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CLINICAL AND EXPERIMENTAL ALLERGY, ISSN 0954-7894, 08/2013, Volume 43, Issue 8, pp. 902 - 913
Background Cysteinyl leukotrienes contribute to Th2-type inflammatory immune responses. Their levels in oesophageal tissue, however, do not distinguish... 
MONTELUKAST | FC-EPSILON-RI | leukotriene | eosinophilic gastrointestinal diseases | EXPRESSION PROFILE | VALIDATION | arachidonic acid metabolism | IMMUNOLOGY | GASTROENTERITIS | CHILDREN | ALLERGY | reflux oesophagitis | PEDIATRIC-PATIENTS | SERUM IGE LEVELS | GENE-EXPRESSION | DIAGNOSTIC UTILITY | Th2 immune response
Journal Article
JOURNAL OF CLINICAL INVESTIGATION, ISSN 0021-9738, 02/1998, Volume 101, Issue 4, pp. 834 - 846
Aspirin causes bronchoconstriction in aspirin-intolerant asthma (AIA) patients by triggering cysteinyl-leukotriene (cys-LT) production, probably by removing... 
MEDICINE, RESEARCH & EXPERIMENTAL | HUMAN-LEUKOCYTES | MAST-CELL ACTIVATION | URINARY LEUKOTRIENE-E4 | NASAL SECRETIONS | cyclooxygenase | INHALED LYSINE-ASPIRIN | AIRWAY-OBSTRUCTION | BRONCHOALVEOLAR LAVAGE | HUMAN EOSINOPHILS | leukotriene C-4 synthase | aspirin | MOLECULAR-CLONING | 5-lipoxygenase | SENSITIVE ASTHMATICS
Journal Article
JOURNAL OF BIOCHEMISTRY, ISSN 0021-924X, 05/2013, Volume 153, Issue 5, pp. 421 - 429
The cysteinyl leukotrienes (cys-LTs), leukotriene C-4 (LTC4) and its metabolites, LTD4 and LTE4, are proinflammatory lipid mediators in asthma and other... 
leukotriene | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PULMONARY INFLAMMATION | INDOMETHACIN | RECEPTOR | VASCULAR-PERMEABILITY | in silico screening | enzyme inhibitor | inflammation | STRUCTURAL BASIS | CLONING | BIOSYNTHESIS | membrane protein | EXPRESSION | REVEALS
Journal Article
FASEB JOURNAL, ISSN 0892-6638, 04/2011, Volume 25, Issue 4, pp. 1417 - 1427
Cysteinyl leukotrienes (cysLTs) are potent proinflammatory mediators with particular relevance for asthma. However, control of cysLT biosynthesis in the time... 
COLONY-STIMULATING FACTOR | DENDRITIC CELLS | Toll-like receptor 2 | BIOCHEMISTRY & MOLECULAR BIOLOGY | PERITONEAL-MACROPHAGES | PHOSPHOLIPASE A | acetylsalicylic acid | CELL BIOLOGY | eicosanoids | macrophages | GROWTH-FACTOR-BETA | EICOSANOID GENERATION | IN-VIVO | BIOLOGY | TRANSCELLULAR BIOSYNTHESIS | REGULATES 5-LIPOXYGENASE ACTIVITY | CYSTEINYL-LEUKOTRIENES
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2015, Volume 290, Issue 8, pp. 5015 - 5027
Leukotriene-C-4 synthase (LTC4S) generates LTC4 from arachidonic acid metabolism. LTC4 is a proinflammatory factor that acts on plasma membrane cysteinyl... 
SMOOTH-MUSCLE | CRAC CURRENTS | OPERATED CALCIUM-ENTRY | STIM1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | MUSCLE-CELL PROLIFERATION | PROMOTER POLYMORPHISM | ORAI1 | CYSTEINYL-LEUKOTRIENES | I-CRAC | C-4 SYNTHASE
Journal Article
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, ISSN 1388-1981, 11/2016, Volume 1861, Issue 11, pp. 1605 - 1613
Cysteinyl leukotrienes (cys-LTs) cause bronchoconstriction in anaphylaxis and asthma. They are formed by 5-lipoxygenase (5-LOX) from arachidonic acid (AA)... 
CYSLT RECEPTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | 5-LIPOXYGENASE-ACTIVATING PROTEIN | HUMAN POLYMORPHONUCLEAR LEUKOCYTES | Leukotriene C-4 | GLUTATHIONE METABOLISM | CELL BIOLOGY | Assay | BIOPHYSICS | HEK293 cells | BIOSYNTHESIS | PHARMACOLOGY | BIOCHEMISTRY | SUPERFAMILY | Inhibitor | LTC4 synthase | MEMBRANE-ASSOCIATED PROTEINS | IN-SITU
Journal Article
by Sun, LH and Chen, AH and Yang, ZF and Chen, JJ and Guan, WD and Wu, JL and Qin, S and Zhong, NS
RESPIROLOGY, ISSN 1323-7799, 11/2013, Volume 18, pp. 40 - 46
Background and objectiveRespiratory syncytial virus (RSV) results in acute wheezing in infants and is frequently associated with recurrent wheezing. Although... 
BRONCHIOLITIS | bronchial epithelial cell | APOPTOSIS | cysteinyl leukotriene | BUDESONIDE | PROLIFERATION | RELEASE | CYSTEINYL LEUKOTRIENES | CELLULAR GROWTH | IL-8 SECRETION | RESPIRATORY SYSTEM | corticosteroid | MTT COLORIMETRIC ASSAY | CORTICOSTEROIDS | respiratory syncytial virus
Journal Article
Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), ISSN 0952-3278, 2003, Volume 69, Issue 2, pp. 111 - 116
Journal Article
The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 2002, Volume 109, Issue 6, pp. 936 - 942
Background: The A to C transversion in the promoter region of the gene encoding leukotriene C-4 synthase (LTC4S) is proposed to be associated with the... 
ANTAGONIST | INTOLERANT ASTHMA | URINARY LEUKOTRIENE-E4 | EOSINOPHILS | TRANSCRIPTION | polymorphism | IMMUNOLOGY | 11-DEHYDROTHROMBOXANE B-2 | EXCRETION | GENE | ALLERGY | leukotriene C-4 synthase | aspirin-induced asthma | cysteinyl leukotrienes | 5-lipoxygenase | EXPRESSION | SENSITIVE ASTHMA
Journal Article
JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY, ISSN 1018-9068, 2009, Volume 19, Issue 5, pp. 375 - 382
Background: Cysteinyl leukotriene production seems to be dysregulated in patients with hypersensitivity to aspirin and other nonsteroidal anti-inflammatory... 
INTOLERANT ASTHMA | CHRONIC IDIOPATHIC URTICARIA | ALLELIC VARIANT | PROMOTER POLYMORPHISM | IMMUNOLOGY | LTC4S | Histamine | ALLERGY | Leukotrienes | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | NSAIDs | KOREAN POPULATION | COLOMBIAN POPULATION | JAPANESE PATIENTS | Aspirin-induced urticaria | BLOMIA-TROPICALIS | HYPERSENSITIVITY
Journal Article
Clinical and Experimental Allergy, ISSN 0954-7894, 08/2011, Volume 41, Issue 8, pp. 1050 - 1053
Journal Article
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, ISSN 1079-5642, 02/2007, Volume 27, Issue 2, pp. 394 - 399
Objective - A majority of the recognized risk factors for atherosclerosis and the development of cardiovascular disease have been derived from the study of... 
atherosclerosis | INTIMAL-MEDIAL THICKNESS | RISK-FACTORS | leukotriene | ASPIRIN-INTOLERANT ASTHMA | coronary artery calcification | 5-LIPOXYGENASE-ACTIVATING PROTEIN | ELECTRON-BEAM CT | BLOOD-PRESSURE | epidemiology | CARDIOVASCULAR-DISEASE | PERIPHERAL VASCULAR DISEASE | MULTILOCUS GENOTYPING ASSAY | calcification | HEMATOLOGY
Journal Article
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, ISSN 1538-7933, 08/2010, Volume 8, Issue 8, pp. 1694 - 1701
Background: Atherosclerosis is an inflammatory condition where cysteinyl leukotrienes have been identified to play an important role. Furthermore, cysteinyl... 
C-REACTIVE PROTEIN | MYOCARDIAL-INFARCTION | myocardial infarction | HUMAN-ENDOTHELIAL-CELLS | STROKE | ISCHEMIC CEREBROVASCULAR-DISEASE | HEART-DISEASE | 5-Lipoxygenase pathway | GENE | NONFASTING TRIGLYCERIDES | venous thromboembolism | cysteinyl leukotrienes | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | ASSOCIATION | ischemic stroke | CORONARY-ARTERY-DISEASE
Journal Article
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, ISSN 1079-5642, 05/2008, Volume 28, Issue 5, pp. 990 - 996
Objective-Cysteinyl leukotrienes are involved in inflammation and possibly in early carotid atherosclerosis. We tested the hypothesis that the -444 A/C and... 
atherosclerosis | STROKE | WOMEN | cysteinyl leukotrienes | PERIPHERAL VASCULAR DISEASE | ischemic cerebrovascular disease | MECHANISMS | LTC4 synthase | HEMATOLOGY | ASSOCIATION | EXPRESSION | 5-lipoxygenase pathway
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 2009, Volume 603, Issue 1, pp. 98 - 107
Asiatic acid is a triterpenoid component possessing antioxidative, anti-inflammatory and hepatoprotective activity. In this issue, we explored the protective... 
Redox | Asiatic acid | D-galactosamine/lipopolysaccharide | Leukotriene C 4 synthase | Hepatotoxicity | ACUTE LIVER-FAILURE | OXIDATIVE STRESS | ANTIINFLAMMATORY ACTIVITY | RAT HEPATOCYTES | Leukotriene C-4 synthase | KAPPA-B | SYNTHESIS ENZYMES | IN-VIVO | TRITERPENE ACIDS | PHARMACOLOGY & PHARMACY | FULMINANT HEPATIC-FAILURE | CYSTEINYL-LEUKOTRIENES
Journal Article
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, ISSN 0091-6749, 07/2000, Volume 106, Issue 1, pp. 72 - 76
Background: Approximately 10% of patients with asthma have a distinct clinical entity in which their symptoms are exacerbated by aspirin and most other... 
PROTEIN | RECEPTOR ANTAGONIST MK-0679 | polymorphism | ARACHIDONIC-ACID | IMMUNOLOGY | EXCRETION | aspirin-intolerant asthma | LEUKOCYTES | ALLERGY | leukotriene C-4 synthase | cysteinyl leukotrienes | 5-LIPOXYGENASE | SENSITIVE ASTHMATICS | ASSOCIATION | SEVERITY | TRANSFERASE
Journal Article
CELLULAR AND MOLECULAR LIFE SCIENCES, ISSN 1420-682X, 01/2005, Volume 62, Issue 1, pp. 87 - 94
Cysteinyl-leukotrienes (cys-LTs) are potent smooth muscle contracting agents, which play key roles in inflammatory and allergic diseases. The committed step in... 
POLYMORPHONUCLEAR LEUKOCYTES | HUMAN-PLATELETS | GSH S-transferase | CYSLT RECEPTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | fever | ASPIRIN-INTOLERANT ASTHMA | VEIN ENDOTHELIAL-CELLS | IDENTIFICATION | leukotrienes | CELL BIOLOGY | CYSTEINYL LEUKOTRIENES | inflammation | BIOSYNTHESIS | MOLECULAR-CLONING | LTC4 synthase | EXPRESSION
Journal Article
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ISSN 0006-291X, 02/2008, Volume 366, Issue 1, pp. 80 - 85
Leukotriene C-4 synthase is a key enzyme in leukotriene biosynthesis. Its gene has been cloned and mapped to mouse chromosome 11. Expression occurs in cells of... 
MOUSE-BRAIN | ACTIVATION | expression | TPA | DMSO | leukotriene | BIOCHEMISTRY & MOLECULAR BIOLOGY | INDUCTION | GFP | retinoic acid | BIOPHYSICS | GENE | CLONING | SP1 | leukotriene C-4 synthase | promoter | INHIBITORS | C4 SYNTHASE
Journal Article
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, ISSN 0306-5251, 10/2003, Volume 56, Issue 4, pp. 422 - 426
Aim Cysteinyl leukotrienes are important pro-inflammatory mediators in the pathogenesis of asthma, while leukotriene C-4 synthase is a key enzyme in their... 
MONTELUKAST | THERAPY | ADENOSINE-MONOPHOSPHATE | leukotriene receptor antagonist | ALLERGIC RHINITIS | PHARMACOLOGY & PHARMACY | asthma | bronchial hyperresponsiveness | CLINICAL-RESPONSE
Journal Article
Journal of Molecular and Cellular Cardiology, ISSN 0022-2828, 2009, Volume 46, Issue 4, pp. 579 - 586
Journal Article
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