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1. Full Text Safety of Very Low Low-Density Lipoprotein Cholesterol Levels With Alirocumab: Pooled Data From Randomized Trials
by Robinson, Jennifer G and Rosenson, Robert S and Farnier, Michel and Chaudhari, Umesh and Sasiela, William J and Merlet, Laurence and Miller, Kathryn and Kastelein, John J. P
Journal of the American College of Cardiology, ISSN 0735-1097, 2017, Volume 69, Issue 5, pp. 471 - 482
PCSK9 | clinical trials | LDL-C | safety | Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Propensity Score | Follow-Up Studies | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Antibodies, Monoclonal - therapeutic use | Cholesterol, LDL - blood | Female | Male | Safety | Hypercholesterolemia - drug therapy | Randomized Controlled Trials as Topic | Laboratories | Vitamin E | Low density lipoprotein | Statins | Index Medicus | Abridged Index Medicus
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2. Full Text Very-Low-Density Lipoprotein–Associated Apolipoproteins Predict Cardiovascular Events and Are Lowered by Inhibition of APOC-III
by Pechlaner, Raimund, MD, PhD and Tsimikas, Sotirios, MD and Yin, Xiaoke, PhD and Willeit, Peter, MD, PhD and Baig, Ferheen, MSc and Santer, Peter, MD and Oberhollenzer, Friedrich, MD and Egger, Georg, MD and Witztum, Joseph L., MD and Alexander, Veronica J., PhD and Willeit, Johann, MD and Kiechl, Stefan, MD and Mayr, Manuel, MD, PhD
Journal of the American College of Cardiology, ISSN 0735-1097, 2017, Volume 69, Issue 7, pp. 789 - 800
Cardiovascular | Internal Medicine | mass spectrometry | triglycerides | proteomics | lipidomics | Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Apolipoprotein C-III - antagonists & inhibitors | Prospective Studies | Cardiovascular Diseases - prevention & control | Humans | Middle Aged | Male | Apolipoproteins - blood | Incidence | Lipoproteins, VLDL - blood | Mass Spectrometry | Cardiovascular Diseases - blood | Cardiovascular Diseases - epidemiology | Female | Aged | Medical colleges | Research institutes | Blood lipids | Apolipoproteins | Low density lipoproteins | Analysis | Mass spectrometry | Heart attack | Blood proteins | Studies | Lipids | Low density lipoprotein | Statins | Index Medicus | Abridged Index Medicus | HDL-C, high-density lipoprotein cholesterol | MS, mass spectrometry | PC, phosphatidylcholine | LDL-C, low-density lipoprotein cholesterol | CE, cholesterol ester | CVD, cardiovascular disease | DAG, diacylglycerol | VLDL, very-low-density lipoprotein | TAG, triacylglycerol | TG, triglyceride | TRL, triglyceride-rich lipoprotein | apo, apolipoprotein | FCS, familial chylomicronemia syndrome | MRM, multiple reaction monitoring | HDL, high-density lipoprotein | LDL, low-density lipoprotein | Original Investigation
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3. Full Text Evaluating the atherogenic burden of individuals with a Friedewald-estimated low-density lipoprotein cholesterol <70 mg/dL compared with a novel low-density lipoprotein estimation method
by Whelton, Seamus P., MD, MPH and Meeusen, Jeffrey W., PhD and Donato, Leslie J., PhD and Jaffe, Allan S., MD and Saenger, Amy, PhD and Sokoll, Lori J., PhD and Blumenthal, Roger S., MD and Jones, Steven R., MD and Martin, Seth S., MD, MHS
Journal of clinical lipidology, ISSN 1933-2874, 2017, Volume 11, Issue 4, pp. 1065 - 1072
Cardiovascular | Lipids | PCSK9 | Non-HDL-C | LDL-C | ASCVD | ApoB | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Blood Chemical Analysis - methods | Cross-Sectional Studies | Nutrition Surveys | Humans | Middle Aged | Male | Apolipoproteins B - blood | Atherosclerosis - blood | Young Adult | Health Surveys | Adolescent | Adult | Cholesterol, LDL - blood | Female | Aged | Index Medicus
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4. Full Text Low‐Density Lipoprotein Cholesterol/High‐Density Lipoprotein Cholesterol Ratio and Carotid Intima‐Media Thickness: A Cohort Study in China
by Qin, Pei and Shi, Jing and Cao, Liming and Li, Xue and Lou, Yanmei and Wang, Changyi and Ma, Jianping and Wang, Li and Peng, Xiaolin and Chen, Hongen and Xu, Shan and Zhao, Ping and Hu, Dongsheng and Hu, Fulan
Lipids, ISSN 0024-4201, 01/2021, Volume 56, Issue 1, pp. 59 - 68
LDL‐C/HDL‐C ratio | Carotid intima‐media | Cohort | Atherosclerosis | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Nutrition & Dietetics | Science & Technology | Index Medicus
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5. Full Text Effects of AMG 145 on low-density lipoprotein cholesterol levels: Results from 2 randomized, double-blind, placebo-controlled, ascending-dose phase 1 studies in healthy volunteers and hypercholesterolemic subjects on statins
by Dias, Clapton S and Shaywitz, Adam J and Wasserman, Scott M and Smith, Brian P and Gao, Bing and Stolman, Dina S and Crispino, Caroline P and Smirnakis, Karen V and Emery, Maurice G and Colbert, Alexander and Gibbs, John P and Retter, Marc W and Cooke, Blaire P and Uy, Stephen T and Matson, Mark and Stein, Evan A
Journal of the American College of Cardiology, ISSN 0735-1097, 11/2012, Volume 60, Issue 19, pp. 1888 - 1898
LDL-C | PCSK9 | hypercholesterolemia | Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Cardiology. Vascular system | Biological and medical sciences | Metabolic diseases | Medical sciences | Disorders of blood lipids. Hyperlipoproteinemia | Proprotein Convertases - antagonists & inhibitors | Hypercholesterolemia - blood | Double-Blind Method | Antibodies, Monoclonal - pharmacology | Humans | Proprotein Convertases - metabolism | Receptors, LDL - antagonists & inhibitors | Cholesterol, LDL - antagonists & inhibitors | Receptors, LDL - metabolism | Antibodies, Monoclonal - therapeutic use | Male | Treatment Outcome | Hypercholesterolemia - drug therapy | Dose-Response Relationship, Drug | Young Adult | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Adult | Cholesterol, LDL - blood | Female | Serine Endopeptidases - metabolism | Cohort Studies | Proprotein Convertase 9 | Index Medicus | Abridged Index Medicus
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6. Full Text Identifying low density lipoprotein cholesterol associated variants in the Annexin A2 ( ANXA2 ) gene
by Fairoozy, Roaa Hani and Cooper, Jackie and White, Jon and Giambartolomei, Claudia and Folkersen, Lasse and Wannamethee, S. Goya and Jefferis, Barbara J and Whincup, Peter and Ben-Shlomo, Yoav and Kumari, Meena and Kivimaki, Mika and Wong, Andrew and Hardy, Rebecca and Kuh, Diana and Gaunt, Tom R and Casas, J.P and McLachlan, Stela and Price, Jackie F and Hingorani, Aroon and Franco-Cereceda, Anders and Grewal, Thomas and Kalea, Anastasia Z and Humphries, Steve E and UCLEB consortium and UCLEB Consortium
Atherosclerosis, ISSN 0021-9150, 2017, Volume 261, pp. 60 - 68
Cardiovascular | Low-density lipoprotein cholesterol-receptor | Annexin A2 | Single nucleotide polymorphism | Proprotein convertase subtilisin/kexin type-9 | Coronary heart disease | Low-density lipoprotein cholesterol | Cardiac & Cardiovascular Systems | Peripheral Vascular Disease | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Humans | Middle Aged | Databases, Genetic | Male | Transfection | Cholesterol, LDL - blood | Female | Genes, Reporter | Coronary Disease - blood | Genetic Predisposition to Disease | Genetic Association Studies | Gene Frequency | Computational Biology | United Kingdom | Biomarkers - blood | Coronary Disease - diagnosis | Proprotein Convertase 9 - metabolism | Hep G2 Cells | Linkage Disequilibrium | Homozygote | Phenotype | Annexin A2 - genetics | Coronary Disease - genetics | K562 Cells | Heterozygote | Polymorphism, Single Nucleotide | Quantitative Trait Loci | Annexin A2 - metabolism | Medical colleges | Low density lipoproteins | Genetic research | Research institutes | Annexins | Epidemiology | Cholesterol | Analysis | Index Medicus | LDL-C, low-density lipoprotein cholesterol | LDLR, low-density lipoprotein cholesterol-receptor | AnxA2, annexin A2 | Proprotein convertase subtilisin | FAIRE, formaldehyde assisted isolation of regulatory elements | NPHSII, Second-Northwick-Park Heart Study | CHRD, cysteine-histidine-rich domain of PCSK9 | UCLEB, UCL-LSHTM-Edinburgh-Bristol consortium | kexin type-9 | PCSK9, proprotein convertase subtilisin | CTCF, CTC-binding factor | Medicin och hälsovetenskap
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7. Full Text Factors influencing low-density lipoprotein cholesterol target achievement in primary care –results from DYSIS China
by Lin, Xue and Xu, RuiYi and Fang, Ligang and Chen, Wei and Hu, Dayi and Zhao, Shuiping and Wang, Yongjun and Li, Jihu and Yan, Xiaowei and on behalf of the DYSIS-China Study Investigators and DYSIS-China Study Investigators
International journal of cardiology, ISSN 0167-5273, 2016, Volume 222, pp. 51 - 56
Cardiovascular | Primary care | LDL-C attainment | Dyslipidemia | Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Hypercholesterolemia - blood | Primary Health Care - methods | Primary Health Care - statistics & numerical data | Cardiovascular Diseases - prevention & control | Humans | Middle Aged | Risk Factors | Medication Therapy Management - statistics & numerical data | Male | China - epidemiology | Hypercholesterolemia - drug therapy | Dose-Response Relationship, Drug | Medication Therapy Management - organization & administration | Lipid Metabolism - drug effects | Cardiovascular Diseases - epidemiology | Cholesterol, LDL - blood | Female | Aged | Anticholesteremic Agents - classification | Anticholesteremic Agents - pharmacology | Hypercholesterolemia - epidemiology | Needs Assessment | Low density lipoproteins | Cholesterol | Hypercholesterolemia | Hospitals | Analysis | Statins | Index Medicus
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8. Full Text Low-density lipoprotein cholesterol in a global cohort of 57,885 statin-treated patients
by Gitt, Anselm K and Lautsch, Dominik and Ferrieres, Jean and Kastelein, John and Drexel, Heinz and Horack, Martin and Brudi, Philippe and Vanneste, Brecht and Bramlage, Peter and Chazelle, Francois and Sazonov, Vasilisa and Ambegaonkar, Baishali
Atherosclerosis, ISSN 0021-9150, 2016, Volume 255, pp. 200 - 209
Cardiovascular | Treatment targets | Low-density lipoprotein cholesterol (LDL-C) | Statins | Dyslipidemia | Cardiovascular disease (CVD) | Cardiac & Cardiovascular Systems | Peripheral Vascular Disease | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Dyslipidemias - drug therapy | Prevalence | Cross-Sectional Studies | Risk Assessment | Comorbidity | Down-Regulation | Humans | Middle Aged | Risk Factors | Male | Treatment Outcome | Biomarkers - blood | Dyslipidemias - blood | Dyslipidemias - epidemiology | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Healthcare Disparities | Cholesterol, LDL - blood | Female | Aged | Dyslipidemias - diagnosis | Medical colleges | Low density lipoproteins | Cardiology | Medicine, Preventive | Cholesterol | Preventive health services | Index Medicus
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9. Full Text Longitudinal Association of PCSK9 Sequence Variations With Low-Density Lipoprotein Cholesterol Levels: The Coronary Artery Risk Development in Young Adults Study
by Huang, Chiang-Ching and Fornage, Myriam and Lloyd-Jones, Donald M and Wei, Gina S and Boerwinkle, Eric and Liu, Kiang
Circulation: Cardiovascular Genetics, ISSN 0016-6731, 08/2009, Volume 2, Issue 4, pp. 354 - 361
PCSK9 | LDL-C | Genetic variant | Longitudinal study | Words | Cardiac & Cardiovascular Systems | Genetics & Heredity | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Humans | Middle Aged | Risk Factors | Genotype | Male | Apolipoproteins E - genetics | Adolescent | Alleles | Coronary Artery Disease - genetics | Serine Endopeptidases - genetics | Adult | Cholesterol, LDL - blood | Female | Polymorphism, Single Nucleotide | Mutation | Proprotein Convertases | Longitudinal Studies | Amino Acid Substitution | Proprotein Convertase 9 | Index Medicus
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10. Full Text Redefining normal low-density lipoprotein cholesterol: A strategy to unseat coronary disease as the nation's leading killer
by Forrester, James S
Journal of the American College of Cardiology, ISSN 0735-1097, 08/2010, Volume 56, Issue 8, pp. 630 - 636
Adult Treatment Panel | LDL-C | ATP | low-density lipoprotein cholesterol | Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Cardiology. Vascular system | Heart | Biological and medical sciences | Medical sciences | Coronary heart disease | Coronary Disease - blood | Risk Assessment | Humans | Risk Factors | Coronary Artery Disease - prevention & control | Ultrasonography, Interventional | Male | Reference Values | Coronary Artery Disease - diagnostic imaging | Coronary Disease - prevention & control | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Adult | Cholesterol, LDL - blood | Practice Guidelines as Topic | Heart attacks | Mortality | Clinical trials | Cardiovascular disease | Mammals | Low density lipoprotein | Cholesterol | Morbidity | Disease prevention | Generic drugs | Ultrasonic imaging | Atherosclerosis | Population | Age | Index Medicus | Abridged Index Medicus
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11. Full Text A review of low-density lipoprotein cholesterol, treatment strategies, and its impact on cardiovascular disease morbidity and mortality
by Wadhera, Rishi K., MD, MPhil and Steen, Dylan L., MD, MS and Khan, Irfan, PhD and Giugliano, Robert P., MD, SM and Foody, JoAnne M., MD, FACC, FAHA
Journal of clinical lipidology, ISSN 1933-2874, 2015, Volume 10, Issue 3, pp. 472 - 489
Cardiovascular | LDL-C | Mortality | Cardiovascular disease | Risk | Epidemiology | Lipid-lowering therapy | Morbidity | Guidelines | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Life Style | Cardiovascular Diseases - metabolism | Cardiovascular Diseases - drug therapy | Humans | Evidence-Based Medicine | Anticholesteremic Agents - adverse effects | Animals | Anticholesteremic Agents - therapeutic use | Cardiovascular Diseases - epidemiology | Cardiovascular Diseases - mortality | Cholesterol, LDL - metabolism | Anticholesteremic Agents - pharmacology | Index Medicus
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