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Developmental Biology, ISSN 0012-1606, 12/2017, Volume 432, Issue 2, pp. 258 - 264
The adult intestinal stem cells (ISCs) are transcriptionally heterogeneous. As the mechanisms governing their developmental specification are still poorly... 
Cellular heterogeneity | Lgr5+ stem cell | Embryonic intestinal epithelial progenitors | Anterior-posterior patterning | Lgr5 | stem cell | MOUSE | ENDODERM | COLON | DEVELOPMENTAL BIOLOGY | Lgr5(+) stem cell | SPECIFICATION | WNT/BETA-CATENIN | DIFFERENTIATION | RECEPTORS | LINEAGE | LGR4 | Index Medicus
Journal Article
Cell Stem Cell, ISSN 1934-5909, 06/2017, Volume 20, Issue 6, pp. 801 - 816.e7
Highly proliferative Lgr5+ stem cells maintain the intestinal epithelium and are thought to be largely homogeneous. Although quiescent intestinal stem cell... 
chemotherapy resistance | Lgr5+ ISC heterogeneity | quiescent stem cell | INTESTINAL STEM | PROGENITOR CELLS | REPLACEMENT | IN-VITRO | MOUSE | CRYPT | BETA-CATENIN | IDENTIFICATION | EXPRESSION | LGR5 | CELL & TISSUE ENGINEERING | CELL BIOLOGY | Index Medicus | RNA | Cèl·lules mare | Stem cells
Journal Article
EMBO Journal, ISSN 0261-4189, 09/2014, Volume 33, Issue 18, pp. 2057 - 2068
Journal Article
International Journal of Biological Sciences, ISSN 1449-2288, 2019, Volume 15, Issue 1, pp. 34 - 43
Lgr5-expressing stem cells contribute to the epithelial turnover of the gastric antrum. However, the mechanism controlling the homeostasis of Lgr5(+ )antral... 
stem cells | Gastric epithelium | Homeostasis | Lgr5 | E-cadherin | Apoptosis | Lgr5+ stem cells | SURVIVAL | REGENERATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | gastric epithelium | apoptosis | SMALL-INTESTINE | Lgr5(+) stem cells | IDENTIFICATION | CANCER | homeostasis | EPITHELIUM | STOMACH | Phenotypes | Cell survival | Clonal deletion | Organoids | p53 Protein | Stem cells | Deletion | Mutants
Journal Article
Nature, ISSN 0028-0836, 09/2014, Volume 513, Issue 7518, pp. 422 - 5
Journal Article
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, ISSN 1661-6596, 07/2019, Volume 20, Issue 14, p. 3547
Lgr5, an intestinal adult stem cell marker, was recently also found in neuronal tissues. We investigated whether retinal Lgr5(+) cells express properties of... 
stem cells | amacrine cells | BIOCHEMISTRY & MOLECULAR BIOLOGY | FATE DETERMINATION | RECEPTOR | retinal development | CHEMISTRY, MULTIDISCIPLINARY | IN-VITRO | GENE | Lgr5(+) cells | LIVER | transcriptomics | interneurons | Lgr5+ cells
Journal Article
Cell Reports, ISSN 2211-1247, 08/2018, Volume 24, Issue 9, pp. 2312 - 2328.e7
IBD syndromes such as Crohn’s disease and ulcerative colitis result from the inflammation of specific intestinal segments. Although many studies have reported... 
GSK3β | SCF | regenerative response | Paneth cells | Wnt | cKit | inflammatory bowel disease | Lgr5+ stem cells | PI3K/AKT | stem cells | Lgr5 | IN-VITRO | COLITIS | SMALL-INTESTINE | C-KIT | COLON | COLORECTAL-CANCER CELLS | IDENTIFICATION | LGR5 | BOWEL-DISEASE | TRANSGENIC MICE | CELL BIOLOGY
Journal Article
Experimental Cell Research, ISSN 0014-4827, 02/2019, Volume 375, Issue 1, pp. 42 - 51
Protein kinase RNA-like Endoplasmic Reticulum Kinase (PERK) is an endoplasmic reticulum stress sensor that possesses pro-survival capability and contributes to... 
Intestinal stem cell | Leucine-rich repeat-containing G-protein coupled receptor 5 (Lgr5) | PERK | Leucine-rich repeat-containing G-protein | ONCOLOGY | coupled receptor 5 (Lgr5) | RESISTANCE | ENDOPLASMIC-RETICULUM STRESS | DIFFERENTIATION | TRANSLATION | CELL BIOLOGY
Journal Article
Nature genetics, ISSN 1061-4036, 11/2017, Volume 49, Issue 11, pp. 1624 - 1632
The G-protein-coupled receptors Lgr4/5/6 are Wnt signalling mediators, but their functions in squamous carcinomas (SCCs) are unclear. Using lineage tracing in... 
skin | stem cells | Lgr5 | Lgr6 | lineage tracing
Journal Article