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EMBO molecular medicine, ISSN 1757-4676, 03/2015, Volume 7, Issue 3, pp. 288 - 298
Journal Article
Circulation (New York, N.Y.), ISSN 1524-4539, 2008, Volume 117, Issue 17, pp. 2253 - 2261
.... Because adipocytes express mineralocorticoid receptor (MR) and MR blockade reduces cardiovascular inflammation and injury, we tested the hypothesis that MR blockade reduces inflammation and expression of proinflammatory cytokines in adipose tissue... 
Obesity | Adipose tissue | Mineralocorticoid receptor | Diabetes mellitus | Inflammation | Aldosterone | Aldosterone antagonists | MACROPHAGE INFILTRATION | CARDIAC & CARDIOVASCULAR SYSTEMS | aldosterone | adipose tissue | PROTEINURIA | diabetes mellitus | mineralocorticoid receptor | inflammation | INSULIN-RESISTANCE | SPIRONOLACTONE | PERIPHERAL VASCULAR DISEASE | aldosterone antagonists | EPLERENONE | TRANSCRIPTIONAL REGULATION | obesity | ADIPOSE-TISSUE | ADIPOCYTOKINES | Diabetes Mellitus, Experimental - drug therapy | Body Weight | Myocardium - immunology | Obesity - drug therapy | Obesity - immunology | Receptors, Mineralocorticoid - metabolism | Male | PPAR gamma - immunology | Adipose Tissue - immunology | RNA, Messenger - metabolism | Inflammation - complications | Inflammation - drug therapy | Mice, Mutant Strains | Adipokines - genetics | Adiponectin - genetics | Diabetes Mellitus, Experimental - complications | Leptin - immunology | Mineralocorticoid Receptor Antagonists | PPAR gamma - genetics | Obesity - complications | Homeostasis - immunology | Aldosterone - pharmacology | Adipokines - immunology | Inflammation - immunology | Leptin - genetics | 3T3-L1 Cells | Diabetes Mellitus, Experimental - immunology | Animals | Triglycerides - blood | Biomarkers | Mice | Adiponectin - immunology | Adipose Tissue - drug effects
Journal Article
Best Practice & Research Clinical Endocrinology & Metabolism, ISSN 1521-690X, 2015, Volume 29, Issue 5, pp. 661 - 670
Journal Article
Journal Article
Expert Opinion on Investigational Drugs, ISSN 1744-7658, 2006, Volume 15, Issue 8, pp. 897 - 915
Obesity is a major public health concern and environmental factors are involved in its development. The hypothalamus is a primary site for the integration of... 
adiponectin | glucagon-like peptide-1 | cholecystokinin | peroxisome proliferator-activated receptor-γ | melanin-concentrating hormone | 3-36 | leptin | ciliary neurotrophic factor | oxyntomodulin | cannabinoid-1 receptor antagonists | ghrelin | peroxisome proliferator-activated receptor-β/δ | somatostatin | growth hormone | peptide YY | bupropion | dopamine | adrenergic receptor agonists | obesity | lipase inhibitors | melanocortin | topiramate | β3-adrenergic receptor agonists | peptide YY3-36, peroxisome proliferator-activated receptor-γ | Obesity | Topiramate | Dopamine | Peroxisome proliferator-activated receptor-β/δ | Peroxisome proliferator-activated receptor-γ | Melanocortin | Peptide YY | Ciliary neurotrophic factor | Oxyntomodulin | Adiponectin | Glucagon-like peptide-1 | Bupropion | Lipase inhibitors | Ghrelin | Melanin-concentrating hormone | Leptin | Cannabinoid-1 receptor antagonists | Cholecystokinin | Somatostatin | Growth hormone | antagonists | BODY-WEIGHT GAIN | beta-adrenergic receptor agonists | CB1 CANNABINOID RECEPTOR | cannabinoid-1 receptor | PHARMACOLOGY & PHARMACY | CARDIOVASCULAR RISK-FACTORS | BINGE-EATING DISORDER | peptide YY3-36 | DIET-INDUCED OBESITY | MELANOCORTIN-1 AND-4 RECEPTORS | peroxisome proliferator-activated receptor-beta/delta | peroxisome proliferator-activated receptor-gamma | INCREASES INSULIN SENSITIVITY | REDUCES FOOD-INTAKE | Recombinant Proteins - therapeutic use | Serotonin 5-HT1 Receptor Agonists | Body Weight | Drugs, Investigational - pharmacology | Obesity - drug therapy | Receptors, G-Protein-Coupled - metabolism | Humans | Receptor, Serotonin, 5-HT2C - metabolism | Drugs, Investigational - therapeutic use | Receptors, Neuropeptide Y - metabolism | Receptor, Melanocortin, Type 4 - metabolism | Anti-Obesity Agents - therapeutic use | Serotonin Receptor Agonists - pharmacology | Receptor, Serotonin, 5-HT1B - metabolism | Receptors, Neuropeptide Y - antagonists & inhibitors | Leptin - pharmacology | Hypothalamus - drug effects | Receptors, Ghrelin | Leptin - therapeutic use | Leptin - genetics | Receptor, Melanocortin, Type 4 - agonists | Recombinant Proteins - pharmacology | Obesity - metabolism | Randomized Controlled Trials as Topic | Serotonin Receptor Agonists - therapeutic use | Animals | Hypothalamus - metabolism | Energy Metabolism | Peroxisome Proliferator-Activated Receptors - drug effects | Peroxisome Proliferator-Activated Receptors - metabolism | Receptors, G-Protein-Coupled - antagonists & inhibitors | Serotonin 5-HT2 Receptor Agonists | Anti-Obesity Agents - pharmacology
Journal Article
Journal Article
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 08/2015, Volume 290, Issue 32, pp. 19888 - 19899
Farnesoid X receptor alpha (FXR alpha) as a bile acid sensor plays potent roles in multiple metabolic processes, and its antagonist has recently revealed special interests in the treatment of metabolic disorders, although the underlying... 
OBESITY | HOMEOSTASIS | NATURAL PRODUCT | CHOLESTEROL | METABOLISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | BILE-ACID RECEPTOR | LIGAND | IDENTIFICATION | ORPHAN NUCLEAR RECEPTOR | AGONIST | Glucose-6-Phosphatase - genetics | Receptors, Leptin - genetics | Humans | Phosphoenolpyruvate Carboxykinase (ATP) - antagonists & inhibitors | Crystallography, X-Ray | Male | Hepatocytes - metabolism | Hepatocytes - cytology | Protein Isoforms - metabolism | ATP-Binding Cassette Transporters - genetics | Protein Isoforms - agonists | Receptors, Cytoplasmic and Nuclear - chemistry | ATP-Binding Cassette Transporters - metabolism | Benzamides - pharmacology | Retinoid X Receptors - genetics | Retinoid X Receptors - metabolism | Hepatocytes - drug effects | Benzamides - chemistry | Recombinant Proteins - metabolism | Signal Transduction | Isoxazoles - antagonists & inhibitors | Gene Expression Regulation | Receptors, Cytoplasmic and Nuclear - agonists | Receptors, Cytoplasmic and Nuclear - genetics | Recombinant Proteins - genetics | Glucose-6-Phosphatase - metabolism | Hep G2 Cells | Mice, Knockout | Isoxazoles - pharmacology | Phosphoenolpyruvate Carboxykinase (ATP) - genetics | Receptors, Leptin - deficiency | Animals | ATP Binding Cassette Subfamily B Member 11 | Retinoid X Receptors - agonists | Glucose-6-Phosphatase - antagonists & inhibitors | Phosphoenolpyruvate Carboxykinase (ATP) - metabolism | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Mice | Molecular Docking Simulation | Mutation | Primary Cell Culture | Protein Isoforms - antagonists & inhibitors | ATP-Binding Cassette Transporters - antagonists & inhibitors | Protein Isoforms - genetics | Receptors, Cytoplasmic and Nuclear - metabolism | Protein Structure and Folding | FXR | homodimerization | molecular pharmacology | crystal structure | nuclear receptor | transcription target gene | metabolic disease | antagonist
Journal Article
Nature neuroscience, ISSN 1546-1726, 2011, Volume 14, Issue 7, pp. 911 - 918
.... These effects were abrogated in mice with insulin receptor deficiency restricted to SF-1 neurons (SF-1(Delta IR) mice... 
BODY-WEIGHT | ENERGY HOMEOSTASIS | FOOD-INTAKE | STEROIDOGENIC FACTOR-1 | NEUROTROPHIC FACTOR | PROOPIOMELANOCORTIN NEURONS | ARCUATE NUCLEUS | VENTROMEDIAL HYPOTHALAMIC NUCLEUS | EXPRESSING NEURONS | NEUROSCIENCES | HEPATIC GLUCOSE-PRODUCTION | Enzyme-Linked Immunosorbent Assay - methods | Tolbutamide - pharmacology | Action Potentials - genetics | Age Factors | Body Weight - drug effects | Steroidogenic Factor 1 - genetics | Male | Green Fluorescent Proteins - genetics | Phosphatidylinositol 3-Kinases - metabolism | Ventromedial Hypothalamic Nucleus - pathology | RNA, Messenger - metabolism | Calorimetry - methods | Eating - physiology | Dose-Response Relationship, Drug | Time Factors | Female | Leptin - administration & dosage | Neurons - metabolism | Steroidogenic Factor 1 - metabolism | Neurons - drug effects | Action Potentials - drug effects | Animals, Newborn | Insulin - pharmacology | Dietary Fats - adverse effects | Glucose Tolerance Test | Obesity - chemically induced | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Mice, Transgenic | Signal Transduction - genetics | Hypoglycemic Agents - pharmacology | Obesity - pathology | Blood Glucose - drug effects | Gene Expression Regulation - drug effects | Eating - drug effects | Patch-Clamp Techniques | Animals | Signal Transduction - drug effects | Receptor, Insulin - metabolism | Mice | Ventromedial Hypothalamic Nucleus - cytology | In Vitro Techniques | Injections, Intraventricular - methods | Obesity | Receptors | Neurons | Physiological aspects | Research | Health aspects | Insulin | Ketogenic diet | Risk factors
Journal Article
Frontiers in immunology, ISSN 1664-3224, 05/2018, Volume 9, Issue MAY, p. 1167
.... To examine whether CRP interferes with leptin action, mediated through its cell surface receptor, docking studies of CRP with the extracellular domain of the leptin receptor were done employing bioinformatics tools... 
Monomeric C-reactive protein | Obesity | Protein-protein docking | Leptin receptor | Leptin | C-reactive protein | Physiological aspects | Development and progression | Genetic aspects | Research | monomeric C-reactive protein | protein–protein docking | leptin | leptin receptor | obesity
Journal Article