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05/2008
Objective: Leukocyte adhesion deficiency (LAD) disorders, LAD-1 and LAD-2 are rare disease of leukocyte function. LAD-1 results from a lock of leukocyte cell... 
Leukocytosis | Integrin | Immunodefficiency | Leukocyte adhesion
Web Resource
Frontiers in Bioscience - Landmark, ISSN 1093-9946, 01/2018, Volume 23, Issue 4, pp. 782 - 795
Journal Article
Journal of cell science, ISSN 0021-9533, 11/2018, Volume 131, Issue 22, p. jcs218214
Integrins are α/β heterodimers that interconvert between inactive and active states. In the active state the α/β cytoplasmic domains recruit... 
Leukocyte adhesion | Integrin inactivator | Integrin interactome | LCP1 | Proteomics
Journal Article
CANCER CELL, ISSN 1535-6108, 06/2011, Volume 19, Issue 6, pp. 715 - 727
Tumor inflammation promotes angiogenesis, immunosuppression, and tumor growth, but the mechanisms controlling inflammatory cell recruitment to tumors are not... 
REGULATORY SUBUNIT | RECRUITMENT | TGF-BETA | ANGIOGENESIS | ONCOLOGY | ALPHA-4 INTEGRINS | LEUKOCYTE ADHESION | SUPPRESSOR-CELLS | PHOSPHOINOSITIDE 3-KINASE | RAS BINDING | CANCER | CELL BIOLOGY
Journal Article
DETECCIÓN DE UN DEFECTO GENÉTICO EN BOVINOS MEDIANTE UNA PRUEBA DE ADN. (Detection of a bovine genetic defect by a DNA probe), 12/2001
The adhesion deficiency of bovine leukocytes to antigens, known as BLAD (bovine leukocyte adhesion deficiency), is a hereditary genetic disease which is lethal... 
bovine leukocyte adhesion deficiency, BLAD, PCR, Holstein breed, RFLP, disease | deficiencia de adhesión leucocitaria bovina, BLAD, PCR, RFLP, Holstein, enfermedad
Journal
SCIENCE SIGNALING, ISSN 1945-0877, 08/2015, Volume 8, Issue 389
The sphingosine 1-phosphate receptor 1 (S1P(1)) is abundant in endothelial cells, where it regulates vascular development and microvascular barrier function.... 
ACTIVATION | PROTEIN-COUPLED RECEPTOR | SPHINGOSINE-1-PHOSPHATE ANALOG | FTY720 | BIOCHEMISTRY & MOLECULAR BIOLOGY | CARDIOVASCULAR-DISEASE | ATHEROSCLEROSIS | TRAFFICKING | LEUKOCYTE ADHESION | DEFICIENT MICE | NF-KAPPA-B | CELL BIOLOGY
Journal Article
2009, 1st ed., Current topics in membranes, ISBN 0123749093, Volume 64.
Web Resource
Journal of Immunology, ISSN 0022-1767, 07/2009, Volume 183, Issue 2, pp. 1480 - 1487
Shiga toxin has the potential to induce expression of inflammation-associated genes, although the underlying mechanisms are not well understood. We examined... 
CROSS-TALK | CELLS | ER STRESS | HEMOLYTIC UREMIC SYNDROME | DOWN-REGULATION | SHIGA TOXIN | ENDOPLASMIC-RETICULUM STRESS | LEUKOCYTE ADHESION | IMMUNOLOGY | UP-REGULATION | TOXIGENIC ESCHERICHIA-COLI
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 04/2015, Volume 6
Myeloid-related proteins (MRPs) 8 and 14 are cytosolic proteins secreted from myeloid cells as proinflammatory mediators. Currently, the functional role of... 
PAQUINIMOD ABR-215757 | INFLAMMATION IN-VIVO | LEUKOCYTE-ADHESION | MULTIDISCIPLINARY SCIENCES | E-SELECTIN | ENDOTHELIAL-CELLS | RECEPTOR | MRP14 | S100 PROTEINS | DISEASE-ACTIVITY | PROTEIN COMPLEX
Journal Article
BLOOD, ISSN 0006-4971, 04/2010, Volume 115, Issue 15, pp. 3118 - 3127
Selectins mediate leukocyte rolling, trigger beta(2)-integrin activation, and promote leukocyte recruitment into inflamed tissue. E-selectin binding to... 
SIGNAL-TRANSDUCTION | PROTEIN | B-CELL | LYMPHOCYTE DEVELOPMENT | INFLAMMATORY RESPONSES | IN-VIVO | PSGL-1 | LEUKOCYTE ADHESION | HEMATOLOGY | PHOSPHOINOSITIDE 3-KINASE | TEC FAMILY KINASES
Journal Article
Blood, ISSN 0006-4971, 09/2018, Volume 132, Issue 13, pp. 1426 - 1437
Inflammation is a major contributor to deep vein thrombosis (DVT). Flow restriction of the inferior vena cava (IVC) in mice induces DVT like that in humans. In... 
ISCHEMIA-REPERFUSION INJURY | RECRUITMENT | INTEGRIN ACTIVATION | INFLAMMATION | IN-VIVO | P-SELECTIN | VENOUS THROMBOSIS | LEUKOCYTE ADHESION | EXTRACELLULAR TRAPS | HEMATOLOGY | MOUSE MODELS
Journal Article
CURRENT BIOLOGY, ISSN 0960-9822, 11/2013, Volume 23, Issue 22, pp. 2288 - 2295
Increased ligand binding to cellular integrins ("activation") plays important roles in processes such as development, cell migration, extracellular matrix... 
IMMOBILIZED FIBRINOGEN | MEMBRANE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PLECKSTRIN HOMOLOGY DOMAIN | RECEPTOR | TALIN | LEUKOCYTE ADHESION | DISTINCT ROLES | BINDING | FOCAL ADHESIONS | BETA | CELL BIOLOGY
Journal Article
PLOS ONE, ISSN 1932-6203, 04/2013, Volume 8, Issue 4
Tumor inflammation, the recruitment of myeloid lineage cells into the tumor microenvironment, promotes angiogenesis, immunosuppression and metastasis.... 
RAP | RECRUITMENT | ANGIOGENESIS | MACROPHAGES | MULTIDISCIPLINARY SCIENCES | MICE | LEUKOCYTE ADHESION | SUPPRESSOR-CELLS | GERANYLGERANYL | CANCER | PROGRESSION
Journal Article
Nature Nanotechnology, ISSN 1748-3387, 2014, Volume 9, Issue 8, pp. 648 - 655
Journal Article
Blood, ISSN 0006-4971, 12/2018, Volume 132, Issue 26, pp. 2754 - 2762
Targeting Talin1 to the plasma membrane is a crucial step in integrin activation, which in leukocytes is mediated by a Rap1/RIAM/Talin1 pathway, whereas in... 
DOMAIN | ACTIVATION | RAP1 | EFFECTOR RIAM | LEUKOCYTE ADHESION DEFICIENCY | TALIN | SECRETION | HEMATOLOGY | BINDING | Index Medicus | Abridged Index Medicus
Journal Article
BLOOD, ISSN 0006-4971, 05/2014, Volume 123, Issue 20, pp. 3156 - 3165
ADAP is a hematopoietic-restricted adapter protein that promotes integrin activation and is a carrier for other adapter proteins, Src kinase-associated... 
ALPHA(IIB)BETA | CYTOSKELETON | JURKAT T-CELLS | AFFINITY | STABILIZATION | FYN | MECHANISMS | LEUKOCYTE ADHESION | HEMATOLOGY | DEFICIENCY-III | IB-IX-V
Journal Article
HAEMATOLOGICA, ISSN 0390-6078, 01/2019, Volume 104, Issue 1, pp. 70 - 81
Thrombosis is the main cause of morbidity and mortality in patients with JAK2(V617F) myeloproliferative neoplasms. Recent studies have reported the presence of... 
POLYCYTHEMIA-VERA | ACTIVATION | MUTATION | HYDROXYUREA | TYROSINE KINASE JAK2 | VENOUS THROMBOSIS | NEUTROPHILS | LEUKOCYTE ADHESION | ESSENTIAL THROMBOCYTHEMIA | HEMATOLOGY | JAK2V617F
Journal Article
Archives of Iranian Medicine, ISSN 1029-2977, 07/2018, Volume 21, Issue 7, pp. 296 - 301
Journal Article
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