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Journal Article
International Journal of Molecular Medicine, ISSN 1107-3756, 06/2016, Volume 37, Issue 6, pp. 1619 - 1626
Previous studies have demonstrated that zinc (Zn) is an essential trace element which is involved in male reproduction. The zinc transporter (ZnT) family,... 
SiRNA | Testosterone synthesis | Zinc | Leydig cells | Zinc transporter | MEDICINE, RESEARCH & EXPERIMENTAL | STEROIDOGENESIS | SYNAPTIC VESICLES | HUMAN HEALTH | GOLGI-APPARATUS | siRNA | zinc transporter | RAT TESTIS | DEFICIENCY | ACUTE REGULATORY PROTEIN | GENE | testosterone synthesis | PANCREATIC BETA-CELLS | zinc | SLC30 FAMILY
Journal Article
Journal of Agricultural and Food Chemistry, ISSN 0021-8561, 09/2011, Volume 59, Issue 18, pp. 9885 - 9891
Journal Article
Reproductive Biology and Endocrinology, ISSN 1477-7827, 07/2013, Volume 11, Issue 1, p. 72
Background: The ubiquitous use of dibutyl phthalate (DBP), one of the most widely used plasticizers, results in extensive exposure to humans and the... 
Mouse Leydig tumor cells | CCAAT/enhancer binding protein-beta | Steroidogenic factors 1 | Monobutyl phthalate | Progesterone | Steroidogenic acute regulatory protein | GATA-4 | TRANSCRIPTION FACTORS | PROMOTER ACTIVITY | FACTOR-I | REPRODUCTIVE BIOLOGY | DI(N-BUTYL) PHTHALATE | URINARY PHTHALATE | ENDOCRINOLOGY & METABOLISM | STAR GENE | BISPHENOL-A | BINDING | EXPOSURE | ACID ESTERS | Cell Survival - drug effects | GATA4 Transcription Factor - metabolism | Male | Phosphoproteins - genetics | Phosphoproteins - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Promoter Regions, Genetic - genetics | Blotting, Western | CCAAT-Enhancer-Binding Protein-beta - metabolism | Chorionic Gonadotropin - pharmacology | Leydig Cell Tumor - metabolism | Dose-Response Relationship, Drug | Gene Expression Regulation - drug effects | Leydig Cell Tumor - genetics | DAX-1 Orphan Nuclear Receptor - metabolism | Animals | Leydig Cell Tumor - pathology | Cell Line, Tumor | Protein Binding | Progesterone - biosynthesis | Mice | Phthalic Acids - pharmacology | Steroidogenic Factor 1 - metabolism | Steroids - biosynthesis | Usage | Transcription factors | RNA | Cytochrome P-450 | DNA binding proteins | Genetic transcription | Phthalates | Placental hormones | Leydig cells | Genetic research | Sodium bicarbonate | Carbonates | Steroid hormones | Protein binding | Studies | Reproductive health | Proteins | Polymerase chain reaction | Cell culture | Biosynthesis | Regulation | Polyvinyl chloride | Gene expression | Drug dosages
Journal Article
ONCOLOGY REPORTS, ISSN 1021-335X, 06/2019, Volume 41, Issue 6, pp. 3565 - 3574
In the western world, there is an increasing trend of occurrence in testicular cancer. Treatment of malignant testicular cancer is primarily combined surgery... 
OVARIAN-CANCER CELLS | SURVIVAL | ACTIVATION | mitogen-activated protein kinase pathway | DEMOLITION | propofol | PROTEIN-KINASE | ER STRESS | apoptosis | Leydig tumor cell | Akt pathway | AUTOPHAGY | INVASION | ONCOLOGY | SEDATION | caspase cascade | UP-REGULATION
Journal Article
ONCOLOGY LETTERS, ISSN 1792-1074, 07/2019, Volume 18, Issue 1, pp. 944 - 954
The incidence of testicular cancer is increasing worldwide. Leydig cell tumors represent one type of sex cord-stromal testis malignancy, which tend to respond... 
sodium arsenite | STEROIDOGENESIS | TRIOXIDE | apoptosis | DEATH | ENDOPLASMIC-RETICULUM STRESS | caspase | testicular cancer | ONCOLOGY | Leydig cells | CORDYCEPIN | GROWTH | dimethylarsenic acid | EXPRESSION | BH3-ONLY PROTEINS | ACUTE PROMYELOCYTIC LEUKEMIA | CYCLE
Journal Article
Biology of Reproduction, ISSN 0006-3363, 2012, Volume 87, Issue 6, p. 150
Mast cells (MC) occur normally in the testis with a species-specific distribution, yet their precise role remains unclear. Testicular MC express histidine... 
Testis | Histamine | Signal transduction | Reproductive immunology | Cyclic adenosine monophosphate (cAMP) | histamine | signal transduction | HUMAN TESTIS | MAST-CELLS | L-HISTIDINE DECARBOXYLASE | testis | TIME-COURSE | cyclic adenosine monophosphate (cAMP) | LUTEINIZING-HORMONE | MALE-INFERTILITY | STEROID-PRODUCTION | REPRODUCTIVE BIOLOGY | RECEPTOR SUBTYPES | reproductive immunology | GROWTH-FACTOR | INDUCED INHIBITION | Leydig Cells - cytology | Leydig Cells - enzymology | Receptors, Histamine H2 - chemistry | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Male | Neoplasm Proteins - antagonists & inhibitors | Stem Cells - cytology | Extracellular Signal-Regulated MAP Kinases - metabolism | Leydig Cells - drug effects | Neoplasm Proteins - metabolism | Stem Cells - metabolism | Leydig Cell Tumor - metabolism | Histamine - metabolism | Histamine Agonists - metabolism | Leydig Cell Tumor - drug therapy | Protein Processing, Post-Translational - drug effects | Leydig Cells - metabolism | Phosphorylation - drug effects | Cyclic AMP - metabolism | Receptors, Histamine H2 - metabolism | Histidine Decarboxylase - antagonists & inhibitors | Leydig Cell Tumor - enzymology | Second Messenger Systems - drug effects | Neoplasm Proteins - biosynthesis | Cells, Cultured | Enzyme Inhibitors - pharmacology | Histidine Decarboxylase - metabolism | Rats | Rats, Sprague-Dawley | Cyclic AMP - antagonists & inhibitors | Animals | Histidine Decarboxylase - biosynthesis | Cell Line, Tumor | Stem Cells - drug effects | Cell Proliferation - drug effects | Mice | Histamine Agonists - pharmacology
Journal Article
OncoTargets and therapy, ISSN 1178-6930, 2015, Volume 8, Issue default, pp. 2345 - 2360
Chemotherapy is not limited to a single treatment, and the evidence demonstrates that different drug combinations can have positive results in patients. In... 
Usage | Paclitaxel | Leydig cells | Nucleosides | Dosage and administration | Models | Observations | Health aspects | Cisplatin | Drug synergism | Apoptosis
Journal Article
Lipids in Health and Disease, ISSN 1476-511X, 2011, Volume 10, Issue 1, pp. 158 - 158
Background: Vitamin K is essential for the posttranslational modification of various Gla proteins. Although it is widespread in several organs, including the... 
menaquinone-4 | testis | testosterone | protein kinase A | vitamin K | I-10 cells | PROTEIN-KINASE-A | HEPATOCELLULAR-CARCINOMA CELLS | INDEPENDENT MECHANISM | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | XENOBIOTIC RECEPTOR SXR | VITAMIN-K SUPPRESSES | FACTOR-KAPPA-B | OSTEOBLASTIC CELLS | NUTRITION & DIETETICS | BIOSYNTHESIS | PHYLLOQUINONE | Cholesterol Side-Chain Cleavage Enzyme - metabolism | Testis - metabolism | Rats, Wistar | Cyclic AMP-Dependent Protein Kinases - chemistry | Male | Leydig Cells - drug effects | Vitamin K 1 - metabolism | Testis - drug effects | Tissue Distribution | Testosterone - metabolism | Liver - drug effects | Protein Processing, Post-Translational - drug effects | Leydig Cells - metabolism | Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors | Phosphorylation - drug effects | Testosterone - blood | Vitamin K 2 - pharmacokinetics | Cyclic AMP-Dependent Protein Kinases - metabolism | Specific Pathogen-Free Organisms | Liver - metabolism | Rats | Up-Regulation - drug effects | Vitamin K 2 - analogs & derivatives | Animals | Carbon-Carbon Ligases - antagonists & inhibitors | Cyclic AMP Response Element-Binding Protein - metabolism | Cell Line, Tumor | Mice | Protein Kinase Inhibitors - pharmacology | Vitamin K 1 - antagonists & inhibitors | Vitamin K 2 - pharmacology | Testosterone | Usage | Physiological aspects | Research | Protein kinases | Health aspects | Enzyme-linked immunosorbent assay | Vitamin K | Proteins | Plasma | Nutrition research | Diet | Rodents | Science | Pituitary gland | Kinases | Gene expression | Manuscripts | Cholesterol
Journal Article