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PLoS ONE, ISSN 1932-6203, 01/2013, Volume 8, Issue 1, p. e52530
High cell-surface GnRH receptor (GnRH-R) levels have been shown to have a major influence on the extent of GnRH agonist-mediated tumor growth inhibition. The... 
ANTAGONIST CETRORELIX | IN-VITRO | MESSENGER-RIBONUCLEIC-ACID | GONADOTROPIN-RELEASING-HORMONE | MULTIDISCIPLINARY SCIENCES | MEDROXYPROGESTERONE ACETATE | LH-RH | ANTIGEN GENE-EXPRESSION | HUMAN-BREAST | MOLECULAR-SIZE | HUMAN ENDOMETRIAL | Binding, Competitive | Prostatic Neoplasms - metabolism | Prostatic Neoplasms - pathology | Receptors, LHRH - agonists | Receptors, LHRH - genetics | Antineoplastic Agents, Hormonal - pharmacology | Humans | Leuprolide - metabolism | Gonadotropin-Releasing Hormone - pharmacology | Male | Antineoplastic Agents, Hormonal - metabolism | Blotting, Western | Gonadotropin-Releasing Hormone - metabolism | HEK293 Cells | Cell Line, Tumor | Microscopy, Atomic Force - methods | Receptors, LHRH - metabolism | Binding Sites | Leuprolide - pharmacology | Atomic force microscopy | Androgens | Oncology, Experimental | Microscope and microscopy | Neurohormones | Research | Prostate cancer | Acetates | Cancer | Post-transcription | Atomic beam spectroscopy | Kinases | Cancer therapies | Cell surface | Western blotting | Signal transduction | Receptors | Cell growth | Cattle | Rodents | Spectrum analysis | Penicillin | Bonding strength | Medical research | Spectroscopy | Narcotics | Mechanical properties | Gene expression | Antibiotics | Microscopy | Cells (biology) | Gonadotropin-releasing hormone | Acetic acid | Prostate | Endocrinology | Apoptosis | Tumors
Journal Article
Journal Article
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 10/2003, Volume 9, Issue 12, pp. 4505 - 4513
Purpose and Experimental Design: To improve conventional chemotherapy, we developed cytotoxic analogues of luteinizing hormone-releasing hormone (LH-RH), which... 
HUMAN OVARIAN CANCERS | ANTAGONIST CETRORELIX | NUDE-MICE | GROWTH-INHIBITION | ONCOLOGY | MESSENGER-RNA EXPRESSION | LH-RH | GENE-EXPRESSION | BONE METASTASIS | CELL-LINES | TUMOR-GROWTH | Receptor, ErbB-3 - metabolism | Receptors, LHRH - genetics | Triptorelin Pamoate - pharmacology | Apoptosis - drug effects | Humans | Receptor, ErbB-2 - metabolism | Gonadotropin-Releasing Hormone - pharmacology | Male | Peptide Fragments - pharmacology | Transplantation, Heterologous | RNA, Messenger - metabolism | Gonadotropin-Releasing Hormone - analogs & derivatives | RNA, Neoplasm - metabolism | Neoplasms, Experimental - pathology | Receptor, Epidermal Growth Factor - metabolism | Doxorubicin - analogs & derivatives | Receptors, LHRH - metabolism | Tumor Cells, Cultured | Drug Evaluation, Preclinical | Gonadotropin-Releasing Hormone - agonists | Prostatic Neoplasms - drug therapy | Prostatic Neoplasms - pathology | Androgens - physiology | Antineoplastic Agents, Hormonal - pharmacology | RNA, Messenger - genetics | Reverse Transcriptase Polymerase Chain Reaction | Prostate-Specific Antigen - blood | Prostatic Neoplasms - secondary | Animals | Mice, Nude | Neoplasms, Hormone-Dependent - pathology | RNA, Neoplasm - genetics | Mice | Neoplasms, Hormone-Dependent - drug therapy | Neoplasms, Experimental - drug therapy | Doxorubicin - pharmacology
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2013, Volume 8, Issue 11, p. e79384
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/1999, Volume 96, Issue 2, pp. 669 - 673
The selectivity of ligands specific for certain cells can be used to preferentially target chemotherapeutic compounds to neoplastic cells. Human breast,... 
COS cells | Receptors | Cell growth | DNA | Cell lines | DNA fragmentation | Antibodies | Hormones | Viability | Apoptosis | ANTAGONIST CETRORELIX | 2-PYRROLINODOXORUBICIN | POTENT | INHIBITION | CANCERS | MULTIDISCIPLINARY SCIENCES | LH-RH | DOXORUBICIN | GROWTH | 500-1000 TIMES | PROTEASES | Gonadotropin releasing hormone | Cell death | Cancer cells | Physiological aspects | Cytopathology | Research | Antineoplastic agents | Cancer
Journal Article
Journal Article