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Paediatrics and international child health, ISSN 2046-9047, 10/2016, Volume 36, Issue 4, pp. 243 - 247
Homozygous familial hypercholesterolaemia (HoFH) is an inherited disease causing an approximately fourfold increase in blood low-density lipoprotein... 
HeFH, heterozygous familial hypercholesterolaemia, is caused by one mutant allele of genes affecting LDLR activity | ADH, autosomal dominant hypercholesterolaemia, refers to hypercholesterolaemia owing to a single mutation of an allele of a gene affecting LDLR activity | PCSK9, a protein called proprotein convertase subtilisin/kexin type 9, increases the rate of degradation of LDLR | Lomitapide | APOB, apolipoprotein B, is the main protein component of LDL and is the ligand for LDL receptors in the liver | FH, familial hypercholesterolaemia, is an inherited condition causing reduced LDLR activity with consequent hypercholesterolaemia | PCSK9 | LDLRAP1, a protein called LDLR adaptor protein 1, facilitates LDLR function | Lipoprotein apheresis | Microsomal triglyceride transfer protein is an enzyme involved in the hepatic assembly of triglyceride, cholesterol and APOB into triglyceride-rich particles which are secreted by the liver. These particles are metabolised to LDL | Evolucomab | LDL, low-density lipoprotein, is a complex of cholesterol attached to a lipoprotein particle which is removed from blood mainly by the liver | Homozygous familial hypercholesterolaemia | HoFH, homozygous familial hypercholesterolaemia is caused by two mutant alleles of genes affecting LDLR activity | ARH, autosomal recessive hypercholesterolaemia, refers to hypercholesterolaemia owing to a mutation of both alleles of a single gene affecting LDLR activity | LDLR, LDL receptors, mediate LDL uptake by the liver | LDLC, LDL cholesterol, refers to the cholesterol component of LDL | Liver transplantation | Life Sciences & Biomedicine | Pediatrics | Science & Technology | Hyperlipoproteinemia Type II - complications | Atherosclerosis - etiology | Hyperlipoproteinemia Type II - therapy | Anticholesteremic Agents - therapeutic use | Atherosclerosis - therapy | Humans | Hyperlipoproteinemia Type II - diagnosis | Organ Transplantation | Index Medicus
Journal Article
Biological chemistry, ISSN 1437-4315, 11/2018, Volume 399, Issue 12, pp. 1363 - 1374
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secreted protein that binds and escorts the low density lipoprotein receptor (LDLR) into the... 
cholesterol | low-density lipoprotein (LDL) | LDL receptor (LDLR) | transgenic mouse | familial hypercholesterolemia (FH) | Index Medicus
Journal Article
Biochemical journal, ISSN 1470-8728, 06/2009, Volume 421, Issue 2, pp. 273 - 282
RAP (receptor-associated protein) is a three domain 38 kDa ER (endoplasmic reticulum)-resident protein that is a chaperone for the LRP (low-density lipoprotein... 
Low-density lipoprotein receptor (LDLR) | Receptor-associated protein (RAP) | YWTD domain | Ligand release | LDLR-associated protein (LRP) | Chaperone | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Protein Structure, Tertiary | Temperature | Molecular Chaperones - metabolism | Low Density Lipoprotein Receptor-Related Protein-1 - chemistry | Low Density Lipoprotein Receptor-Related Protein-1 - metabolism | Models, Molecular | Spectrometry, Fluorescence | Molecular Chaperones - chemistry | LDL-Receptor Related Protein-Associated Protein - chemistry | Protein Folding | Protein Conformation | Kinetics | Binding Sites | LDL-Receptor Related Protein-Associated Protein - metabolism | Hydrogen-Ion Concentration | Index Medicus | receptor-associated protein (RAP) | ITC, isothermal titration calorimetry | low-density lipoprotein receptor (LDLR) | TEV, tobacco etch virus | RAP, receptor-associated protein | LA34, third and fourth CR domains from the ligand-binding cluster of LDLR | CR, complement-like repeat | CRxy, LRP fragment containing domains CRx and CRy | 2-ME, 2-mercaptoethanol | (CR)x LRP fragment containing x CR domains | chaperone | ligand release | D1, D2 and D3, first, second and third domains of RAP | IPTG, isopropyl β-D-thiogalactoside | CRxyz, LRP fragment containing domains CRx, CRy and CRz | LRP, low-density lipoprotein receptor-related protein | (V)LDLR, (very-) low-density lipoprotein receptor | GST, glutathione transferase | ER, endoplasmic reticulum
Journal Article
Atherosclerosis, ISSN 0021-9150, 2008, Volume 204, Issue 1, pp. 147 - 155
Abstract Dietary very long chain omega (ω)-3 polyunsaturated fatty acids (PUFA) have been associated with reduced CVD risk, the mechanisms of which have yet to... 
Cardiovascular | Macrophage cholesterol accumulation | Diet | Atherosclerosis | ω-3 Fatty acids | Inflammation | ω-6:EPA + DHA ratio | LDLr−/− mouse | Elicited peritoneal Mϕ | LDLr-/- mouse | Elicited peritoneal Mφ{symbol} | Cardiac & Cardiovascular Systems | Peripheral Vascular Disease | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Tumor Necrosis Factor-alpha - metabolism | Dietary Fats - metabolism | Inflammation - pathology | Body Weight | Atherosclerosis - genetics | Cholesterol - blood | Macrophages, Peritoneal - pathology | Male | Eicosapentaenoic Acid - administration & dosage | Aorta - metabolism | RNA, Messenger - metabolism | Fatty Acids, Omega-6 - administration & dosage | Inflammation - metabolism | CD36 Antigens - metabolism | Time Factors | Interleukin-6 - blood | Dietary Fats - administration & dosage | Inflammation Mediators - metabolism | Receptors, LDL - deficiency | ATP-Binding Cassette Transporters - metabolism | Chemokine CCL2 - metabolism | ATP Binding Cassette Transporter 1 | Disease Models, Animal | Eating | Receptors, LDL - genetics | Atherosclerosis - pathology | Cells, Cultured | Eicosapentaenoic Acid - metabolism | Lipoproteins - blood | Docosahexaenoic Acids - administration & dosage | Fatty Acids, Omega-6 - metabolism | Atherosclerosis - metabolism | Mice, Knockout | Aorta - pathology | Animals | Inflammation - genetics | Inflammation - prevention & control | Mice | Scavenger Receptors, Class B - metabolism | Macrophages, Peritoneal - metabolism | Atherosclerosis - prevention & control | Docosahexaenoic Acids - metabolism | Cholesterol | Index Medicus | atherosclerosis | mouse | ω-3 fatty acids | inflammation | elicited peritoneal Mϕ | macrophage cholesterol accumulation | diet | ω-6:EPA+DHA ratio | LDLr
Journal Article
Journal of cardiovascular development and disease, ISSN 2308-3425, 05/2018, Volume 5, Issue 2, p. 31
The low-density lipoprotein receptor is responsible for the binding and uptake of plasma LDL particles and plays a critical role in maintaining cellular... 
SNP—single-nucleotide polymorphism | allele specific PCR | OR—odds ratio | CI—confidence interval | CAD—coronary artery disease | LDLR rs688C/T | LDLR—low-density lipoprotein receptor
Journal Article
Free radical biology & medicine, ISSN 0891-5849, 04/2018, Volume 118, pp. 85 - 97
Lipids are responsible for the atheromatous plaque formation during atherosclerosis by their deposition in the subendothelial intima of the aorta, leading to... 
Atherosclerosis | SREBP2 | AMPK | Metformin | Cardiovascular diseases | LDLR | Cholesterol | Biochemistry & Molecular Biology | Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Index Medicus
Journal Article