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Molecular cell, ISSN 1097-2765, 2017, Volume 67, Issue 3, pp. 498 - 511.e6
Journal Article
Journal of allergy and clinical immunology, ISSN 0091-6749, 2012, Volume 130, Issue 5, pp. 1144 - 1152.e11
Background Signals emanating from the antigen T-cell receptor (TCR) are required for T-cell development and function. The T lymphocyte–specific protein... 
Allergy and Immunology | LCK, SRC tyrosine kinase | recurrent infections | CD4 | T-cell receptor signaling | autoinflammation | immunodeficiency | genetic defect | lymphopenia | ACTIVATION | COMPLEX | SRC tyrosine kinase | PROTEIN-TYROSINE KINASES | P56(LCK) | IMMUNOLOGY | MICE LACKING | SIGNAL-TRANSDUCTION | ALLERGY | LCK | MUTATION | DOCK8 DEFICIENCY | FYN | ANTIGEN RECEPTOR | Genetic Predisposition to Disease | T-Lymphocytopenia, Idiopathic CD4-Positive - diagnosis | Receptors, Antigen, T-Cell - metabolism | Genes, Recessive - genetics | Humans | Cells, Cultured | Child, Preschool | T-Lymphocytopenia, Idiopathic CD4-Positive - genetics | Mutation, Missense - genetics | Polymorphism, Genetic | CD4-Positive T-Lymphocytes - immunology | DNA Mutational Analysis | Pedigree | Immunologic Deficiency Syndromes - genetics | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - chemistry | Female | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - genetics | Calcium Signaling - genetics | France | Immunologic Deficiency Syndromes - diagnosis | Tyrosine | Antigens | T cells | Genes | Immunodeficiency | T cell receptors | Infections | Kinases | Viral infections | Immune system | Autoimmunity | Calcium mobilization | Phosphorylation | CD8 antigen | Recurrent infection | Inflammation | Lymphocytes T | Risk factors | CD4 antigen | Calcium signalling | T-cell receptor | Missense mutation | Lymphopenia | Lck protein | Respiratory tract diseases | Differentiation | Protein-tyrosine kinase | Age | uniparental disomy | Life Sciences | Biochemistry, Molecular Biology
Journal Article
The Journal of Immunology, ISSN 0022-1767, 02/2010, Volume 184, Issue 3, pp. 1436 - 1444
Mycolactone is a diffusible lipid toxin produced by Mycobacterium ulcerans, the causative agent of a necrotizing skin disease referred to as Buruli ulcer.... 
WHOLE-BLOOD | MYCOBACTERIUM-ULCERANS INFECTION | CYTOKINE PRODUCTION | STIMULATION | TOXIN | DISEASE | BURULI ULCER | IMMUNOLOGY | VIRULENCE | LYMPHOCYTE-ACTIVATION | LESIONS | Intracellular Fluid - immunology | T-Lymphocytes - enzymology | Humans | Bacterial Toxins - toxicity | Buruli Ulcer - enzymology | Mycobacterium ulcerans - immunology | Signal Transduction - immunology | Buruli Ulcer - immunology | Intracellular Fluid - drug effects | Lymphocyte Activation - genetics | Lymphocyte Activation - immunology | Immunity, Cellular - drug effects | Protein Processing, Post-Translational - drug effects | Time Factors | T-Lymphocytes - drug effects | Protein Processing, Post-Translational - immunology | Immunosuppressive Agents - pharmacology | Immunity, Cellular - genetics | Jurkat Cells | Macrolides | Mice, Inbred C57BL | Cells, Cultured | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - metabolism | Immunosuppressive Agents - toxicity | Intracellular Fluid - enzymology | Animals | Signal Transduction - drug effects | Bacterial Toxins - pharmacology | Lymphocyte Activation - drug effects | T-Lymphocytes - immunology | Mice | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - genetics | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - physiology | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) | Immunosuppressive Agents | Signal Transduction | T-Lymphocytes | Lymphocyte Activation | Life Sciences | Microbiology and Parasitology | Mycobacterium ulcerans | Bacterial Toxins | Protein Processing, Post-Translational | Buruli Ulcer | Intracellular Fluid | Immunity, Cellular
Journal Article
Nature immunology, ISSN 1529-2916, 2016, Volume 17, Issue 5, pp. 574 - 582
It has been proposed that the local segregation of kinases and the tyrosine phosphatase CD45 underpins T cell antigen receptor (TCR) triggering, but how such... 
DIMENSIONS | ACTIVATION | PROTEIN | RECOGNITION | STRUCTURAL BASIS | CRYSTAL-STRUCTURE | ELECTRON-MICROSCOPY | RECEPTOR | IMMUNOLOGY | EXPRESSION | ANTIGEN | Protein Structure, Tertiary | Leukocyte Common Antigens - metabolism | Receptors, Antigen, T-Cell - metabolism | Jurkat Cells | Humans | Leukocyte Common Antigens - chemistry | Models, Molecular | Crystallography, X-Ray | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - immunology | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - metabolism | Microscopy, Electron | Leukocyte Common Antigens - immunology | Signal Transduction - immunology | Microscopy, Fluorescence - methods | T-Lymphocytes - metabolism | Time Factors | HEK293 Cells | ZAP-70 Protein-Tyrosine Kinase - immunology | ZAP-70 Protein-Tyrosine Kinase - metabolism | Receptors, Antigen, T-Cell - immunology | T-Lymphocytes - immunology | Cell receptors | Immune response | Cellular signal transduction | Genetic aspects | Properties | T cells | Health aspects | Biological Sciences | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) | Immunologi | Signal Transduction | T-Lymphocytes | ZAP-70 Protein-Tyrosine Kinase | Receptors, Antigen, T-Cell | Journal Article | Naturvetenskap | Immunology | Research Support, Non-U.S. Gov't | Biologi | Natural Sciences | Microscopy, Fluorescence | Leukocyte Common Antigens
Journal Article
Oncogene, ISSN 1476-5594, 2018, Volume 38, Issue 10, pp. 1734 - 1750
Migration of human glioma cells (hGCs) within the brain parenchyma makes glioblastoma one of the most aggressive and lethal tumors. Studies of the cellular and... 
HETEROGENEITY | KINASE LCK | INVASION | ACTIVATION | MYELINATION | ONCOLOGY | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENETICS & HEREDITY | NEURONS | PHENOTYPE | SCHWANN-CELLS | CELL BIOLOGY | Paxillin - metabolism | Oligodendroglia - metabolism | Paxillin - genetics | Neoplastic Stem Cells - drug effects | Coculture Techniques | Humans | Male | Ganglia, Spinal - cytology | Brain Neoplasms - metabolism | Glioma - metabolism | Glioma - genetics | Proto-Oncogene Proteins c-crk - metabolism | Gene Expression Regulation, Neoplastic - drug effects | Oligodendroglia - cytology | Phosphorylation - drug effects | Pyrazoles - pharmacology | Pyrimidines - administration & dosage | Cells, Cultured | Brain Neoplasms - genetics | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - metabolism | Pyrimidines - pharmacology | Brain Neoplasms - drug therapy | Proto-Oncogene Proteins c-crk - genetics | Xenograft Model Antitumor Assays | Cell Movement - drug effects | Pyrazoles - administration & dosage | Animals | Pseudopodia - metabolism | Pseudopodia - genetics | Mice | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - genetics | Glioma - drug therapy | rac1 GTP-Binding Protein - metabolism | Ganglia, Spinal - metabolism | rac1 GTP-Binding Protein - genetics | Development and progression | Genetic aspects | Research | Gene expression | Drug therapy | Glioblastoma multiforme | Cell migration | Cell culture | Phosphorylation | Statistical analysis | Cell survival | Therapeutic applications | Axonogenesis | Brain tumors | Gene regulation | Glioblastoma | Parenchyma | Pseudopodia | Rac1 protein | Ribonucleic acid--RNA | Kinases | Cell adhesion & migration | Molecular modelling | Dorsal root ganglia | Glioma cells | Lck protein | Stem cells | Xenografts | Paxillin
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2018, Volume 115, Issue 40, pp. 10094 - 10099
Journal Article
The Journal of Immunology, ISSN 0022-1767, 09/2002, Volume 169, Issue 6, pp. 2997 - 3005
The role of TCR signals triggered by recognition of self MHCs in maintaining the survival of naive peripheral T cells remains controversial. Here we examine... 
CD4 | TYROSINE PHOSPHORYLATION | DENDRITIC CELLS | MURINE THYMOCYTES | LCK | IN-VIVO | P56(LCK) | RECEPTOR | IMMUNOLOGY | HOMEOSTATIC PROLIFERATION | MICE LACKING | T-Lymphocyte Subsets - immunology | Phosphorylation | T-Lymphocyte Subsets - cytology | Proto-Oncogene Proteins c-fyn | Cell Survival - genetics | Interphase - immunology | Thymus Gland - enzymology | src-Family Kinases - deficiency | Signal Transduction - immunology | Thymus Gland - growth & development | src-Family Kinases - physiology | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - deficiency | Receptors, Antigen, T-Cell - metabolism | Mice, Inbred C57BL | Thymus Gland - cytology | CD5 Antigens - biosynthesis | Mice, Transgenic | Proto-Oncogene Proteins - genetics | Signal Transduction - genetics | Proto-Oncogene Proteins - deficiency | Cell Survival - immunology | CD3 Complex - metabolism | Receptors, Antigen, T-Cell - physiology | Drug Synergism | Receptors, Interleukin-7 - physiology | Animals | T-Lymphocyte Subsets - enzymology | T-Lymphocyte Subsets - metabolism | Proto-Oncogene Proteins - physiology | Lymphocyte Count | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - biosynthesis | Lymphopenia - immunology | Mice | Gene Expression Regulation, Enzymologic - immunology | Interphase - genetics | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - genetics | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - physiology | Lymphopenia - genetics | Transgenes - immunology | src-Family Kinases - genetics
Journal Article
Journal Article