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life sciences & biomedicine (22) 22
science & technology (22) 22
lca, lithocholic acid (14) 14
bile acids (13) 13
dca, deoxycholic acid (13) 13
humans (13) 13
cdca, chenodeoxycholic acid (11) 11
biochemistry & molecular biology (10) 10
ca, cholic acid (10) 10
fxr, farnesoid x receptor (10) 10
lithocholic acid (10) 10
lca (9) 9
udca, ursodeoxycholic acid (9) 9
digestive system (8) 8
acids (7) 7
farnesoid x receptor (7) 7
cdca (6) 6
deoxycholic acid (6) 6
male (6) 6
pharmacology & pharmacy (6) 6
review (6) 6
analysis (5) 5
bile (5) 5
bile acids and salts - metabolism (5) 5
19, fibroblast growth factor 15 (4) 4
aged (4) 4
animals (4) 4
bsep, bile salt export pump (4) 4
chenodeoxycholic acid (4) 4
colorectal cancer (4) 4
cyp7a1, cholesterol 7α-hydroxylase (4) 4
dca (4) 4
endocrinology & metabolism (4) 4
female (4) 4
fgf15 (4) 4
fgf15/19, fibroblast growth factor 15/19 (4) 4
homeostasis (4) 4
middle aged (4) 4
nafld, non-alcoholic fatty liver disease (4) 4
receptors, cytoplasmic and nuclear - metabolism (4) 4
tca, taurocholic acid (4) 4
therapeutics. pharmacology (4) 4
vitamin d (4) 4
abridged index medicus (3) 3
adult (3) 3
bas, bile acids (3) 3
bile acid (3) 3
bile acids and salts - analysis (3) 3
bile acids and salts - blood (3) 3
biological and medical sciences (3) 3
bsep (3) 3
cell biology (3) 3
cholic acid (3) 3
egfr, epidermal growth factor receptor (3) 3
fxr (3) 3
gastroenterology & hepatology (3) 3
gastroenterology and hepatology (3) 3
gca, glycocholic acid (3) 3
gut microbiota (3) 3
hdca, hyodeoxycholic acid (3) 3
intestine (3) 3
lithocholic acid - pharmacology (3) 3
liver (3) 3
liver diseases (3) 3
medicine (3) 3
nash, non-alcoholic steatohepatitis (3) 3
oca, obeticholic acid (3) 3
psc, primary sclerosing cholangitis (3) 3
pxr, pregnane x receptor (3) 3
shp, small heterodimer partner (3) 3
t2d, type 2 diabetes (3) 3
tcdca, taurochenodeoxycholic acid (3) 3
tudca, tauroursodeoxycholic acid (3) 3
udca (3) 3
ursodeoxycholic acid (3) 3
6-ecdca, 6-ethylchenodeoxycholic acid (2) 2
abc, atp-binding cassette (2) 2
activation (2) 2
ae2, anion exchanger 2 (2) 2
akt (2) 2
alfacalcidol (2) 2
allo dca (2) 2
allo lca (2) 2
asbt (2) 2
ba, bile acid (2) 2
ba, bile acids (2) 2
beta (2) 2
bile acids and salts - chemistry (2) 2
binding sites (2) 2
biochemistry (2) 2
biology (2) 2
calcifediol (2) 2
cancer (2) 2
care and treatment (2) 2
cell line, tumor (2) 2
cholestasis (2) 2
cholesterol 7α-hydroxylase (2) 2
chromatography (2) 2
colon (2) 2
colon cancer (2) 2
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1. Full Text Lithocholic Acid Stimulates IL‐8 Expression in Human Colorectal Cancer Cells Via Activation of Erk1/2 MAPK and Suppression of STAT3 Activity
by Nguyen, Thi Thinh and Lian, Sen and Ung, Trong Thuan and Xia, Yong and Han, Jae Young and Jung, Young Do
Journal of cellular biochemistry, ISSN 0730-2312, 09/2017, Volume 118, Issue 9, pp. 2958 - 2967
COLORECTAL CANCER | LCA | ANGIOGENESIS | IL‐8 | STAT3 | IL-8 | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Interleukin-8 - genetics | Mitogen-Activated Protein Kinase 3 - genetics | Interleukin-8 - biosynthesis | Colorectal Neoplasms - genetics | Humans | Enzyme Activation - drug effects | Neoplasm Proteins - metabolism | MAP Kinase Signaling System - drug effects | MAP Kinase Signaling System - genetics | Lithocholic Acid - pharmacology | Mitogen-Activated Protein Kinase 3 - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | Cell Line, Tumor | Gene Expression Regulation, Neoplastic - drug effects | Colorectal Neoplasms - pathology | Enzyme Activation - genetics | Neoplasm Proteins - genetics | Colorectal Neoplasms - metabolism | Gene Expression Regulation, Neoplastic - genetics | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Interleukins | Bile acids | Colorectal cancer | Cell proliferation | Phosphorylation | Interleukin | Colorectal carcinoma | Stat3 protein | Extracellular signal-regulated kinase | MAP kinase | Activation | Pharmacology | Metastases | Mutagenesis | Acids | Interleukin 8 | Bile | Cancer | Index Medicus
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2. Full Text Lithocholic acid: a new emergent protector of intestinal calcium absorption under oxidant conditions
by Marchionatti, Ana M and Pérez, Adriana and Rivoira, María A and Rodríguez, Valeria A and Tolosa de Talamoni, Nori G
Biochemistry and cell biology, ISSN 0829-8211, 2017, Volume 95, Issue 2, pp. 273 - 279
absorption | absorption intestinale de Ca | intestinal Ca | ALC | apoptosis | LCA | apoptose | NaDOC | oxidative stress | stress oxydant | Oxidative stress | Intestinal Ca | Apoptosis | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Oxidative Stress | Plasma Membrane Calcium-Transporting ATPases - genetics | Apoptosis - drug effects | Calcium - metabolism | Enterocytes - metabolism | Alkaline Phosphatase - metabolism | Intestinal Absorption - drug effects | Sodium-Calcium Exchanger - genetics | Protein Carbonylation - drug effects | Receptors, Calcitriol - genetics | Plasma Membrane Calcium-Transporting ATPases - metabolism | Lithocholic Acid - pharmacology | Sodium-Calcium Exchanger - metabolism | Duodenum - metabolism | Ion Transport - drug effects | Calcitriol - metabolism | Intestinal Absorption - physiology | Animals, Newborn | Alkaline Phosphatase - genetics | Enterocytes - cytology | Mitochondria - metabolism | Deoxycholic Acid - antagonists & inhibitors | Mitochondria - drug effects | Receptors, Calcitriol - metabolism | Gene Expression Regulation - drug effects | Animals | Deoxycholic Acid - pharmacology | Enterocytes - drug effects | Chickens | Duodenum - drug effects | Alkaline phosphatase | Normalizing | Calcium | Digestive system | Calcitriol | Biochemistry | Biology | Gene expression | Cells | Calcium absorption | Studies | Molecules | Reduction | Absorption | Acids | Vitamin D | Intestine | Absorption rates | Ligands | Index Medicus
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3. Full Text Lithocholic acid upregulates uPAR and cell invasiveness via MAPK and AP-1 signaling in colon cancer cells
by Baek, Min Kyung and Park, Jung Sun and Park, Ji Hye and Kim, Mi Ha and Kim, Ho Dong and Bae, Woo Kyun and Chung, Ik Joo and Shin, Boo Ahn and Jung, Young Do
Cancer letters, ISSN 0304-3835, 2009, Volume 290, Issue 1, pp. 123 - 128
Hematology, Oncology and Palliative Medicine | Erk-1/2 | uPAR | Colon cancer | LCA | AP-1 | Life Sciences & Biomedicine | Oncology | Science & Technology | Up-Regulation | Colonic Neoplasms - genetics | Gene Expression | Transcription Factor AP-1 - genetics | Humans | Lithocholic Acid - metabolism | Gene Expression Regulation, Neoplastic | RNA, Messenger - analysis | Transcription Factor AP-1 - metabolism | Blotting, Western | Colonic Neoplasms - metabolism | Receptors, Urokinase Plasminogen Activator - metabolism | Blotting, Northern | Transfection | Colonic Neoplasms - pathology | Cell Line, Tumor | Mitogen-Activated Protein Kinases - genetics | Signal Transduction - physiology | Electrophoretic Mobility Shift Assay | Neoplasm Invasiveness - genetics | Mitogen-Activated Protein Kinases - metabolism | Bile acids | Cancer cells | Index Medicus
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4. Full Text Bile acid transporters and regulatory nuclear receptors in the liver and beyond
by Halilbasic, Emina and Claudel, Thierry and Trauner, Michael
Journal of hepatology, ISSN 0168-8278, 2012, Volume 58, Issue 1, pp. 155 - 168
Gastroenterology and Hepatology | Gallstones | Liver cancer | Bile acids | Fatty liver disease | Cholestasis | Liver regeneration | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Animals | Carrier Proteins - metabolism | Cholestasis - metabolism | Membrane Glycoproteins - metabolism | Humans | Liver - metabolism | Bile Acids and Salts - metabolism | Liver Diseases - metabolism | Liver Regeneration - physiology | Receptors, Cytoplasmic and Nuclear - metabolism | Drug resistance in microorganisms | Corticosteroids | Glucagon | Calcifediol | Ursodiol | Deoxycholic acid | Epidermal growth factor | Vitamin D | Physiological aspects | Fibroblast growth factors | Alfacalcidol | Index Medicus | IBABP (FABP6, ILBP), intestinal bile acid-binding protein, fatty acid-binding protein 6 | PFIC, progressive familial intrahepatic cholestasis | TNFα, tumor necrosis factor α | 3 (human) | SRC2, p160 steroid receptor coactivator | NAFLD, non-alcoholic fatty liver disease | BA, bile acid | bile acid receptor | 8, cholesterol efflux pump, ATP-binding cassette, subfamily G, member 5 | UDCA, ursodeoxycholic acid | LRH-1 (NR5A2), liver receptor homolog-1 | LCA, lithocholic acid | LXRα (NR1H3), liver X receptor alpha | PPARγ (NR1C3), peroxisome proliferator-activated receptor gamma | OSTαβ, organic solute transporter alpha | ABCG5 | AMPK, AMP activated protein kinase | NASH, non-alcoholic steatohepatitis | SHP (NR0B2), short heterodimer partner | OATP1A2 (SLCO1A2, OATP1, OATP-A, SLC21A3), solute carrier organic anion transporter family, member 1A2 | EGFR, epidermal growth factor receptor | IL6, interleukin 6 | TGR5, G protein-coupled bile acid receptor | PH, partial hepatectomy | AE2, anion exchanger 2 | PSC, primary sclerosing cholangitis | OATP1B1 (SLCO1B1, OATP2, OATP-C, SLC21A6), solute carrier organic anion transporter family, member 1B1 | RARα (NR1B1), retinoic acid receptor alpha | GLP-1, glucagon like peptide 1 | VDR (NR1I1), vitamin D receptor. Please note that for the convenience of better readability and clarity, abbreviations for transporters and nuclear receptors were capitalized throughout this article when symbols were identical for human and rodents | MRP2 (ABCC2), multidrug resistance-associated protein 2, ATP-binding cassette, subfamily C, member 2 | NTCP (SLC10A1), sodium | CAR (NR1I3), constitutive androstane receptor | taurocholate cotransporting polypeptide, solute carrier family 10, member 1 | PPARα (NR1C1), peroxisome proliferator-activated receptor alpha | Review | GR (NR3C1), glucocorticoid receptor | Bile acids, Cholestasis, Fatty liver disease, Gallstones, Liver regeneration, Liver cancer | 19, fibroblast growth factor 15 | Mdr2 | ICP, intrahepatic cholestasis of pregnancy | BRIC, benign recurrent intrahepatic cholestasis | OATP1B3 (SLCO1B3, OATP8, SLC21A8), solute carrier organic anion transporter family, member 1B3 | MRP3 (ABCC3), multidrug resistance-associated protein 3, ATP-binding cassette, subfamily C, member 3 | beta | MDR1 (ABCB1), p-glycoprotein, ATP-binding cassette, subfamily B, member 1 | norUDCA, norursodeoxycholic acid | 6-ECDCA, 6-ethylchenodeoxycholic acid | FXR (NR1H4), farnesoid X receptor | BCRP (ABCG2), breast cancer resistance protein, ATP-binding cassette, subfamily G, member 2 | HNF4α (NR2A1), hepatocyte nuclear factor 4 alpha | PBC, primary biliary cirrhosis | MDR3 (ABCB4), multidrug resistance protein 2 (rodents) | HNF1α, hepatocyte nuclear factor 1 alpha | NR, nuclear receptor | FGF15 | RXRα (NR2B1), retinoid X receptor alpha | PXR (NR1I2), pregnane X receptor | BSEP (ABCB11), bile salt export pump | HCC, hepatocellular carcinoma | MRP4 (ABCC4), multidrug resistance-associated protein 4, ATP-binding cassette, subfamily C, member 4 | TPN, total parenteral nutrition
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5. Full Text Bile acids are nutrient signaling hormones
by Zhou, Huiping and Hylemon, Phillip B
Steroids, ISSN 0039-128X, 08/2014, Volume 86, pp. 62 - 68
cholic acid | extracellular signal-regulated kinase | apical sodium dependent transporter | Liver | deoxycholic acid | pregnane X receptor | M1-5 | 12α-hydroxylase | G-6-Pase | liver-related homolog-1 | G-protein coupled receptor | sodium taurocholate cotransporting polypeptide | farnesoid x receptor | NTCP | ASBT | SHP | liver X receptor | sphingosine 1-phosphate | BSEP | bile salt export protein (ABCB11) | DCA | Bile acids | PEPCK | sterol 27-hydroxylase | phosphatidylinositol-3-kinase | glycocholic acid | lithocholic acid | LCA | PKCζ | CYP7B1 | Insulin | CYP27A1 | ERK1/2 | TCA | glycodeoxycholic acid | HNF4a | fibroblast growth factor 15/19 | GPCR | P13K | cholangiocarcinoma | FXR | NAFLD | non-alcoholic fatty liver disease | FGF15/19 | sphingosine 1-phosphate receptor 2 | LXR | PXR | CYP7A1 | PEP carboxykinse | EGFR | Glucose metabolism | S1P | cholesterol 7α-hydroxylase | hepatocyte nuclear factor 4 | GDCA | S1PR2 | protein kinase B | CCA | CDCA | GCA | epidermal growth factor receptor | taurocholate | AKT | CYP8B1 | oxysterol 7α-hydroxylase | muscarinic receptor 1-5 | LRH-1 | small heterodimer partner | chenodeoxycholic acid | glucose-6-phosphatase | Sphingosine 1-phosphate receptor 2 | Biochemistry & Molecular Biology | Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Bile Acids and Salts - blood | Metabolic Diseases - metabolism | Receptors, G-Protein-Coupled - metabolism | Signal Transduction | Humans | Glucose - metabolism | Bile Acids and Salts - metabolism | Lipid Metabolism | Food | Receptors, Cytoplasmic and Nuclear - metabolism | Glucose | Hormones | Dextrose | Deoxycholic acid | Index Medicus
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6. Full Text Synbiotic-driven improvement of metabolic disturbances is associated with changes in the gut microbiome in diet-induced obese mice
by Ke, Xinxin and Walker, Alesia and Haange, Sven-Bastiaan and Lagkouvardos, Ilias and Liu, Yuwen and Schmitt-Kopplin, Philippe and von Bergen, Martin and Jehmlich, Nico and He, Xin and Clavel, Thomas and Cheung, Peter C.K
Molecular metabolism (Germany), ISSN 2212-8778, 04/2019, Volume 22, pp. 96 - 109
Gut microbiota | Obesity | Dietary intervention | High-fat diet | Synbiotics | Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Animals | Obesity - chemically induced | Mice, Inbred C57BL | Gastrointestinal Microbiome | Diet, High-Fat - adverse effects | Male | Mice, Obese | Mice | Obesity - metabolism | Index Medicus
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7. Full Text Quantitative profiling of 19 bile acids in rat plasma, liver, bile and different intestinal section contents to investigate bile acid homeostasis and the application of temporal variation of endogenous bile acids
by Yang, Tingting and Shu, Ting and Liu, Guanlan and Mei, Huifang and Zhu, Xiaoyu and Huang, Xin and Zhang, Luyong and Jiang, Zhenzhou
The Journal of steroid biochemistry and molecular biology, ISSN 0960-0760, 09/2017, Volume 172, pp. 69 - 78
cholic acid | Chronopharmacokinetics | Rat | Homeostasis | UDCA | deoxycholic acid | LC–MS/MS | Profile | QC | ursodeoxycholic acid | BAs | bile acids | Bile acid | methanol | acetonitrile | CA | CDCA | internal standard | DCA | quality control | high-performance liquid chromatography-tandem mass spectrometry | beta-MCA | lithocholic acid | IS | LCA | taurine-conjugated bile acids | ACN | beta-muricholic acid | T-BAs | G-BAs | MeOH | glycine-conjugated bile acids | HDCA | hyodeoxycholic acid | chenodeoxycholic acid | Biochemistry & Molecular Biology | Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Glycine - blood | Metabolomics | Bile Acids and Salts - blood | Bile Acids and Salts - classification | Bile Acids and Salts - chemistry | Colon - chemistry | Ileum - chemistry | Rats | Jejunum - chemistry | Male | Chromatography, High Pressure Liquid | Rats, Sprague-Dawley | Liver - chemistry | Taurine - blood | Tandem Mass Spectrometry | Animals | Glycine - chemistry | Time Factors | Duodenum - chemistry | Homeostasis - physiology | Cecum - chemistry | Taurine - chemistry | Taurine | Liver diseases | Liver | Physiological aspects | Ursodiol | Nitriles | Glycine | Mass spectrometry | Investigations | High performance liquid chromatography | Deoxycholic acid | Taurocholic acid | Bile acids | Duodenum | Cecum | Microflora | Reabsorption | Mass spectroscopy | Cholic acid | Metabolism | High-performance liquid chromatography | Ileum | Bile duct | Jejunum | Acids | Intestine | Circulatory system | Temporal variations | Colon | Circulation | Index Medicus
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8. Full Text A Phase 1b Safety Study of SER-287, a Spore-Based Microbiome Therapeutic, for Active Mild to Moderate Ulcerative Colitis
by Henn, Matthew R and O’Brien, Edward J and Diao, Liyang and Feagan, Brian G and Sandborn, William J and Huttenhower, Curtis and Wortman, Jennifer R and McGovern, Barbara H and Wang-Weigand, Sherry and Lichter, David I and Chafee, Meghan and Ford, Christopher B and Bernardo, Patricia and Zhao, Peng and Simmons, Sheri and Tomlinson, Amelia D and Cook, David N and Pomerantz, Roger J and Misra, Bharat K and Auninš, John G and