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The EMBO Journal, ISSN 0261-4189, 10/2014, Volume 33, Issue 20, pp. 2314 - 2331
Journal Article
Neuron (Cambridge, Mass.), ISSN 0896-6273, 2009, Volume 64, Issue 6, pp. 807 - 827
Journal Article
Journal Article
Journal Article
Journal of allergy and clinical immunology, ISSN 0091-6749, 2017, Volume 140, Issue 6, pp. 1651 - 1659.e1
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2015, Volume 290, Issue 32, pp. 19433 - 19444
Journal Article
Journal of allergy and clinical immunology, ISSN 0091-6749, 12/2018, Volume 142, Issue 6, pp. 1956 - 1967.e6
... receptor family CARD-containing 4 protein (NLRC4). Here we investigate the mechanism by which a novel mutation in the leucine-rich repeat (LRR) domain of NLRC4 (c.G1965C, p.W655C... 
Autoinflammatory disease | periodic fever syndrome | inflammasome | IL-18 | macrophage activation syndrome | Nod-like receptor | NLRC4 | IPAF | RECRUITMENT | PROTEIN | NLRP3 INFLAMMASOME | IMMUNOLOGY | IDENTIFICATION | SPHINGOMONAS-PAUCIMOBILIS | ASC | INNATE IMMUNE DETECTION | ALLERGY | BACTERIAL LIGANDS | CASPASE-1 ACTIVATION | Calcium-Binding Proteins - chemistry | CARD Signaling Adaptor Proteins - immunology | Inflammasomes - chemistry | Humans | THP-1 Cells | Infant | Male | Leucine | Inflammasomes - genetics | Syndrome | CARD Signaling Adaptor Proteins - genetics | Macrophage Activation | Calcium-Binding Proteins - immunology | Inflammasomes - immunology | HEK293 Cells | CARD Signaling Adaptor Proteins - chemistry | Protein Domains | Female | Infant, Newborn | Calcium-Binding Proteins - genetics | Oligomers | Analysis | NOD, Nucleotide-binding oligomerization domain | IL-18BP, IL-18 binding protein | CARD, Caspase activation and recruitment domain | CRISPR, Clustered Regularly Interspaced Short Palindromic Repeats | HD, Hinge domain | ASC, Apoptosis-associated Speck-like protein containing a caspase recruitment domain | NLRC4, NOD-like receptor family CARD-containing 4 protein | NLRC4-AID, NLRC4-associated autoinflammatory disorder | MAS, Macrophage activation syndrome | CSF, Cerebrospinal fluid | NAIP, NLR family apoptosis inhibitor protein | WT, Wild-type | KO, Knockout | AIFEC, Autoinflammation with infantile enterocolitis | NBD, Nucleotide-binding domain | T3SS, Type 3 secretion system | NLRP3, NOD-like receptor family, pyrin domain containing 3 | LRR, Leucine-rich repeat
Journal Article
Nature structural & molecular biology, ISSN 1545-9985, 2015, Volume 22, Issue 2, pp. 167 - 174
... the creation of high-affinity protein reagents and therapeutics. Here we describe a general approach to control the shape of the binding surface on repeat-protein scaffolds and apply it to leucine-rich-repeat proteins... 
DOMAIN | LIGAND-BINDING | RECOGNITION | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ALPHA | LEUCINE-RICH REPEAT | TLR4-MD-2 COMPLEX | SHAPE COMPLEMENTARITY | CELL BIOLOGY | BIOPHYSICS | STRUCTURAL BASIS | AFFINITY | Crystallography, X-Ray | Protein Conformation | Proteins - chemistry | Protein Engineering - methods | Proteins | Physiological aspects | Research | Structure | Protein binding | Molecular biology | Binding sites | Crystal structure
Journal Article
Journal Article