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leucascandrolide-a (126) 126
chemistry, organic (102) 102
stereoselective-synthesis (38) 38
chemistry, multidisciplinary (37) 37
diastereoselective synthesis (37) 37
stereoisomerism (34) 34
index medicus (33) 33
prins cyclization (31) 31
aldehydes (26) 26
stereocontrolled total-synthesis (25) 25
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macrolides - chemical synthesis (21) 21
natural-products (21) 21
synthesis (21) 21
formal total-synthesis (19) 19
cyclization (18) 18
molecular structure (18) 18
macrolide (17) 17
enantioselective total-synthesis (16) 16
formal synthesis (16) 16
macrolides - chemistry (16) 16
neopeltolide (15) 15
animals (14) 14
article (14) 14
formal total synthesis (14) 14
ring-closing metathesis (14) 14
tetrahydropyranols (14) 14
tetrahydropyrans (14) 14
alcohols (13) 13
catalysis (13) 13
-leucascandrolide-a (12) 12
asymmetric-synthesis (12) 12
chemical properties (12) 12
enantioselective synthesis (12) 12
organic compounds (12) 12
segment (12) 12
sesquiterpenes - chemical synthesis (12) 12
fragment (11) 11
macrolactone (11) 11
catalysts (10) 10
macrolides - pharmacology (10) 10
prins cyclisation (10) 10
tetrahydropyran (10) 10
total synthesis (10) 10
-neopeltolide (9) 9
ketones (9) 9
olefin metathesis (9) 9
pyrans - chemical synthesis (9) 9
reductive cleavage sequence (9) 9
analysis (8) 8
antineoplastic agents - chemical synthesis (8) 8
biological evaluation (8) 8
biological products - chemical synthesis (8) 8
carbonyl-compounds (8) 8
pyrans - chemistry (8) 8
structure (8) 8
-leucascandrolide-a macrolactone (7) 7
absolute-configuration (7) 7
cell proliferation - drug effects (7) 7
construction (7) 7
diels-alder reactions (7) 7
ethers (7) 7
lactones (7) 7
letter (7) 7
molecular conformation (7) 7
organic-synthesis (7) 7
palladium (7) 7
research (7) 7
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allylation (6) 6
antineoplastic agents - chemistry (6) 6
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cell line, tumor (6) 6
conjugate addition (6) 6
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humans (6) 6
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leucascandrolide (6) 6
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aldol addition-reactions (5) 5
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cascade reaction (5) 5
chemical synthesis (5) 5
cyclization reaction (5) 5
efficient (5) 5
macrocycles (5) 5
macrolide-neopeltolide (5) 5
mitsunobu reaction (5) 5
natural-product synthesis (5) 5
oxazoles (5) 5
oxazoles - chemistry (5) 5
oxidation (5) 5
reductive cleavage (5) 5
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tetrahydropyran rings (5) 5
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ORGANIC LETTERS, ISSN 1523-7060, 01/2014, Volume 16, Issue 2, pp. 468 - 471
Asymmetric S-E' reactions of (E)- and (Z)-gamma-substituted-alpha,beta-unsaturated aldehydes have been studied for the stereocontrolled preparation of... 
LEUCASCANDROLIDE-A | FORMAL SYNTHESIS | PHORBOXAZOLE-A | ALLYLATION | CHEMISTRY, ORGANIC
Journal Article
Organic and Biomolecular Chemistry, ISSN 1477-0520, 06/2014, Volume 12, Issue 21, pp. 3323 - 3335
This review focuses on the methodology used for the construction of tetrahydropyran (THP) rings in the synthesis of natural products over the last seven years.... 
CORE | CONJUGATE ADDITION-REACTION | LEUCASCANDROLIDE-A | ABSOLUTE-CONFIGURATION | BIOLOGICAL EVALUATION | CHEMISTRY, ORGANIC | FORMAL TOTAL-SYNTHESIS | MACROLACTONE | STEREOSELECTIVE-SYNTHESIS | CLOSING METATHESIS | (+)-NEOPELTOLIDE
Journal Article
Organic Letters, ISSN 1523-7060, 08/2016, Volume 18, Issue 16, pp. 4092 - 4095
The first total synthesis of the proposed structure of cytotoxic macrolide maltepolide C has been achieved via an E-selective intramolecular Heck cyclization... 
ALCOHOLS | KETONES | CHEMISTRY, ORGANIC | FORMAL TOTAL-SYNTHESIS | AGLYCONE | HECK REACTION | STRUCTURE ELUCIDATION | LEUCASCANDROLIDE
Journal Article
European Journal of Organic Chemistry, ISSN 1434-193X, 03/2013, Volume 2013, Issue 7, pp. 1193 - 1208
Journal Article
Angewandte Chemie (International ed. in English), ISSN 1433-7851, 1/2015, Volume 54, Issue 1, pp. 215 - 220
Mo-, W- and Ru-based complexes that control the stereochemical outcome of olefin metathesis reactions have been recently introduced. However, the complementary... 
olefin metathesis | enantioselective synthesis | synthesis | leucascandrolide A | neopeltolide | catalysis
Journal Article
ORGANIC & BIOMOLECULAR CHEMISTRY, ISSN 1477-0520, 07/2019, Volume 17, Issue 28, pp. 6771 - 6776
Design, synthesis and functional analysis of fluorescent derivatives of neopeltolide, an antiproliferative marine macrolide, are reported herein. Live cell... 
LEUCASCANDROLIDE-A | MACROLIDE | BIOLOGICAL EVALUATION | CHEMISTRY, ORGANIC | FORMAL TOTAL-SYNTHESIS | ENDOPLASMIC-RETICULUM | STEREOSELECTIVE-SYNTHESIS | IDENTIFICATION | ENANTIOSELECTIVE TOTAL-SYNTHESIS | MACROLACTONE CORE | (+)-NEOPELTOLIDE
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 11/2016, Volume 138, Issue 44, pp. 14538 - 14541
Journal Article
ORGANIC LETTERS, ISSN 1523-7060, 02/2016, Volume 18, Issue 3, pp. 608 - 611
BF3 center dot OEt2-mediated one-pot formal (4 + 2) and (5 + 2) stereocontrolled cycloaddition of 4-alkenols 3 and 4 with veratrol affords the respective... 
LEUCASCANDROLIDE-A | ASYMMETRIC-SYNTHESIS | CASCADE REACTIONS | NATURAL-PRODUCTS | BIOLOGICAL EVALUATION | TUBULIN POLYMERIZATION | CHEMISTRY, ORGANIC | FRIEDEL-CRAFTS ALKYLATION | ARYLTETRALIN LIGNANS | TRANSFORMATIONS | PRINS CYCLIZATION
Journal Article
Organic & biomolecular chemistry, ISSN 1477-0520, 06/2014, Volume 12, Issue 21, pp. 3323 - 3335
This review focuses on the methodology used for the construction of tetrahydropyran (THP) rings in the synthesis of natural products over the last seven years.... 
Chemistry, Organic - methods | Biological Products - chemical synthesis | Pyrans - chemical synthesis | Biological Products - chemistry | Oxidation-Reduction | Pyrans - chemistry | Kinetics | Cycloaddition Reaction
Journal Article
Tetrahedron, ISSN 0040-4020, 2009, Volume 65, Issue 52, pp. 10830 - 10836
A series of monodeuterated benzylic and allylic ethers were subjected to oxidative carbon–hydrogen bond cleavage to determine the impact of structural... 
INITIATED CYCLIZATION REACTIONS | LEUCASCANDROLIDE-A | ELECTRON | COMPLEX | HETEROCYCLES | BOND-FORMING REACTIONS | RADICAL CATIONS | REACTIVITY | CHEMISTRY, ORGANIC | POTENTIALS | PRINS CYCLIZATION
Journal Article
Organic Letters, ISSN 1523-7060, 04/2015, Volume 17, Issue 8, pp. 1826 - 1829
A three-step method for the synthesis of 2-(hetero)aryl-5-(trimethylsilylethynyl)oxazoles is described. Easily accessible bis(trimethylsilyl)acetylene and... 
OXAZOLES | CHEMISTRY, ORGANIC | LEUCASCANDROLIDE-A | CINNAMIC-ACIDS | N-NITRENES | C-1 | Oxazoles - chemical synthesis | Molecular Structure | Acrylates - chemistry | Oxazoles - chemistry
Journal Article
CHEMISTRY-A EUROPEAN JOURNAL, ISSN 0947-6539, 04/2018, Volume 24, Issue 19, pp. 4810 - 4814
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 01/2008, Volume 130, Issue 3, pp. 804 - 805
The total synthesis and structural revision of the marine natural product neopeltolide is reported. The key bond-forming step involves a Lewis acid-catalyzed... 
ALCOHOLS | LEUCASCANDROLIDE-A | KETONES | ALDEHYDES | CHEMISTRY, MULTIDISCIPLINARY | Animals | Macrolides - chemical synthesis | Porifera | Antineoplastic Agents - chemical synthesis | Macrolide antibiotics | Research | Molecular structure | Structure | Natural products
Journal Article
Organic Letters, ISSN 1523-7060, 03/2008, Volume 10, Issue 5, pp. 853 - 856
Cyclic thionocarbamates, namely chiral oxazolidinethiones (OZT) and aromatic oxazolinethiones (OXT), were involved, for the first time, in Sonogashira... 
BORONIC ACIDS | LEUCASCANDROLIDE-A | METHODOLOGY | REAGENTS | HETEROCYCLES | NUCLEOSIDES | CHEMISTRY | CHEMISTRY, ORGANIC | INHIBITORS | ACCESS | HETEROAROMATIC THIOETHER
Journal Article
The Journal of Organic Chemistry, ISSN 0022-3263, 12/2016, Volume 81, Issue 24, pp. 12275 - 12290
The synthesis of the C1–C27 fragment of hemicalide, a marine metabolite displaying a unique potent antiproliferative activity, has been accomplished. The... 
LEUCASCANDROLIDE-A | FORMAL SYNTHESIS | CONFIGURATION | CHEMISTRY, ORGANIC | ALDOL REACTIONS | RUTHENIUM | METHYLENATION | OLEFIN METATHESIS | TETRASUBSTITUTED OLEFINS | CATALYSTS | MARINE NATURAL-PRODUCTS | Organic chemistry | Chemical Sciences
Journal Article
Organic Letters, ISSN 1523-7060, 09/2016, Volume 18, Issue 18, pp. 4534 - 4537
A convergent synthesis of one isomer of the C14–C29 fragment of mirabalin is disclosed. The key steps include a Marshall allenylation, a Mukaiyama aldol... 
LEUCASCANDROLIDE-A | ABSOLUTE STEREOSTRUCTURE | ANTITUMOR MACROLIDE | POTENT CYTOTOXIC MACROLIDE | CATALYZED ASYMMETRIC HYDROGENATIONS | CHEMISTRY, ORGANIC | SPONGE THEONELLA-SWINHOEI | DIMERIC MACROLIDE | OXOCARBENIUM IONS | NEOSIPHONIA-SUPERSTES | FORMAL TOTAL SYNTHESIS
Journal Article
ORGANIC & BIOMOLECULAR CHEMISTRY, ISSN 1477-0520, 2016, Volume 14, Issue 28, pp. 6840 - 6852
6-Substituted-2H-dihydropyran-4-one products of the Maitland-Japp reaction have been converted into tetrahydropyrans containing uncommon substitution patterns.... 
HIGHLY SUBSTITUTED TETRAHYDROPYRAN-4-ONES | LEUCASCANDROLIDE-A | DIELS-ALDER REACTIONS | DIASTEREOSELECTIVE SYNTHESIS | MICHAEL | CONSTRUCTION | CHEMISTRY, ORGANIC | STEREOSELECTIVE-SYNTHESIS | FUNCTIONALIZED TETRAHYDROPYRAN-4-ONES | CONJUGATE ADDITION | PRINS CYCLIZATION
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 2006, Volume 47, Issue 1, pp. 47 - 49
Journal Article
Organic Letters, ISSN 1523-7060, 02/2015, Volume 17, Issue 4, pp. 816 - 819
A diastereomer of wortmannilactone C has been synthesized according to a convergent and versatile strategy from tert-butyl 3-hydroxy­propanoate and ethyl... 
ALCOHOLS | ESTER | CORE | LEUCASCANDROLIDE-A | ABSOLUTE-CONFIGURATION | FRAGMENT | CHEMISTRY, ORGANIC | MACROLIDES | O-METHYLMANDELATE | CARBOXYLIC-ACIDS | Molecular Structure | Macrolides - chemistry | Macrolides - chemical synthesis | Stereoisomerism | Lactones - chemistry
Journal Article
Journal of Molecular Structure, ISSN 0022-2860, 03/2018, Volume 1156, pp. 684 - 689
This article describes the stereodivergent formation of 2,4,6-triaryl-tetrahydro- -pyrans from 1,3,5-triarylpentane-1,5-diols in the presence of the catalytic... 
Heterocycles | 1,3,5-Triarylpentane-1,5-diols | Cyclodehydration | Diastereoselectivity | 2,4,6-Triaryltetrahydro-2H-pyrans | LEUCASCANDROLIDE-A | NATURAL-PRODUCTS | CHEMISTRY, PHYSICAL | 6-MEMBERED OXYGENATED HETEROCYCLES | ALDEHYDES | PRINS CYCLIZATION | TETRAHYDROPYRAN RINGS | BLEPHAROCALYXINS C-E | CHIRALITY | ALPINIA-BLEPHAROCALYX | DIARYLHEPTANOIDS
Journal Article
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