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JOURNAL OF EXPERIMENTAL MEDICINE, ISSN 0022-1007, 04/2006, Volume 203, Issue 4, pp. 837 - 842
Neutrophils serve as a vanguard of the acute innate immune response to invading pathogens. Neutrophils are also abundant at sites of autoimmune inflammation,... 
RHEUMATOID-ARTHRITIS | MEDICINE, RESEARCH & EXPERIMENTAL | COLLAGEN-INDUCED ARTHRITIS | SERUM TRANSFER MODEL | CYSTEINYL LEUKOTRIENES | INFLAMMATORY RESPONSES | SYNOVIAL-FLUID | MAST-CELLS | DEFICIENT MICE | 5-LIPOXYGENASE | IMMUNOLOGY | AUTOIMMUNE-DISEASE
Journal Article
JOURNAL OF LEUKOCYTE BIOLOGY, ISSN 0741-5400, 06/2019, Volume 105, Issue 6, pp. 1131 - 1142
Leukotriene B-4 (LTB4) plays a prominent role in innate immunity as it induces phagocyte recruitment, the release of antimicrobial effectors, and as it... 
METABOLITES | host defense | lipoxin A | eosinophils | RANDOMIZED DOUBLE-BLIND | ARACHIDONIC-ACID | IMMUNOLOGY | RECEPTOR ANTAGONIST | resolvin E-1 | CELL BIOLOGY | POLYMORPHONUCLEAR GRANULOCYTES | IN-VITRO | INHIBITION | leukotriene B-4 | PLUS PLACEBO | CYSTIC-FIBROSIS | HEMATOLOGY | 5-oxo-ETE | neutrophils
Journal Article
CARDIOVASCULAR RESEARCH, ISSN 0008-6363, 10/2018, Volume 114, Issue 12, pp. 1656 - 1666
Aims Both leukotrienes and neutrophils have been linked to plaque destabilization. Despite being evoked, the role of leukotriene B-4 (LTB4) in neutrophil... 
ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | MYOCARDIAL-INFARCTION | Neutrophils | RISK | Plaque destabilization | SYSTEMIC INFLAMMATION | Leukotrienes | Atherosclerosis | ATHEROSCLEROSIS DEVELOPMENT | Lipopolysaccharide | CARDIOVASCULAR-DISEASE | SMOOTH-MUSCLE-CELLS | INTRAPLAQUE HEMORRHAGE | 5-LIPOXYGENASE | EXPRESSION
Journal Article
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, ISSN 0003-9861, 01/2001, Volume 385, Issue 2, pp. 231 - 241
Leukotriene B-4 (LTB4) is known as one of the most potent chemoattractants and activators of leukocytes and is involved in inflammatory diseases. Enzymes... 
A HYDROLASE | CYTOSOLIC PHOSPHOLIPASE A | BIOCHEMISTRY & MOLECULAR BIOLOGY | ACTIVATED RECEPTOR-ALPHA | BLT | 5-LIPOXYGENASE-ACTIVATING PROTEIN | HUMAN POLYMORPHONUCLEAR LEUKOCYTES | AMINO-ACID SEQUENCE | BIOPHYSICS | PPAR | OMEGA-HYDROXYLASE | leukotriene B-4 | LTB4 | GPCR | MOLECULAR-CLONING | CDNA CLONING | ACUTE INFLAMMATORY RESPONSES
Journal Article
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, ISSN 1073-449X, 09/2017, Volume 196, Issue 6, pp. 713 - 726
Journal Article
ACTA DERMATO-VENEREOLOGICA, ISSN 0001-5555, 09/2017, Volume 97, Issue 8, pp. 922 - 927
A recent study suggests that interleukin-31 (IL-31) exerts its effect via indirect mechanisms rather than through direct stimulation of cutaneous nerves.... 
itch | ANTAGONIST | scratching | PRURITUS | dorsal root ganglia | RECEPTOR | interleukin-31 | keratinocytes | NC/NGA MICE | IL-31 | DERMATOLOGY | SCRATCHING BEHAVIOR | ATOPIC-DERMATITIS | leukotriene B-4 | SKIN | HISTAMINE | T-CELLS
Journal Article
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 10/2005, Volume 175, Issue 7, pp. 4217 - 4225
Bronchial asthma is an increasingly common disorder that remains poorly understood and difficult to manage. The disease is characterized by airway... 
HYPERREACTIVITY | RECRUITMENT | LEUKOTRIENE B-4 RECEPTOR | INFLAMMATION | ALLERGIC-ASTHMA | INTERLEUKIN-13 | EOSINOPHIL ACCUMULATION | MICE | MODEL | IMMUNOLOGY | CD8(+) T-CELLS
Journal Article
Hypertension, ISSN 0194-911X, 12/2015, Volume 66, Issue 6, pp. 1227 - 1239
A recent study demonstrated a significant role for leukotriene B-4 (LTB4) causing pulmonary vascular remodeling in pulmonary arterial hypertension. LTB4 was... 
fibroblasts | pulmonary artery | inflammation | NADPH oxidase | p38 mitogen-activated protein kinases | leukotriene B | vascular remodeling | PROTEIN | MANAGEMENT | MYOCARDIAL-INFARCTION | P38 MAPK | INJURY | SYSTEMIC-SCLEROSIS | PROLIFERATIVE RESPONSE | KINASE INHIBITION | PATHWAY | leukotriene B-4 | PERIPHERAL VASCULAR DISEASE | 5-LIPOXYGENASE
Journal Article
JOURNAL OF ANATOMY, ISSN 0021-8782, 03/2015, Volume 226, Issue 3, pp. 268 - 277
Leukotriene B-4 (LTB4) is a potent chemoattractant associated with the development of osteoarthritis (OA), while its receptors BLT1 and BLT2 have been found in... 
KNEE | chondrocytes | osteoarthritis | INTERLEUKIN-1-BETA | ANATOMY & MORPHOLOGY | cartilage | CYCLOOXYGENASE | EICOSANOID PATHWAYS | CARTILAGE HOMEOSTASIS | inflammation | BLT2 | OSTEOBLASTS | BLT1 | leukotriene B-4 | EXPLANTS
Journal Article
JOURNAL OF EXPERIMENTAL MEDICINE, ISSN 0022-1007, 08/2000, Volume 192, Issue 3, pp. 421 - 431
Leukotriene B-4 (LTB4) is a potent chemoattractant and activator of both granulocytes and macrophages. The actions of LTB4 appear to be mediated by a specific... 
MEDICINE, RESEARCH & EXPERIMENTAL | COLLAGEN-INDUCED ARTHRITIS | CYTOSOLIC PHOSPHOLIPASE A | POLYMORPHONUCLEAR LEUKOCYTES | leukotriene | BLT | IMMUNOLOGY | gene cluster | HUMAN INTERLEUKIN-8 RECEPTOR | low-affinity receptor | IN-VITRO | HUMAN-NEUTROPHILS | PROTEIN-COUPLED RECEPTOR | OMEGA-HYDROXYLASE | PHARMACOLOGICAL PROFILE | MOLECULAR-CLONING | cloning
Journal Article
FRONTIERS IN IMMUNOLOGY, ISSN 1664-3224, 01/2018, Volume 8
Aspergillus fumigatus is a mold that causes severe pulmonary infections. Our knowledge of how immune competent hosts maintain control of fungal infections... 
FUNGAL-INFECTION | LUNG | CHRONIC GRANULOMATOUS-DISEASE | eosinophils | IMMUNOLOGY | leukotrienes | NEUTROPHIL RECRUITMENT | respiratory tract infections | fungal infection | CANDIDA-ALBICANS | IMMUNE-RESPONSES | INFLAMMATION | leukotriene B-4 | PARACOCCIDIOIDOMYCOSIS | Aspergillus fumigatus | hypoxia inducible factor-1 alpha | neutrophils | FUMIGATUS | INNATE IMMUNITY
Journal Article
EUROPEAN JOURNAL OF PHARMACOLOGY, ISSN 0014-2999, 03/2019, Volume 847, pp. 19 - 25
Chronic renal failure (CRF) is a progressive disease with severe pruritus and dry skin as the major symptoms. However, the mechanisms of CRF-induced pruritus... 
PROTEINASE-ACTIVATED RECEPTOR-2 | CELLS | beta 2-microglobulin | Chronic renal failure | ONDANSETRON | MODEL | Leukotriene B-4 | SCRATCHING BEHAVIOR | Itch | INJECTION | DOUBLE-BLIND | Thromboxane A | UREMIC PRURITUS | HEMODIALYSIS | PHARMACOLOGY & PHARMACY | SKIN
Journal Article
PHARMACOLOGICAL REPORTS, ISSN 1734-1140, 08/2014, Volume 66, Issue 4, pp. 699 - 703
Background: Proteinase-activated receptor-2 (PAR(2)) is involved in dermatophyte-induced scratching and leukotriene B-4 (LTB4) release from keratinocytes. We... 
RESPONSES | Itch | PAIN | Proteinase-activated receptor 2 | METABOLISM | 5-Lipoxygenase | MOUSE | RECEPTOR | PHARMACOLOGY & PHARMACY | SKIN | Dermatophyte | Leukotriene B-4
Journal Article
EUROPEAN RESPIRATORY JOURNAL, ISSN 0903-1936, 07/2008, Volume 32, Issue 1, pp. 113 - 120
Severity of oxygen desaturation is predictive of early atherosclerosis in obstructive sleep apnoea (OSA). Leukotriene (LT)B-4 is a lipid mediator involved in... 
atherosclerosis | polymorphonuclear cells | OXIDATIVE STRESS | sleep apnoea | NEUTROPHILS | RISK | 5-LIPOXYGENASE-ACTIVATING PROTEIN | ARACHIDONIC-ACID | STROKE | EARLY SIGNS | RESPIRATORY SYSTEM | leukotriene B-4 | POSITIVE AIRWAY PRESSURE | EXPRESSION | THICKNESS
Journal Article
ALLERGY, ISSN 0105-4538, 11/2005, Volume 60, Issue 11, pp. 1361 - 1369
Background: Acetylcholine (ACh) plays an important role in smooth muscle contraction and in the development of airway narrowing; preliminary evidences led us... 
CHRONIC-BRONCHITIS | CELLS | ACTIVATED PROTEIN-KINASE | ACETYLCHOLINE | SUBTYPES | MACROPHAGES | ASTHMATIC SUBJECTS | IMMUNOLOGY | muscarinic receptors | ERK1/2 | OBSTRUCTIVE PULMONARY-DISEASE | CHEMOTACTIC ACTIVITY | ALLERGY | induced sputum | leukotriene B-4 | EXPRESSION | chronic obstructive pulmonary disease
Journal Article
CHEST, ISSN 0012-3692, 04/2003, Volume 123, Issue 4, pp. 1240 - 1247
Study objectives: Neutrophilic inflammation is a major feature of COPD. Several factors in bronchial secretions have been identified as chemoattractants for... 
CYTOKINES | CARDIAC & CARDIOVASCULAR SYSTEMS | AIRWAY INFLAMMATION | MARKERS | human neutrophils | OBSTRUCTIVE PULMONARY-DISEASE | IN-VITRO | FLUTICASONE PROPIONATE | RESPIRATORY SYSTEM | CHEMOATTRACTANT | induced sputum | leukotriene B-4 | EXACERBATIONS | TNF-ALPHA | INHIBITORS | chemotaxis | COPD | interleukin 8
Journal Article
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ISSN 0006-291X, 12/2012, Volume 429, Issue 3-4, pp. 197 - 203
We investigated the role of leukotriene B-4 (LTB4)-leukotriene receptor (BLT) signaling in preadipocyte differentiation into mature adipocytes. Blockade of BLT... 
Human | GAMMA | Adipocyte | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | siRNA | PROLIFERATION | ADENOCARCINOMA CELL-LINE | Leukotriene | OBESITY | BIOPHYSICS | Receptor | BETA-IG-H3 | PATHWAY | INSULIN-RESISTANCE | LIPOXIN | BIOSYNTHESIS | Preadipocyte | TGFBI | Differentiation
Journal Article
by Park, J and Jang, JH and Park, GS and Chung, Y and You, HJ and Kim, JH
BMB REPORTS, ISSN 1976-6696, 2018, Volume 51, Issue 8, pp. 373 - 377
Triple-negative breast cancer (TNBC) is considered to be a notorious type of cancer due to its aggressive metastatic potential and poor prognosis. Recent... 
SURVIVAL | CELLS | CYTOKINES | Leukotriene B4 receptor-2 | BIOCHEMISTRY & MOLECULAR BIOLOGY | MONOCYTES | PHENOTYPE | IL-6 | Triple-negative breast cancer | ADHESION | INVASION | BLT2 | GROWTH | TNBC | EXPRESSION
Journal Article
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