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1. Full Text Nodal signalling is involved in left-right asymmetry in snails
by Grande, Cristina and Patel, Nipam H
Nature, ISSN 0028-0836, 02/2009, Volume 457, Issue 7232, pp. 1007 - 1011
Many animals display specific internal or external features with left-right asymmetry. In vertebrates, the molecular pathway that leads to this asymmetry uses... 
CONSERVED ROLE | DEUTEROSTOMES | EVOLUTION | LIMNAEA | MULTIDISCIPLINARY SCIENCES | SEA-URCHIN EMBRYO | AXES | ESTABLISHMENT | INHERITANCE | INVERSUS | EXPRESSION | Paired Box Transcription Factors - genetics | Signal Transduction | Snails - genetics | Snails - drug effects | Snails - metabolism | Molecular Sequence Data | Nodal Protein - metabolism | Snails - embryology | Body Patterning - physiology | Animals | Nodal Protein - genetics | Gene Expression Regulation, Developmental | Body Patterning - genetics | Paired Box Transcription Factors - metabolism | Physiological aspects | Cellular signal transduction | Genetic aspects | Research | Snails | Genes | Studies | Cell division | Mollusks | Embryos | Cells
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2. Full Text Left–right asymmetry in the level of active Nodal protein produced in the node is translated into left–right asymmetry in the lateral plate of mouse embryos
by Kawasumi, Aiko and Nakamura, Tetsuya and Iwai, Naomi and Yashiro, Kenta and Saijoh, Yukio and Belo, Jose Antonio and Shiratori, Hidetaka and Hamada, Hiroshi
Developmental Biology, ISSN 0012-1606, 05/2011, Volume 353, Issue 2, pp. 321 - 330
Left–right (L–R) asymmetry in the mouse embryo is generated in the node and is dependent on cilia-driven fluid flow, but how the initial asymmetry is... 
Smad | Nodal signaling | Node | Left–right asymmetry | Left-right asymmetry | INHIBITION | MUTATION | GENES | LEFT-RIGHT AXIS | REQUIRES | MICE | DEVELOPMENTAL BIOLOGY | EXPRESSION | Phosphorylation | Humans | Male | Smad3 Protein - metabolism | Mesoderm - cytology | Mice, Neurologic Mutants | Biological Transport, Active | Nodal Protein - genetics | Forkhead Transcription Factors - metabolism | Female | Forkhead Transcription Factors - deficiency | Mesoderm - embryology | Signal Transduction | Smad2 Protein - metabolism | Mice, Transgenic | Forkhead Transcription Factors - genetics | Body Patterning - physiology | Mice, Knockout | Pregnancy | Animals | Enhancer Elements, Genetic | Left-Right Determination Factors - genetics | Mesoderm - metabolism | Mice | Nodal Protein - physiology | Body Patterning - genetics | Embryonic development | node
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3. Full Text Cerberus-Nodal-Lefty-Pitx signaling cascade controls left-right asymmetry in amphioxus
by Li, Guang and Liu, Xian and Xing, Chaofan and Zhang, Huayang and Shimeld, Sebastian M and Wang, Yiquan
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 04/2017, Volume 114, Issue 14, pp. 3684 - 3689
Many bilaterally symmetrical animals develop genetically programmed left-right asymmetries. In vertebrates, this process is under the control of Nodal... 
Embryonic development | Amphioxus | Nodal|left-right asymmetry | TALEN | left-right asymmetry | embryonic development | MULTIDISCIPLINARY SCIENCES | BRANCHIOSTOMA-BELCHERI | SEA-URCHIN EMBRYO | amphioxus | Nodal | MAINTENANCE | EVOLUTION | CONSERVATION | LATERALITY | GENE | PATHWAY | AXIS FORMATION | EXPRESSION | left–right asymmetry | Biological Sciences
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4. Full Text Chiral blastomere arrangement dictates zygotic left–right asymmetry pathway in snails
by Shimizu, Miho and Kuroda, Reiko and Endo, Bunshiro and Abe, Masanori
Nature, ISSN 0028-0836, 12/2009, Volume 462, Issue 7274, pp. 790 - 794
Most animals display internal and/or external left–right asymmetry. Several mechanisms for left–right asymmetry determination have been proposed for... 
ORIGIN | SHELL | MECHANISM | EMBRYO | ELEGANS | MULTIDISCIPLINARY SCIENCES | NODAL FLOW | LEFT-RIGHT AXIS | UNCONVENTIONAL MYOSIN | HANDEDNESS | DROSOPHILA | Embryo, Nonmammalian - cytology | Lymnaea - genetics | Zygote - cytology | Blastomeres - physiology | Situs Inversus - pathology | Embryo, Nonmammalian - metabolism | Zygote - metabolism | Molecular Sequence Data | Embryo, Nonmammalian - embryology | Nodal Protein - metabolism | Blastomeres - cytology | Lymnaea - anatomy & histology | Transcription Factors - genetics | Body Patterning - physiology | Transcription Factors - metabolism | Lymnaea - cytology | Animals | Nodal Protein - genetics | Situs Inversus - embryology | Lymnaea - embryology | Zygote - growth & development | Animals, Congenic | Body Patterning - genetics | Embryonic development | Snails | Physiological aspects | Shells | Genetic aspects | Symmetry (Biology) | Natural history | Research | Gene expression | Blastocyst | Mollusks | Asymmetry | Embryos | Morphology | Positioning | Vertebrates | Pathways | Chirality | Upstream | Genetics | Signalling
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5. Full Text Asymmetry of the Brain: Development and Implications
by Duboc, Véronique and Dufourcq, Pascale and Blader, Patrick and Roussigné, Myriam
Annual Review of Genetics, ISSN 0066-4197, 11/2015, Volume 49, Issue 1, pp. 647 - 672
Although the left and right hemispheres of our brains develop with a high degree of symmetry at both the anatomical and functional levels, it has become clear... 
zebrafish epithalamus | genetics of brain lateralization | animal models | human hemispheric specialization | Genetics of brain lateralization | Animal models | Human hemispheric specialization | Zebrafish epithalamus | NODAL-RELATED GENE | LEFT-HANDEDNESS | HEMISPHERIC-SPECIALIZATION | LEFT-RIGHT DIFFERENCE | BEHAVIORAL LATERALIZATION | CEREBRAL LATERALIZATION | SIGNALING PATHWAY | GENETICS & HEREDITY | NEUROANATOMICAL ASYMMETRIES | FUNCTIONAL LATERALIZATION | HABENULAR NUCLEI | Epithalamus - physiology | Brain - embryology | Brain - anatomy & histology | Epithalamus - anatomy & histology | Humans | Brain - growth & development | Brain - physiology | Functional Laterality - genetics | Posture | Animals | Hormones - metabolism | Language | Zebrafish - physiology | Functional Laterality - physiology | Symmetry (Biology) | Observations | Methods | Brain mapping
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6. Full Text TGFβ signaling in establishing left–right asymmetry
by Shiratori, Hidetaka and Hamada, Hiroshi
Seminars in Cell and Developmental Biology, ISSN 1084-9521, 08/2014, Volume 32, pp. 80 - 84
Two TGFβ-related proteins, Nodal and Lefty, are asymmetrically expressed and play central roles in establishing left–right (L–R) asymmetry of our body. Nodal... 
Nodal | Lefty | Node | Left–right asymmetry | Left-right asymmetry | NODAL EXPRESSION | FLUID-FLOW | SITUS-SPECIFIC MORPHOGENESIS | DEVELOPMENTAL BIOLOGY | MOUSE EMBRYO | CELL BIOLOGY | INHIBITION | PATHWAY | CHICK-EMBRYO | LEFT-RIGHT SYMMETRY | LATERAL PLATE MESODERM | PITX2 | Left-Right Determination Factors - metabolism | Nodal Protein - metabolism | Signal Transduction - genetics | Embryo, Mammalian - metabolism | Animals | Nodal Protein - genetics | Transforming Growth Factor beta - genetics | Embryo, Mammalian - embryology | Embryo, Mammalian - cytology | Gene Expression Regulation, Developmental | Left-Right Determination Factors - genetics | Mice | Models, Genetic | Body Patterning - genetics | Transforming Growth Factor beta - metabolism
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7. Full Text Nodal signalling determines biradial asymmetry in Hydra
by Watanabe, Hiroshi and Schmidt, Heiko A and Kuhn, Anne and Höger, Stefanie K and Kocagöz, Yigit and Laumann-Lipp, Nico and Özbek, Suat and Holstein, Thomas W
Nature, ISSN 0028-0836, 11/2014, Volume 515, Issue 7525, pp. 112 - 115
In bilaterians, three orthogonal body axes define the animal form, with distinct anterior-posterior, dorsal-ventral and left-right asymmetries. The key... 
MAXIMUM-LIKELIHOOD PHYLOGENIES | EVOLUTION | HEAD ORGANIZER | EMBRYO | MULTIDISCIPLINARY SCIENCES | LEFT-RIGHT AXIS | GENE FAMILY | BODY AXES | CARTESIAN COORDINATE SYSTEM | WNT | EXPRESSION | Feedback, Physiological | Animals | Nodal Protein - genetics | Gene Expression Regulation, Developmental | Hydra - metabolism | Hydra - genetics | Nodal Protein - metabolism | Signal Transduction - genetics | Body Patterning - genetics | beta Catenin - metabolism | Paired Box Transcription Factors - metabolism | Hydra - embryology | Physiological aspects | Coelenterata | Cellular signal transduction | Research | Properties | Asymmetry | Kinases | Genes | Symmetry
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8. Full Text Left-Right Asymmetry and Kinesin Superfamily Protein KIF3A: New Insights in Determination of Laterality and Mesoderm Induction by kif3A-/- Mice Analysis
by Sen Takeda and Yoshiaki Yonekawa and Yosuke Tanaka and Yasushi Okada and Shigenori Nonaka and Nobutaka Hirokawa
The Journal of Cell Biology, ISSN 0021-9525, 5/1999, Volume 145, Issue 4, pp. 825 - 836
KIF3A is a classical member of the kinesin superfamily proteins (KIFs), ubiquitously expressed although predominantly in neural tissues, and which forms a... 
Homozygotes | Molecules | Phenotypes | Neurons | Cell lines | Antibodies | Mice | Embryos | Cells | Cilia | Gene targeting | kif3A | Microtubule | Left-right asymmetry | Kinesin | left-right asymmetry | DYNEIN | kinesin | MEMBRANE | gene targeting | CELL BIOLOGY | microtubule | GENE | MOTOR | MUTATION | NEURONS | ORGANELLE TRANSPORT | EXPRESSION | EMBRYOS | MOTILITY | Gene Targeting | Protein Biosynthesis | Mice, Inbred C57BL | Trans-Activators | Embryonic Induction | Kinesin - metabolism | Mice, Knockout | Hedgehog Proteins | Animals | Recombination, Genetic | Body Patterning | Kinesin - genetics | Mesoderm - metabolism | Fluorescent Dyes | Proteins | Mesoderm | Genetic aspects | Research | Regular
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