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Publication DateDiabetes, ISSN 0012-1797, 12/2008, Volume 57, Issue 12, pp. 3258 - 3266
OBJECTIVE-White adipose tissue is a critical regulator of whole-body glucose metabolism. Preadipocyte factor-1 (Pref-1) is a secreted protein that inhibits...
DIABETES-MELLITUS | SKELETAL-MUSCLE | PROTEIN-KINASE-C | PHOSPHATIDYLINOSITOL 3-KINASE ACTIVITY | GENE | INHIBITS ADIPOCYTE DIFFERENTIATION | MOUSE MODEL | ENDOCRINOLOGY & METABOLISM | CONGENITAL GENERALIZED LIPODYSTROPHY | HEPATIC STEATOSIS | ADIPOSE-TISSUE | Dietary Fats - metabolism | Glucose Tolerance Test | Insulin - physiology | Intercellular Signaling Peptides and Proteins - genetics | Mice, Transgenic | Obesity - physiopathology | Lipodystrophy, Familial Partial - genetics | Adiponectin - physiology | Recombinant Fusion Proteins - metabolism | Lipodystrophy, Familial Partial - physiopathology | Intercellular Signaling Peptides and Proteins - physiology | Leptin - physiology | Animals | Insulin Resistance - physiology | Obesity - etiology | Mice | Glucose Clamp Technique | Blood Glucose - metabolism | Body Composition - physiology | Disease Models, Animal | Type 2 diabetes | Adipose tissues | Evaluation | Obesity | Complications and side effects | Causes of | Insulin resistance | Development and progression | Lipodystrophy | Models | Genetic aspects | Cell differentiation | Obesity Studies
DIABETES-MELLITUS | SKELETAL-MUSCLE | PROTEIN-KINASE-C | PHOSPHATIDYLINOSITOL 3-KINASE ACTIVITY | GENE | INHIBITS ADIPOCYTE DIFFERENTIATION | MOUSE MODEL | ENDOCRINOLOGY & METABOLISM | CONGENITAL GENERALIZED LIPODYSTROPHY | HEPATIC STEATOSIS | ADIPOSE-TISSUE | Dietary Fats - metabolism | Glucose Tolerance Test | Insulin - physiology | Intercellular Signaling Peptides and Proteins - genetics | Mice, Transgenic | Obesity - physiopathology | Lipodystrophy, Familial Partial - genetics | Adiponectin - physiology | Recombinant Fusion Proteins - metabolism | Lipodystrophy, Familial Partial - physiopathology | Intercellular Signaling Peptides and Proteins - physiology | Leptin - physiology | Animals | Insulin Resistance - physiology | Obesity - etiology | Mice | Glucose Clamp Technique | Blood Glucose - metabolism | Body Composition - physiology | Disease Models, Animal | Type 2 diabetes | Adipose tissues | Evaluation | Obesity | Complications and side effects | Causes of | Insulin resistance | Development and progression | Lipodystrophy | Models | Genetic aspects | Cell differentiation | Obesity Studies
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Loading RightsMolecular Medicine, ISSN 1076-1551, 11/2008, Volume 14, Issue 11-12, pp. 741 - 751
Obesity is associated with on array of health problems in adult and pediatric populations. Understanding the pathogenesis of obesity and its metabolic sequelae...
POLYCYSTIC-OVARY-SYNDROME | MEDICINE, RESEARCH & EXPERIMENTAL | RETINOL-BINDING PROTEIN-4 | MESSENGER-RNA EXPRESSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | PLASMA VISFATIN CONCENTRATIONS | TUMOR-NECROSIS-FACTOR | HUMAN ADIPOSE-TISSUE | COMPLEMENT-RELATED PROTEIN | FATTY-ACID OXIDATION | COLONY-ENHANCING FACTOR | TYPE-2 DIABETES-MELLITUS | Resistin - metabolism | Humans | Leptin - metabolism | Adipokines - metabolism | Retinol-Binding Proteins, Plasma - physiology | Leptin - physiology | Resistin - physiology | Animals | Nicotinamide Phosphoribosyltransferase - metabolism | Insulin Resistance - physiology | Interleukin-6 - physiology | Retinol-Binding Proteins, Plasma - metabolism | Adipokines - physiology | Interleukin-6 - metabolism | Nicotinamide Phosphoribosyltransferase - physiology | Review
POLYCYSTIC-OVARY-SYNDROME | MEDICINE, RESEARCH & EXPERIMENTAL | RETINOL-BINDING PROTEIN-4 | MESSENGER-RNA EXPRESSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | PLASMA VISFATIN CONCENTRATIONS | TUMOR-NECROSIS-FACTOR | HUMAN ADIPOSE-TISSUE | COMPLEMENT-RELATED PROTEIN | FATTY-ACID OXIDATION | COLONY-ENHANCING FACTOR | TYPE-2 DIABETES-MELLITUS | Resistin - metabolism | Humans | Leptin - metabolism | Adipokines - metabolism | Retinol-Binding Proteins, Plasma - physiology | Leptin - physiology | Resistin - physiology | Animals | Nicotinamide Phosphoribosyltransferase - metabolism | Insulin Resistance - physiology | Interleukin-6 - physiology | Retinol-Binding Proteins, Plasma - metabolism | Adipokines - physiology | Interleukin-6 - metabolism | Nicotinamide Phosphoribosyltransferase - physiology | Review
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Loading RightsJournal of the American College of Cardiology, ISSN 0735-1097, 10/2008, Volume 52, Issue 15, pp. 1201 - 1210
Leptin is an adipocyte-derived hormone and cytokine that regulates energy balance through a wide range of functions, including several that are important to...
atherosclerosis | cardiovascular disease | leptin resistance | inflammation | obesity | C-REACTIVE PROTEIN | CARDIAC & CARDIOVASCULAR SYSTEMS | MYOCARDIAL-INFARCTION | WEIGHT-LOSS | NECROSIS-FACTOR-ALPHA | SERUM LEPTIN | DIET-INDUCED OBESITY | BLOOD-PRESSURE | DIABETES-MELLITUS | APPARENTLY HEALTHY-MEN | PLASMA LEPTIN | Leptin - physiology | Cardiovascular Diseases - etiology | Animals | Cardiovascular Diseases - metabolism | Humans | Obesity - physiopathology | Inflammation | Obesity - metabolism | Obesity | Insulin resistance | Weight control | Mutation | Rodents
atherosclerosis | cardiovascular disease | leptin resistance | inflammation | obesity | C-REACTIVE PROTEIN | CARDIAC & CARDIOVASCULAR SYSTEMS | MYOCARDIAL-INFARCTION | WEIGHT-LOSS | NECROSIS-FACTOR-ALPHA | SERUM LEPTIN | DIET-INDUCED OBESITY | BLOOD-PRESSURE | DIABETES-MELLITUS | APPARENTLY HEALTHY-MEN | PLASMA LEPTIN | Leptin - physiology | Cardiovascular Diseases - etiology | Animals | Cardiovascular Diseases - metabolism | Humans | Obesity - physiopathology | Inflammation | Obesity - metabolism | Obesity | Insulin resistance | Weight control | Mutation | Rodents
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Loading RightsAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology, ISSN 0363-6119, 09/2013, Volume 305, Issue 6, pp. R566 - R581
In addition to effects on appetite and metabolism, leptin influences many neuroendocrine and physiological systems, including the sympathetic nervous system....
Blood pressure | Adipose tissue | Renin-angiotensin system | Renal | Sympathetic | blood pressure | PHYSIOLOGY | sympathetic | HIGH-FAT DIET | adipose tissue | ARCUATE PROOPIOMELANOCORTIN NEURONS | DIET-INDUCED OBESITY | BLOOD-PRESSURE | renal | ENERGY-BALANCE | WHITE ADIPOSE-TISSUE | CORONARY ENDOTHELIAL DYSFUNCTION | SYMPATHETIC-NERVE ACTIVITY | BARDET-BIEDL-SYNDROME | renin-angiotensin system | Brain - metabolism | Animals | Obesity - complications | Humans | Leptin - metabolism | Myocardium - metabolism | Sympathetic Nervous System - metabolism | Hypertension - etiology | Hypertension - metabolism | Obesity - metabolism | Physiological aspects | Nervous system, Sympathetic | Obesity | Complications and side effects | Health aspects | Leptin | Carl Ludwig Distinguished Lectureship Award from the Neural Control and Autonomic Regulation (NCAR) Section, 2011
Blood pressure | Adipose tissue | Renin-angiotensin system | Renal | Sympathetic | blood pressure | PHYSIOLOGY | sympathetic | HIGH-FAT DIET | adipose tissue | ARCUATE PROOPIOMELANOCORTIN NEURONS | DIET-INDUCED OBESITY | BLOOD-PRESSURE | renal | ENERGY-BALANCE | WHITE ADIPOSE-TISSUE | CORONARY ENDOTHELIAL DYSFUNCTION | SYMPATHETIC-NERVE ACTIVITY | BARDET-BIEDL-SYNDROME | renin-angiotensin system | Brain - metabolism | Animals | Obesity - complications | Humans | Leptin - metabolism | Myocardium - metabolism | Sympathetic Nervous System - metabolism | Hypertension - etiology | Hypertension - metabolism | Obesity - metabolism | Physiological aspects | Nervous system, Sympathetic | Obesity | Complications and side effects | Health aspects | Leptin | Carl Ludwig Distinguished Lectureship Award from the Neural Control and Autonomic Regulation (NCAR) Section, 2011
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Loading RightsFASEB Journal, ISSN 0892-6638, 08/2015, Volume 29, Issue 8, pp. 3182 - 3192
Insulin resistance is a major characteristic of obesity and type 2 diabetes, but the underlying mechanism is unclear. Recent studies have shown a metabolic...
Aging | Glucose metabolism | Capsaicin | Hyperinsulinemic-euglycemic clamp | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRP CHANNELS | LOCOMOTOR-ACTIVITY | PAIN SENSATION | hyperinsulinemic-euglycemic clamp | MICE LACKING | CELL BIOLOGY | CAPSAICIN RECEPTOR | SKELETAL-MUSCLE | BODY-WEIGHT | IMPAIRED NOCICEPTION | ENERGY HOMEOSTASIS | capsaicin | CALCIUM | BIOLOGY | aging | glucose metabolism | Dietary Fats - metabolism | Leptin - metabolism | Mice, Inbred C57BL | Cells, Cultured | Diet, High-Fat - adverse effects | Male | Diabetes Mellitus, Type 2 - metabolism | Obesity - metabolism | TRPV Cation Channels - metabolism | Insulin - metabolism | Animals | Insulin Resistance - physiology | Glucose - metabolism | Adipose Tissue, Brown - metabolism | Mice | Energy Metabolism - physiology | Aging - metabolism | Research Communication
Aging | Glucose metabolism | Capsaicin | Hyperinsulinemic-euglycemic clamp | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRP CHANNELS | LOCOMOTOR-ACTIVITY | PAIN SENSATION | hyperinsulinemic-euglycemic clamp | MICE LACKING | CELL BIOLOGY | CAPSAICIN RECEPTOR | SKELETAL-MUSCLE | BODY-WEIGHT | IMPAIRED NOCICEPTION | ENERGY HOMEOSTASIS | capsaicin | CALCIUM | BIOLOGY | aging | glucose metabolism | Dietary Fats - metabolism | Leptin - metabolism | Mice, Inbred C57BL | Cells, Cultured | Diet, High-Fat - adverse effects | Male | Diabetes Mellitus, Type 2 - metabolism | Obesity - metabolism | TRPV Cation Channels - metabolism | Insulin - metabolism | Animals | Insulin Resistance - physiology | Glucose - metabolism | Adipose Tissue, Brown - metabolism | Mice | Energy Metabolism - physiology | Aging - metabolism | Research Communication
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Loading RightsThe Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 02/2004, Volume 89, Issue 2, pp. 447 - 452
PLASMA ADIPONECTIN CONCENTRATIONS | CONGENITAL LEPTIN DEFICIENCY | TUMOR-NECROSIS-FACTOR | ACTIVATED PROTEIN-KINASE | SUBCUTANEOUS ADIPOSE-TISSUE | FATTY-ACID OXIDATION | ENDOCRINOLOGY & METABOLISM | WEIGHT-LOSS | TNF-ALPHA | TYPE-2 DIABETES-MELLITUS | FACTOR-ALPHA | Animals | Cytokines - metabolism | Insulin Resistance - physiology | Adipocytes - metabolism | Humans
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Loading RightsJournal of Clinical Investigation, ISSN 0021-9738, 2000, Volume 106, Issue 4, pp. 473 - 481
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Loading RightsHepatology, ISSN 0270-9139, 07/2004, Volume 40, Issue 1, pp. 46 - 54
Adiponectin has antilipogenic and anti‐inflammatory effects, while tumor necrosis factor α (TNF‐α) reduces insulin sensitivity and has proinflammatory effects....
NONALCOHOLIC FATTY LIVER | METABOLIC SYNDROME | HOMEOSTASIS MODEL ASSESSMENT | TYPE-2 DIABETIC-PATIENTS | ADIPOSE-SPECIFIC PROTEIN | NECROSIS-FACTOR-ALPHA | PLASMA-PROTEIN | NATURAL-HISTORY | GASTROENTEROLOGY & HEPATOLOGY | FACTOR RECEPTOR | GLUCOSE-TOLERANCE | Tumor Necrosis Factor-alpha - metabolism | Multivariate Analysis | Prognosis | Fatty Liver - pathology | Humans | Middle Aged | Male | Case-Control Studies | Adiponectin | Antigens, CD - metabolism | Necrosis | Leptin - blood | Receptors, Tumor Necrosis Factor, Type II | Adult | Female | Antigens, CD - chemistry | Receptors, Tumor Necrosis Factor - metabolism | Diagnosis, Differential | Hepatitis - etiology | Receptors, Tumor Necrosis Factor - chemistry | Fatty Liver - blood | Fatty Liver - physiopathology | Intercellular Signaling Peptides and Proteins | Insulin Resistance | Solubility | Hepatitis - pathology | Fatty Liver - diagnosis | Proteins - metabolism
NONALCOHOLIC FATTY LIVER | METABOLIC SYNDROME | HOMEOSTASIS MODEL ASSESSMENT | TYPE-2 DIABETIC-PATIENTS | ADIPOSE-SPECIFIC PROTEIN | NECROSIS-FACTOR-ALPHA | PLASMA-PROTEIN | NATURAL-HISTORY | GASTROENTEROLOGY & HEPATOLOGY | FACTOR RECEPTOR | GLUCOSE-TOLERANCE | Tumor Necrosis Factor-alpha - metabolism | Multivariate Analysis | Prognosis | Fatty Liver - pathology | Humans | Middle Aged | Male | Case-Control Studies | Adiponectin | Antigens, CD - metabolism | Necrosis | Leptin - blood | Receptors, Tumor Necrosis Factor, Type II | Adult | Female | Antigens, CD - chemistry | Receptors, Tumor Necrosis Factor - metabolism | Diagnosis, Differential | Hepatitis - etiology | Receptors, Tumor Necrosis Factor - chemistry | Fatty Liver - blood | Fatty Liver - physiopathology | Intercellular Signaling Peptides and Proteins | Insulin Resistance | Solubility | Hepatitis - pathology | Fatty Liver - diagnosis | Proteins - metabolism
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Loading RightsAnnual Review of Physiology, ISSN 0066-4278, 2008, Volume 70, Issue 1, pp. 537 - 556
The adipose tissue-derived hormone leptin acts via its receptor (LRb) in the brain to regulate energy balance and neuroendocrine function. LRb signaling via...
Obesity | VTA | Diabetes | Hypothalamus | PHYSIOLOGY | DOMAIN-CONTAINING PROTEIN | BRAIN REWARD CIRCUITRY | RECEPTORS IN-VITRO | DIET-INDUCED OBESITY | TYROSINE-PHOSPHATASE | BODY-WEIGHT | AGOUTI-RELATED PROTEIN | CENTRAL-NERVOUS-SYSTEM | HYPOTHALAMIC ARCUATE NUCLEUS | diabetes | hypothalamus | obesity | REGULATES FOOD-INTAKE | Animals | Hypothalamus - physiology | Humans | Leptin - metabolism | Obesity - physiopathology | Signal Transduction - physiology | Leptin - genetics | Feedback, Physiological - physiology | Obesity - metabolism | Adipose tissues | Physiological aspects | Genetic aspects | Research | Neuroendocrinology | Leptin
Obesity | VTA | Diabetes | Hypothalamus | PHYSIOLOGY | DOMAIN-CONTAINING PROTEIN | BRAIN REWARD CIRCUITRY | RECEPTORS IN-VITRO | DIET-INDUCED OBESITY | TYROSINE-PHOSPHATASE | BODY-WEIGHT | AGOUTI-RELATED PROTEIN | CENTRAL-NERVOUS-SYSTEM | HYPOTHALAMIC ARCUATE NUCLEUS | diabetes | hypothalamus | obesity | REGULATES FOOD-INTAKE | Animals | Hypothalamus - physiology | Humans | Leptin - metabolism | Obesity - physiopathology | Signal Transduction - physiology | Leptin - genetics | Feedback, Physiological - physiology | Obesity - metabolism | Adipose tissues | Physiological aspects | Genetic aspects | Research | Neuroendocrinology | Leptin
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Loading RightsObesity Reviews, ISSN 1467-7881, 03/2015, Volume 16, Issue 3, pp. 207 - 224
The consumption of Western diets, high in sugar and saturated fat, is a crucial contributor to the alarming incidence of obesity and its associated...
Diet-induced obesity | Research Support, Non-U.S. Gov't | Inflammation | Public Health, Environmental and Occupational Health | Hypothalamus | Endocrinology, Diabetes and Metabolism | Review | Journal Article | Leptin resistance | leptin resistance | Diet‐induced obesity | inflammation | hypothalamus | FOOD-INTAKE | ENDOPLASMIC-RETICULUM STRESS | AUTOPHAGY | SATURATED FATTY-ACIDS | BETA/NF-KAPPA-B | BODY-WEIGHT | INSULIN-RESISTANCE | ENDOCRINOLOGY & METABOLISM | NEURONS | MICE | BRAIN | Oxidative Stress | Signal Transduction | Obesity - complications | Humans | Leptin - metabolism | Rats | Obesity - physiopathology | Hypothalamus - physiopathology | Inflammation - etiology | Obesity - metabolism | Inflammation - metabolism | Animals | Hypothalamus - metabolism | Energy Metabolism | Diet, High-Fat | Mice | Inflammation - physiopathology | Obesity | Brain | Leptin
Diet-induced obesity | Research Support, Non-U.S. Gov't | Inflammation | Public Health, Environmental and Occupational Health | Hypothalamus | Endocrinology, Diabetes and Metabolism | Review | Journal Article | Leptin resistance | leptin resistance | Diet‐induced obesity | inflammation | hypothalamus | FOOD-INTAKE | ENDOPLASMIC-RETICULUM STRESS | AUTOPHAGY | SATURATED FATTY-ACIDS | BETA/NF-KAPPA-B | BODY-WEIGHT | INSULIN-RESISTANCE | ENDOCRINOLOGY & METABOLISM | NEURONS | MICE | BRAIN | Oxidative Stress | Signal Transduction | Obesity - complications | Humans | Leptin - metabolism | Rats | Obesity - physiopathology | Hypothalamus - physiopathology | Inflammation - etiology | Obesity - metabolism | Inflammation - metabolism | Animals | Hypothalamus - metabolism | Energy Metabolism | Diet, High-Fat | Mice | Inflammation - physiopathology | Obesity | Brain | Leptin
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Loading RightsFrontiers of Medicine, ISSN 2095-0217, 6/2013, Volume 7, Issue 2, pp. 207 - 222
Leptin is secreted into the bloodstream by adipocytes and is required for the maintenance of energy homeostasis and body weight. Leptin deficiency or genetic...
leptin resistance | Medicine & Public Health | leptin receptor | leptin signaling | energy balance | Medicine/Public Health, general | obesity | MEDICINE, RESEARCH & EXPERIMENTAL | ONCOLOGY | Animals | Homeostasis - physiology | Humans | Leptin - metabolism | Risk Factors | Neurons - physiology | Signal Transduction - physiology | Mice | Neurons - metabolism | Body Weight - physiology | Energy Metabolism - physiology | Obesity - metabolism | Neural networks | Leptin | Homeostasis
leptin resistance | Medicine & Public Health | leptin receptor | leptin signaling | energy balance | Medicine/Public Health, general | obesity | MEDICINE, RESEARCH & EXPERIMENTAL | ONCOLOGY | Animals | Homeostasis - physiology | Humans | Leptin - metabolism | Risk Factors | Neurons - physiology | Signal Transduction - physiology | Mice | Neurons - metabolism | Body Weight - physiology | Energy Metabolism - physiology | Obesity - metabolism | Neural networks | Leptin | Homeostasis
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