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lekti (94) 94
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serine peptidase inhibitor kazal-type 5 (50) 50
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Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 10/2019, Volume 29, Issue 20, p. 126675
The connection between Netherton syndrome and overactivation of epidermal/dermal proteases, particularly Kallikrein 5 (KLK5) has been well established and it... 
Netherton syndrome | KLK5 | LEKTI | KLK1 | KLKB1 | SPINK5 | CHEMISTRY, MEDICINAL | DISEASE | CHEMISTRY, ORGANIC
Journal Article
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT, ISSN 1610-0379, 05/2016, Volume 14, Issue 5, pp. 519 - 522
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 03/2019, Volume 29, Issue 6, pp. 821 - 825
Netherton syndrome (NS) is a rare and debilitating severe autosomal recessive genetic skin disease with high mortality rates particularly in neonates. NS is... 
Netherton syndrome | TLSP | KLK1 | SPINK5 | KLK5 | LEKTI | FBDD | CHEMISTRY, MEDICINAL | CHEMISTRY, ORGANIC | Care and treatment | Trypsin | Protease inhibitors | Mortality | Kallikrein | Skin diseases | Thrombin | Skin | Drug discovery
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 06/2019, Volume 29, Issue 12, pp. 1454 - 1458
The connection between Netherton syndrome and overactivation of epidermal/dermal proteases particularly KLK5 has been well established. To treat sufferers of... 
Netherton syndrome | KLK5 | LEKTI | KLK1 | KLKB1 | SPINK5 | CHEMISTRY, MEDICINAL | DISEASE | BIOLOGICAL EVALUATION | CHEMISTRY, ORGANIC | Kallikrein | Skin diseases | Thrombin | Skin | Protease inhibitors
Journal Article
Journal of Proteomics, ISSN 1874-3919, 07/2012, Volume 75, Issue 13, pp. 3925 - 3937
Lympho-Epithelial Kazal-Type-related Inhibitor (LEKTI) has been demonstrated to be an inhibitor of various kallikreins and is thought to play a role in the... 
LEKTI | Dermcidin | QTOF MS | Mass spectrometry | Cathepsin G | Kallikreins | Cathepsin g | TRYPSIN | BIOCHEMICAL RESEARCH METHODS | SWEAT | ATOPIC-DERMATITIS | PEPTIDES | DESQUAMATION | INHIBITOR LEKTI | SUBTILISIN-A | CATHEPSIN-G | TECHNOLOGY | EXPRESSION | Proteins | Kallikrein | Cathepsins | Usage | Skin | Protein binding
Journal Article
Cell and Tissue Research, ISSN 0302-766X, 2/2013, Volume 351, Issue 2, pp. 289 - 300
Journal Article
Structure, ISSN 0969-2126, 09/2018, Volume 26, Issue 9, pp. 1178 - 1186.e3
Despite being initially identified in the blood filtrate, LEKTI is a 15-domain Kazal-type inhibitor mostly known in the regulation of skin desquamation. In the... 
MD simulation | Kazal | NMR | blood coagulation | factor XIa | lympho-epithelial Kazal-type related inhibitor | LEKTI | factor Xa | serine protease | SYSTEM | MOLECULAR-DYNAMICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ALGORITHMS | RESTRAINTS | CELL BIOLOGY | BIOPHYSICS | LANGEVIN | SERINE-PROTEASE INHIBITOR | SECONDARY STRUCTURE | PROTEINS | ASSOCIATION | Molecular dynamics | Thrombin | Skin | Analysis
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 07/2018, Volume 26, Issue 12, pp. 3639 - 3653
A series of 1,3,6-trisubstituted 1,4-diazepan-7-ones were prepared as kallikrein 7 (KLK7, stratum corneum chymotryptic enzyme) inhibitors. Previously reported... 
Serine protease | Structure-based drug design | 1,4-Diazepan-7-one | KLK7 inhibitor | Species differences | CHEMISTRY, MEDICINAL | SERINE PROTEASES | BIOCHEMISTRY & MOLECULAR BIOLOGY | STRATUM-CORNEUM | LEKTI | CHEMISTRY, ORGANIC | KLK7 | FAMILY | ATOPIC-DERMATITIS | EPIDERMAL BARRIER DYSFUNCTION | DESQUAMATION | SKIN | EXPRESSION | Enzymes | Analysis | Crystals | Kallikrein | Thrombin | Enantiomers | Structure
Journal Article
Journal Article
Journal of Dermatological Science, ISSN 0923-1811, 08/2019, Volume 95, Issue 2, pp. 50 - 55
Journal Article