHOSPHORYLATION | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | RESONANCE ENERGY-TRANSFER | FLUID MOSAIC MODEL | CELL BIOLOGY | BIOPHYSICS | LIPID RAFTS | CHRONIC LYMPHOCYTIC-LEUKEMIA | ARGININE METHYLATION | LIVING CELLS | Animals | Lymphocyte Activation | Humans | Receptors, Antigen, B-Cell - immunology | Oligomers | Tyrosine | Antigens | Immunoglobulins | Epidermal growth factor | Analysis | Fluorescence | T cells | Protein kinases
Journal Article
Journal Article
Journal Article
Scientific Reports, ISSN 2045-2322, 05/2015, Volume 5, Issue 1, pp. 10627 - 10627
Journal Article
Toxins, ISSN 2072-6651, 01/2013, Volume 5, Issue 1, pp. 106 - 119
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 2009, Volume 50, Issue 3, pp. 298 - 301
Three subunits of the potent actin polymerization inhibitor Latrunculin B were synthesized and assembled using olefin–olefin ring closing metathesis chemistry... 
(+)-LATRUNCULIN-A | ACTIN-BINDING PROPERTIES | ALDOL ADDITIONS | MAGNIFICA | ANALOGS | MACROLIDE | CHIRAL AUXILIARIES | CHEMISTRY, ORGANIC | DISRUPT MICROFILAMENT ORGANIZATION | FOCUSED LIBRARY | MARINE TOXINS | Olefins
Journal Article
Journal of Phycology, ISSN 0022-3646, 04/2009, Volume 45, Issue 2, pp. 404 - 412
Journal Article
Journal of Cellular and Molecular Medicine, ISSN 1582-1838, 05/2015, Volume 19, Issue 5, pp. 1010 - 1020
Connective tissue growth factor (CTGF) induces extracellular matrix (ECM) synthesis and contractility in human trabecular meshwork (HTM) cells. Both processes... 
IGF‐1 | cell viability | glaucoma | heat shock | αB‐crystallin | endothelin‐1 | oxidative stress | CTGF | trabecular meshwork | angiotensin‐II | Glaucoma | Oxidative stress | Trabecular meshwork | αB-crystallin | Endothelin-1 | Angiotensin-II | Cell viability | IGF-1 | Heat shock | MEDICINE, RESEARCH & EXPERIMENTAL | angiotensin-II | FACTOR-BETA | AQUEOUS-HUMOR | OUTFLOW FACILITY | ALPHA-B-CRYSTALLIN | LATRUNCULIN-B | CELL BIOLOGY | B-crystallin | HEAT-SHOCK PROTEINS | OPEN-ANGLE GLAUCOMA | GENE-EXPRESSION | endothelin-1 | AGE | Crystallins - metabolism | Insulin-Like Growth Factor I - pharmacology | Oxidants - pharmacology | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Endothelin-1 - pharmacology | Humans | Middle Aged | Cell Survival - genetics | Extracellular Matrix - metabolism | RNA Interference | Adult | Trabecular Meshwork - cytology | Angiotensin II - pharmacology | Gene Expression Regulation - genetics | Cells, Cultured | Hydrogen Peroxide - pharmacology | Crystallins - genetics | Hot Temperature | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Gene Expression Regulation - drug effects | Trabecular Meshwork - metabolism | Aged | Connective Tissue Growth Factor - genetics | Connective Tissue Growth Factor - metabolism | Microscopy, Fluorescence | Analysis | Angiotensin | Insulin-like growth factors | Immunohistochemistry | Cell culture | Hydrogen peroxide | Endothelin | Pathogenesis | Experiments | Western blotting | Connective tissues | Proteins | Control | Synthesis | Outflow | Extracellular matrix | Growth factors | Optic nerve | Aqueous humour | Contractility | Connective tissue growth factor | Humour | Insulin | Crystallin | Cytoskeleton | Regulation | Viability | Intraocular pressure | Original
Journal Article
Acta Biomaterialia, ISSN 1742-7061, 06/2018, Volume 73, p. 412
Macrophage hyperfunction or dysfunction is tightly associated with various diseases, such as osteoporosis, inflammatory disorder, and cancers. However, nearly... 
Drug delivery systems | Toxicity | Immunoglobulin G | Cytotoxicity | Viruses | Drug delivery | Macrophages | Doxorubicin | Proteins | Osteoporosis | Hepatitis | Phagocytes | Endocytosis | Biomedical materials | Biocompatibility | Hepatitis B virus | Binding | Protein L | Immunoglobulins | Protein G | Nanomaterials | Fc receptors | latrunculin B | Aggregates | Liposomes | Phagocytosis | Virosomes | Hepatitis B
Journal Article
Aquaculture, ISSN 0044-8486, 2005, Volume 244, Issue 1, pp. 159 - 169
Marine sponges are a rich source of bioactive metabolites that can potentially be used as lead compounds to treat various human diseases. Due to the difficulty... 
Sponge culture | Negombata magnifica | Latrunculin B | Sea ranching | sponge culture | DYSIDEA-AVARA | RED-SEA | AQUACULTURE | NATURAL-PRODUCTS | DRUG DISCOVERY | sea ranching | BIOACTIVE METABOLITES | FISHERIES | latrunculin B | MARINE & FRESHWATER BIOLOGY | GROWTH | CELL-CULTURE | INVERTEBRATES | CRAMBE CRAMBE POECILOSCLERIDA
Journal Article
mAbs, ISSN 1942-0862, 01/2015, Volume 7, Issue 1, pp. 199 - 211
Epratuzumab has demonstrated therapeutic activity in patients with non-Hodgkin lymphoma, acute lymphoblastic leukemia, systemic lupus erythematosus, and... 
BCR | HUV-EC | immobilized | human B-cell lymphoma | CD22 | epratuzumab | Epratuzumab | Human B-cell lymphoma | Immobilized | CLINICAL-TRIAL | DNP | LatB | MONOCLONAL-ANTIBODY | 7-dichlorodihydrofluorescein diacetate | Yes novel tyrosine kinase | phosphate-buffered saline | F(ab) fragment-specific | MTS | F(ab) fragment of affinity-purified goat anti-human IgG Fc fragment-specific | BSA | 7-AAD | Fc fragment | FBS | FITC-DNase I | PBS | Syk | spleen tyrosine kinase | poly(ADP-ribose) polymerase | Alexa Fluor 488-conjugated annexin V | 4-dinitrophenyl | ITIM | membrane IgM | GAH | fetal bovine serum | isotype gamma 2 | rhodamine-conjugated F(ab) fragment of affinity-purified goat anti-human IgG | LYMPHOCYTIC-LEUKEMIA | B-CELL | Lck | ROS | ANTI-CD22 ANTIBODY | LIPID RAFTS | 488-annexin V | bovine serum albumin | MEDICINE, RESEARCH & EXPERIMENTAL | ethyl ester | endothelial cells | SYSTEMIC-LUPUS-ERYTHEMATOSUS | PARP | INHIBITORY RECEPTORS | TMRE | HUMAN ENDOTHELIAL-CELLS | CM-H2DCF-DA | F(ab') fragment of affinity-purified goat anti-human IgM | ERKs | immunoreceptor tyrosine-based inhibition motif | MAP kinases | reactive oxygen species | ANTIGEN-RECEPTOR | fluorescein isothiocyanate-conjugated DNase I | 3- | Lyn | phospholipase C | 7-aminoactinomycin D | extracellular signal-regulated kinases | mitochondria membrane potential | 5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium | tetramethylrhodamine | Anti-IgM | m | JNKs | c-Jun N-terminal kinases | PLC2 | mIgM | latrunculin B | Rhodamine-anti-IgG | jasplakinolide | mitogen-activated protein kinases | human umbilical vein endothelial cells | B-cell antigen receptor | Caspases - immunology | Apoptosis - drug effects | Humans | Neoplasm Proteins - immunology | Sialic Acid Binding Ig-like Lectin 2 - antagonists & inhibitors | Neoplasm Proteins - antagonists & inhibitors | Sialic Acid Binding Ig-like Lectin 2 - immunology | Protein Transport - drug effects | Receptors, Antigen, B-Cell - antagonists & inhibitors | Receptors, Antigen, B-Cell - immunology | Membrane Microdomains - immunology | Protein Transport - immunology | Apoptosis - immunology | Burkitt Lymphoma - immunology | Signal Transduction - drug effects | Antibodies, Monoclonal, Humanized - pharmacology | Cell Line, Tumor | Immunologic Capping - drug effects | Burkitt Lymphoma - drug therapy
Journal Article