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Oncogene, ISSN 0950-9232, 10/2012, Volume 31, Issue 41, pp. 4472 - 4483
Elevated levels of the oncoprotein, osteopontin (OPN), are associated with poor outcome of several types of cancers including melanoma. We have previously... 
SPP1 | GSK3b | cancer | PP2A | DNAJB6 | OPN | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN PHOSPHATASE 2A | CELL BIOLOGY | BREAST-CANCER | METASTATIC MELANOMA | J-DOMAIN | ONCOLOGY | MRJ CO-CHAPERONE | GENETICS & HEREDITY | TUMOR-SUPPRESSOR | GSK3 beta | WNT | EXPRESSION | T-CELLS | PROGRESSION | Osteopontin - genetics | Neoplasm Transplantation | Okadaic Acid - pharmacology | Phosphorylation | Molecular Chaperones - metabolism | Oligonucleotide Array Sequence Analysis | HSC70 Heat-Shock Proteins - metabolism | Humans | Lymphoid Enhancer-Binding Factor 1 - genetics | Gene Expression Regulation, Neoplastic | Transcriptome | Glycogen Synthase Kinase 3 beta | Osteopontin - metabolism | Epithelial-Mesenchymal Transition | Female | Transcription, Genetic | Protein Interaction Domains and Motifs | T Cell Transcription Factor 1 - metabolism | Melanoma - metabolism | Protein Structure, Tertiary | Skin Neoplasms - pathology | HSP40 Heat-Shock Proteins - metabolism | Nerve Tissue Proteins - physiology | HSP40 Heat-Shock Proteins - genetics | Protein Phosphatase 2 - antagonists & inhibitors | Down-Regulation | Molecular Chaperones - genetics | Glycogen Synthase Kinase 3 - metabolism | Lymphoid Enhancer-Binding Factor 1 - metabolism | Molecular Chaperones - physiology | Nerve Tissue Proteins - genetics | beta Catenin - metabolism | Melanoma - secondary | Skin Neoplasms - metabolism | T Cell Transcription Factor 1 - genetics | Nerve Tissue Proteins - metabolism | Animals | Mice, Nude | HSP40 Heat-Shock Proteins - physiology | Protein Phosphatase 2 - metabolism | Cell Line, Tumor | Protein Binding | Mice | Protein Processing, Post-Translational | Transcription | Wnt protein | Tumor cells | catenin | Melanoma | Glycogen synthase kinase 3 | Heat shock proteins | Osteopontin | Lymphocytes T | Malignancy | Tcf protein | Chaperones | Dephosphorylation | Hsp40 protein | protein phosphatase | LEF protein | Enhancers | Hsc70 protein | Cancer | Tumors | GSK3β
Journal Article
Biochemical Journal, ISSN 0264-6021, 03/2007, Volume 402, Issue 3, pp. 515 - 523
Wnt-5a is a representative ligand that activates a beta-catenin-independent pathway in Writ signalling. In the present paper, the roles of the... 
Posttranslational modification | Frizzled 5 (Fz5) | Glycosylation | Palmitoylation | Wnt-5a | PROTEIN | PHOSPHORYLATION | frizzled 5 (Fz5) | BIOCHEMISTRY & MOLECULAR BIOLOGY | glycosylation | post-translational modification | BETA-CATENIN | INVASION | PATHWAY | CELL-MIGRATION | GROWTH | FOCAL ADHESION KINASE | DEPENDENT ACTIVATION | EXPRESSION | palmitoylation | Proto-Oncogene Proteins - metabolism | Amino Acid Sequence | Cell Line | Signal Transduction | Humans | Molecular Sequence Data | Proto-Oncogene Proteins - genetics | Proto-Oncogene Proteins - chemistry | Wnt-5a Protein | Wnt Proteins - metabolism | Transcription Factor 7-Like 2 Protein | Wnt Proteins - chemistry | Wnt Proteins - isolation & purification | TCF Transcription Factors - metabolism | Sequence Alignment | Animals | Wnt Proteins - genetics | Fatty Acids, Monounsaturated - metabolism | Protein Binding | Mice | Protein Processing, Post-Translational | Proto-Oncogene Proteins - isolation & purification | Cell Movement | HEK-293T cells, HEK-293 cells expressing the large T-antigen of SV40 (simian virus 40) | CM, conditioned medium | WT, wild-type | ECM, extracellular matrix | NLK, Nemo-like kinase | LRP5 | JNK, c-Jun N-terminal kinase | GFP, green fluorescent protein | Fz, Frizzled | PKC, protein kinase C | FAK, focal adhesion kinase | CRD, cysteine-rich domain | Lef, lymphoid enhancer factor | MALDI–TOF-MS, matrix-assisted laser-desorption ionization–time-of-flight MS | 6, lipoprotein receptor-related protein 5 | siRNA, small interfering RNA | Tcf, T-cell factor | PNGase F, peptide N-glycosidase F | HEK-293, human embryonic kidney-293 | TFA, trifluoroacetic acid
Journal Article
Scientific Reports, ISSN 2045-2322, 02/2016, Volume 6, Issue 1, p. 22113
Journal Article
Seminars in Cancer Biology, ISSN 1044-579X, 06/2018, Volume 50, pp. 77 - 89
The FOXO3 and FOXM1 forkhead box transcription factors, functioning downstream of the essential PI3K-Akt, Ras-ERK and JNK/p38MAPK signalling cascades, are... 
TO-MESENCHYMAL TRANSITION | IN-VITRO | ACTIVATED PROTEIN-KINASE | STEM-LIKE CELLS | ONCOLOGY | DNA-DAMAGE RESPONSE | ESTROGEN-RECEPTOR-ALPHA | JUN NH2-TERMINAL KINASE | FOXO TRANSCRIPTION FACTORS | FORKHEAD BOX M1 | NEGATIVE BREAST-CANCER | DNA Repair - drug effects | Humans | Gene Expression Regulation, Neoplastic | Antineoplastic Agents - therapeutic use | Neoplasms - drug therapy | Cell Self Renewal - genetics | Forkhead Box Protein O3 - genetics | Drug Resistance, Neoplasm - genetics | Neoplasms - genetics | Forkhead Box Protein M1 - genetics | Cell Proliferation - drug effects | Neoplasms - pathology | Drug Resistance, Neoplasm - drug effects | AURKA, aurora kinase A | Fox, forkhead box | Bim, B-cell lymphoma 2 interacting mediator | EGF, epidermal growth factor | JNK | BRIP1, BRCA1-interacting protein-terminal helicase 1 | GICs, glioma-initiating cells | MCL, mantle cell lymphoma | PKB, protein kinase B | SCs, stem cells | LEF, T-cell factor | Skp2, S-phase kinase-associated protein 2 | SSBs, single-strand breaks | mTOR, mammalian target of rapamycin | NBS1, Nijmegen breakage syndrome 1 | stress activated protein kinase | MEK, mitogen-activated protein kinase kinase | PIP3, phosphatidylinositol- 3,4,5-trisphosphate | BER, base excision repair | lymphoid enhancer factor | VEGF, vascular endothelial growth factor | AML, acute myeloid leukaemia | ER+ve, estreogen receptor positive | EXO1, exonuclease 1 | EGFR, epidermal growth factor receptor | MDR1, multidrug resistance protein 1 | ChIP-seq, chromatin immunoprecipitation with massively parallel DNA sequencing | ABCB1, ATP-binding cassette sub-family B member 1 | TCF | SOD-2, superoxide dismutase | TKIs, tyrosine kinase inhibitors | PDK, phosphoinositide-dependent kinase | IFNɣ, interferon-ɣ | BRCA2, breast cancer-associated gene 2 | DDR, DNA damage response | Cks1, cyclin-dependent kinases regulatory subunit 1 | ESR1, estrogen receptor alpha gene | NHEJ, non-homologous end joining | XRCC1, X-ray cross-complementing group 1 | OTUB1, OUT domain-containing ubiquitin aldehyde-binding protein 1 | IGF, insulin growth factor | TRAIL, tumour necrosis factor-related apoptosis inducing ligand | ER, estrogen receptor | MRN, MER11-RAD50-NBS1 | BRCA1, breast cancer susceptibility gene product 1 | FasL, fas ligand | RTKs, receptor tyrosine kinases | Sox1, sex determining region Y box 2 | GADD45, DNA damage-inducible protein 45 | MMR, mismatch repair | PI3K, phosphatidylinositol 3-kinase | ROS, reactive oxygen species | NAMPT, nicotinamide-phosphribosyltransferase | miRs, Micro-RNAs | FHRE, forkhead response element | ATM, Ataxia-telangiectasia mutated | NER, nucleotide excision repair | ERK, extracellular signal-regulated kinase | HR, homologous recombination | AMPK, adenosine monophosphate-activated protein kinase | DSBs, double strands breaks | PA, Psammaplysene A | CML, chronic myeloid leukaemia | HCC, hepatocellular carcinoma | Mst1, macrophage stimulating 1 | Rb2, retinoblastoma-related p130 | SAPK, c-Jun N-terminal kinase | CSCs, cancer stem cells
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 03/2017, Volume 232, Issue 3, pp. 517 - 525
Identification of cellular proteins, in addition to already known transcription factors such as NF‐κB, Sp1, C‐EBPβ, NFAT, ATF/CREB, and LEF‐1, which interact... 
CD4+T CELLS | PHYSIOLOGY | LONG TERMINAL REPEAT | PROTEIN-KINASE | PYRUVATE-KINASE M2 | VIRION PRODUCTION | HUMAN-IMMUNODEFICIENCY-VIRUS | NF-KAPPA-B | T-CELLS | NUCLEAR TRANSLOCATION | GENE-TRANSCRIPTION | CELL BIOLOGY | Sequence Deletion | Tetradecanoylphorbol Acetate - pharmacology | Humans | Monocytes - metabolism | Protein Transport - drug effects | Protein Subunits - metabolism | Cell Nucleus - metabolism | U937 Cells | Protein Binding - drug effects | Membrane Proteins - metabolism | Binding Sites | Promoter Regions, Genetic | Virus Replication - drug effects | HIV-1 - drug effects | HIV Long Terminal Repeat - genetics | HIV-1 - genetics | Monocytes - drug effects | Macrophages - metabolism | Carrier Proteins - metabolism | Transcription Factor RelA - metabolism | Models, Biological | Thyroid Hormones - metabolism | Macrophages - drug effects | Cell Nucleus - drug effects | Protein Multimerization - drug effects | Physiological aspects | Cellular proteins | HIV (Viruses) | Analysis | NF-κB protein | Chromatin | Transcription factors | Immunoprecipitation | Pyruvate kinase | Pyruvic acid | Activation | Infections | CCAAT/enhancer-binding protein | Cyclic AMP response element-binding protein | NF-AT protein | Kinases | Macrophages | Sp1 protein | Latency | Proteins | Lysates | LEF protein | Monocytes | Clonal deletion | Human immunodeficiency virus--HIV | Deletion | Binding sites
Journal Article
Neuropharmacology, ISSN 0028-3908, 03/2012, Volume 62, Issue 3, pp. 1230 - 1241
In the decade since ( ) was first identified it has become one of the most convincing risk genes for major mental illness. As a multi-functional scaffold... 
Schizophrenia | Neurodevelopment | Association studies | Synapse | DISC1 | Signalling | NEURONAL MIGRATION | ASSOCIATION ANALYSIS | CANDIDATE GENES | AMYLOID PRECURSOR PROTEIN | BIPOLAR DISORDER | NEUROSCIENCES | PERICENTRIN PCNT GENE | PHARMACOLOGY & PHARMACY | MAJOR DEPRESSIVE DISORDER | CENTROSOMAL PROTEINS | TRANSCRIPTION FACTOR | GRAY-MATTER | Nerve Tissue Proteins - metabolism | Carrier Proteins - genetics | Schizophrenia - metabolism | Animals | Carrier Proteins - metabolism | Schizophrenia - genetics | Signal Transduction | Humans | Nerve Tissue Proteins - genetics | Neurogenesis | Enzymes | Synthesis | Glycogen | Genes | Medical genetics | Amyloid beta-protein | Chemical properties | DNA binding proteins | Glutamate | T cells | Protein binding | PI3 K, Phosphatidylinositiol 3-kinase | DISC1, Disrupted in schizophrenia 1 | CRE, cAMP response element | LIS1, Lissencephaly 1 | APP, Amyloid precursor protein | PACAP, Pituitary adenylate cyclase-activating polypeptide | TCF, Lymphoid enhancer factor | T cell factor | CNV, Copy number variation | PDE4, Phosphodiesterase 4 | PCNT, Pericentrin | DBZ, DISC1-binding zinc finger | FEZ1, Fasciculation and elongation protein zeta 1 | BACE1, β-site APP-cleaving enzyme-1 | Rac1, Ras-related C3 botulinum toxin substrate 1 | NDEL1, NDE-like 1 | PCM1, Pericentriolar material 1 | GSK3β, Glycogen synthase kinase 3β | BBS4, Bardet–Biedl syndrome 4 | LEF | Dixdc1, Dishevelled-axin domain containing-1 | NRG, Neuregulin | CEP290, Centrosomal protein 290 kDa | TNIK, Traf2 and Nck interacting kinase | NDE1, Nuclear distribution factor E homologue 1 or Nuclear distribution element 1 | PSD, Post-synaptic density | GluR, Glutamate receptor | mTOR, Mammalian target of rapamycin | ATF4, Activating transcription factor 4 | Kal7, Kalirin-7
Journal Article
Journal Article