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Nature Reviews Genetics, ISSN 1471-0056, 05/2015, Volume 16, Issue 5, pp. 299 - 311
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2008, Volume 105, Issue 51, pp. 20380 - 20385
Journal Article
Journal Article
Nature Genetics, ISSN 1061-4036, 2014, Volume 46, Issue 4, pp. 364 - 370
The identification of activating NOTCH1 mutations in T cell acute lymphoblastic leukemia (T-ALL) led to clinical testing of g-secretase inhibitors (GSIs) that... 
NOTCH1 | INHIBITION | CHROMATIN | PATHWAY | GENES | GENETICS & HEREDITY | C-MYC | ACUTE MYELOID-LEUKEMIA | CANCER | LENTIVIRAL RNAI LIBRARY | GENOME | Chromatin - metabolism | Humans | Flow Cytometry | Chromatin Immunoprecipitation | Gene Expression Regulation, Neoplastic - drug effects | Indoles | Nuclear Proteins - genetics | Real-Time Polymerase Chain Reaction | Gene Expression Regulation, Neoplastic - genetics | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Enzyme-Linked Immunosorbent Assay | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Signal Transduction - genetics | Transcription Factors - genetics | Enzyme Inhibitors - therapeutic use | Azepines - pharmacology | Transcription Factors - metabolism | Triazoles - pharmacology | Drug Resistance, Neoplasm - genetics | Animals | Epigenesis, Genetic - genetics | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Mice | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Histones - metabolism | Receptor, Notch1 - antagonists & inhibitors | Receptor, Notch1 - genetics | Chromatin - genetics | Care and treatment | Pharmacology, Experimental | Acute lymphocytic leukemia | Research | Drug resistance | Proteins | Genotype & phenotype | Leukemia | Epigenetics | Genomes | Kinases | Gene expression | Cancer therapies
Journal Article
Chemical science, ISSN 2041-6520, 03/2015, Volume 6, Issue 3, pp. 1701 - 1705
Sorting of target cells from a heterogeneous pool is technically difficult when the selection criterion is complex, e.g. a dynamic response, a morphological... 
Journal Article
Nature Medicine, ISSN 1078-8956, 04/2015, Volume 21, Issue 4, pp. 335 - 343
Journal Article
EMBO Molecular Medicine, ISSN 1757-4676, 07/2013, Volume 5, Issue 7, pp. 1051 - 1066
Journal Article
Molecular Cell, ISSN 1097-2765, 10/2017, Volume 68, Issue 1, pp. 247 - 257.e5
The genome-wide perturbation of transcriptional networks with CRISPR-Cas technology has primarily involved systematic and targeted gene modulation. Here, we... 
global transcriptional perturbations | Perturbing Regulatory Interactions by Synthetic Modulators | CRISPR screening | randomized gRNA library | alpha-synuclein | PRISM | synthetic transcription factors | Parkinson’s disease | Parkinson's disease | YEAST | OXIDATIVE STRESS | PROTEIN | HUMAN-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENOME-WIDE ANALYSIS | SACCHAROMYCES-CEREVISIAE | EXPRESSION | LENTIVIRAL RNAI LIBRARY | PARKINSONS-DISEASE | MOLECULAR PATHWAYS | CELL BIOLOGY | Neurons - pathology | RNA, Guide - genetics | RNA, Guide - metabolism | Saccharomyces cerevisiae - genetics | alpha-Synuclein - antagonists & inhibitors | Humans | Gene Expression Profiling | Gene Regulatory Networks | Saccharomyces cerevisiae - metabolism | Clustered Regularly Interspaced Short Palindromic Repeats | Transcription, Genetic | Neurons - metabolism | Parkinson Disease - metabolism | alpha-Synuclein - genetics | Transgenes | Parkinson Disease - pathology | Gene Expression Regulation | Parkinson Disease - genetics | Transcription Factors - genetics | Transcription Factors - metabolism | Phenotype | High-Throughput Screening Assays | Models, Biological | CRISPR-Cas Systems | Cell Line, Tumor | alpha-Synuclein - metabolism | Security software | Cell death | Analysis | Genes | Genomics | Genetic aspects | Rankings | DNA binding proteins | Genetic transcription | Electrical engineering | Anopheles | Medical screening
Journal Article
Chemical Science, ISSN 2041-6520, 03/2015, Volume 6, Issue 3, pp. 1701 - 1705
Sorting of target cells from a heterogeneous pool is technically difficult when the selection criterion is complex, e.g. a dynamic response, a morphological... 
PHENYLNITRENE | PHOTODEGRADABLE HYDROGELS | LIGHT | SKIN | AZIDE | CHEMISTRY, MULTIDISCIPLINARY | LASER-CAPTURE MICRODISSECTION | LENTIVIRAL RNAI LIBRARY | Flow cytometry | Firing | Preserves | Fluorescence | Crosslinking | Illumination | Criteria | Culture
Journal Article