X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
ldlr (463) 463
humans (443) 443
index medicus (420) 420
receptors, ldl - genetics (310) 310
cholesterol (275) 275
male (248) 248
animals (238) 238
female (227) 227
familial hypercholesterolemia (219) 219
atherosclerosis (210) 210
hypercholesterolemia (199) 199
low density lipoproteins (186) 186
mice (177) 177
biochemistry & molecular biology (167) 167
lipids (167) 167
mutation (162) 162
hyperlipoproteinemia type ii - genetics (145) 145
ldlr gene (121) 121
adult (120) 120
middle aged (119) 119
lipoprotein receptors (117) 117
receptors, ldl - metabolism (113) 113
genetic aspects (112) 112
lipoproteins (103) 103
analysis (98) 98
pcsk9 (98) 98
density-lipoprotein receptor (96) 96
genetics & heredity (96) 96
expression (91) 91
peripheral vascular disease (91) 91
polymerase chain reaction (91) 91
metabolism (81) 81
mice, knockout (80) 80
genes (78) 78
proteins (74) 74
ldl receptor (73) 73
mutations (73) 73
cell biology (72) 72
article (69) 69
diagnosis (69) 69
disease (69) 69
genotype (69) 69
gene expression (68) 68
mice, inbred c57bl (68) 68
cardiovascular disease (66) 66
phenotype (65) 65
alleles (64) 64
liver (63) 63
cardiac & cardiovascular systems (62) 62
cardiovascular (61) 61
gypa (61) 61
hbgg (60) 60
identification (60) 60
protein (60) 60
gene (59) 59
lipid metabolism (59) 59
pharmacology & pharmacy (59) 59
receptor density (59) 59
research (59) 59
gene frequency (58) 58
inflammation (58) 58
low-density-lipoprotein (58) 58
aged (57) 57
cholesterol - blood (57) 57
d7s8 (57) 57
medicine, legal (57) 57
genetics (56) 56
physiological aspects (56) 56
cholesterol - metabolism (55) 55
apob (54) 54
proprotein convertase 9 (54) 54
adolescent (53) 53
low-density lipoprotein receptor (50) 50
low density lipoprotein (49) 49
molecular sequence data (49) 49
liver - metabolism (48) 48
serine endopeptidases - genetics (48) 48
genetic research (47) 47
ldl (47) 47
risk (47) 47
apolipoproteins (46) 46
biophysics (46) 46
dna (46) 46
pedigree (46) 46
coronary-heart-disease (45) 45
dna mutational analysis (45) 45
low density lipoprotein receptors (45) 45
child (44) 44
health aspects (44) 44
cholesterol, ldl - blood (43) 43
hyperlipoproteinemia type ii - diagnosis (43) 43
rodents (43) 43
medicine (42) 42
population (42) 42
apolipoproteins b - genetics (41) 41
population genetics (41) 41
protein binding (41) 41
research article (41) 41
risk factors (41) 41
heterozygote (40) 40
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Atherosclerosis, ISSN 0021-9150, 2017, Volume 261, pp. 60 - 68
Abstract Background and aims Annexin-A2 (AnxA2) is an endogenous inhibitor of proprotein convertase subtilisin/kexin type-9 (PCSK9). The repeat-one (R1) domain... 
Cardiovascular | Low-density lipoprotein cholesterol-receptor | Annexin A2 | Single nucleotide polymorphism | Proprotein convertase subtilisin/kexin type-9 | Coronary heart disease | Low-density lipoprotein cholesterol | CARDIAC & CARDIOVASCULAR SYSTEMS | INSULATOR | PROTEIN CTCF | PCSK9 | SUGGESTS | LINKING | SITES | PERIPHERAL VASCULAR DISEASE | TRANSCRIPTIONAL REGULATORY ELEMENT | Humans | Middle Aged | Databases, Genetic | Male | Transfection | Cholesterol, LDL - blood | Female | Genes, Reporter | Coronary Disease - blood | Genetic Predisposition to Disease | Genetic Association Studies | Gene Frequency | Computational Biology | United Kingdom | Biomarkers - blood | Coronary Disease - diagnosis | Proprotein Convertase 9 - metabolism | Hep G2 Cells | Linkage Disequilibrium | Homozygote | Phenotype | Annexin A2 - genetics | Coronary Disease - genetics | K562 Cells | Heterozygote | Polymorphism, Single Nucleotide | Quantitative Trait Loci | Annexin A2 - metabolism | Medical colleges | Low density lipoproteins | Genetic research | Research institutes | Annexins | Epidemiology | Cholesterol | Analysis | LDL-C, low-density lipoprotein cholesterol | LDLR, low-density lipoprotein cholesterol-receptor | AnxA2, annexin A2 | Proprotein convertase subtilisin | FAIRE, formaldehyde assisted isolation of regulatory elements | NPHSII, Second-Northwick-Park Heart Study | CHRD, cysteine-histidine-rich domain of PCSK9 | UCLEB, UCL-LSHTM-Edinburgh-Bristol consortium | kexin type-9 | PCSK9, proprotein convertase subtilisin | CTCF, CTC-binding factor
Journal Article
Journal Article
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2016, Volume 67, Issue 22, pp. 2578 - 2589
Journal Article
Atherosclerosis, ISSN 0021-9150, 12/2019, Volume 291, pp. 44 - 51
Familial hypercholesterolemia (FH) is a primary hyperlipemia. It is an autosomal dominant genetic disorder of lipoproteins metabolism mainly caused by... 
LDLR mutations | In vitro functional studies | Familial hypercholesterolemia
Journal Article
Journal Article
PLOS ONE, ISSN 1932-6203, 08/2008, Volume 3, Issue 8, p. e2986
Background: Rare mutations of the low-density lipoprotein receptor gene (LDLR) cause familial hypercholesterolemia, which increases the risk for coronary... 
POPULATION | HEART-DISEASE | METAANALYSIS | MYOCARDIAL-INFARCTION | CARDIOVASCULAR EVENTS | BIOLOGY | POLYMORPHISM | HYPERCHOLESTEROLEMIA | PREVALENCE | EPIDEMIOLOGY | GENOME-WIDE ASSOCIATION | Receptors, LDL - genetics | Oligonucleotide Array Sequence Analysis | Risk Assessment | Humans | Risk Factors | Cholesterol, LDL - drug effects | Chromosome Mapping | Random Allocation | Case-Control Studies | Genetic Variation | Cholesterol, LDL - genetics | Coronary Disease - prevention & control | Anticholesteremic Agents - therapeutic use | Coronary Disease - genetics | Cholesterol, LDL - blood | Polymorphism, Single Nucleotide | Chromosomes, Human, Pair 10 | Medical research | Hypercholesterolemia | Blood cholesterol | Low density lipoproteins | Genes | Medicine, Experimental | Genetic research | Genetics | Genetic aspects | Single nucleotide polymorphisms | Coronary heart disease | Risk factors | Lipoproteins (low density) | Risk | Lipids | Cardiovascular disease | Genomes | Single-nucleotide polymorphism | Gene polymorphism | Epidemiology | Consortia | Confidence intervals | Randomization | Population | Lipoprotein (low density) receptors | Children | Heart diseases | Statistical analysis | Mortality | Coronary artery | Health risks | Environmental health | Genetic diversity | Regression analysis | Metabolism | LDLR gene | Apolipoproteins | Coronary artery disease | Low density lipoprotein | Cholesterol | Studies | Genetic variance | Hospitals | Coronary vessels | Alleles | Biomarkers | Receptor density | Adults | Mutation | Polymorphism
Journal Article
Molecular Nutrition & Food Research, ISSN 1613-4125, 11/2014, Volume 58, Issue 11, pp. 2133 - 2145
Journal Article
Current Pharmaceutical Design, ISSN 1381-6128, 08/2011, Volume 17, Issue 24, pp. 2575 - 2591
Journal Article
Molecular Therapy, ISSN 1525-0016, 11/2017, Volume 25, Issue 11, pp. 2513 - 2525
A causal role of hypercholesterolemia in non-ischemic heart failure has never been demonstrated. Adeno-associated viral serotype 8 (AAV8)-low-density... 
metabolic remodeling | heart failure | gene transfer | low-density lipoprotein receptor | cholesterol-lowering therapy | adeno-associated viral vectors | gene therapy | cardiac hypertrophy | non-ischemic cardiomyopathy | hypercholesterolemia | MAMMALIAN TARGET | MEDICINE, RESEARCH & EXPERIMENTAL | PRESSURE-OVERLOAD | OXIDATIVE STRESS | LIPID-METABOLISM | FATTY-ACID-METABOLISM | PROLIFERATOR-ACTIVATED RECEPTOR | CELL-GROWTH | COENZYME Q | HYPERTROPHIED RAT-HEART | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CARDIAC-HYPERTROPHY | GENETICS & HEREDITY | Constriction, Pathologic - metabolism | Dependovirus - genetics | Constriction, Pathologic - pathology | Genetic Vectors - administration & dosage | TOR Serine-Threonine Kinases - metabolism | Cardiomegaly - etiology | Cardiomyopathies - etiology | TOR Serine-Threonine Kinases - genetics | Cardiomegaly - mortality | Cardiomyopathies - mortality | Myocardium - metabolism | Receptors, LDL - deficiency | Female | Heart Function Tests | Biomarkers - metabolism | Receptors, LDL - genetics | Gene Expression | Dependovirus - metabolism | Genetic Vectors - chemistry | Genetic Vectors - metabolism | Myocardium - pathology | Cholesterol - metabolism | Constriction, Pathologic - complications | Cardiomyopathies - therapy | Mice, Knockout | Acetyl-CoA C-Acetyltransferase - genetics | Animals | Aorta - surgery | Cardiomyopathies - metabolism | Survival Analysis | Mice | Hemodynamics | Acetyl-CoA C-Acetyltransferase - metabolism | Cardiomegaly - metabolism | Cardiomegaly - therapy | Genetic Therapy - methods | TOR protein | Oxidative stress | Cardiomyopathy | Cardiovascular disease | Ischemia | Conflicts of interest | Aorta | Coenzyme A | Lipoprotein (low density) receptors | Heart diseases | Heart failure | Mortality | Cardiomyocytes | Rapamycin | LDLR gene | Metabolism | Pressure | Cholesterol | Lipoproteins | Hypercholesterolemia | Magnetic resonance imaging | Coronary vessels | Cardiac function | Fibrosis | Receptor density | Software | Gene therapy | Hypertrophy | Apoptosis | Original
Journal Article
Human Gene Therapy Clinical Development, ISSN 2324-8637, 12/2018, Volume 29, Issue 4, pp. 214 - 225
Atherosclerosis (AS) is a complex, chronic inflammatory disease that is characterized by plaque buildup within arterial vessel walls. Preclinical trials have... 
atherosclerosis | lncRNAs | miRNAs | vorinostat | mRNAs | MEDICINE, RESEARCH & EXPERIMENTAL | RISK | HYPERCHOLESTEROLEMIA | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | INFECTION | HCV | DYSFUNCTION | CORONARY-HEART-DISEASE | HEPATITIS-C | LDLR | INSIGHTS
Journal Article
Journal Article