Nature, ISSN 0028-0836, 02/2009, Volume 457, Issue 7232, pp. 1007 - 1011
Many animals display specific internal or external features with left-right asymmetry. In vertebrates, the molecular pathway that leads to this asymmetry uses...
CONSERVED ROLE | DEUTEROSTOMES | EVOLUTION | LIMNAEA | MULTIDISCIPLINARY SCIENCES | SEA-URCHIN EMBRYO | AXES | ESTABLISHMENT | INHERITANCE | INVERSUS | EXPRESSION | Paired Box Transcription Factors - genetics | Signal Transduction | Snails - genetics | Snails - drug effects | Snails - metabolism | Molecular Sequence Data | Nodal Protein - metabolism | Snails - embryology | Body Patterning - physiology | Animals | Nodal Protein - genetics | Gene Expression Regulation, Developmental | Body Patterning - genetics | Paired Box Transcription Factors - metabolism | Physiological aspects | Cellular signal transduction | Genetic aspects | Research | Snails | Genes | Studies | Cell division | Mollusks | Embryos | Cells
CONSERVED ROLE | DEUTEROSTOMES | EVOLUTION | LIMNAEA | MULTIDISCIPLINARY SCIENCES | SEA-URCHIN EMBRYO | AXES | ESTABLISHMENT | INHERITANCE | INVERSUS | EXPRESSION | Paired Box Transcription Factors - genetics | Signal Transduction | Snails - genetics | Snails - drug effects | Snails - metabolism | Molecular Sequence Data | Nodal Protein - metabolism | Snails - embryology | Body Patterning - physiology | Animals | Nodal Protein - genetics | Gene Expression Regulation, Developmental | Body Patterning - genetics | Paired Box Transcription Factors - metabolism | Physiological aspects | Cellular signal transduction | Genetic aspects | Research | Snails | Genes | Studies | Cell division | Mollusks | Embryos | Cells
Journal Article
Developmental Biology, ISSN 0012-1606, 05/2011, Volume 353, Issue 2, pp. 321 - 330
Left–right (L–R) asymmetry in the mouse embryo is generated in the node and is dependent on cilia-driven fluid flow, but how the initial asymmetry is...
Smad | Nodal signaling | Node | Left–right asymmetry | Left-right asymmetry | INHIBITION | MUTATION | GENES | LEFT-RIGHT AXIS | REQUIRES | MICE | DEVELOPMENTAL BIOLOGY | EXPRESSION | Phosphorylation | Humans | Male | Smad3 Protein - metabolism | Mesoderm - cytology | Mice, Neurologic Mutants | Biological Transport, Active | Nodal Protein - genetics | Forkhead Transcription Factors - metabolism | Female | Forkhead Transcription Factors - deficiency | Mesoderm - embryology | Signal Transduction | Smad2 Protein - metabolism | Mice, Transgenic | Forkhead Transcription Factors - genetics | Body Patterning - physiology | Mice, Knockout | Pregnancy | Animals | Enhancer Elements, Genetic | Left-Right Determination Factors - genetics | Mesoderm - metabolism | Mice | Nodal Protein - physiology | Body Patterning - genetics | Embryonic development | node
Smad | Nodal signaling | Node | Left–right asymmetry | Left-right asymmetry | INHIBITION | MUTATION | GENES | LEFT-RIGHT AXIS | REQUIRES | MICE | DEVELOPMENTAL BIOLOGY | EXPRESSION | Phosphorylation | Humans | Male | Smad3 Protein - metabolism | Mesoderm - cytology | Mice, Neurologic Mutants | Biological Transport, Active | Nodal Protein - genetics | Forkhead Transcription Factors - metabolism | Female | Forkhead Transcription Factors - deficiency | Mesoderm - embryology | Signal Transduction | Smad2 Protein - metabolism | Mice, Transgenic | Forkhead Transcription Factors - genetics | Body Patterning - physiology | Mice, Knockout | Pregnancy | Animals | Enhancer Elements, Genetic | Left-Right Determination Factors - genetics | Mesoderm - metabolism | Mice | Nodal Protein - physiology | Body Patterning - genetics | Embryonic development | node
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 04/2017, Volume 114, Issue 14, pp. 3684 - 3689
Many bilaterally symmetrical animals develop genetically programmed left-right asymmetries. In vertebrates, this process is under the control of Nodal...
Embryonic development | Amphioxus | Nodal|left-right asymmetry | TALEN | left-right asymmetry | embryonic development | MULTIDISCIPLINARY SCIENCES | BRANCHIOSTOMA-BELCHERI | SEA-URCHIN EMBRYO | amphioxus | Nodal | MAINTENANCE | EVOLUTION | CONSERVATION | LATERALITY | GENE | PATHWAY | AXIS FORMATION | EXPRESSION | left–right asymmetry | Biological Sciences
Embryonic development | Amphioxus | Nodal|left-right asymmetry | TALEN | left-right asymmetry | embryonic development | MULTIDISCIPLINARY SCIENCES | BRANCHIOSTOMA-BELCHERI | SEA-URCHIN EMBRYO | amphioxus | Nodal | MAINTENANCE | EVOLUTION | CONSERVATION | LATERALITY | GENE | PATHWAY | AXIS FORMATION | EXPRESSION | left–right asymmetry | Biological Sciences
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Chiral blastomere arrangement dictates zygotic left–right asymmetry pathway in snails
Nature, ISSN 0028-0836, 12/2009, Volume 462, Issue 7274, pp. 790 - 794
Most animals display internal and/or external left–right asymmetry. Several mechanisms for left–right asymmetry determination have been proposed for...
ORIGIN | SHELL | MECHANISM | EMBRYO | ELEGANS | MULTIDISCIPLINARY SCIENCES | NODAL FLOW | LEFT-RIGHT AXIS | UNCONVENTIONAL MYOSIN | HANDEDNESS | DROSOPHILA | Embryo, Nonmammalian - cytology | Lymnaea - genetics | Zygote - cytology | Blastomeres - physiology | Situs Inversus - pathology | Embryo, Nonmammalian - metabolism | Zygote - metabolism | Molecular Sequence Data | Embryo, Nonmammalian - embryology | Nodal Protein - metabolism | Blastomeres - cytology | Lymnaea - anatomy & histology | Transcription Factors - genetics | Body Patterning - physiology | Transcription Factors - metabolism | Lymnaea - cytology | Animals | Nodal Protein - genetics | Situs Inversus - embryology | Lymnaea - embryology | Zygote - growth & development | Animals, Congenic | Body Patterning - genetics | Embryonic development | Snails | Physiological aspects | Shells | Genetic aspects | Symmetry (Biology) | Natural history | Research | Gene expression | Blastocyst | Mollusks | Asymmetry | Embryos | Morphology | Positioning | Vertebrates | Pathways | Chirality | Upstream | Genetics | Signalling
ORIGIN | SHELL | MECHANISM | EMBRYO | ELEGANS | MULTIDISCIPLINARY SCIENCES | NODAL FLOW | LEFT-RIGHT AXIS | UNCONVENTIONAL MYOSIN | HANDEDNESS | DROSOPHILA | Embryo, Nonmammalian - cytology | Lymnaea - genetics | Zygote - cytology | Blastomeres - physiology | Situs Inversus - pathology | Embryo, Nonmammalian - metabolism | Zygote - metabolism | Molecular Sequence Data | Embryo, Nonmammalian - embryology | Nodal Protein - metabolism | Blastomeres - cytology | Lymnaea - anatomy & histology | Transcription Factors - genetics | Body Patterning - physiology | Transcription Factors - metabolism | Lymnaea - cytology | Animals | Nodal Protein - genetics | Situs Inversus - embryology | Lymnaea - embryology | Zygote - growth & development | Animals, Congenic | Body Patterning - genetics | Embryonic development | Snails | Physiological aspects | Shells | Genetic aspects | Symmetry (Biology) | Natural history | Research | Gene expression | Blastocyst | Mollusks | Asymmetry | Embryos | Morphology | Positioning | Vertebrates | Pathways | Chirality | Upstream | Genetics | Signalling
Journal Article
Annual Review of Genetics, ISSN 0066-4197, 11/2015, Volume 49, Issue 1, pp. 647 - 672
Although the left and right hemispheres of our brains develop with a high degree of symmetry at both the anatomical and functional levels, it has become clear...
zebrafish epithalamus | genetics of brain lateralization | animal models | human hemispheric specialization | Genetics of brain lateralization | Animal models | Human hemispheric specialization | Zebrafish epithalamus | NODAL-RELATED GENE | LEFT-HANDEDNESS | HEMISPHERIC-SPECIALIZATION | LEFT-RIGHT DIFFERENCE | BEHAVIORAL LATERALIZATION | CEREBRAL LATERALIZATION | SIGNALING PATHWAY | GENETICS & HEREDITY | NEUROANATOMICAL ASYMMETRIES | FUNCTIONAL LATERALIZATION | HABENULAR NUCLEI | Epithalamus - physiology | Brain - embryology | Brain - anatomy & histology | Epithalamus - anatomy & histology | Humans | Brain - growth & development | Brain - physiology | Functional Laterality - genetics | Posture | Animals | Hormones - metabolism | Language | Zebrafish - physiology | Functional Laterality - physiology | Symmetry (Biology) | Observations | Methods | Brain mapping
zebrafish epithalamus | genetics of brain lateralization | animal models | human hemispheric specialization | Genetics of brain lateralization | Animal models | Human hemispheric specialization | Zebrafish epithalamus | NODAL-RELATED GENE | LEFT-HANDEDNESS | HEMISPHERIC-SPECIALIZATION | LEFT-RIGHT DIFFERENCE | BEHAVIORAL LATERALIZATION | CEREBRAL LATERALIZATION | SIGNALING PATHWAY | GENETICS & HEREDITY | NEUROANATOMICAL ASYMMETRIES | FUNCTIONAL LATERALIZATION | HABENULAR NUCLEI | Epithalamus - physiology | Brain - embryology | Brain - anatomy & histology | Epithalamus - anatomy & histology | Humans | Brain - growth & development | Brain - physiology | Functional Laterality - genetics | Posture | Animals | Hormones - metabolism | Language | Zebrafish - physiology | Functional Laterality - physiology | Symmetry (Biology) | Observations | Methods | Brain mapping
Journal Article
Seminars in Cell and Developmental Biology, ISSN 1084-9521, 08/2014, Volume 32, pp. 80 - 84
Two TGFβ-related proteins, Nodal and Lefty, are asymmetrically expressed and play central roles in establishing left–right (L–R) asymmetry of our body. Nodal...
Nodal | Lefty | Node | Left–right asymmetry | Left-right asymmetry | NODAL EXPRESSION | FLUID-FLOW | SITUS-SPECIFIC MORPHOGENESIS | DEVELOPMENTAL BIOLOGY | MOUSE EMBRYO | CELL BIOLOGY | INHIBITION | PATHWAY | CHICK-EMBRYO | LEFT-RIGHT SYMMETRY | LATERAL PLATE MESODERM | PITX2 | Left-Right Determination Factors - metabolism | Nodal Protein - metabolism | Signal Transduction - genetics | Embryo, Mammalian - metabolism | Animals | Nodal Protein - genetics | Transforming Growth Factor beta - genetics | Embryo, Mammalian - embryology | Embryo, Mammalian - cytology | Gene Expression Regulation, Developmental | Left-Right Determination Factors - genetics | Mice | Models, Genetic | Body Patterning - genetics | Transforming Growth Factor beta - metabolism
Nodal | Lefty | Node | Left–right asymmetry | Left-right asymmetry | NODAL EXPRESSION | FLUID-FLOW | SITUS-SPECIFIC MORPHOGENESIS | DEVELOPMENTAL BIOLOGY | MOUSE EMBRYO | CELL BIOLOGY | INHIBITION | PATHWAY | CHICK-EMBRYO | LEFT-RIGHT SYMMETRY | LATERAL PLATE MESODERM | PITX2 | Left-Right Determination Factors - metabolism | Nodal Protein - metabolism | Signal Transduction - genetics | Embryo, Mammalian - metabolism | Animals | Nodal Protein - genetics | Transforming Growth Factor beta - genetics | Embryo, Mammalian - embryology | Embryo, Mammalian - cytology | Gene Expression Regulation, Developmental | Left-Right Determination Factors - genetics | Mice | Models, Genetic | Body Patterning - genetics | Transforming Growth Factor beta - metabolism
Journal Article
Nature, ISSN 0028-0836, 11/2014, Volume 515, Issue 7525, pp. 112 - 115
In bilaterians, three orthogonal body axes define the animal form, with distinct anterior-posterior, dorsal-ventral and left-right asymmetries. The key...
MAXIMUM-LIKELIHOOD PHYLOGENIES | EVOLUTION | HEAD ORGANIZER | EMBRYO | MULTIDISCIPLINARY SCIENCES | LEFT-RIGHT AXIS | GENE FAMILY | BODY AXES | CARTESIAN COORDINATE SYSTEM | WNT | EXPRESSION | Feedback, Physiological | Animals | Nodal Protein - genetics | Gene Expression Regulation, Developmental | Hydra - metabolism | Hydra - genetics | Nodal Protein - metabolism | Signal Transduction - genetics | Body Patterning - genetics | beta Catenin - metabolism | Paired Box Transcription Factors - metabolism | Hydra - embryology | Physiological aspects | Coelenterata | Cellular signal transduction | Research | Properties | Asymmetry | Kinases | Genes | Symmetry
MAXIMUM-LIKELIHOOD PHYLOGENIES | EVOLUTION | HEAD ORGANIZER | EMBRYO | MULTIDISCIPLINARY SCIENCES | LEFT-RIGHT AXIS | GENE FAMILY | BODY AXES | CARTESIAN COORDINATE SYSTEM | WNT | EXPRESSION | Feedback, Physiological | Animals | Nodal Protein - genetics | Gene Expression Regulation, Developmental | Hydra - metabolism | Hydra - genetics | Nodal Protein - metabolism | Signal Transduction - genetics | Body Patterning - genetics | beta Catenin - metabolism | Paired Box Transcription Factors - metabolism | Hydra - embryology | Physiological aspects | Coelenterata | Cellular signal transduction | Research | Properties | Asymmetry | Kinases | Genes | Symmetry
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 5/1999, Volume 145, Issue 4, pp. 825 - 836
KIF3A is a classical member of the kinesin superfamily proteins (KIFs), ubiquitously expressed although predominantly in neural tissues, and which forms a...
Homozygotes | Molecules | Phenotypes | Neurons | Cell lines | Antibodies | Mice | Embryos | Cells | Cilia | Gene targeting | kif3A | Microtubule | Left-right asymmetry | Kinesin | left-right asymmetry | DYNEIN | kinesin | MEMBRANE | gene targeting | CELL BIOLOGY | microtubule | GENE | MOTOR | MUTATION | NEURONS | ORGANELLE TRANSPORT | EXPRESSION | EMBRYOS | MOTILITY | Gene Targeting | Protein Biosynthesis | Mice, Inbred C57BL | Trans-Activators | Embryonic Induction | Kinesin - metabolism | Mice, Knockout | Hedgehog Proteins | Animals | Recombination, Genetic | Body Patterning | Kinesin - genetics | Mesoderm - metabolism | Fluorescent Dyes | Proteins | Mesoderm | Genetic aspects | Research | Regular
Homozygotes | Molecules | Phenotypes | Neurons | Cell lines | Antibodies | Mice | Embryos | Cells | Cilia | Gene targeting | kif3A | Microtubule | Left-right asymmetry | Kinesin | left-right asymmetry | DYNEIN | kinesin | MEMBRANE | gene targeting | CELL BIOLOGY | microtubule | GENE | MOTOR | MUTATION | NEURONS | ORGANELLE TRANSPORT | EXPRESSION | EMBRYOS | MOTILITY | Gene Targeting | Protein Biosynthesis | Mice, Inbred C57BL | Trans-Activators | Embryonic Induction | Kinesin - metabolism | Mice, Knockout | Hedgehog Proteins | Animals | Recombination, Genetic | Body Patterning | Kinesin - genetics | Mesoderm - metabolism | Fluorescent Dyes | Proteins | Mesoderm | Genetic aspects | Research | Regular
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