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Atherosclerosis, ISSN 0021-9150, 01/2019, Volume 280, pp. 118 - 125
Limiting the pro-inflammatory immune response is critical for the treatment of atherosclerosis. Regulatory B cells (Bregs) can modulate the immune response... 
Western type diet | Interleukin-10 | Atherosclerosis | Cardiovascular disease | Regulatory B cells | B cells | Ldlr−/- mice | Ldlr | mice | CARDIAC & CARDIOVASCULAR SYSTEMS | TOLERANCE | B10 CELLS | LIGATION | SUBSET | LUPUS | PERIPHERAL VASCULAR DISEASE | Ldlr(-/-) mice | EXPRESSION
Journal Article
Journal of Medical Genetics, ISSN 0022-2593, 2019
Familial hypercholesterolaemia (FH) is a devastating genetic disease that leads to extremely high cholesterol levels and severe cardiovascular disease, mainly... 
gene therapy | ldl-c | familial hypercholesterolaemia | ldlr
Journal Article
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, ISSN 1386-1425, 10/2012, Volume 96, pp. 940 - 945
► Protein profile in atherosclerotic tissue is monitored by FT-IR imaging. ► HCA and a model for prediction of secondary structure content of proteins is used.... 
Proteins | FT-IR | Protein secondary structure | ApoE/LDLR−/− mice | Atherosclerosis | HCA | ApoE/LDLR | mice | ApoE/LDLR-/- mice | INFORMATION-CONTENT | CLASSIFICATION | LESION | CLUSTER-ANALYSIS | INFRARED-SPECTRA | CHEMOMETRICS | SPECTROSCOPY | SECONDARY STRUCTURE DETERMINATION | Apolipoproteins
Journal Article
Nutrients, ISSN 2072-6643, 07/2019, Volume 11, Issue 7, p. 1665
GQEQSHQDEGVIVR (T9) is a peptide originated by the tryptic digestion of lupin β-conglutin that is absorbed in human intestinal Caco-2 cells. A previous study... 
HepG2 | bioactive peptides | PCSK9 | lupin | LDLR
Journal Article
Atherosclerosis, ISSN 0021-9150, 10/2019, Volume 289, pp. 101 - 108
More than 4970 variants in the low-density lipoprotein receptor ( ) gene and 350 variants in the proprotein convertase subtilisin/kexin 9 ( ) gene have been... 
Pathogenic variant | PCSK9 | Familial hypercholesterolemia | LDLR | Annotation | Index Medicus
Journal Article
Atherosclerosis, ISSN 0021-9150, 04/2015, Volume 239, Issue 2, pp. 295 - 298
A previous report suggested that 88% of individuals in the general population with total cholesterol (TC)>9.3mmol/L have familial hypercholesterolaemia (FH).... 
Diagnosis | APOB | LDLR | Familial hypercholesterolaemia | Cholesterol
Journal Article
Molecular and Cellular Endocrinology, ISSN 0303-7207, 12/2019, Volume 498, pp. 110547 - 110547
Lipids play a critical role in energy metabolism, and a suite of proteins is required to deliver lipids to tissues. Several of these proteins require an... 
LPL | Lipoprotein | Lipid metabolism | LDLR | ER quality control | Index Medicus
Journal Article
Metabolism, ISSN 0026-0495, 05/2019, Volume 94, pp. 88 - 95
Low-density lipoprotein cholesterol (LDL-C) is the hallmark of atherosclerotic cardiovascular diseases. The hepatic LDL receptor (LDLR) plays an important role... 
PCSK9 | Protein degradation | LDLR | Endosome | Low-density lipoprotein cholesterol
Journal Article
Journal Article
Atherosclerosis, ISSN 0021-9150, 2008, Volume 204, Issue 1, pp. 147 - 155
Abstract Dietary very long chain omega (ω)-3 polyunsaturated fatty acids (PUFA) have been associated with reduced CVD risk, the mechanisms of which have yet to... 
Cardiovascular | Macrophage cholesterol accumulation | Diet | Atherosclerosis | ω-3 Fatty acids | Inflammation | ω-6:EPA + DHA ratio | LDLr−/− mouse | Elicited peritoneal Mϕ | LDLr-/- mouse | Elicited peritoneal Mφ{symbol} | omega-3 Fatty acids | CARDIAC & CARDIOVASCULAR SYSTEMS | Elicited peritoneal M phi | LDLr-/ mouse | SCAVENGER RECEPTORS | AGE-ASSOCIATED INCREASE | CHOLESTEROL-METABOLISM | FLAXSEED-OIL | CARDIOVASCULAR-DISEASE | PERIPHERAL VASCULAR DISEASE | FISH-OIL | CORONARY-HEART-DISEASE | UP-REGULATION | omega-6:EPA + DHA ratio | ALPHA-LINOLENIC ACID | ADIPOSE-TISSUE | Tumor Necrosis Factor-alpha - metabolism | Dietary Fats - metabolism | Inflammation - pathology | Body Weight | Atherosclerosis - genetics | Cholesterol - blood | Macrophages, Peritoneal - pathology | Male | Eicosapentaenoic Acid - administration & dosage | Aorta - metabolism | RNA, Messenger - metabolism | Fatty Acids, Omega-6 - administration & dosage | Inflammation - metabolism | CD36 Antigens - metabolism | Time Factors | Interleukin-6 - blood | Dietary Fats - administration & dosage | Inflammation Mediators - metabolism | Receptors, LDL - deficiency | ATP-Binding Cassette Transporters - metabolism | Chemokine CCL2 - metabolism | ATP Binding Cassette Transporter 1 | Disease Models, Animal | Eating | Receptors, LDL - genetics | Atherosclerosis - pathology | Cells, Cultured | Eicosapentaenoic Acid - metabolism | Lipoproteins - blood | Docosahexaenoic Acids - administration & dosage | Fatty Acids, Omega-6 - metabolism | Atherosclerosis - metabolism | Mice, Knockout | Aorta - pathology | Animals | Inflammation - genetics | Inflammation - prevention & control | Mice | Scavenger Receptors, Class B - metabolism | Macrophages, Peritoneal - metabolism | Atherosclerosis - prevention & control | Docosahexaenoic Acids - metabolism | Cholesterol | Index Medicus | atherosclerosis | mouse | ω-3 fatty acids | inflammation | elicited peritoneal Mϕ | macrophage cholesterol accumulation | diet | ω-6:EPA+DHA ratio | LDLr
Journal Article
Journal of Agricultural and Food Chemistry, ISSN 0021-8561, 06/2018, Volume 66, Issue 24, pp. 6083 - 6093
Pinostrobin, a flavonoid phytochemical found in variety of plants, has been demonstrated to possess numerous bioactivities such as antioxidant,... 
FoxO3a | PCSK9 | flavonoid | LDLR | pinostrobin | CHOLESTEROL | FOOD SCIENCE & TECHNOLOGY | TRANSCRIPTION | DOWN-REGULATION | ANTIBODY | STATINS | ATORVASTATIN | LIPOPROTEIN RECEPTOR LDLR | HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA | AGRICULTURE, MULTIDISCIPLINARY | CARDIOVASCULAR-DISEASE | DEGRADATION | CHEMISTRY, APPLIED | Index Medicus
Journal Article