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Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 45, pp. 18699 - 18712
In the CNS, microglia are activated in response to injury or infection and in neurodegenerative diseases. The endocytic and cell signaling receptor, LDL... 
NERVOUS-SYSTEM | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | shedding | GLIAL-CELLS | ALPHA-2-MACROGLOBULIN RECEPTOR | NEUROPATHIC PAIN | PLASMINOGEN-ACTIVATOR | neuroinflammation | lipoprotein receptor-related protein (LRP) | metalloprotease | SCHWANN-CELLS | receptor-associated protein | INFLAMMATORY RESPONSE | microglia | NF-KAPPA-B | INNATE IMMUNITY | Microglia - metabolism | Tumor Suppressor Proteins - antagonists & inhibitors | Humans | Nitric Oxide Synthase Type II - chemistry | Male | Calreticulin - genetics | Cerebral Cortex - cytology | Cerebral Cortex - metabolism | Inflammation Mediators - agonists | Nerve Tissue Proteins - chemistry | Microglia - immunology | Cell-Derived Microparticles - drug effects | RNA Interference | Tumor Suppressor Proteins - genetics | Inflammation Mediators - metabolism | Calreticulin - metabolism | Cell-Derived Microparticles - metabolism | Cerebral Cortex - drug effects | LDL-Receptor Related Protein-Associated Protein - metabolism | Animals, Newborn | Microglia - cytology | Recombinant Proteins - metabolism | Nerve Tissue Proteins - antagonists & inhibitors | Receptors, LDL - agonists | Receptors, LDL - genetics | Tumor Suppressor Proteins - metabolism | Lipopolysaccharides - toxicity | Microglia - drug effects | Mice, Inbred C57BL | Receptors, LDL - antagonists & inhibitors | Cells, Cultured | Receptors, LDL - metabolism | Mice, Transgenic | Nerve Tissue Proteins - genetics | Mice, Knockout | Gene Expression Regulation - drug effects | Nerve Tissue Proteins - metabolism | Animals | Nitric Oxide Synthase Type II - genetics | Cell-Derived Microparticles - immunology | Cerebral Cortex - immunology | Ligands | Tumor Suppressor Proteins - agonists | Nitric Oxide Synthase Type II - metabolism | Index Medicus | Cell Biology
Journal Article
Journal Article
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 11/2017, Volume 493, Issue 1, pp. 509 - 513
Journal Article
FASEB Journal, ISSN 0892-6638, 02/2013, Volume 27, Issue 2, pp. 511 - 521
Journal Article
Biochemical Journal, ISSN 0264-6021, 02/2007, Volume 402, Issue 1, pp. 17 - 23
PrPC (cellular prion protein) is located at the surface of neuronal cells in detergent-insoluble lipid rafts, yet is internalized by clathrin-dependent... 
Receptor-associated protein (RAP) | Clathrin | Low-density lipoprotein receptor-related protein-1 (LRP1) | Prion | dependent endocytosis | Amyloid precursor protein (APP) | receptor-associated protein (RAP) | clathrin | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | Cu2+ dependent endocytosis | low-density lipoprotein receptor-related protein-1 (LRP1) | AMYLOID PRECURSOR PROTEIN | amyloid precursor protein (APP) | INTERNALIZATION | METABOLISM | LIPID RAFTS | SURFACE | prion | GENE FAMILY | DEGRADATION | BINDING | UROKINASE | Receptors, LDL - genetics | Humans | Low Density Lipoprotein Receptor-Related Protein-1 - metabolism | Receptors, LDL - metabolism | Low Density Lipoprotein Receptor-Related Protein-1 - genetics | Clathrin - metabolism | Endocytosis | Animals | Amyloid beta-Protein Precursor - metabolism | Copper - metabolism | Ligands | Mice | Neuroblastoma - metabolism | Neurons - metabolism | PrPC Proteins - metabolism | Tumor Cells, Cultured | PrPC Proteins - genetics | LDL-Receptor Related Protein-Associated Protein - metabolism | Microscopy, Fluorescence | RNA, Small Interfering - metabolism | Index Medicus | Cu2+-dependent endocytosis | uPA, urokinase-type plasminogen activator | GPI, glycosyl-phosphatidylinositol | uPAR, uPA receptor | Accelerated Publication | RAP, receptor-associated protein | LRP, LDL receptor-related protein | PAI-1, plasminogen activator inhibitor-1 | PrPSc, infectious form of the prion protein | siRNA, small interfering RNA | HSPG, heparin sulfate proteoglycan | HRP, horseradish peroxidase | KPI, Kunitz-type protease inhibitor | LDL, low-density lipoprotein | APP, amyloid precursor protein | PrPC, cellular form of the prion protein
Journal Article
The American Journal of Human Genetics, ISSN 0002-9297, 08/2013, Volume 93, Issue 2, pp. 313 - 320
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 11/2008, Volume 28, Issue 48, pp. 12604 - 12613
Human immunodeficiency virus (HIV)-1 infection of the CNS produces changes in dendritic morphology that correlate with cognitive decline in patients with HIV-1... 
Neurotoxicity | PSD95 | LRP | Tat | NeuroAIDs | Proteasome | proteasome | DEMENTIA | TYPE-1 ENCEPHALITIS | D-ASPARTATE RECEPTORS | NEUROSCIENCES | DENDRITIC SPINES | EXCITOTOXICITY | POLYAMINE-SENSITIVE-SITE | RAT HIPPOCAMPAL-NEURONS | REQUIRE FUNCTION | neurotoxicity | HIV-1 TAT | CENTRAL-NERVOUS-SYSTEM | NeuroAIDS | Disks Large Homolog 4 Protein | Neurons - pathology | Hippocampus - virology | Calcium Signaling - physiology | Humans | Nerve Degeneration - physiopathology | Receptors, N-Methyl-D-Aspartate - metabolism | Brain - virology | Green Fluorescent Proteins - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Synapses - pathology | Membrane Proteins - analysis | LDL-Receptor Related Protein-Associated Protein - pharmacology | Ubiquitination | Synapses - metabolism | AIDS Dementia Complex - pathology | HIV - metabolism | Membrane Proteins - metabolism | Intracellular Signaling Peptides and Proteins - genetics | LDL-Receptor Related Protein-Associated Protein - metabolism | tat Gene Products, Human Immunodeficiency Virus - toxicity | AIDS Dementia Complex - physiopathology | Green Fluorescent Proteins - metabolism | Neurons - virology | Tumor Suppressor Proteins - metabolism | Green Fluorescent Proteins - analysis | Synaptic Membranes - pathology | Membrane Proteins - genetics | Brain - physiopathology | Cells, Cultured | Intracellular Signaling Peptides and Proteins - analysis | Rats | Receptors, LDL - metabolism | Biological Assay - methods | Hippocampus - pathology | Nerve Degeneration - pathology | Down-Regulation - physiology | Animals | Nerve Degeneration - virology | Brain - pathology | Hippocampus - physiopathology | Synaptic Membranes - metabolism | tat Gene Products, Human Immunodeficiency Virus - metabolism | Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 10/2008, Volume 118, Issue 10, pp. 3491 - 3502
Journal Article
Cell, ISSN 0092-8674, 2004, Volume 116, Issue 3, pp. 367 - 379
Increased vascular permeability is a key feature of inflammatory conditions. In severe infections, leakage of plasma from the vasculature induces a... 
PATHOGENESIS | HUMAN NEUTROPHILS | HUMAN HBP/CAP37/AZUROCIDIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | SURFACE-PROTEINS | PYOGENES | A STREPTOCOCCAL INFECTIONS | HEPARIN-BINDING PROTEIN | CYSTEINE PROTEINASE | CD11C/CD18 | LEUKOCYTE | CELL BIOLOGY | Capillary Permeability - physiology | Pneumonia - physiopathology | Shock, Septic - etiology | Humans | Capillary Permeability - drug effects | Neutrophils - ultrastructure | Peptide Fragments - pharmacology | Shock, Septic - metabolism | Bacterial Outer Membrane Proteins - pharmacology | Chemotaxis, Leukocyte - physiology | Streptococcus pyogenes - pathogenicity | Pneumonia - chemically induced | Carrier Proteins - pharmacology | Inflammation Mediators - metabolism | Female | LDL-Receptor Related Protein-Associated Protein - metabolism | Neutrophils - metabolism | Disease Models, Animal | Microscopy, Electron, Scanning | Neutrophils - enzymology | Antigens, Bacterial | Pneumonia - microbiology | Shock, Septic - physiopathology | Streptococcus pyogenes - metabolism | Ions - metabolism | Macromolecular Substances | CD18 Antigens - metabolism | Metals - metabolism | Animals | Carrier Proteins - metabolism | Bacterial Outer Membrane Proteins - metabolism | Signal Transduction - drug effects | CD18 Antigens - drug effects | Fibrinogen - metabolism | Signal Transduction - physiology | Mice | Streptococcal Infections - complications | In Vitro Techniques | Streptococcus pyogenes | Research | Risk factors | Fibrinogen | Neutrophils | Index Medicus | Infectious Medicine | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap | Infektionsmedicin
Journal Article
Biochemical Journal, ISSN 0264-6021, 2015, Volume 468, Issue 1, pp. 65 - 72
Journal Article
Circulation Research, ISSN 0009-7330, 03/2009, Volume 104, Issue 5, pp. 619 - 627
Journal Article