Articles

Search Articles

Advanced search
Help

Catalogue

Articles

Databases

X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
ldlr (463) 463
humans (443) 443
index medicus (420) 420
receptors, ldl - genetics (310) 310
cholesterol (275) 275
male (248) 248
animals (238) 238
female (227) 227
familial hypercholesterolemia (219) 219
atherosclerosis (210) 210
hypercholesterolemia (199) 199
low density lipoproteins (186) 186
mice (177) 177
biochemistry & molecular biology (167) 167
lipids (167) 167
mutation (162) 162
hyperlipoproteinemia type ii - genetics (145) 145
ldlr gene (121) 121
adult (120) 120
middle aged (119) 119
lipoprotein receptors (117) 117
receptors, ldl - metabolism (113) 113
genetic aspects (112) 112
lipoproteins (103) 103
analysis (98) 98
pcsk9 (98) 98
density-lipoprotein receptor (96) 96
genetics & heredity (96) 96
expression (91) 91
peripheral vascular disease (91) 91
polymerase chain reaction (91) 91
metabolism (81) 81
mice, knockout (80) 80
genes (78) 78
proteins (74) 74
ldl receptor (73) 73
mutations (73) 73
cell biology (72) 72
article (69) 69
diagnosis (69) 69
disease (69) 69
genotype (69) 69
gene expression (68) 68
mice, inbred c57bl (68) 68
cardiovascular disease (66) 66
phenotype (65) 65
alleles (64) 64
liver (63) 63
cardiac & cardiovascular systems (62) 62
cardiovascular (61) 61
gypa (61) 61
hbgg (60) 60
identification (60) 60
protein (60) 60
gene (59) 59
lipid metabolism (59) 59
pharmacology & pharmacy (59) 59
receptor density (59) 59
research (59) 59
gene frequency (58) 58
inflammation (58) 58
low-density-lipoprotein (58) 58
aged (57) 57
cholesterol - blood (57) 57
d7s8 (57) 57
medicine, legal (57) 57
genetics (56) 56
physiological aspects (56) 56
cholesterol - metabolism (55) 55
apob (54) 54
proprotein convertase 9 (54) 54
adolescent (53) 53
low-density lipoprotein receptor (50) 50
low density lipoprotein (49) 49
molecular sequence data (49) 49
liver - metabolism (48) 48
serine endopeptidases - genetics (48) 48
genetic research (47) 47
ldl (47) 47
risk (47) 47
apolipoproteins (46) 46
biophysics (46) 46
dna (46) 46
pedigree (46) 46
coronary-heart-disease (45) 45
dna mutational analysis (45) 45
low density lipoprotein receptors (45) 45
child (44) 44
health aspects (44) 44
cholesterol, ldl - blood (43) 43
hyperlipoproteinemia type ii - diagnosis (43) 43
rodents (43) 43
medicine (42) 42
population (42) 42
apolipoproteins b - genetics (41) 41
population genetics (41) 41
protein binding (41) 41
research article (41) 41
risk factors (41) 41
heterozygote (40) 40
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


1. Full Text Low‐Density Lipoprotein Receptor Gene Familial Hypercholesterolemia Variant Database: Update and Pathological Assessment
by Usifo, Ebele and Leigh, Sarah E. A and Whittall, Ros A and Lench, Nicholas and Taylor, Alison and Yeats, Corin and Orengo, Christine A and Martin, Andrew C. R and Celli, Jacopo and Humphries, Steve E
Annals of Human Genetics, ISSN 0003-4800, 09/2012, Volume 76, Issue 5, pp. 387 - 401
Summary Familial hypercholesterolemia (FH) is caused predominately by variants in the low‐density lipoprotein receptor gene (LDLR). We report here an update of... 
locus specific variant database | Familial hypercholesterolemia | LDLR | in silico pathogenicity prediction | Locus specific variant database | DIAGNOSIS | MESSENGER-RNA | SERVER | MUTATION | GENETICS & HEREDITY | Genetic Variation | Receptors, LDL - genetics | Humans | Protein Isoforms | Mutation | Databases as Topic | Hyperlipoproteinemia Type II - genetics | Databases | Hypercholesterolemia | Molecular genetics | Neural networks | Analysis | Low density lipoproteins | Children's hospitals | Genes | Amino acids | Low density lipoprotein | Cholesterol | Data bases | Pathogenicity | Conserved sequence | software | Lipoprotein (low density) receptors | Promoters | Computer programs | lipoprotein receptors
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
2. Full Text Screening of common genetic variants in the APOB gene related to familial hypercholesterolemia in a Saudi population: A case-control study
by Batais, Mohammed Ali and Almigbal, Turky H and Shaik, Noor Ahmad and Alharbi, Fawaziah Khalaf and Alharbi, Khalid Khalaf and Ali Khan, Imran
Medicine, ISSN 0025-7974, 01/2019, Volume 98, Issue 4, p. e14247
Familial hypercholesterolemia (FH) is a monogenic dominant inherited disorder of lipid metabolism characterized by elevated low-density lipoprotein levels, and... 
Val2095Glu | Saudi population | MEDICINE, GENERAL & INTERNAL | METAANALYSIS | EFFICACY | familial hypercholesterolemia | ApoB gene | MUTATIONS | POLYMORPHISM | rs151009667 | LDLR | GENOME-WIDE ASSOCIATION | Gene Frequency | Humans | Middle Aged | Genotype | Male | Apolipoprotein B-100 - genetics | Hyperlipoproteinemia Type II - ethnology | Case-Control Studies | Saudi Arabia | Polymorphism, Restriction Fragment Length | Polymerase Chain Reaction | Arabs - genetics | Adult | Female | Polymorphism, Single Nucleotide | Odds Ratio | Hyperlipoproteinemia Type II - genetics | Polymerase chain reaction | Usage | Hypercholesterolemia | Genetic variation | Genetic aspects | Research | Single nucleotide polymorphisms
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
3. Full Text Identifying low density lipoprotein cholesterol associated variants in the Annexin A2 ( ANXA2 ) gene
by Fairoozy, Roaa Hani and Cooper, Jackie and White, Jon and Giambartolomei, Claudia and Folkersen, Lasse and Wannamethee, S. Goya and Jefferis, Barbara J and Whincup, Peter and Ben-Shlomo, Yoav and Kumari, Meena and Kivimaki, Mika and Wong, Andrew and Hardy, Rebecca and Kuh, Diana and Gaunt, Tom R and Casas, J.P and McLachlan, Stela and Price, Jackie F and Hingorani, Aroon and Franco-Cereceda, Anders and Grewal, Thomas and Kalea, Anastasia Z and Humphries, Steve E and UCLEB Consortium and UCLEB consortium
Atherosclerosis, ISSN 0021-9150, 2017, Volume 261, pp. 60 - 68
Abstract Background and aims Annexin-A2 (AnxA2) is an endogenous inhibitor of proprotein convertase subtilisin/kexin type-9 (PCSK9). The repeat-one (R1) domain... 
Cardiovascular | Low-density lipoprotein cholesterol-receptor | Annexin A2 | Single nucleotide polymorphism | Proprotein convertase subtilisin/kexin type-9 | Coronary heart disease | Low-density lipoprotein cholesterol | CARDIAC & CARDIOVASCULAR SYSTEMS | INSULATOR | PROTEIN CTCF | PCSK9 | SUGGESTS | LINKING | SITES | PERIPHERAL VASCULAR DISEASE | TRANSCRIPTIONAL REGULATORY ELEMENT | Humans | Middle Aged | Databases, Genetic | Male | Transfection | Cholesterol, LDL - blood | Female | Genes, Reporter | Coronary Disease - blood | Genetic Predisposition to Disease | Genetic Association Studies | Gene Frequency | Computational Biology | United Kingdom | Biomarkers - blood | Coronary Disease - diagnosis | Proprotein Convertase 9 - metabolism | Hep G2 Cells | Linkage Disequilibrium | Homozygote | Phenotype | Annexin A2 - genetics | Coronary Disease - genetics | K562 Cells | Heterozygote | Polymorphism, Single Nucleotide | Quantitative Trait Loci | Annexin A2 - metabolism | Medical colleges | Low density lipoproteins | Genetic research | Research institutes | Annexins | Epidemiology | Cholesterol | Analysis | LDL-C, low-density lipoprotein cholesterol | LDLR, low-density lipoprotein cholesterol-receptor | AnxA2, annexin A2 | Proprotein convertase subtilisin | FAIRE, formaldehyde assisted isolation of regulatory elements | NPHSII, Second-Northwick-Park Heart Study | CHRD, cysteine-histidine-rich domain of PCSK9 | UCLEB, UCL-LSHTM-Edinburgh-Bristol consortium | kexin type-9 | PCSK9, proprotein convertase subtilisin | CTCF, CTC-binding factor
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
4. Full Text Use of next-generation sequencing to detect LDLR gene copy number variation in familial hypercholesterolemia
by Iacocca, Michael A and Wang, Jian and Dron, Jacqueline S and Robinson, John F and McIntyre, Adam D and Cao, Henian and Hegele, Robert A
Journal of Lipid Research, ISSN 0022-2275, 2017, Volume 58, Issue 11, pp. 2202 - 2209
Familial hypercholesterolemia (FH) is a heritable condition of severely elevated LDL cholesterol, caused predominantly by autosomal codominant mutations in the... 
Diagnostic tools | DNA variation | Precision medicine | LDL | Lipid and lipoprotein metabolism | Genetic testing | Lipoprotein receptors | Bioinformatics | Coronary heart disease | Molecular biology/genetics | INDIVIDUALS | DEPENDENT PROBE AMPLIFICATION | POPULATION | DIAGNOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DISEASE | PREVALENCE | MUTATIONS | MONOGENIC DYSLIPIDEMIAS | DENSITY-LIPOPROTEIN RECEPTOR | Receptors, LDL - genetics | Humans | Middle Aged | Computational Biology | Female | Male | High-Throughput Nucleotide Sequencing - methods | DNA Copy Number Variations | Hyperlipoproteinemia Type II - genetics | Lipoproteins (low density) | Hypercholesterolemia | Copy number | Data processing | Lipoprotein (low density) receptors | Mutation | LDLR gene | Low density lipoprotein | Cholesterol | Deoxyribonucleic acid--DNA | DNA sequencing | molecular biology | lipid and lipoprotein metabolism | Patient-Oriented and Epidemiological Research | genetics | genetic testing | bioinformatics | precision medicine | coronary heart disease | diagnostic tools | lipoprotein receptors
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
5. Full Text Diagnostic Yield and Clinical Utility of Sequencing Familial Hypercholesterolemia Genes in Patients With Severe Hypercholesterolemia
by Khera, Amit V., MD and Won, Hong-Hee, PhD and Peloso, Gina M., PhD and Lawson, Kim S., MS and Bartz, Traci M., MS and Deng, Xuan, MSc and van Leeuwen, Elisabeth M and Natarajan, Pradeep, MD, MMSc and Emdin, Connor A., HBSc and Bick, Alexander G., PhD and Morrison, Alanna C., PhD and Brody, Jennifer A., BA and Gupta, Namrata, PhD and Nomura, Akihiro, MD and Kessler, Thorsten, MD and Duga, Stefano, PhD and Bis, Joshua C., PhD and van Duijn, Cornelia M., PhD and Cupples, L. Adrienne, PhD and Psaty, Bruce, MD, PhD and Rader, Daniel J., MD and Danesh, John, DPhil and Schunkert, Heribert, MD and McPherson, Ruth, MD and Farrall, Martin, MD and Watkins, Hugh, MD, PhD and Lander, Eric, PhD and Wilson, James G., MD and Correa, Adolfo, MD, PhD and Boerwinkle, Eric, PhD and Merlini, Piera Angelica, MD and Ardissino, Diego, MD and Saleheen, Danish, MBBS, PhD and Gabriel, Stacey, PhD and Kathiresan, Sekar, MD
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2016, Volume 67, Issue 22, pp. 2578 - 2589
Abstract Background Approximately 7% of American adults have severe hypercholesterolemia (untreated low-density lipoprotein [LDL] cholesterol ≥190 mg/dl),... 
Cardiovascular | Internal Medicine | coronary artery disease | gene sequencing | genetics | low-density lipoprotein cholesterol | POPULATION | CARDIAC & CARDIOVASCULAR SYSTEMS | VARIANTS | AUTOSOMAL-DOMINANT HYPERCHOLESTEROLEMIA | PREVALENCE | GUIDANCE | HEART | MUTATIONS | SPECTRUM | ASSOCIATION | LDLR | Receptors, LDL - genetics | Humans | Middle Aged | Hyperlipoproteinemia Type II - diagnosis | Male | Proprotein Convertase 9 - genetics | Apolipoprotein B-100 - genetics | Case-Control Studies | Genetic Variation | Cholesterol, LDL - blood | Female | Heterozygote | Coronary Artery Disease - epidemiology | Sequence Analysis | Cohort Studies | Hypercholesterolemia - epidemiology | Hyperlipoproteinemia Type II - genetics | Medical colleges | Care and treatment | Low density lipoproteins | Genes | Coronary heart disease | Population genetics | Epidemiology | Blood | Hypercholesterolemia | Analysis and chemistry | Atherosclerosis | Genetic research | Genetic aspects | Diagnosis | Research institutes | Cardiology | Trans fatty acids | Heart attacks | Cardiovascular disease | Lipids | Apolipoproteins | Low density lipoprotein | Cholesterol | Proteins | Studies | Confidence intervals | Consortia | Algorithms | Coronary vessels | Population | Mutation | Deoxyribonucleic acid--DNA
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
6. Full Text Functional analysis of six uncharacterised mutations in LDLR gene
by Gomez, Andrea and Colombo, Roberto and Pontoglio, Alessandro and Helman, Lorena and Kaeser, Luciana and Giunta, Gustavo and Parolin, Maria L and Toscanini, Ulises and Cuniberti, Luis
Atherosclerosis, ISSN 0021-9150, 12/2019, Volume 291, pp. 44 - 51
Familial hypercholesterolemia (FH) is a primary hyperlipemia. It is an autosomal dominant genetic disorder of lipoproteins metabolism mainly caused by... 
LDLR mutations | In vitro functional studies | Familial hypercholesterolemia
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
7. Full Text Recombinant elastin-based nanoparticles for targeted gene therapy
by Monfort, D.A and Koria, P
Gene Therapy, ISSN 0969-7128, 10/2017, Volume 24, Issue 10, pp. 610 - 620
Among viruses, lentiviral vectors have been popular vectors for gene delivery due to their efficient mode of gene delivery. However, the nonspecific delivery... 
MEDICINE, RESEARCH & EXPERIMENTAL | STEM-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOXORUBICIN | CANCER | LENTIVIRAL VECTORS | DELIVERY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | PROTEIN-BASED POLYMERS | PURIFICATION | GENETICS & HEREDITY | VESICULAR STOMATITIS-VIRUS | FUSION PROTEINS | POLYPEPTIDE | Recombinant Proteins - metabolism | Elastin - metabolism | Gene Transfer Techniques | Receptors, LDL - genetics | Humans | Receptors, LDL - metabolism | Recombinant Proteins - genetics | Fibroblast Growth Factor 7 - genetics | Genetic Vectors - genetics | Fibroblast Growth Factor 7 - metabolism | Elastin - genetics | Nanoparticles - metabolism | HEK293 Cells | Cell Line, Tumor | Lentivirus - genetics | Genetic Therapy - methods | Nanoparticles | Usage | Care and treatment | Genetic disorders | Gene mutations | Research | Diagnosis | Gene therapy | Polypeptides | Gene transfer | Elastin | Viruses | Keratinocyte growth factor | Growth factor receptors | Low density lipoprotein | Side effects | Receptors | Receptor density | Growth factors | Recombinant | Expression vectors | VSV-G | nanoparticles | transduction | KGF | drug delivery | Fusion proteins | LDLR | lentiviral vector
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
8. Full Text Lifelong Reduction of LDL-Cholesterol Related to a Common Variant in the LDL-Receptor Gene Decreases the Risk of Coronary Artery Disease-A Mendelian Randomisation Study
by Linsel-Nitschke, P and Gotz, A and Erdmann, J and Braenne, I and Braund, P and Hengstenberg, C and Stark, K and Fischer, M and Schreiber, S and El Mokhtari, NE and Schaefer, A and Schrezenmeier, J and Rubin, D and Hinney, A and Reinehr, T and Roth, C and Ortlepp, J and Hanrath, P and Hall, AS and Mangino, M and Lieb, W and Lamina, C and Heid, IM and Doering, A and Gieger, C and Peters, A and Meitinger, T and Wichmann, HE and Konig, IR and Ziegler, A and Kronenberg, F and Samani, NJ and Schunkert, H and Cardiogenics Consortium and WTCCC and Wellcome Trust Case Control Consortium (WTCCC) and for the Wellcome Trust Case Control Consortium (WTCCC) and the Cardiogenics Consortium
PLOS ONE, ISSN 1932-6203, 08/2008, Volume 3, Issue 8, p. e2986
Background: Rare mutations of the low-density lipoprotein receptor gene (LDLR) cause familial hypercholesterolemia, which increases the risk for coronary... 
POPULATION | HEART-DISEASE | METAANALYSIS | MYOCARDIAL-INFARCTION | CARDIOVASCULAR EVENTS | BIOLOGY | POLYMORPHISM | HYPERCHOLESTEROLEMIA | PREVALENCE | EPIDEMIOLOGY | GENOME-WIDE ASSOCIATION | Receptors, LDL - genetics | Oligonucleotide Array Sequence Analysis | Risk Assessment | Humans | Risk Factors | Cholesterol, LDL - drug effects | Chromosome Mapping | Random Allocation | Case-Control Studies | Genetic Variation | Cholesterol, LDL - genetics | Coronary Disease - prevention & control | Anticholesteremic Agents - therapeutic use | Coronary Disease - genetics | Cholesterol, LDL - blood | Polymorphism, Single Nucleotide | Chromosomes, Human, Pair 10 | Medical research | Hypercholesterolemia | Blood cholesterol | Low density lipoproteins | Genes | Medicine, Experimental | Genetic research | Genetics | Genetic aspects | Single nucleotide polymorphisms | Coronary heart disease | Risk factors | Lipoproteins (low density) | Risk | Lipids | Cardiovascular disease | Genomes | Single-nucleotide polymorphism | Gene polymorphism | Epidemiology | Consortia | Confidence intervals | Randomization | Population | Lipoprotein (low density) receptors | Children | Heart diseases | Statistical analysis | Mortality | Coronary artery | Health risks | Environmental health | Genetic diversity | Regression analysis | Metabolism | LDLR gene | Apolipoproteins | Coronary artery disease | Low density lipoprotein | Cholesterol | Studies | Genetic variance | Hospitals | Coronary vessels | Alleles | Biomarkers | Receptor density | Adults | Mutation | Polymorphism
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
9. Full Text Curcumin enhances cell‐surface LDLR level and promotes LDL uptake through downregulation of PCSK9 gene expression in HepG2 cells
by Tai, Mi‐Hsueh and Chen, Po‐Kong and Chen, Pei‐Yi and Wu, Ming‐Jiuan and Ho, Chi‐Tang and Yen, Jui‐Hung
Molecular Nutrition & Food Research, ISSN 1613-4125, 11/2014, Volume 58, Issue 11, pp. 2133 - 2145
Scope Curcumin has been demonstrated as having numerous desirable characteristics, such as antioxidant, anti‐inflammatory, and antiatherogenic activities. We... 
HNF‐1α | PCSK9 | Curcumin | Hypercholesterolemia | LDLR | HNF-1α | AUTOSOMAL-DOMINANT HYPERCHOLESTEROLEMIA | FOOD SCIENCE & TECHNOLOGY | RECEPTOR EXPRESSION | CHEMOPREVENTIVE AGENT CURCUMIN | TARGET GENES | HNF-1 alpha | LIVER-REGENERATION | HIGH-RISK | ENDOPLASMIC-RETICULUM | HEME OXYGENASE-1 | HUMAN HEPATOCELLULAR-CARCINOMA | CORONARY-HEART-DISEASE | Hepatocyte Nuclear Factor 1-alpha - genetics | Curcumin - chemistry | Humans | Gene Expression Regulation, Neoplastic | Hepatocytes - metabolism | Hepatocyte Nuclear Factor 1-alpha - metabolism | RNA, Messenger - metabolism | Hypercholesterolemia - drug therapy | Proprotein Convertases - genetics | Serine Endopeptidases - genetics | Transcription, Genetic | Cell Membrane - metabolism | Cell Membrane - drug effects | Hepatocytes - drug effects | Receptors, LDL - genetics | Proprotein Convertases - metabolism | RNA, Messenger - genetics | Curcumin - pharmacology | Receptors, LDL - metabolism | Down-Regulation - drug effects | Hep G2 Cells | Drug Synergism | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Cholesterol, LDL - metabolism | Serine Endopeptidases - metabolism | Proprotein Convertase 9 | Antioxidants | RNA | Low density lipoproteins | Genes | Genetic aspects | Gene expression | Statins
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
10. Gene Therapy for Familial Hypercholesterolemia
by van Craeyveld, Eline and Jacobs, Frank and Gordts, Stephanie C and de Geest, Bart
Current Pharmaceutical Design, ISSN 1381-6128, 08/2011, Volume 17, Issue 24, pp. 2575 - 2591
Familial hypercholesterolemia (FH) is an inherited metabolic disorder characterized by high levels of plasma low density lipoproteins (LDL) and an increased... 
Familial hypercholesterolemia | Gene therapy | Low density lipoprotein receptor gene transfer | Atherosclerosis | atherosclerosis | INTIMA-MEDIA THICKNESS | LONG-TERM | LDL RECEPTOR GENE | WHHL-HH RABBITS | SCAFFOLD ATTACHMENT REGION | LOW-DENSITY-LIPOPROTEIN | gene therapy | APOLIPOPROTEIN-B | STEROL-REGULATED TRANSPORT | low density lipoprotein receptor gene transfer | TRANSGENE EXPRESSION | PHARMACOLOGY & PHARMACY | APO A-I | Hyperlipoproteinemia Type II - complications | Gene Transfer Techniques | Hyperlipoproteinemia Type II - therapy | Receptors, LDL - genetics | Humans | Atherosclerosis - etiology | Animals | Receptors, LDL - deficiency | Cholesterol, LDL - blood | Genetic Vectors | Atherosclerosis - prevention & control | Disease Models, Animal | Genetic Therapy - methods | Hyperlipoproteinemia Type II - genetics | Lipoproteins (low density) | Animal models | Apheresis | Hyperlipidemia | Regression analysis | LDLR gene | Coronary heart disease | Immunosuppressive agents | Graft rejection | Apolipoprotein B | Immunosuppression | Lipoproteins | Allografts | Hypercholesterolemia | Reviews | Arteriosclerosis | Lipoprotein (low density) receptors | Metabolic disorders
Journal Article
Details down arrow
11. Full Text Cholesterol-Lowering Gene Therapy Counteracts the Development of Non-ischemic Cardiomyopathy in Mice
by Muthuramu, Ilayaraja and Amin, Ruhul and Postnov, Andrey and Mishra, Mudit and Aboumsallem, Joseph Pierre and Dresselaers, Tom and Himmelreich, Uwe and Van Veldhoven, Paul P and Gheysens, Olivier and Jacobs, Frank and De Geest, Bart
Molecular Therapy, ISSN 1525-0016, 11/2017, Volume 25, Issue 11, pp. 2513 - 2525
A causal role of hypercholesterolemia in non-ischemic heart failure has never been demonstrated. Adeno-associated viral serotype 8 (AAV8)-low-density... 
metabolic remodeling | heart failure | gene transfer | low-density lipoprotein receptor | cholesterol-lowering therapy | adeno-associated viral vectors | gene therapy | cardiac hypertrophy | non-ischemic cardiomyopathy | hypercholesterolemia | MAMMALIAN TARGET | MEDICINE, RESEARCH & EXPERIMENTAL | PRESSURE-OVERLOAD | OXIDATIVE STRESS | LIPID-METABOLISM | FATTY-ACID-METABOLISM | PROLIFERATOR-ACTIVATED RECEPTOR | CELL-GROWTH | COENZYME Q | HYPERTROPHIED RAT-HEART | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CARDIAC-HYPERTROPHY | GENETICS & HEREDITY | Constriction, Pathologic - metabolism | Dependovirus - genetics | Constriction, Pathologic - pathology | Genetic Vectors - administration & dosage | TOR Serine-Threonine Kinases - metabolism | Cardiomegaly - etiology | Cardiomyopathies - etiology | TOR Serine-Threonine Kinases - genetics | Cardiomegaly - mortality | Cardiomyopathies - mortality | Myocardium - metabolism | Receptors, LDL - deficiency | Female | Heart Function Tests | Biomarkers - metabolism | Receptors, LDL - genetics | Gene Expression | Dependovirus - metabolism | Genetic Vectors - chemistry | Genetic Vectors - metabolism | Myocardium - pathology | Cholesterol - metabolism | Constriction, Pathologic - complications | Cardiomyopathies - therapy | Mice, Knockout | Acetyl-CoA C-Acetyltransferase - genetics | Animals | Aorta - surgery | Cardiomyopathies - metabolism | Survival Analysis | Mice | Hemodynamics | Acetyl-CoA C-Acetyltransferase - metabolism | Cardiomegaly - metabolism | Cardiomegaly - therapy | Genetic Therapy - methods | TOR protein | Oxidative stress | Cardiomyopathy | Cardiovascular disease | Ischemia | Conflicts of interest | Aorta | Coenzyme A | Lipoprotein (low density) receptors | Heart diseases | Heart failure | Mortality | Cardiomyocytes | Rapamycin | LDLR gene | Metabolism | Pressure | Cholesterol | Lipoproteins | Hypercholesterolemia | Magnetic resonance imaging | Coronary vessels | Cardiac function | Fibrosis | Receptor density | Software | Gene therapy | Hypertrophy | Apoptosis | Original
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
12. Varinostat alters gene expression profiles in aortic tissues from ApoE -/- mice
by Ye, Yicong and Ye, Yicong and Zhao, Xiliang and Zhao, Xiliang and Lu, Yiyun and Lu, Yiyun and Long, Bo and Long, Bo and Zhang, Shuyang and Zhang, Shuyang
Human Gene Therapy Clinical Development, ISSN 2324-8637, 12/2018, Volume 29, Issue 4, pp. 214 - 225
Atherosclerosis (AS) is a complex, chronic inflammatory disease that is characterized by plaque buildup within arterial vessel walls. Preclinical trials have... 
atherosclerosis | lncRNAs | miRNAs | vorinostat | mRNAs | MEDICINE, RESEARCH & EXPERIMENTAL | RISK | HYPERCHOLESTEROLEMIA | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | INFECTION | HCV | DYSFUNCTION | CORONARY-HEART-DISEASE | HEPATITIS-C | LDLR | INSIGHTS
Journal Article
Details down arrow
13. Full Text Quercetin and Ethanol Attenuate the Progression of Atherosclerotic Plaques With Concomitant Up Regulation of Paraoxonase1 (PON1) Gene Expression and PON1 Activity in LDLR−/− Mice
by Leckey, Leslie C and Garige, Mamatha and Varatharajalu, Ravi and Gong, Maokai and Nagata, Takako and Spurney, Christopher F and Lakshman, Raj M
Alcoholism: Clinical and Experimental Research, ISSN 0145-6008, 09/2010, Volume 34, Issue 9, pp. 1535 - 1542
Background:  As moderate wine drinking is atheroprotective, it is clinically relevant to elucidate its possible mechanism/s of action/s. Our objective is to... 
Paraoxonase | Ethanol | LDLR−/− Mouse | Atherosclerosis | Quercetin | Mouse | LDLR | OXIDATION | ATHEROGENESIS | RECEPTOR-DEFICIENT | CORONARY | LOW-DENSITY-LIPOPROTEIN | SUBSTANCE ABUSE | SERUM PARAOXONASE | IN-VIVO | E-DEFICIENT MICE | CONSUMPTION | Aryldialkylphosphatase - blood | Receptors, LDL - genetics | Gene Expression - drug effects | Aorta - drug effects | Liver - metabolism | Mice, Inbred C57BL | Ethanol - administration & dosage | Aryldialkylphosphatase - genetics | Mice, Knockout | Aorta - pathology | Up-Regulation - drug effects | Ethanol - pharmacology | Animals | Quercetin - pharmacology | Quercetin - administration & dosage | Mice | Plaque, Atherosclerotic - drug therapy | Atherosclerosis - prevention & control | Disease Models, Animal | atherosclerosis | mouse | quercetin | paraoxonase | ethanol
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights