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lats2 (114) 114
index medicus (76) 76
humans (71) 71
cancer (48) 48
oncology (48) 48
protein-serine-threonine kinases - metabolism (48) 48
apoptosis (47) 47
protein-serine-threonine kinases - genetics (47) 47
cell biology (41) 41
expression (41) 41
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adaptor proteins, signal transducing - metabolism (14) 14
human homolog (14) 14
phosphoproteins - metabolism (14) 14
protein-kinase (14) 14
cell growth (13) 13
medicine, research & experimental (13) 13
middle aged (13) 13
polymerase chain reaction (13) 13
promoter hypermethylation (13) 13
cell-proliferation (12) 12
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rna (12) 12
yes-associated protein (12) 12
genetics & heredity (11) 11
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taz (8) 8
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1. Full Text miR-363 confers taxane resistance in ovarian cancer by targeting the Hippo pathway member, LATS2
by Mohamed, Zeinab and Hassan, Mohamed Kamel and Okasha, Safwat and Mitamura, Takashi and Keshk, Sarah and Konno, Yusuke and Kato, Tatsuya and EL-Khamisy, Sherif F and Ohba, Yusuke and Watari, Hidemichi
Oncotarget, ISSN 1949-2553, 07/2018, Volume 9, Issue 53, pp. 30053 - 30065
Ovarian cancer is the most aggressive female reproductive tract tumours. Taxane (paclitaxel; TX) is widely used for ovarian cancer treatment. However, ovarian... 
LATS2 | Taxane | MiR-363 | Chemoresistance | Ovarian cancer
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2. Full Text YAP1‐LATS2 feedback loop dictates senescent or malignant cell fate to maintain tissue homeostasis
by He, Chunbo and Lv, Xiangmin and Huang, Cong and Hua, Guohua and Ma, Bowen and Chen, Xingcheng and Angeletti, Peter C and Dong, Jixin and Zhou, Jin and Wang, Zhengfeng and Rueda, Bo R and Davis, John S and Wang, Cheng
EMBO reports, ISSN 1469-221X, 03/2019, Volume 20, Issue 3, p. n/a
Dysfunction of the homeostasis‐maintaining systems in specific cell types or tissues renders the organism susceptible to a range of diseases, including... 
YAP1‐LATS2 feedback loop | the Hippo pathway | cellular senescence | tumorigenesis | tissue homeostasis | YAP1-LATS2 feedback loop | PROTEIN | MECHANISM | HIPPO SIGNALING PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | YAP | PROLIFERATION | CELL BIOLOGY | ORGAN SIZE | ONCOGENE | LATS2 | GROWTH | SIZE-CONTROL | Transformation | Senescence | Epithelial cells | Switches | Homeostasis | Feedback loops | Tissues | Yes-associated protein | Hoses | Proteins | Signal transduction | Negative feedback | Clonal deletion | Cell fate | Feedback | Deletion | Tumor suppressor genes | Transformations | Control theory | Cancer
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3. Full Text Isoliquiritigenin suppresses the proliferation and induced apoptosis via miR-32/LATS2/Wnt in nasopharyngeal carcinoma
by Wang, Ting-Ting and Chen, Zhen-Zhang and Xie, Peng and Zhang, Wen-Jun and Du, Ming-Yu and Liu, Ya-Tian and Zhu, Hua-Yun and Guo, Ye-Song
European Journal of Pharmacology, ISSN 0014-2999, 08/2019, Volume 856, p. 172352
Nasopharyngeal Carcinoma is limited by the various severe side-effects and surgery is rarely performed. Iosliquiritigenin has a series of biological... 
Nasopharyngeal carcinoma | Cell proliferation | Isoliquiritigenin | LATS2 | Wnt | microRNA-32 | MIGRATION | ACTIVATION | CELL-PROLIFERATION | CANCER | INVASION | MIR-32 | PHARMACOLOGY & PHARMACY | EXPRESSION | TUMORIGENESIS
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4. Full Text Genomic Profiling of Vulvar Lichen Sclerosus Patients Shows Possible Pathogenetic Disease Mechanisms
by Haefner, Hope K and Welch, Kathryn C and Rolston, Aimee M and Koeppe, Erika S and Stoffel, Elena M and Kiel, Mark J and Berger, Mitchell B
Journal of Lower Genital Tract Disease, ISSN 1089-2591, 07/2019, Volume 23, Issue 3, pp. 214 - 219
Objective Vulvar lichen sclerosus (LS) is known to occur in families, suggesting a genetic link. Genomic profiling of patients with vulvar LS was investigated... 
genomic profiling | LATS2, co-repressor of androgen signaling | vulvar lichen sclerosus | ANKRD18A, ankyrin repeat protein | CD177, neutrophil activation | CD200, inhibitory signal to macrophages | inhibitory signal to macrophages | CELLS | SUSCEPTIBILITY | ankyrin repeat protein | ANTIGENS | co-repressor of androgen signaling | OBSTETRICS & GYNECOLOGY | neutrophil activation | WOMEN | LATS2 | ANKRD18A | ASSOCIATION | CD200 | CD177 | EXTRACELLULAR-MATRIX PROTEIN-1
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5. Full Text Putative tumor suppressor Lats2 induces apoptosis through downregulation of Bcl-2 and Bcl-xL
by Ke, Hengning and Pei, Jing and Ni, Zhenya and Xia, Hong and Qi, Huilin and Woods, Tishonna and Kelekar, Ameeta and Tao, Wufan
Experimental Cell Research, ISSN 0014-4827, 08/2004, Volume 298, Issue 2, pp. 329 - 338
Lats2, also known as Kpm, is the second mammalian member of the novel Lats tumor suppressor gene family. Recent studies have demonstrated that Lats2 negatively... 
Bcl-2 | Caspase | Putative tumor suppressor | Bcl-x | Human Lats2 | Apoptosis
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6. Full Text LIM-domain protein AJUBA suppresses malignant mesothelioma cell proliferation via Hippo signaling cascade
by Tanaka, I and Osada, H and Fujii, M and Fukatsu, A and Hida, T and Horio, Y and Kondo, Y and Sato, A and Hasegawa, Y and Tsujimura, T and Sekido, Y
ONCOGENE, ISSN 0950-9232, 01/2015, Volume 34, Issue 1, pp. 73 - 83
Malignant mesothelioma (MM) is one of the most aggressive neoplasms usually associated with asbestos exposure and is highly refractory to current therapeutic... 
APOPTOSIS | GROWTH-CONTROL | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | YAP | MITOTIC PROGRESSION | FOXM1 | CANCER | DROSOPHILA | CELL BIOLOGY | ORGANIZATION | Hippo pathway | LATS2 | ONCOLOGY | malignant nnesothelioma | GENETICS & HEREDITY | SCAFFOLD PROTEINS | AJUBA | YAP PATHWAY
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7. Full Text Agenetic variant in large tumor suppressor kinase 2 of Hippo signaling pathway contributes to prognosis of hepatocellular carcinoma
by Shen, Lili and Wen, Juan and Zhao, Tingting and Hu, Zhibin and Song, Ci and Gu, Dongying and He, Mingliang and Lee, Nikki P and Xu, Zhi and Chen, Jinfei
OncoTargets and Therapy, 04/2016, Volume 9, pp. 1945 - 1951
Hepatocellular carcinoma | Retrospective study | Single-nucleotide polymorphism | LATS2 | Prognosis
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8. Full Text Downregulation of miR-31 stimulates expression of LATS2 via the hippo pathway and promotes epithelial-mesenchymal transition in esophageal squamous cell carcinoma
by Gao, Yanping and Yi, Jun and Zhang, Kai and Bai, Fan and Feng, Bing and Wang, Rui and Chu, Xiaoyuan and Chen, Longbang and Song, Haizhu
Journal of Experimental and Clinical Cancer Research, ISSN 1756-9966, 11/2017, Volume 36, Issue 1, pp. 161 - 20
Background: Dysregulation of miRNAs is associated with cancer development by coordinately suppressing abundant target genes. Emerging evidence indicates that... 
miR-31 | Esophageal squamous cell carcinoma | Hippo pathway | LATS2 | TAZ | EMT | CANCER-CELLS | METASTASIS | LARGE TUMOR-SUPPRESSOR | TARGETING LATS2 | SELF-RENEWAL | PROLIFERATION | MICRORNA-31 | INVASION | HOMOLOG 2 | ONCOLOGY | GROWTH | Neoplasm Transplantation | Cell Proliferation | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Gene Expression Regulation, Neoplastic | Male | Esophageal Neoplasms - pathology | Esophageal Neoplasms - metabolism | Tumor Suppressor Proteins - genetics | Epithelial-Mesenchymal Transition | Female | 3' Untranslated Regions | Protein-Serine-Threonine Kinases - metabolism | Esophageal Squamous Cell Carcinoma | Tumor Suppressor Proteins - metabolism | Signal Transduction | Neoplasm Invasiveness | Down-Regulation | Protein-Serine-Threonine Kinases - genetics | Animals | Esophageal Neoplasms - genetics | Cell Line, Tumor | Mice | MicroRNAs - genetics | Neoplasm Staging | Squamous cell carcinoma | MicroRNA | Physiological aspects | Development and progression | Genetic aspects | Research | Esophageal cancer | Medical research | Transcription factors | Homeostasis | Breast cancer | Metastasis | Gene expression | Kinases | Ovarian cancer | Proteins | Cell growth | Medical prognosis | MicroRNAs | Stem cells | Cell cycle | Tumors | Apoptosis
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9. Full Text Measuring the Kinase Activities of the LATS/NDR Protein Kinases
by Hergovich, Alexander
Methods in molecular biology (Clifton, N.J.), ISSN 1064-3745, 2019, Volume 1893, pp. 305 - 317
The Hippo tissue growth control and regeneration pathway is a main regulator of the YAP/TAZ effectors. In this regard, the LATS/NDR serine/threonine protein... 
LATS1 | NDR1 | NDR2 | Hippo pathway | Kinase assays | Kinase substrates | LATS2 | STK38 | STK38L | Protein kinases
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10. Full Text A recellularized human colon model identifies cancer driver genes
by Chen, Huanhuan Joyce and Wei, Zhubo and Sun, Jian and Bhattacharya, Asmita and Savage, David J and Serda, Rita and Mackeyev, Yuri and Curley, Steven A and Bu, Pengcheng and Wang, Lihua and Chen, Shuibing and Cohen-Gould, Leona and Huang, Emina and Shen, Xiling and Lipkin, Steven M and Copeland, Neal G and Jenkins, Nancy A and Shuler, Michael L
Nature Biotechnology, ISSN 1087-0156, 01/2016, Volume 34, Issue 8, pp. 845 - 851
Refined cancer models are needed to bridge the gaps between cell line, animal and clinical research. Here we describe the engineering of an organotypic colon... 
INVASION | LATS2 | MICROENVIRONMENT | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | TUMOR-SUPPRESSOR | PROLIFERATION | HOMOLOG | TISSUES | Adenomatous Polyposis Coli Protein - genetics | Tissue Engineering - methods | Colon - pathology | Humans | Carcinogenesis - genetics | Cells, Cultured | Gene Expression Profiling - methods | Neoplasm Proteins - metabolism | Colon - metabolism | Colonic Neoplasms - metabolism | Organogenesis | Cell-Free System - metabolism | Colonic Neoplasms - pathology | Genes, Neoplasm - genetics | Causes of | Genetic aspects | Models | Colon cancer | Cellular biology | Gene expression | Colorectal cancer | Index Medicus
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11. Full Text Long noncoding RNA DDX11-AS1 epigenetically represses LATS2 by interacting with EZH2 and DNMT1 in hepatocellular carcinoma
by Li, Xiangcheng and Li, Yong and Zhuang, Wenlong and Huang, Maosheng
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 07/2019, Volume 514, Issue 4, pp. 1051 - 1057
Long noncoding RNAs (lncRNAs), a group of transcripts without protein coding potential, have been reported to play critical roles in progression of... 
Hepatocellular carcinoma | LATS2 | Epigenetic | DDX11-AS1 | METHYLATION | METASTASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | CANCER | BIOPHYSICS | GENE | PROMOTES | PROGRESSION | Epigenetic inheritance | Methyltransferases | Liver | Transplantation of organs, tissues, etc | Development and progression | Antisense RNA | Hepatoma | Health aspects
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12. Full Text Yes-associated protein isoform 1 (Yapl) promotes cardiomyocyte survival and growth to protect against myocardial ischemic injury
by Del Re, Dominic P and Yang, Yanfei and Nakano, Noritsugu and Cho, Jaeyeaon and Zhai, Peiyong and Yamamoto, Takanobu and Zhang, Nailing and Yabuta, Norikazu and Nojima, Hiroshi and Pan, Duojia and Sadoshima, Junichi
Journal of Biological Chemistry, ISSN 0021-9258, 02/2013, Volume 288, Issue 6, pp. 3977 - 3988
Yap1 is an important regulator of cardiomyocyte proliferation and embryonic heart development, yet the function of endogenous Yap1 in the adult heart remains... 
MYOCYTE APOPTOSIS | REGULATOR | HYPERTROPHY | LATS2 | ORGAN SIZE CONTROL | BIOCHEMISTRY & MOLECULAR BIOLOGY | HEART-FAILURE | MST1 | HIPPO PATHWAY | PROLIFERATION | Myocardial Ischemia - metabolism | Oxidants - pharmacology | Cell Survival - genetics | Cardiomegaly - pathology | Phosphoproteins - metabolism | Protein Isoforms - metabolism | Myocardium - metabolism | Muscle Proteins - metabolism | Gene Expression Regulation - genetics | Cells, Cultured | Hydrogen Peroxide - pharmacology | Mice, Transgenic | Myocardium - pathology | Phosphoproteins - genetics | Myocardial Ischemia - pathology | Gene Expression Regulation - drug effects | Muscle Proteins - genetics | Myocytes, Cardiac - pathology | Animals | Adaptor Proteins, Signal Transducing - genetics | Myocytes, Cardiac - metabolism | Heterozygote | Mice | Adaptor Proteins, Signal Transducing - metabolism | Cardiomegaly - genetics | Chronic Disease | Apoptosis | Cardiomegaly - metabolism | Yap1 | Molecular Bases of Disease | Cardiac Muscle | Myocardial Infarction | Heart Failure | Cardiac Hypertrophy
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13. Full Text CADM1 associates with Hippo pathway core kinases; membranous co–expression of CADM1 and LATS2 in lung tumors predicts good prognosis
by Ito, Takeshi and Nakamura, Atsuko and Tanaka, Ichidai and Tsuboi, Yumi and Morikawa, Teppei and Nakajima, Jun and Takai, Daiya and Fukayama, Masashi and Sekido, Yoshitaka and Niki, Toshiro and Matsubara, Daisuke and Murakami, Yoshinori
Cancer Science, ISSN 1347-9032, 07/2019, Volume 110, Issue 7, pp. 2284 - 2295
Cell adhesion molecule‐1 (CADM1) is a member of the immunoglobulin superfamily that functions as a tumor suppressor of lung tumors. We herein demonstrated that... 
YAP1 | Hippo pathway | LATS2 | CADM1 | lung adenocarcinoma | YES-ASSOCIATED PROTEIN | SUPPRESSOR | ORGAN SIZE CONTROL | ADENOCARCINOMA | ADHESION | ONCOLOGY | CLONING | GENE-TRANSFER | DIFFERENTIATION | TSLC1 | EXPRESSION | Prognosis | Gene expression | Lung cancer | Analysis | Tumors | Original
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14. Full Text The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERα
by Britschgi, Adrian and Duss, Stephan and Kim, Sungeun and Couto, Joana Pinto and Brinkhaus, Heike and Koren, Shany and De Silva, Duvini and Mertz, Kirsten D and Kaup, Daniela and Varga, Zsuzsanna and Voshol, Hans and Vissieres, Alexandra and Leroy, Cedric and Roloff, Tim and Stadler, Michael B and Scheel, Christina H and Miraglia, Loren J and Orth, Anthony P and Bonamy, Ghislain M. C and Reddy, Venkateshwar A and Bentires-Alj, Mohamed
Nature, ISSN 0028-0836, 01/2017, Volume 541, Issue 7638, pp. 541 - 545
Cell fate perturbations underlie many human diseases, including breast cancer(1,2). Unfortunately, the mechanisms by which breast cell fate are regulated are... 
MULTIDISCIPLINARY SCIENCES | GROWTH | MOUSE | STEM-CELL | DIFFERENTIATION | TAZ | YAP PATHWAY | CANCER | TUMORIGENESIS | GLAND | MAMMARY EPITHELIAL-CELLS | Protein-Serine-Threonine Kinases - deficiency | Tumor Suppressor Proteins - metabolism | Signal Transduction | Breast - cytology | Breast - enzymology | Humans | Cells, Cultured | Ubiquitin - metabolism | Phosphoproteins - agonists | Adaptor Proteins, Signal Transducing - agonists | Phosphoproteins - metabolism | Cell Lineage | Carrier Proteins - metabolism | Estrogen Receptor alpha - agonists | Proteolysis | Tumor Suppressor Proteins - deficiency | Estrogen Receptor alpha - metabolism | Female | Cell Differentiation | Proteasome Endopeptidase Complex - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Breast - pathology | Genes, Tumor Suppressor | Protein-Serine-Threonine Kinases - metabolism | LATS1 | LATS2 | c-KIT | ERα | Hippo | cell fate | luminal progenitor | YAP | breast cancer | breast
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15. Full Text Science signaling podcast: 10 February 2015
by Luo, Kunxin and VanHook, Annalisa M
Science Signaling, ISSN 1945-0877, 02/2015, Volume 8, Issue 363
Science Signaling | LATS2 | Hippo | Ski oncoprotein | Epithelialtomesenchymal transition | Breast cancer | Metastasis | TAZ | EMT
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16. Full Text The effect of miR-372 on genome instability in MKN-45 cell line
by Ghasemi, Sorayya and Mozdarani, Hossein and Soleimani, Masoud
Journal of Isfahan Medical School, ISSN 1027-7595, 2015, Volume 32, Issue 311
LATS2 | Gastric cancer (GC) | miR-372 | Genomic instability
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17. Full Text LATS tumor suppressor: A new governor of cellular homeostasis
by Visser, Stacy and Yang, Xiaolong
Cell Cycle, ISSN 1538-4101, 10/2010, Volume 9, Issue 19, pp. 3892 - 3903
Accumulating evidence points to the LATS (Large Tumor Suppressor) family of human tumor suppressors (LATS1 and LATS2) as new resident governors of cellular... 
Binding | Proteins | Landes | Calcium | Bioscience | Biology | Cell | Cycle | Cancer | Organogenesis | Cell proliferation | LATS1 | LATS2 | Cell cycle | Tumor suppressor | Cell migration | Apoptosis | PROMOTER HYPERMETHYLATION | cell proliferation | cell cycle | DOWN-REGULATION | tumor suppressor | apoptosis | DROSOPHILA LATS | PROTEIN-KINASES | NEGATIVE REGULATOR | CELL BIOLOGY | GENE | MITOTIC APPARATUS | HIPPO | cell migration | NDR KINASES | HUMAN HOMOLOG | Neoplasms - metabolism | Tumor Suppressor Proteins - metabolism | Signal Transduction | Humans | Gene Expression Regulation | Protein-Serine-Threonine Kinases - genetics | Homeostasis | Animals | Neoplasms - genetics | Tumor Suppressor Proteins - genetics | Cytoskeleton - metabolism | Neoplasms - pathology | Genes, Tumor Suppressor | Protein-Serine-Threonine Kinases - metabolism | Cell Movement | Evolution, Molecular
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18. Full Text The clinical significance and biological function of large tumour suppressor 2 in hepatocellular carcinoma
by Liang, Rong and Lin, Yan and Yuan, Chun‐Ling and Liu, Zhi‐Hui and Li, Yong‐Qiang and Luo, Xiao‐Ling and Ye, Jia‐Zhou and Ye, Hai‐Hong
Cell Proliferation, ISSN 0960-7722, 06/2017, Volume 50, Issue 3, pp. e12340 - n/a
Objectives Present evidence has suggested that large tumour suppressor 2 (LATS2) is abnormally expressed in most human cancer. However, the clinical and... 
KPM | LATS2 | biomarker | hepatocellular carcinoma | APOPTOSIS | INVASION | RISK-FACTORS | DOWN-REGULATION | PROLIFERATION | LATS2 GENE | HEPATITIS-B | EXPRESSION | CANCER | MOTILITY | CELL BIOLOGY | Tumor Suppressor Proteins - metabolism | Cell Proliferation | Carcinoma, Hepatocellular - diagnosis | Humans | Middle Aged | RNA, Messenger - genetics | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Male | RNA, Messenger - metabolism | Liver Neoplasms - diagnosis | Tumor Suppressor Proteins - genetics | Liver Neoplasms - metabolism | Female | Protein-Serine-Threonine Kinases - metabolism | Carcinoma, Hepatocellular - metabolism | Immunohistochemistry | Metastasis | Hepatoma | RNA | Gene expression | Vimentin | Cell proliferation | Biotechnology | Leukocyte migration | Hepatocellular carcinoma | mRNA | Tissues | E-cadherin | Gelatinase B | Metastases | Cell adhesion & migration | Gelatinase A | Polymerase chain reaction | Liver cancer | Cell lines | Biomarkers | Bioindicators | In vitro methods and tests | Cell migration | Cancer | Tumors
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19. Full Text Lats2 phosphorylates p21/CDKN1A after UV irradiation and regulates apoptosis
by Suzuki, Hirokazu and Yabuta, Norikazu and Okada, Nobuhiro and Torigata, Kosuke and Aylon, Yael and Oren, Moshe and Nojima, Hiroshi
Journal of Cell Science, ISSN 0021-9533, 2013, Volume 126, Issue 19, pp. 4358 - 4368
LATS2 (Large tumor suppressor 2), a member of the conserved AGC Ser/Thr (S/T) kinase family, is a human tumor suppressor gene. Here, we show that in response... 
Lats2 | Phosphorylation | Cdkn1A | P21 | Apoptosis | UV | CDKN1A | PROTEIN | DNA-DAMAGE RESPONSE | KINASE | PUTATIVE TUMOR-SUPPRESSOR | FAS-MEDIATED APOPTOSIS | p21 | CELL BIOLOGY | P53-MEDIATED APOPTOSIS | CASPASE 3 | SIGNALING PATHWAY | DEGRADATION
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